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Aggregate 2024年第2期5卷 386-400页

作者： Bruna Gregatti Carvalho Aya Nakayama Hiromi Miwa sangwon han Lucimara Gaziola de la Torre Dino Di Carlo Junmin Lee han-Jun Kim Ali Khademhosseini Natan Roberto de Barros Terasaki Institute for Biomedical Innovation(TIBI) Los AngelesCaliforniaUSA Department of Materials and Bioprocess Engineering School of Chemical EngineeringUniversity of Campinas(UNICAMP)CampinasBrazil Department of Bioengineering University of California at Los Angeles(UCLA)Los AngelesCaliforniaUSA Department of Biophysics Paulista School of MedicineFederal University of São Paulo(UNIFESP)CampinasBrazil Department of Materials Science and Engineering Pohang University of Science and Technology(POSTECH)PohangRepublic of Korea Institute for Convergence Research and Education in Advanced Technology Yonsei UniversityIncheonRepublic of Korea College of Pharmacy Korea UniversityPohangRepublic of Korea Centre for Biomaterials Cellular and Molecular Theranostics(CBCMT)Vellore Institute of Technology(VIT)VelloreIndia

Messenger RNA(mRNA)therapy is the intracellular delivery of mRNA to produce desired therapeutic *** strategies for local mRNA delivery is still required where direct intra-articular injections are inappropriate for targeting a specific *** mRNA delivery efficiency depends on protecting nucleic acids against nuclease-mediated degradation and safe site-specific intracellular ***,novel mRNA-releasing matrices based on RGD-moiety-rich gelatin methacryloyl(GelMA)microporous annealed particle(MAP)scaffolds are *** concentration in aerogel-based microgels(μgels)produced through a microfluidic process,MAP stiffnesses,and microporosity are crucial parameters for cell adhesion,spreading,and *** being loaded with mRNA complexes,MAP scaffolds composed of 10%GelMAμgels display excellent cell viability with increasing cell infiltration,adhesion,proliferation,and gene *** intracellular delivery is achieved by the sustained release of mRNA complexes from MAP scaffolds and cell adhesion on mRNA-releasing *** findings highlight that hybrid systems can achieve efficient protein expression by delivering mRNA complexes,making them promising mRNA-releasing biomaterials for tissue engineering.

关键词： GelMA lipid-based nanocarriers MAP scaffolds microfluidics mRNA

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Structure of Abelian rings

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Frontiers of Mathematics in China 2017年第1期12卷 117-134页

作者： Juncheol han Yang LEE sangwon PARK Department of Mathematics Education Pusan National University Pusan 46241 Korea Department of Mathematics Dong-A University~ Pusan 49315 Korea

Let R be a ring with identity. We use J（R）, G（R）, and X（R） to denote the Jacobson radical, the group of all units, and the set of all nonzero nonunits in R, respectively. A ring is said to be Abelian if every idempotent is central. It is shown, for an Abelian ring R and an idempotent-lifting ideal N J（R） of R, that H has a complete set of primitive idempotents if and only if R/N has a complete set of primitive idempotents. The structure of an Abelian ring R is completely determined in relation with the local property when X（R） is a union of 2, 3, 4, and 5 orbits under the left regular action on X（R） by G（R）. For a semiperfect ring R which is not local, it is shown that if G（R） is a cyclic group with 2 ∈ G（R）, then R is finite. We lastly consider two sorts of conditions for G（R） to be an Abelian group.

关键词： Abelian ring regular group action local ring semiperfect ring finite ring Abelian group idempotent-lifting complete set of primitive idempotents

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