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Acta Pharmaceutica Sinica B 2022年第11期12卷 4249-4261页

作者： sang hoon lee Jae Geun Song Hyo-Kyung Han College of Pharmacy Dongguk University-SeoulGoyang 10326South Korea

This study aimed to develop a pH-responsive folic acid-grafted organic/inorganic hybrid nanocomposite system for site-selective oral delivery of therapeutic antibodies. A folic acid-grafted aminoclay(FA-AC) was prepared via an in situ sol-gel method. Then, a drug-loaded nanocomplex was prepared via the electrostatic interaction of FA-AC with infliximab(IFX), a model antibody, and coated with Eudragit? S100(EFA-AC-IFX). FA-AC exhibited favorable profiles as a drug carrier including low cytotoxicity, good target selectivity, and capability to form a nanocomplex with negatively charged macromolecules. A pH-responsive FA-AC-based nanocomplex containing IFX(EFA-AC-IFX) was also obtained in a narrow size distribution with high entrapment efficiency(>87%). The conformational stability of IFX entrapped in EFA-AC-IFX was well maintained in the presence of proteolytic enzymes. EFA-ACIFX exhibited pH-dependent drug release, minimizing premature drug release in gastric conditions and the upper intestine. Accordingly, oral administration of EFA-AC-IFX to colitis-induced mice was effective in alleviating the progression of ulcerative colitis, while oral IFX solution had no efficacy. These results suggest that a pH-responsive FA-AC-based nanocomposite system can be a new platform for the site-selective oral delivery of therapeutic antibodies.

关键词： Infliximab Aminoclay Colonic delivery:TNF-x Infammation Folate rceptor Anibody Nanocomposite

Dispersion of ultrafine SiC particles in molten Al-12Si alloy

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 33-36页

作者： Jin-Ju PARK sang-hoon lee Min-Ku lee Chang-Kyu RHEE Nuclear Materials Research Division Korea Atomic Energy Research Institute Daejeon 305-353 Korea

The bulk A1-12 Si eutectic composites were fabricated through a conventional liquid metal casting route, especially with the help of ultrafine ceramic powders made by self-propagating high-temperature synthesis （SHS） process. The SHS powders were fabricated by the chemical reaction between micro-sized SiC and A1 particles at very high combustion temperatures, producing the coarse A1 particles （several tens of microns） containing ultrafine SiC ceramic particles. Microstructural observation revealed that the addition of ultrafine SiC particles has a crumbling tendency of Si eutectic phase. It is suggested that the casting method combined with SHS process is promising for fabricating the Al-based MMC with ultrafine ceramic particles.

关键词： AI-12Si alloy dispersion self-propagating high-temperature synthesis (SHS) ultrafine ceramic SiC

Inpatient use of racemic epinephrine for children admitted with croup

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World Journal of Pediatrics 2019年第6期15卷 586-594页

作者： Elaine Chiang Omar Afandi sang hoon lee Srinivasan Suresh Raymond DPitetti Sriram Ramgopal Division of Pediatric Emergency Medicine Department of PediatricsUniversity of Pittsburgh School of MedicinePittsburghPAUSA Department of Pediatrics University of Pittsburgh School of MedicinePittsburghPAUSA Department of Pediatrics University of CincinnatiCollege of MedicineCincinnatiOHUSA Division of Emergency Medicine Cincinnati Children's Hospital Medical CenterCincinnatiOHUSA Division of Health Informatics Department of PediatricsUniversity of Pittsburgh School of MedicineChildren's Hospital of PittsburghPittsburghPAUSA UPMC Children's Hospital of Pittsburgh PittsburghPAUSA

Background Pediatric patients with croup are frequently admitted if they require two doses of racemic epinephrine(RE)in the emergency department(ED).We aimed to identify factors associated with the need for additional therapy(>2 RE doses)among pediatric patients with *** We performed a single-center retrospective study of consecutive patients admitted from the ED with a diagnosis of croup between January 1,2011 and December 31,*** outcome was need for>2 doses of *** out-comes included time to third RE and 72-hour return *** performed logistic regression to identify factors associated with use of>2 RE doses during hospitalization,and survival analysis to identify time to dosing of 3rd RE from 2nd *** Of 353 included admissions[250(70.8%)males,median age 1.48,interquartile range 0.97-2.51 years],106/353(30.0%)required>2 *** univariate logistic regression,only recent use of steroids within 1 day prior to presentation(4.18,1.48-11.83;P=0.007)was associated with need for>2 *** from third RE was 0.74(95%CI 0.69-0.78),which was similar to the survival at 12 hours(0.70,95%CI 0.65-0.75).Return visits occurred in 19(5.4%)patients,of whom 12/19(63.2%)were given *** Patients hospitalized for croup with recent use of steroids prior to ED presentation have a greater need for>2 RE during *** majority who require inpatient RE will do so within 8-12 *** data provide informa-tion for risk stratification and duration of monitoring for patients hospitalized with croup.

关键词： Laryngotracheobronchitis Racemic epinephrine Spasmodic croup Steroids Viral croup

Fabrication of cast carbon steel with ultrafine TiC particles

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 54-57页

作者： sang-hoon lee Jin-Ju PARK Sung-Mo HONG Byoung-Sun HAN Min-Ku lee Chang-Kyu RHEE Nuclear Materials Research Division Korea Atomic Energy Research Institute Daejeon 305-353 Korea

The carbon steels dispersed with ultrafine TiC particles were fabricated by conventional casting method. The casting process is more economical than other available routes for metal matrix composite production, and the large sized components to be fabricated in short processing time. However, it is extremely difficult to obtain uniform dispersion of ultrafine ceramic particles in liquid metals due to the poor wettability and the specific gravity difference between the ceramic particle and metal matrix. In order to solve these problems, the mechanical milling (MM) and surface-active processes were introduced. As a result, Cu coated ultrafine TiC powders made by MM process using high energy ball milling machine were mixed with Sn powders as a surfactant to get better wettability by lowering the surface tension of carbon steel melt. The microstructural investigations by OM show that ultrafine TiC particles are distributed uniformly in carbon steel matrix. The grain sizes of the cast matrix with ultrafine TiC particles are much smaller than those without ultrafine TiC particles. This is probably due to the fact that TiC particles act as nucleation sites during solidification. The wear resistance of cast carbon steel composites added with MMed TiC/Cu-Sn powders is improved due to grain size refinement.

关键词： TiC particles mechanical milling carbon steel casting dispersion wettability

Formation of interfacial brittle phases sigma phase and IMC in hybrid titanium-to-stainless steel joint

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 7-11页

作者： Min Ku lee Jung Gu lee Jong Keuk lee Sung Mo HONG sang hoon lee Jin Ju PARK Jae Woo KIM Chang Kyu RHEE Nuclear Materials Research Division Korea Atomic Energy Research Institute Daejeon 305-353 Korea

The microstructures of the brazed joints for commercially pure Ti and stainless steel were investigated by the applications of various filler alloys including Ag-, Ti-, Zr- and Ni-based alloys. Generally, the dissimilar joints between Ti and stainless steel were dominated by the Ti-based intermetallic compounds （IMCs）, e.g. （Ti, Zr）2（Fe, Ni）, TiFe, TiCu, and Ti2（Fe, Ni）, due to a significant dissolution of Ti from the base metal. The （Fe-Cr） cr phase was also observed near the stainless steel due to a segregation of Cr into the interface region. This research demonstrates empirically that the brittleness of the Ti and stainless steel joint can not be avoided only by applying single braze alloy or single insert metal, and thus an introduction of additional suitable interlayer between the filler alloy and the base metal is necessary to prevent the brittleness of the joint.

关键词： brazing titanium stainless steel intermetallic compounds (IMCs)

Small bowel ulcer bleeding due to suspected clopidogrel use in a patient with clopidogrel resistance:A case report

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World Journal of Clinical Cases 2021年第15期9卷 3689-3695页

作者： sang hoon lee Dong Ryeol Ryu Sung Joon lee Sung Chul Park Byung Ryul Cho Seung Koo lee sang Ji Choi Hyun Seok Cho Division of Gastroenterology Department of Internal MedicineKangwon National University HospitalKangwon National University School of MedicineChuncheon-si 24289South Korea Division of Cardiology Department of Internal MedicineKangwon National University HospitalKangwon National University School of MedicineChuncheon-si 24289South Korea Department of Anatomic Pathology Kangwon National University HospitalKangwon National University School of MedicineChuncheon-si 24289South Korea Department of Surgery Kangwon National University HospitalKangwon National University School of MedicineChuncheon-si 24289South Korea Department of Hospital Medicine Kangwon National University HospitalChuncheon-si 24289South Korea

BACKGROUND Clopidogrel is a platelet aggregation inhibitor used for the management of cardiovascular *** antiplatelet therapy decreases cardiovascular events after successful coronary drug-eluting stenting,it increases the risk of gastrointestinal(GI)*** 20%of the patients who take clopidogrel exhibit resistance to the *** SUMMARY We report the first case of a small bowel bleeding ulcer in an 86-year-old man with clopidogrel *** had a history of taking clopidogrel due to unstable *** was no evidence of bleeding in the stomach,duodenum,or colon through upper and lower GI *** abdominal computed tomography showed the extravasation of radiocontrast media at the *** of unstable vital signs,emergency surgery was *** ulcers with inflammation were found in the *** pathologic findings revealed simple *** VerifyNow P2Y12 test showed clopidogrel *** year after changing to aspirin,capsule endoscopy was performed and the small bowel ulcers were *** Small bowel ulcers and bleeding due to clopidogrel are not very common,but the prevalence is expected to increase in older age patients with risk factors despite clopidogrel resistance.

关键词： Clopidogrel Resistance Small bowel Multiple ulcers Hematochezia Surgery Case report

Carcinoma of the middle bile duct:Is bile duct segmental resection appropriate?

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World Journal of Gastroenterology 2009年第47期15卷 5966-5971页

作者： Hyung Geun lee sang hoon lee Dong Do Yoo Kwang Yeol Paik Jin Seok Heo Seong Ho Choi Dong Wook Choi Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 135-710South Korea

AIM:To compare survival between bile duct segmental resection(BDSR)and pancreaticoduodenectomy(PD) for treating distal bile duct cancers. METHODS:Retrospective analysis was conducted for 45 patients in a BDSR group and for 149 patients in a PD group. RESULTS:The T-stage(P<0.001),lymph node invasion (P=0.010)and tumor differentiation(P=0.005)were significant prognostic factors in the BDSR *** 3-and 5-year overall survival rates for the BDSR group and PD group were 51.7%and 36.6%,respectively and 46.0%and 38.1%,respectively(P=0.099).The BDSR group and PD group did not show any significant difference in survival when this was adjusted for the TNM *** 3-and 5-year survival rates were: stageⅠa[BDSR(100.0%and 100.0%)vs PD(76.9% and 68.4%)(P=0.226)];stageⅠb[BDSR(55.8% and 32.6%)vs PD(59.3%and 59.3%)(P=0.942)]; stageⅡb[BDSR(19.2%and 19.2%)vs PD(31.9%and 14.2%)(P=0.669)]. CONCLUSION:BDSR can be justified as an alternative radical operation for patients with middle bile duct inselected patients with no adjacent organ invasion and resection margin is negative.

关键词： Bile duct cancer Segmental resection Pancreaticoduodenectomy

Gene editing of authentic Brassica rapa flavonol synthase 1 generates dihydroflavonol-accumulating Chinese cabbage

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Horticulture Research 2023年第12期10卷 58-69页

作者： sangkyu Park Hyo lee Jaeeun Song Chan Ju Lim Jinpyo Oh sang hoon lee Saet Buyl lee Jong-Yeol lee Sunhyung Lim Jin A.Kim Beom-Gi Kim Metabolic Engineering Division National Institute of Agricultural SciencesRural Development AdministrationJeonju54874South Korea Institute of Biotechnology and Breeding Asiaseed Inc.Icheon17414South Korea Food and Nutrition Division National Institute of Agricultural SciencesRural Development AdministrationWanju55365South Korea Department of Horticultural Biotechnology School of BiotechnologyHankyong National UniversityAnseong17579South Korea

Flavonols are the major class of flavonoids of green Chinese cabbage(Brassica rapa ***).The *** genome harbors seven flavonol synthase genes(BrFLSs),but they have not been functionally ***,transcriptome analysis showed four BrFLSs mainly expressed in Chinese *** them,only BrFLS1 showed major FLS activity and additional flavanone 3β-hydroxylase(F3H)activity,while BrFLS2 and BrFLS3.1 exhibited only marginal F3H *** generated BrFLS1-knockout(BrFLS1-KO)Chinese cabbages using CRISPR/Cas9-mediated genome editing and obtained transgene-free homozygous plants without off-target mutation in the T1 generation,which were further advanced to the T2 generation showing normal ***-ESI-QTOF-MS analysis revealed that flavonol glycosides were dramatically decreased in the T2 plants,while dihydroflavonol glycosides accumulated concomitantly to levels corresponding to the reduced levels of *** PCR analysis revealed that the early steps of phenylpropanoid and flavonoid biosynthetic pathway were upregulated in the BrFLS1-KO *** accordance,total phenolic contents were slightly enhanced in the BrFLS1-KO plants,which suggests a negative role of flavonols in phenylpropanoid and flavonoid biosynthesis in Chinese *** surveys revealed that the BrFLS1-KO Chinese cabbages showed normal head formation and reproductive phenotypes,but subtle morphological changes in their heads were *** addition,their seedlings were susceptible to osmotic stress compared to the controls,suggesting that flavonols play a positive role for osmotic stress tolerance in *** *** this study,we showed that CRISPR/Cas9-mediated BrFLS1-KO successfully generated a valuable breeding resource of Chinese cabbage with distinctive metabolic traits and that CRISPR/Cas9 can be efficiently applied in functional Chinese cabbage breeding.

关键词： steps slightly phenolic

Cholecystoduodenal fistula presenting with upper gastrointestinal bleeding: A case report

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World Journal of Clinical Cases 2021年第2期9卷 410-415页

作者： Jin Myung Park Chang Don Kang Ji Hyun Kim sang hoon lee Seung-Joo Nam Sung Chul Park Sung Joonlee Seungkoo lee Department of Internal Medicine Kangwon National University School of MedicineChuncheon 24289Kangwon DoSouth Korea Department of Gastroenterology Kangwon National University HospitalChuncheon 24289Kangwon DoSouth Korea Anatomy and Pathology Kangwon National University School of MedicineChuncheon 200947Kangwon DoSouth Korea Department of Pathology Kangwon National University HospitalChuncheon 24289Kangwon DoSouth Korea

BACKGROUND Cholecystoduodenal fistula is a rare complication of *** are usually non-specific and often indistinguishable from those of etiologic diseases,but it rarely presents as severe gastrointestinal *** associated with cholecystoduodenal fistula usually requires surgery because significant bleeding from the cystic artery is unlikely to be resolved by conservative management or endoscopic *** SUMMARY We report a case of cholecystoduodenal fistula that presented with hematemesis which was diagnosed by endoscopy and computed *** hemostasis could not be achieved,but surgical treatment was ***,we have presented a literature *** Cholecystoduodenal fistula should be considered as differential diagnosis when a patient with history of gallstone disease presents with gastrointestinal bleeding.

关键词： Biliary fistula Hematemesis Cholecystitis Gallstones Cholecystectomy Case report

Introduction to CPM-OFDM： An Energy Efficient Multiple Access Transmission Scheme

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通讯和计算机（中英文版） 2015年第1期12卷 37-43页

作者： Mohammad Irfan sang hoon lee Soo Young Shin Wireless Emerging Networking System Lab Kumoh National Institute of Technology South-Korea