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α1-COP modulates plasmodesmata function through sphingolipid enzyme regulation

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Journal of Integrative Plant Biology 2024年第8期66卷 1639-1657页

作者： Arya Bagus Boedi Iswanto Minh Huy Vu Jong Cheol Shon Ritesh Kumar Shuwei Wu Hobin Kang Da-Ran kim Geon Hui Son Woe Yoen kim Youn-Sig Kwak Kwang Hyeon Liu sang hee kim Jae-Yean kim Division of Applied Life Science(BK21 FOUR Program) Plant Molecular Biology and Biotechnology Research CenterGyeongsang National UniversityJinju 52828Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences Kyungpook National UniversityDaegu 702-701Korea Departement of Plant Medicine Gyeongsang National UniversityJinju 52828Korea Division of Life Science Gyeongsang National UniversityJinju 52828Korea

Callose,aβ-1,3-glucan plant cell wall polymer,regulates symplasmic channel size at plasmodesmata(PD)and plays a crucial role in a variety of plant ***,elucidating the molecular mechanism of PD callose homeostasis is *** screened and identified an Arabidopsis mutant plant with excessive callose deposition at PD and found that the mutated gene wasα1-COP,a member of the coat protein I(COPI)coatomer *** report that loss of function ofα1-COP elevates the callose accumulation at PD by affecting subcellular protein localization of callose degradation enzyme Pd *** process is linked to the functions of ERH1,an inositol phosphoryl ceramide synthase,and glucosylceramide synthase through physical interactions with theα1-COP ***,the loss of function ofα1-COP alters the subcellular localization of ERH1 and GCS proteins,resulting in a reduction of Glc Cers and Glc HCers molecules,which are key sphingolipid(SL)species for lipid raft *** findings suggest thatα1-COP protein,together with SL modifiers controlling lipid raft compositions,regulates the subcellular localization of GPI-anchored PDBG2 proteins,and hence the callose turnover at PD and symplasmic movement of *** findings provide the first key clue to link the COPI-mediated intracellular trafficking pathway to the callose-mediated intercellular signaling pathway through PD.

关键词： callose coatomer proteins membrane-bound vesicle plasmodesmata sphingolipid enzymes

The processed C-terminus of AvrRps4 effector suppresses plant immunity via targeting multiple WRKYs

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Journal of Integrative Plant Biology 2024年第8期66卷 1769-1787页

作者： Quang-Minh Nguyen Arya Bagus Boedi Iswanto Hobin Kang Jiyun Moon Kieu Anh Thi Phan Geon Hui Son Mi Chung Suh Eui-Hwan Chung Walter Gassmann sang hee kim Division of Applied Life Science(BK21 Four Program) Plant Molecular Biology and Biotechnology Research CenterGyeongsang National UniversityJinju 52828Korea Department of Life Science Sogang UniversitySeoul 04107Korea Department of Plant Biotechnology Korea UniversitySeoul 02841Korea Division of Plant Science and Technology Christopher S.Bond Life Sciences Center and Interdisciplinary Plant GroupUniversity of MissouriColumbiaMissouri 65211USA Division of Life Science and Research Institute of Molecular Alchemy Gyeongsang National UniversityJinju 52828Korea

Pathogens generate and secrete effector proteins to the host plant cells during pathogenesis to promote virulence and *** the plant carries resistance(R)proteins that recognize pathogen effectors,effector-triggered immunity(ETI)is activated,resulting in a robust immune response and hypersensitive response(HR).The bipartite effector AvrRps4 from Pseudomonas syringae *** has been well studied in terms of avirulence *** planta,AvrRps4 is processed into two *** Cterminal fragment of AvrRps4(AvrRps4^(C))induces HR in turnip and is recognized by the paired resistance proteins AtRRS1/AtRPS4 in ***,we show that AvrRps4^(C)targets a group of Arabidopsis WRKY,including WRKY46,WRKY53,WRKY54,and WRKY70,to induce its virulence ***,AvrRps4^(C)suppresses the general binding and transcriptional activities of immune-positive regulator WRKY54 and WRKY54-mediated ***4^(C)interferes with WRKY54's binding activity to target gene SARD1 in vitro,suggesting WRKY54 is sequestered from the SARD1 promoter by AvrRps4^(C).Through the interaction of Avr Rps4^(C)with four WRKYs,AvrRps4 enhances the formation of homo-/heterotypic complexes of four WRKYs and sequesters them in the cytoplasm,thus inhibiting their function in plant ***,our results provide a detailed virulence mechanism of AvrRps4 through its C-terminus.

关键词： AvrRps4 bacterial effector effector-triggered immunity immune response suppression transcription factor WRKY

Night Vehicle Detection Using Variable Haar-Like Feature

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Journal of Measurement Science and Instrumentation 2011年第4期2卷 337-340页

作者： Jae-do kim sang-hee kim Young-joon HAN Hern-soo HAHN Dept. of Electronic Engineering Soongsil University Seoul 156-743 Korea Metabuild Co. Seoul Korea

This paper proposes a night-time vehicle detection method using variable Haar-like *** specific features of front vehicle cannot be obtained in road image at night-time because of light reflection and ambient light,and it is also difficult to define optimal brightness and color of rear lamp according to road *** comparison,the difference of vehicle region and road surface is more robust for road illumination ***,we select the candidates of vehicles by analysing the difference,and verify the candidates using those brightness and complexity to detect vehicle *** feature of brightness difference is detected using variable horizontal Haar-like mask according to vehicle size in the location of *** the region occurring rapid change is selected as the *** proposed method is evaluated by testing on the various real road conditions.

关键词： vehicle detection variable Haar-like feature brightness distribution analysis

Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram kim Myeong‑Chang Sung Gwang‑hee Lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo Dong‑Wan kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

Accurate Approximation of the Earth Mover's Distance in Linear Time

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Journal of Computer Science & Technology 2014年第1期29卷 142-154页

作者： Min-hee Jang sang-Wook kim Christos Faloutsos Sunju Park Computer Science Department Carnegie Mellon University ACM IEEE Department of Electronics and Computer Engineering Hanyang University School of Business Yonsei University

Color descriptors are one of the important features used in content-based in, age retrieval. The dominant color descriptor （DCD） represents a few perceptually dominant colors in an image through color quantization. For image retrieval based on DCD, the earth mover＇s distance （EMD） and the optimal color composition distance were proposed to measure the dissimilarity between two images. Although providing good retrieval results, both methods are too time-consuming to be used in a large image database. To solve the problem, we propose a new distance function that calculates an approximate earth mover＇s distance in linear time. To calculate the dissimilarity in linear time, the proposed approach employs the space-filling curve for multidimensional color space. To improve the accuracy, the proposed approach uses multiple curves and adjusts the color positions. As a result, our approach achieves order-of-magnitude time improvement but incurs small errors. We have performed extensive experiments to show the effectiveness and efficiency of the proposed approach. The results reveal that our approach achieves almost the same results with the EMD in linear time.

关键词： earth mover's distance approximation content-based image retrieval

Repetitive response to gemcitabine that led to curative resection in cholangiocarcinoma

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World Journal of Gastroenterology 2009年第36期15卷 4593-4595页

作者： Seong Hun kim In hee kim sang Wook kim Seung-Ok Lee Division of Gastroenterology and Hepatology Department of Internal MedicineChonbuk National University Medical SchoolJeonju 561-712South Korea

This study reports a case of unresectable intrahepatic mass-forming cholangiocarcinoma which showed a dramatic response to gemcitabine that led to curative resection and a long-term survival of more than five *** and five cycles of gemcitabine monotherapy were administered separately over a three-year period and a radical excision was performed at 4.5 years after *** case indicates the role of gemcitabine as a neoadjuvant chemotherapeutic agent for cholangiocarcinoma and guarantees a randomized controlled prospective study.

关键词： Cholangiocarcinoma Gemcitabine Neoadjuvant chemotherapy

S100A4 released from highly bone-metastatic breast cancer cells plays a critical role in osteolysis

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Bone Research 2019年第4期7卷 424-436页

作者： Haemin kim Bongjun kim sang Il kim Hyung Joon kim Brian YRyu Junho Chung Zang hee Lee Hong-hee kim Department of Cell and Developmental Biology BK21 Program and DRISeoul National UniversitySeoulKorea Department of Biochemistry and Molecular Biology Seoul National University College of MedicineSeoulKorea Cancer Research Institute Seoul National University College of MedicineSeoulKorea Department of Cancer Biology Seoul National University College of MedicineSeoulKorea Department of Oral Physiology BK21 PLUS Projectand Dental and Life Science InstituteSchool of DentistryPusan National UniversityYangsanKorea Interdisciplinary Program in Bioinformatics Seoul National University College of Natural SciencesSeoulKorea Department of Biomedical Sciences Seoul National University Graduate SchoolSeoulKorea

Bone destruction induced by breast cancer metastasis causes severe complications,including death,in breast cancer *** between cancer cells and skeletal cells in metastatic bone microenvironments is a principal element that drives tumor progression and ***-derived factors play fundamental roles in this form of *** identify soluble factors released from cancer cells in bone metastasis,we established a highly bone-metastatic subline of MDA-MB-231 breast cancer *** subline(mtMDA)showed a markedly elevated ability to secrete S100A4 protein,which directly stimulated osteoclast formation via surface receptor *** S100A4 stimulated osteoclastogenesis in vitro and bone loss in *** medium from mtMDA cells in which S100A4 was knocked down had a reduced ability to stimulate ***,the S100A4 knockdown cells elicited less bone destruction in mice than the control knockdown *** addition,administration of an anti-S100A4 monoclonal antibody(mAb)that we developed attenuated the stimulation of osteoclastogenesis and bone loss by mtMDA in *** together,our results suggest that S100A4 released from breast cancer cells is an important player in the osteolysis caused by breast cancer bone metastasis.

关键词： S100A4 breast metastatic

Topology optimization of reactive material structures for penetrative projectiles

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Defence Technology（防务技术） 2022年第7期18卷 1205-1218页

作者： Shinyu kim Saekyeol kim Taekyun kim sangin Choi Tae hee Lee Jung Su Park sang-Hyun Jung Department of Automotive Engineering Hanyang University222 Wangsimni-roSeongdong-guSeoul04763Republic of Korea The 4th R&D Institute Agency for Defense Development35Yuseong P.O.BoxDaejeon34186Republic of Korea

Recently,reactive materials have been developed for penetrative projectiles to improve impact resistance and energy ***,the design of a reactive material structure,involving shape and size,is challenging because of difficulties such as high non-linearity of impact resistance,manufacturing limitations of reactive materials and high expenses of penetration *** this study,a design optimization methodology for the reactive material structure is developed based on the finite element analysis.A finite element model for penetration analysis is introduced to save the expenses of the *** resistance is assessed through the analysis,and result is calibrated by comparing with experimental *** on the model,topology optimization is introduced to determine shape of the *** design variables and constraints of the optimization are proposed considering the manufacturing limitations,and the optimal shape that can be manufactured by cold spraying is *** on the optimal shape,size optimization is introduced to determine the geometric dimensions of the *** a result,optimal design of the reactive material structure and steel case of the penetrative projectile,which maximizes the impact resistance,is *** the design process proposed in this study,reactive material structures can be designed considering not only mechanical performances but also manufacturing limitations,with reasonable time and cost.

关键词： Reactive material Penetrative projectile Topology optimization Manufacturing constraint Cold gas dynamic spray Additive manufacturing

Health risks of pest control and disinfection workers after the COVID-19 outbreak in South Korea

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Journal of Environmental Sciences 2024年第5期139卷 350-363页

作者： Yun-hee Choi Da-An Huh Lita kim sang ji Lee Kyong Whan Moon Department of Health and Safety Convergence Science Korea UniversityAnam-ro 145Seongbuk-guSeoul 02841South Korea BK21 FOUR R&E Center for Learning Health System Korea UniversityAnam-ro 145Seongbuk-guSeoul 02841South Korea Institute of Sciences Korea UniversityAnam-ro 145Seongbuk-guSeoul 02841South Korea Department of Health and Environmental Science Korea UniversityAnam-ro 145Seongbuk-guSeoul 02841South Korea

The exposure patterns of pest control and disinfection workers have changed after the coronavirus disease 2019(COVID-19)outbreak,but the health risks of chemical exposure have not been *** identified these workers’chemical exposure patterns and risks before and after the COVID-19 *** used data conducted between 2018(pre-pandemic)and 2021(post-pandemic)from three-year cross-sectional surveys on pest control and disinfection *** and dermal exposure concentrations were estimated using equations based on a biocidal product risk assessment model from the Korean National Institute of Environmental *** non-carcinogenic and carcinogenic risks of chemicals were calculated using the United States Environmental Protection Agency risk assessment *** found that the annual work frequency(50^(th)percentile)of foggers using disinfectants increased the most among all the work types,from 140 uses/year to 176 uses/year after the COVID-19 ***,all chemicals’non-carcinogenic and carcinogenic risks increased regardless of exposure *** the worst scenario(95^(th)percentile),the margin of exposure for citric acid,benzethonium chloride,benzyl-C12-16-alkyldimethyl chlorides,and sodium chlorite of inhalation exposure,and isopropyl alcohol and benzyl-C12-16-alkyldimethyl chlorides of dermal exposure were acceptable(>100)before the COVID-19outbreak but became unacceptable(10^(-6))before and after the COVID-19 outbreak but comparatively high after the COVID-19 ***,significantly more workers experienced health symptoms after the COVID-19outbreak(p<0.05),with the most common being muscle lethargy(31%),skin/face stinging(28.7%),and breath shortness/neck pain(24.1%).

关键词： Biocide Disinfection Health risk assessment Occupational exposure Pest control