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journal of Pharmaceutical Analysis 2024年第3期14卷 427-430页

作者： ju Yeon lee Muhammad Shoaib jin-Woong Choi Rishabh C.Choudhary Tai Yin Nara Yoon Kei Hayashida Seunguk j.Baek Santiago j.Miyara Lance B.Becker junhwan Kim Research Center of Bioconvergence Analysis Korea Basic Science InstituteCheongjuSouth Korea Bio-Analytical Science University of Science and TechnologyCheongjuSouth Korea Laboratory for Critical Care Physiology Feinstein Institutes for Medical ResearchManhassetNY11030USA Donald and Barbara Zucker School of Medicine at Hofstra/Northwell School of Medicine HempsteadNY11549USA Mathematics and Computer Science Adelphi UniversityGarden CityNY11530USA Department of Emergency Medicine North Shore University HospitalManhassetNY11030USA

Cardiac arrest(CA)is a life-threatening condition with complex pathophysiology and limited treatment *** gain deeper insights into the pathological state of vital organs,we employed a proteomics analysis in rodents to assess proteome alterations in the brain,heart,kidney,and liver using a rat model of *** brain displayed severe protein alterations in essential cellular pathways,including three major energy-generating pathways after CA,which worsened after resuscitation,resulting in the most significant overall protein changes among the ***,the liver,experiencing the most substantial protein alterations post-CA,demonstrated significant recovery,presenting the least protein changes post-resuscitation.

关键词： alterations organs damage

Effect of 1Al addition on deformation behavior of Mg

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journal of Magnesium and Alloys 2021年第2期9卷 489-498页

作者： ji Hyun Hwang A.Zargaran Gyeongbae Park O.lee B.-j.lee Nack j.Kim Center for Advanced Aerospace Materials Pohang University of Science and Technology(POSTECH)PohangSouth Korea

Deformation behavior of 1 Al containing Mg alloy has been investigated in the present *** annealing,the Mg-1 Al alloy shows a typical basal *** compared to the pure Mg having a similar texture and grain size,the Mg-1 Al alloy shows much higher strength and larger *** trace analyses of the tensile strained specimens show that non-basal slips such as pyramidal I and II slips can be easily activated at an early stage of deformation in the Mg-1 Al alloy and the grains in the Mg-1 Al alloy are seen to accommodate a larger degree of deformation than those in the pure Mg at a given *** increasing tensile strain,however,there is a strain localization along the initially formed slip lines of non-basal slips,forming surface steps without activating multiple slip lines.

关键词： Deformation behavior Slip trace analysis Non-basal slip Strain localization Ductility

A Review of Rechargeable Zinc-Air Batteries:Recent Progress and Future Perspectives

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Nano-Micro Letters 2024年第7期16卷 358-401页

作者： Ghazanfar Nazir Adeela Rehman jong-Hoon lee Choong-Hee Kim jagadis Gautam Kwang Heo Sajjad Hussain Muhammad Ikram Abeer AAlObaid Seul-Yi lee Soo-jin Park Department of Nanotechnology and Advanced Materials Engineering Hybrid Materials Research Center(HMC)Sejong UniversitySeoul 05006Republic of Korea Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-RoSeodaemun-GuSeoul 03722Republic of Korea Department of Chemistry Inha UniversityIncheon 22212Republic of Korea Solar Cell Applications Research Lab Department of PhysicsGovernment College University LahoreLahore 54000 PunjabPakistan Department of Chemistry College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia

Zinc-air batteries(ZABs)are gaining attention as an ideal option for various applications requiring high-capacity batteries,such as portable electronics,electric vehicles,and renewable energy *** offer advantages such as low environmental impact,enhanced safety compared to Li-ion batteries,and cost-effectiveness due to the abundance of ***,early research faced challenges due to parasitic reactions at the zinc anode and slow oxygen redox *** advancements in restructuring the anode,utilizing alternative electrolytes,and developing bifunctional oxygen catalysts have significantly improved *** have achieved battery reversibility over thousands of cycles,introduced new electrolytes,and achieved energy efficiency records surpassing 70%.Despite these achievements,there are challenges related to lower power density,shorter lifespan,and air electrode corrosion leading to performance *** review paper discusses different battery configurations,and reaction mechanisms for electrically and mechanically rechargeable ZABs,and proposes remedies to enhance overall battery *** paper also explores recent advancements,applications,and the future prospects of electrically/mechanically rechargeable ZABs.

关键词： Zinc-air batteries Energy storage Affordability Reversibility

Hypocrellin A-based photodynamic action induces apoptosis in A549 cells through ROS-mediated mitochondrial signaling pathway

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Acta Pharmaceutica Sinica B 2019年第2期9卷 279-293页

作者： Shanshan Qi Lingyuan Guo Shuzhen Yan Robert j.lee Shuqin Yu Shuanglin Chen jiangsu Province Key Laboratory for Microbes and Functional Genomics College of Life SciencesNanjing Normal University College of Pharmacy the Ohio State University Cancer Pharmacology Crown Bioscience Inc. jiangsu Province Key Laboratory for Molecular and Medical Biotechnology College of Life SciencesNanjing Normal University

Over recent decades, many studies have reported that hypocrellin A(HA) can eliminate cancer cells with proper irradiation in several cancer cell lines. However, the precise molecular mechanism underlying its anticancer effect has not been fully defined. HA-mediated cytotoxicity and apoptosis in human lung adenocarcinoma A549 cells were evaluated after photodynamic therapy(PDT). A temporal quantitative proteomics approach by isobaric tag for relative and absolute quantitation(iTRAQ) 2 D liquid chromatography with tandem mass spectrometric(LC–MS/MS) was introduced to help clarify molecular cytotoxic mechanisms and identify candidate targets of HA-induced apoptotic cell death. Specific caspaseinhibitors were used to further elucidate the molecular pathway underlying apoptosis in PDT-treated A549 cells. Finally, down-stream apoptosis-related protein was evaluated. Apoptosis induced by HA was associated with cell shrinkage, externalization of cell membrane phosphatidylserine, DNA fragmentation,and mitochondrial disruption, which were preceded by increased intracellular reactive oxygen species(ROS) generations. Further studies showed that PDT treatment with 0.08 mmol/L HA resulted in mitochondrial disruption, pronounced release of cytochrome c, and activation of caspase-3,-9, ***, HA may be a possible therapeutic agent directed toward mitochondria and a promising photodynamic anticancer candidate for further evaluation.

关键词： Hypocrellin A Photodynamic therapy Reactive oxygen species Proteomic LC–MS/MS iTRAQ

Characterization of a smog chamber for studying formation of gas-phase products and secondary organic aerosol

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journal of Environmental Sciences 2024年第2期136卷 570-582页

作者： Qi Yuan Zhuozhi Zhang Meng Wang Kin Fai Ho Tao Wang Shuncheng lee Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina School of Public Health and Primary Care The Chinese University of Hong KongShatinHong KongChina

Smog chambers provide a potent approach to explore the secondary organic aerosol formation under varied *** study describes the construction and characterization of a new smog chamber facility for studying the formation mechanisms of gas-phase products and secondary organic aerosol from the photooxidation of volatile organic *** chamber is a 5.4 m^(3) Fluorinated Ethylene Propylene(FEP)Teflon reactor with the potential to perform photooxidation experiments at controlled temperature and relative *** characterizations were conducted for evaluation of stability of environmental parameters,mixing time,background contamination,light intensity,and wall losses of gases and *** photolysis rate of NO_(2)(j_(NO2))ranged from(1.02-3.32)×10^(-3)sec^(-1),comparable to the average j_(NO2)in ambient *** wall loss rates for NO,NO_(2),and O_(3)were 0.47×10^(-4),0.37×10^(-4),and 1.17×10^(-4)min^(-1),while wall loss of toluene was obsoletely found in a 6 hr *** particle number wall loss rates are(0.01-2.46)×10^(-3)min^(-1)for 40-350 nm with an average lifetime of more than one day.A series of toluene photooxidation experiments were carried out in absence of NO_xunder dry *** results of the simulation experiments demonstrated that the chamber is well designed to simulate photolysis progress in the atmosphere.

关键词： Smog chamber Gas-phase oxidation Chamber characterization Chemical mechanism

MICROSTRUCTURE AND PROPERTIES OF ANNEALED ZnO THIN FILMS DEPOSITED BY MAGNETRON SPUTTERING

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Acta Metallurgica Sinica(English Letters) 2005年第3期18卷 177-183页

作者： j.lee W.Gao Z.Li M.Hodgson A.Asadov j.Metson DepartmentofMechanicalEngineering TheUniversityofAucklandAuckland1004NewZealand DepartmentofChemicalandMaterialsEngineering TheUniversityofAucklandAuckland1004NewZealand DepartmentofChemistry TheUniversityofAucklandPrivateBag92019Auckland1004NewZealand

ZnO thin films were deposited on a glass substrate by dc (direct current) and rf (radio frequency) magnetron sputtering. Post-deposition annealing was performed in different atmospheres and at different temperatures. The correlation of the annealing conditions with the microstructure and properties of the ZnO films wer e investigated by ultraviolet-visible spectroscopy, X-ray diffraction, conductiv ity measurement and scanning electron microscopy. Only the strong 002 peak could be observed by X-ray diffraction. The post-deposition annealing of ZnO films wa s found to alter the film's microstructure and properties, including crystallini ty, porosity, grain size, internal stress level and resistivity. It was also fou nd that after annealing, the conductivity of poorly conductive samples often imp roved. However, annealing does not improve the conductivity of samples with high conductivity prior to annealing. The resistivity of as-grown films can be decre ased from 102 to 10-4Ω·cm after annealing in nitrogen. To explain the effects of annealing on the conductivity of ZnO, it is believed that annealing may alter the presence and distribution of oxygen defects, reduce the lattice stress, cau se diffusion, grain coarsening and recrystallization. Annealing will reduce the density of grain boundaries in less dense films, which may decrease the resistiv ity of the films. On the other hand, annealing may also increase the porosity of thin films, leading to an increase in resistivity.

关键词： zinc oxide thin films microstructure magnetron sputtering post-deposition annealing electrical conductivity

Extreme Antarctic Cold of Late Winter 2023

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Advances in Atmospheric Sciences 2024年第10期41卷 1873-1880页

作者： Anastasia j.TOMANEK David E.MIKOLAjCZYK Matthew A.LAZZARA Stefano DI BATTISTA Minghu DING Mariana FONTOLAN LITELL David H.BROMWICH Taylor P.NORTON Linda M.KELLER lee j.WELHOUSE Antarctic Meteorological Research and Data Center Space Science and Engineering CenterUniversity of Wisconsin-Madison Department of Physical Sciences School of Engineering Science and MathematicsMadison Area Technical College Meteogiornale State Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences Byrd Polar and Climate Research Center The Ohio State University Department of Geography The Ohio State University

Extreme cold temperatures were observed in july and August 2023, coinciding with the WINFLY(winter fly-in)period of mid to late August into September 2023, meaning aircraft operations into Mc Murdo Station and Phoenix Airfield were adversely impacted. Specifically, with temperatures below-50℃, safe flight operation was not possible because of the risk of failing hydraulics and fuel turning to gel onboard the aircraft. The cold temperatures were measured across a broad area of the Antarctic, from East Antarctica toward the Ross Ice Shelf, and stretching across West Antarctica to the Antarctic Peninsula. A review of automatic weather station measurements and staffed station observations revealed a series of sites recording new record low temperatures. Four separate cold phases were identified, each a few days in duration and occurring from mid-july to the end of August 2023. A brief analysis of 500-hPa geopotential height anomalies shows how the mid-tropospheric atmospheric environment evolves in relation to these extreme cold temperatures. The monthly 500-hPa geopotential height anomalies show strong negative anomalies in August. Examination of composite geopotential height anomalies during each of the four cold phases suggests various factors leading to cold temperatures, including both southerly off-content flow and calm atmospheric conditions. Understanding the atmospheric environment that leads to such extreme cold temperatures can improve prediction of such events and benefit Antarctic operations and the study of Antarctic meteorology and climatology.

关键词： Antarctica extreme cold temperature automatic weather station networks

Historic accounts of Mansonella parasitaemias in the South Pacific and their relevance to lymphatic filariasis elimination efforts today

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Asian Pacific journal of Tropical Medicine 2016年第3期9卷 201-207页

作者： j.lee Crainey Tullio Romao Ribeiro da Silva Sergio Luiz Bessa Luz Ecologia de Doencas Transmissiveis na Amazonia Instituto Leonidas e Maria Deane-Fiocruz Amazonia Rua Terezina

There are two species of filarial parasites with sheathless microfilariae known to commonly cause parasitaemias in humans:Mansonella perstans and Mtinsonella *** most contemporary accounts of the distribution of these parasites,neither is usually considered to occur anywhere in the Eastern ***,Sir Patrick Manson,who first described both parasite species,recorded the existence of sheathless sharp-tailed Mansonella ozzardilike parasites occurring in the blood of natives from New Guinea in each and every version of his manual for tropical disease that he wrote before his death in ***'s reports were based on his own identifications and were made from at least two independent blood sample collections that were taken from the *** region Mansonella perstans parasitaemias were also later(in 1923) reported to occur in New Guinea and once before this(in 1905) in *** Mansonella-parasilaernias are generally regarded as benign,they are thought to be of public health importance because they can affect the epidemiological monitoring of other filarial *** this article,we reviewed the historic literature concerning Pacific-origin Mansonella-parasitaemias in an attempt to explain how,despite repeated reports of Pacificregion Mansonella-parasilaemias,by as early as the 1970 s,the WHO had arrived at the presentday view that Wuchereria bancrofti is the only cause of filarial parasitaemias in Papua New *** have also evaluated the evidence supporting the contemporary existence of Pacificarea parasitaemia-causing Mansonella parasites and assessed the relevance such parasites could have for present-day lymphatic filariasis elimination efforts in the region.

关键词： Mansonella ozzardi Mansonella perstans Wuchereria bancrofti Papua New Guinea Lymphatic filariasis Global Programme to Eliminate Lymphatic Filariasis

Integrating evolutionary genomics of forest trees to inform future tree breeding amid rapid climate change

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Plant Communications 2024年第10期5卷 59-81页

作者： jiajun Feng Xuming Dan Yangkai Cui Yi Gong Minyue Peng Yupeng sang Par K.Ingvarsson jing Wang Key Laboratory for Bio-Resources and Eco-Environment of Ministry of Education College of Life SciencesSichuan UniversityChengduChina Department of Plant Biology Linnean Centre for Plant BiologySwedish University of Agricultural SciencesUppsalaSweden

Global climate change is leading to rapid and drastic shifts in environmental conditions,posing threats to biodiversity and nearly all life forms *** trees serve as foundational components of terrestrial ecosystems and play a crucial and leading role in combating and mitigating the adverse effects of extreme climate events,despite their own vulnerability to these ***,understanding and monitoring how natural forests respond to rapid climate change is a key priority for biodiversity conserva*** progress in evolutionary genomics,driven primarily by cutting-edge multi-omics technologies,offers powerful new tools to address several key *** include precise delineation of species and evolutionary units,inference of past evolutionary histories and demographic fluctuations,identification of environmentally adaptive variants,and measurement of genetic load *** the urgency to deal with more extreme environmental stresses grows,understanding the genomics of evolutionary history,local adaptation,future responses to climate change,and conservation and restoration of natural forest trees will be critical for research at the nexus of global change,population genomics,and conservation *** this review,we explore the application of evolutionary genomics to assess the effects of global climate change using multi-omics approaches and discuss the outlook for breeding of climate-adapted trees.

关键词： forest trees climate change multi-omics evolutionary genomics breeding

Molecular components in j/ψandρ-πpuzzle

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Chinese Physics C 2024年第5期48卷 141-150页

作者：郭星导陈殿勇李学潜苑仲元桑士晶 College of Physics and New Energy Xuzhou University of TechnologyXuzhou 221111China School of Physics Southeast UniversityNanjing 211189China Department of Physics Nankai UniversityTianjin 300071China Lanzhou Center for Theoretical Physics Lanzhou UniversityLanzhou 730000China

Motivated by the large branching fractions of j/ψ→f0(1710)ω/f0(1710)ϕand the light exotic candidates,we found that there may exist molecular states composed of f0(1710)ωand f0(1710)ϕ,which correspond to X(2440)and X(2680)observed a few decades *** branching fractions of X(2440)and X(2680)to various PV and KKω(ϕ)channels were estimated in the molecular *** addition,the large branching fractions of j/ψ→f0(1710)ω/f0(1710)ϕindicate sizable molecular components in the j/ψ***,we consider j/ψas the superposition of thecc¯(1S),f0(1710)ω,and f0(1710)ϕmolecular *** molecular components have a significant impact on the light hadron decays of j/ψ,which may elucidate the long standingρ−πpuzzle.

关键词： ρ-πpuzzle j/ψ molecular state