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Phyton-International Journal of Experimental Botany 2023年第7期92卷 2017-2034页

作者： sang ik song Department of Bioscience and Bioinformatics Myongji UniversityYongin17058Korea

Small ubiquitin-like modifier(SUMO)E3 ligases that facilitate the conjugation of SUMO proteins to target substrates contain an SP-RING domain which is like the RING domain found in ubiquitin E3 *** this study,we isolated and characterized the Oryza sativa protein inhibitor of activated STAT like1(OsPIAL1)containing SP-RING domains,as the rice homolog of Arabidopsis ***1 interacts with OsSUMO proteins but does not interact with rice SUMO-conjugating enzymes(OsSCEs).An analysis of transgenic rice plant shows that OsPIAL1 is involved in SUMO conjugation to SCEs but not in SUMO conjugation to *** addition,this OsPIAL1 activity requires drought stress *** profiles show that the OsPIAL1 gene is induced by only drought stress in the leaves,whereas it is repressed by ABA and abiotic stresses in the *** stress leads to the fastest decrease in OsPIAL1 transcripts in the ***,the stress experiments indicate that the transgenic rice plants overexpressing OsPIAL1 exhibit a drought stress-tolerant phenotype but a salt stress hypersensitive *** results and those from Arabidopsis pial mutants suggest that PIALs act as a positive regulator in the drought stress response but as a negative regulator in the salt stress response.

关键词： Drought stress high-salinity stress Oryza sativa OsPIAL1 SUMO

Cellular Localization of Rice SUMO/SUMO Conjugates and in vitro Sumoylation Using Rice Components

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Rice science 2020年第1期27卷 1-4页

作者： Joungsu JOO Dong Hee CHOI sang Hyon KIM sang ik song Department of Bioscience and Bioinformatics Myongji University

Many proteins are regulated by post-translational modifications,such as the reversible covalent attachment of ubiquitin and ubiquitin-like proteins in eukaryotes(Kerscher et al, 2006). Post-translational modification of proteins by the SUMO protein family is involved in diverse cellular processes, including development, hormonal responses, and biotic and abiotic stress signaling(Park et al, 2011). SUMO modification can modulate protein-protein interactions, intracellular localization or the activities of the protein(Gareau and Lima, 2010).

关键词： SUMO modification translational

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Sarcopenia:Clinical implications in ovarian cancer,diagnosis,etiology,and management

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Sports Medicine and Health Science 2020年第4期2卷 202-210页

作者： Aeran Seol Se ik Kim Yong sang song Department of Obstetrics and Gynecology Seoul National University College of MedicineSeoulRepublic of Korea Cancer Research Institute Seoul National University College of MedicineSeoulRepublic of Korea

Sarcopenia,loss of skeletal muscle and function,is a common condition among the elderly and is known to cause adverse health outcomes and increased risk of morbidity and *** progressive and generalized disorder imposes a considerable socioeconomic *** is observed commonly in cancer *** Asia is one of the fastest aging regions in the world,it is clear that incidences of both sarcopenia and ovarian cancer will increase together in Asian *** cancer patients are vulnerable to develop sarcopenia during the treatment course and progress of disease,and a considerable number of patients with ovarian cancer seems to have physical inactivity and sarcopenia already at the time of ***,management of sarcopenia should be conducted together in parallel with ovarian cancer treatment and ***,in this article,we will review the clinical importance of sarcopenia in the aspect of ovarian *** of sarcopenia,diagnosis,etiology,and intervention will be also introduced.

关键词： Sarcopenia Ovarian carcinoma Definition Physiology Practice Intervention

CXC chemokines and chemokine receptors in gastric cancer: From basic findings towards therapeutic targeting

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World Journal of Gastroenterology 2014年第7期20卷 1681-1693页

作者： Hyo Jin Lee ik-Chan song Hwan-Jung Yun Deog-Yeon Jo Samyong Kim Division of Hematology/Oncology Department of Internal MedicineSchool of Medicine Chungnam National University and Chungnam National University HospitalDaejeon 301-721South Korea Cancer Research Institute Chungnam National UniversityDaejeon 301-721South Korea Division of Hematology/Oncology Department of Internal MedicineChungnam National University HospitalDaejeon 301-721South Korea

Gastric cancer is the fourth most common cancer,and the second-highest cause of cancer-related deaths *** extensive research to identify novel diagnostic and therapeutic agents,patients with advanced gastric cancer suffer from a poor quality of life and poor prognosis,and treatment is dependent mainly on conventional cytotoxic *** improve the quality of life and survival of gastric cancer patients,a better understanding of the underlying molecular pathologies,and their application towards the development of novel targeted therapies,is urgently *** are a group of small proteins associated with cytoskeletal rearrangements,the directional migration of several cell types during development and physiology,and the host immune response via interactions with G-protein coupled *** is also growing evidence to suggest that chemokines not only play a role in the immune system,but are also involved in the development and progression of *** gastric cancer,CXC chemokines and chemokine receptors regulate the trafficking of cells in and out of the tumor *** chemokines and their receptors can also directly influence tumorigenesis by modulating tumor transformation,survival,growth,invasion and metastasis,as well as indirectly by regulating angiogenesis,and tumor-leukocyte *** this review,we will focus on the roles of CXC chemokines and their receptors in the development,progression,and metastasis of gastric tumors,and discuss their therapeutic potential for gastric cancer.

关键词： Chemokine Chemokine receptor Gastric neoplasm Therapeutic target

Inversion of two-phase extensional basin systems during subduction of the Paleo-Pacific Plate in the SW Korean Peninsula:Implication for the Mesozoic “Laramide-style” orogeny along East Asian continental margin

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Geoscience Frontiers 2019年第3期10卷 909-925页

作者： Seung-ik Park Jungrae Noh Hee Jun Cheong sanghoon Kwon Yungoo song Sung Won Kim M.Santosh Department of Geology Kyungpook National University Department of Earth System Sciences Yonsei University School of Earth Sciences The Ohio State University Geology Division Korea Institute of Geoscience and Mineral Resources School of Earth Sciences and Resources China University of Geosciences Department of Earth Sciences University of Adelaide

During subduction, continental margins experience shortening along with inversion of extensional sedimentary basins. Here we explore a tectonic scenario for the inversion of two-phase extensional basin systems, where the Early-Middle Jurassic intra-arc volcano-sedimentary Oseosan Volcanic Complex was developed on top of the Late Triassic-Early Jurassic post-collisional sequences, namely the Chungnam Basin. The basin shortening was accommodated mostly by contractional faults and related folds. In the basement, regional high-angle reverse faults as well as low-angle thrusts accommodate the overall shortening, and are compatible with those preserved in the cover. This suggests that their spatial and temporal development is strongly dependent on the initial basin geometry and inherited *** in transport direction observed along the basement-sedimentary cover interface is a characteristic structural feature, reflecting sequential kinematic evolution during basin inversion. Propagation of basement faults also enhanced shortening of the overlying sedimentary cover sequences. We constrain timing of the Late Jurassic-Early Cretaceous(ca. 158-110 Ma) inversion from altered K-feldspar 40 Ar/39 Ar ages in stacked thrust sheets and K-Ar illite ages of fault gouges, along with previously reported geochronological data from the area. This "non-magmatic phase" of the Daebo Orogeny is contemporaneous with the timing of magmatic quiescence across the Korean Peninsula. We propose the role of flat/low-angle subduction of the Paleo-Pacific Plate for the development of the "Laramide-style" basement-involved orogenic event along East Asian continental margin.

关键词： Two-phase extensional basin systems Paleo-Pacific Plate Inversion tectonics “Laramide-style” orogeny East Asian continental margin

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Tailoring uniform γ-MnO2 nanosheets on highly conductive three-dimensional current collectors for high-performance supercapacitor electrodes

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Nano Research 2015年第3期8卷 990-1004页

作者： sangbaek Park Hyun-Woo Shim Chan Woo Lee Hee Jo song ik Jae Park Jae-Chan Kim Kug Sun Hong Dong-Wan Kim Department of Materials Science and Engineering Seoul National University Seou1151-744 R. O. Korea School of Civil Environmental and Architectural Engineering Korea University Seou1136-713 R. O. Korea

Recent efforts have focused on the fabrication and application of three- dimensional （3-D） nanoarchitecture electrodes, which can exhibit excellent electrochemical performance. Herein, a novel strategy towards the design and synthesis of size- and thickness-tunable two-dimensional （2-D） MnO2 nanosheets on highly conductive one-dimensional （l-D） backbone arrays has been developed via a facile, one-step enhanced chemical bath deposition （ECBD） method at a low temperature （-50 ℃）. Inclusion of an oxidizing agent, BrO3-, in the solution was crucial in controlling the heterogeneous nucleation and growth of the nanosheets, and in inducing the formation of the tailored and uniformly arranged nanosheet arrays. We fabricated supercapacitor devices based on 3-D MnO2 nanosheets with conductive Sb-doped SnO2 nanobelts as the backbone. They achieved a specific capacitance of 162 F·g-1 at an extremely high current density of 20 A·g% and good cycling stability that shows a capacitance retention of -92% of its initial value, along with a coulombic efficiency of almost 100% after 5,000 cycles in an aqueous solution of I M Na2SO4. The results were attributed to the unique hierarchical structures, which provided a short diffusion path of electrolyte ions by means of the 2-D sheets and direct electrical connections to the current collector by 1-D arrays as well as the prevention of aggregation by virtue of the well-aligned 3-D structure.

关键词： nanosheets manganese oxide chemical bath deposition SnO2 nanobelts supercapacitor

Magnetic resonance evaluation of human mesenchymal stem cells in corpus cavernosa of rats and rabbits

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Asian Journal of Andrology 2007年第3期9卷 361-367页

作者： Yun-Seob song Ja-Hyeon Ku Eun-Seop song Jung-Hoon Kim Jin-Suck Jeon Kong-Hee Lee Sook-Ja Kim Hee-Jeong Cheong ik-Sung Lim Dongho Choi Jong-Ho Won Department of Urology Stem Cell therapy Center Soonchunhyang School of Medicine Seoul 140-743 Korea Department of Urology Seoul National University Hospital Seoul 110-744 Korea Department of Obstetrics and Gynecology Inha University School of Medicine Incheon 400-103 Korea Department of Radiology Soonchunhyang School of Medicine Seoul 140-743 Korea Department of Internal Medicine Soonchunhyang School of Medicine Seoul 140-743 Korea Department of Urology Soonchunhyang School of Medicine Seoul 140-743 Korea Stem Cell therapy Center Soonchunhyang School of Medicine Seoul 140-743 Korea Department of Industrial Management ＆ Engineering Namseoul University College of Engineering Cheonan 330-707 Korea Department of Surgery Stem Cell therapy Center Soonchunhyang School of Medicine Seoul 140-743 Korea Department of Internal Medicine Stem Cell therapy Center Soonchunhyang School of Medicine Seoul 140-743 Korea

Aim： To investigate whether the biological process of superparamagnetic iron oxide （SPIO）-labeled human mesenchymal stem cells （hMSCs） may be monitored non-invasively by using in vivo magnetic resonance （MR） imaging with conventional 1.5-T system examinations in corpus cavernosa of rats and rabbits. Methods： The labeling efficiency and viability of SP10-labeled hMSCs were examined with Prussian blue and Tripan blue, respectively. After SPIO-labeled hMSCs were transplanted to the corpus cavernosa of rats and rabbits, serial T2-weighted MR images were taken and histological examinations were carried out over a 4-week period. Results： hMSCs loaded with SPIO compared to unlabeled cells had a similar viability. For SPIO-labeled hMSCs more than lx 105 concentration in vitro, MR images showed a decrease in signal intensity. MR signal intensity at the areas of SPIO-labeled hMSCs in the rat and rabbit corpus cavernosa decreased and was confined locally. After injection of SPIO-labeled hMSCs into the corpus cavernosum, MR imaging demonstrated that hMSCs could be seen for at least 12 weeks after injection. The presence of iron was confirmed with Prussian blue staining in histological sections. Conclusion： SP10-labeled hMSCs in corpus cavernosa of rats and rabbits can be evaluated non-invasively by molecular MR imaging. Our findings suggest that MR imaging has the ability to test the long-term therapeutic potential of hMSCs in animals in the setting of erectile dysfunction.

关键词： human mesenchymal stem cells magnetic resonance stem cells penis cell labeling corpus cavemosa

Low-intensity treadmill exercise and/or bright light promote neurogenesis in adult rat brain

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Neural Regeneration Research 2013年第10期8卷 922-929页

作者： Sung Jin Kwon Jeongsook Park So Yun Park Kwang Seop song Sun Tae Jung So Bong Jung ik Ryeul Park Wan Sung Choi Sun Ok Kwon Department of Physical Education Gyeongsang National University Department of Anatomy and Neurobiology Medical Research Center for Neural DysfunctionInstitute of Health ScienceSchool of MedicineGyeongsang National University Department of Liberal Arts Gyeongnam National University of Science and Technology

The hippocampus is a brain region responsible for learning and memory functions. The purpose of this study was to investigate the effects of low-intensity exercise and bright light exposure on neurogenesis and brain-derived neurotrophic factor expression in adult rat hippocampus. Male Sprague-Dawley rats were randomly assigned to control, exercise, light, or exercise ＋ light groups （n = 9 per group）. The rats in the exercise group were subjected to treadmill exercise （5 days per week, 30 minutes per day, over a 4-week period）, the light group rats were irradiated （5 days per week, 30 minutes per day, 10 000 Ix, over a 4-week period）, the exercise ＋ light group rats were subjected to treadmill exercise in combination with bright light exposure, and the control group rats remained sedentary over a 4-week period. Compared with the control group, there was a significant increase in neurogenesis in the hippocampal dentate gyrus of rats in the exercise, light, and exercise ＋ light groups. Moreover, the expression level of brain-derived neurotrophic factor in the rat hippocampal dentate gyrus was significantly higher in the exercise group and light group than that in the control group. Interestingly, there was no significant difference in brain-derived neurotrophic factor expression between the control group and exercise ＋ light group. These results indicate that low-intensity treadmill exercise （first 5 minutes at a speed of 2 m/min, second 5 minutes at a speed of 5 m/min, and the last 20 minutes at a speed of 8 m/min） or bright-light exposure therapy induces positive biochemical changes in the brain. In view of these findings, we propose that moderate exercise or exposure to sunlight during childhood can be beneficial for neural development.

关键词： neural regeneration neurogenesis neurorehabilitation exercise bright light brain-derivedneurotrophic factor hippocampus childhood grants-supported paper neuroregeneration

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基于加权空间划分的高效全局K-means聚类算法

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吉林大学学报（工学版） 2024年第5期54卷 1393-1400页

作者：曲福恒潘曰涛杨勇胡雅婷宋剑飞魏成宇长春理工大学计算机科学技术学院长春130022 吉林电子信息职业技术学院吉林省吉林市132021 吉林农业大学信息技术学院长春130118

针对全局K-means聚类算法穷举样本点导致计算量大的问题,提出一种基于加权空间划分的高效全局K-means聚类算法。算法首先对样本空间进行网格划分,然后提出密度准则与距离准则对网格进行过滤,保留密度较大且相互距离较远的网格作为候选... 详细信息

针对全局K-means聚类算法穷举样本点导致计算量大的问题,提出一种基于加权空间划分的高效全局K-means聚类算法。算法首先对样本空间进行网格划分,然后提出密度准则与距离准则对网格进行过滤,保留密度较大且相互距离较远的网格作为候选中心网格。为避免全局K-means算法只在样本集中选取候选中心的局限性,提出权重准则和中心迭代策略扩充候选中心,增加候选中心多样性。最后,通过增量聚类方式遍历候选中心得到最终的聚类结果。在UCI数据集上的实验结果表明:与全局K-means算法相比,新算法在保证聚类精度的前提下,计算效率平均提高了89.39%~95.79%。与K-means++、ik-+和近期提出的CD算法相比,新算法精度更高,并且克服了因随机初始化导致的聚类结果不稳定问题。

关键词：人工智能 K-means算法聚类中心网格划分权重增量式聚类

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Screening of drought tolerant rice germplasms and analysis of drought tolerant QTL under long-term drought stress conditions

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Screening of drought tolerant rice germplasms and analysis o...