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Unravelling host-mediated effects on hemiparasitic Mexican mistletoe Psittacanthus calyculatus(DC.)*** traits linked to mutualisms with pollinators and seed dispersers

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Journal of Plant Ecology 2018年第6期11卷 827-842页

作者： sandra rodríguez-Mendieta Carlos Lara Juan Francisco Ornelas Centro de Investigación en Ciencias Biológicas Universidad Autónoma de Tlaxcalakm 10.5 Carretera San Martín Texmelucan-TolucaSan Felipe IxtacuixtlaTlaxcala 90120Mexico Departamento de Biología Evolutiva Instituto de EcologíaA.C.(INECOL)Carretera antigua a Coatepec 351XalapaVeracruz 91080Mexico

Aims While the influence of mistletoe-host interactions on each other’s evolution is well-recognized,the role of interactions between mis-tletoes and its mutualistic pollinators and seed dispersers mediated by host species is relatively *** Here,we examine the effects of host species(Mexican hawthorn Crataegus mexicana DC,black cherry Prunus serotina Ehrh.,leather-leaf Mexican oak Quercus crassipes Bonpl.)on flower morphology,nectar production,pollinator visitation rate and female reproduct-ive fitness in hemiparasitic Mexican mistletoe Psittacanthus caly-culatus(DC.)***(Loranthaceae)populations at three different *** first measured the lengths of corolla,style,stamen,exerted stamen and anther,the length and width of the ovary and nectar availability for mistletoe flowers in natural ***,we evaluated flower visitation and measured(length and width)and weighed the fruits and its seeds of mistletoes growing on each of the three host ***,we evaluated the effects of host species,location and flower traits on fruit or seed size variation(both as proxies of reproductive fitness).Important Findings We found mistletoes growing on natural hosts *** and *** produced larger flowers,fruits and seeds than mistle-toes on cultivated ***,these differences varied across *** amount of available nectar and hummingbird vis-itation rates in flowers of mistletoes on *** was higher at the three sites than in flowers of mistletoes on *** or *** effects of host species,study site and floral trait covariates affected significantly all fitness measures,indicating that mistletoes’reproductive fitness is affected differently depending on the host species and their site of *** host-associated differ-ences in reproduction might have implications for interactions with mutualistic vectors.

关键词： floral and fruit traits hosts hummingbirds local host adaptation mistletoes nectar parasitic plants pollination Psittacanthus

Successful cetuximab rechallenge in metastatic colorectal cancer:A case report

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World Journal of Clinical Oncology 2024年第9期15卷 1232-1238页

作者： Alexandra Guedes sandra Silva sandra Custódio Andreia Capela Department of Medical Oncology Centro Hospitalar Gaia/EspinhoVila Nova de Gaia 4434-502Portugal

BACKGROUND Metastatic colorectal cancer(mCRC)treatment has been evolving and increasingly driven by tumor biology and gene expression *** with epidermal growth factor receptor(EGFR)inhibitors(anti-EGFR)represents a promising strategy for patients with RAS wild-type(RAS-wt)mCRC and circulating tumor DNA has emerged as a potential selection ***,we report the case of a RAS-wt mCRC patient who had a successful response to cetuximab *** SUMMARY Our patient was diagnosed with stage IV RAS-wt,microsatellite-stable rectosigmoid junction *** was started on first-line treatment with FOLFIRI and cetuximab and achieved partial response,allowing for a left hepatectomy(R0),followed by post-operative chemotherapy and an anterior resection;progression-free survival(PFS)of 16 months was *** to hepatic and nodal relapse,second-line treatment with FOLFOX and bevacizumab was started with partial response;metastasectomy was performed(R0),achieving a PFS of 11 *** a 15 months anti-EGFR-free interval,FOLFIRI and cetuximab were reintroduced upon disease progression,again with partial response and a PFS of 16 *** extensive hepatic relapse,cetuximab was reintroduced and a marked clinical and analytical improvement was seen,after only one *** status was confirmed on circulating tumor *** patient’s overall survival exceeded 5 *** Our case provides real-world data to support cetuximab rechallenge in later lines of RAS-wt mCRC treatment.

关键词： Metastatic colorectal cancer RAS mutation RAS wild type Anti-epidermal growth factor receptor Cetuximab Rechallenge Case report

Geochemical elements in suspended particulate matter of Ensenada de La Paz Lagoon,Baja California Peninsula,Mexico:Sources,distribution,mass balance and ecotoxicological risks

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Journal of Environmental Sciences 2024年第2期136卷 422-436页

作者： sandra Soledad Morales-García Pilar de Acacia Pérez-Escamilla Suresh Babu Sujitha Pichaimani Godwyn-Paulson Andrés Felipe Zuniga-Cabezas Muthuswamy Ponniah Jonathan Instituto Politécnico Nacional(IPN) Centro Mexicano para la Producción más Limpia(CMPL)Av.Acueducto s/nCol.Barrio la Laguna TicománDel Gustavo A.MaderoC.P.07340Ciudad de MéxicoMexico Instituto Politécnico Nacional(IPN) Escuela Superior de Ingeniería y Arquitectura(ESIA)Unidad Ticomán***án 600Delg.Gustavo A.MaderoC.P.07340Ciudad de México(CDMX)Mexico Instituto Politécnico Nacional(IPN) Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y Desarrollo(CIIEMAD)Calle 30 de Junio de 1520Barrio la Laguna TicománDel.Gustavo A.MaderoC.P.07340Ciudad de MéxicoMéxico

The present study aimed to evaluate multi-element concentrations(Al,As,Ca,Cd,Co,Cr,Cu,Fe,Mg,Mn,Mo,Ni,Pb,Sr)in suspended particulate material(SPM)collected from Ensenada de La Paz(ELP)lagoon,Baja California Sur,Mexico in two different periods(September and May)to comprehend their origin,geochemical behavior,mass transfer and associated ecotoxicological *** 24 hr variation coefficient of volumetric SPM levels were found to be 51.7%in September and 40.5%in May,signifying the effects of oceanic *** calculated enrichment factor(EF)values for all the studied elements were of higher magnitude because of the high surface area and oxide nature of SPM,and in this study,Mo had the highest EF of 46.77 probably due to its origin from continental *** the ecotoxicological perspective,the integrated toxic risk index revealed low toxic risk to the benthic ***,the mean-ERM-Quotient calculated using the particulate concentrations of As,Cd,Cr,Cu,Ni,Pb indicated 9%probability of toxicity to *** comprehensive geochemical and ecotoxicological assessment of particulate metal concentrations in the ELP lagoon signify low to moderate contamination.

关键词： Suspended particulate material Heavy metals Risk assessment Mass transfer Ensenada de La Paz

Reproductive ecology of the black rat (Rattus rattus) in Madagascar: the influence of density-dependent and -independent effects

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Integrative Zoology 2024年第1期19卷 66-86页

作者： Kathryn SCOBIE Soanandrasana RAHELINIRINA Voahangy SOARIMALALA Fehivola Mandanirina ANDRIAMIARIMANANA Corinne RAHAINGOSOAMAMITIANA Toky RANDRIAMORIA Soloandry RAHAJANDRAIBE Xavier LAMBIN Minoarisoa RAJERISON sandra TELFER School of Biological Sciences University of AberdeenAberdeenUK Plague Unit Institut Pasteur de MadagascarAntananarivoMadagascar Association Vahatra AntananarivoMadagascar

The black rat(Rattus rattus)poses a severe threat to food security and public health in Madagascar,where it is a major cause of pre-and post-harvest crop losses and an important reservoir for many zoonotic diseases,including ***,ecologically based rodent management(EBRM)strategies have been developed using ecologi-cal information to inform decisions on where and when to target *** could deliver improved health and well-being outcomes in Madagascar if adapted to the local ecological *** data collected from removal studies,we explored spatio-temporal patterns in the breeding activity of the black rat(***)in domestic and agricultural habitats across Madagascar and investigated to what extent these trends are influenced by rainfall and rat *** identified clear spatio-temporal variation in the seasonality of *** *** was highly seasonal both inside and outside of houses,but seasonal trends varied between these two ***-sonal trends were explained,in part,by variation in rainfall;however,the effect of rainfall on reproductive rates did itself vary by season and habitat type.A decline in breeding intensity with increasing rat density was recorded outside of *** has important implications for control,as populations may compensate for removal through increased *** recommend that sustained control initiated before the main breeding season,combined with improved hygiene and adequate rodent-proofing in homes and grain stores,could curtail population growth and reduce pre-and post-harvest losses provided that these measures overcome the compensatory response of rodent populations.

关键词： Madagascar Rattus rattus reproductive ecology rodent control

Navigating a Change:An In-depth Analysis of the National Education Policy’s Impact on Learning and Development

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Journalism and Mass Communication 2024年第4期14卷 241-259页

作者： Ujjvala Kanungo sandra Satheesh Stuti Mehra University of Delhi DelhiIndia

The patterns and trends in formal higher education are *** world economy is moving towards a knowledge based economy,the needs and requirements of formal higher education are also *** are currently reevaluating their options of formalizing their growing education sector by drafting new education policy that aims to meet the demands of this futuristic knowledge based and technology driven economy with involvement of Artificial Intelligence and Machine Learning(AIML).Factors addressing core competence of employability,holistic development and attainment of skills are the new mantras of evolving modern day’s *** be in sync with such demand,requirement,and challenges,the Indian government took a significant step in drafting a New Education Policy popularly known as‘NEP 2020’.This paper makes an attempt to analyze the significant characteristics and dimensions of this NEP 2020 by undertaking a survey among stakeholders mostly students to arrive at certain key findings such as inducing centric,employable,skillful,and holistic development of students attaining such higher *** also points out some of the implementation issues which require lead time to be adjusted with the system.

关键词： NEP2020 holistic education technology integration learning

The delivery of N-myc downstream-regulated gene 2(NDRG2)self-amplifying mRNA via modified lipid nanoparticles as a potential treatment for drug-resistant and metastatic cancers

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Medical Review 2024年第3期4卷 235-238页

作者： sandra E.Reznik Amit K.Tiwari Vivek Chavda Charles R.Ashby Jr. Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensUSA Departments of Pathology and Obstetrics and Gynecology and Women’s Health Montefiore Medical Center/Albert Einstein College of MedicineBronxUSA Department of Pharmaceutical Sciences College of Pharmacy University of Arkansas for Medical Sciences Little RockUSA Department of Pharmaceutics and Pharmaceutical Technology L.M.College of Pharmacy AhmedabadIndia Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA

The protein,N-myc downstream-regulated gene 2(NDRG2),a tumor suppressor,is significantly decreased or absent in many types of *** is a significant negative correlation between the levels of NDRG2 and the development and progression of cancer tumor recurrence and tumor invasion,in different *** contrast,the in vitro and in vivo overexpression of the NDRG2 protein decreases the proliferation,growth,adhesion and migration of many types of cancer *** in vitro overexpression of NDRG2 increases the efficacy of certain anticancer drugs in specific types of cancer *** hypothesize that the delivery of the mRNA of the NDRG2 protein,encapsulated by lipid nanoparticles,could represent a potential treatment of metastatic and drug-resistant *** would be accomplished using a self-amplifying mRNA that encodes the NDRG2 protein and an RNA-dependent-RNA polymerase,obtained from an in vitrotranscribed(IVT)*** IVT mRNA would be encapsulated in a lipid *** efficacy of the nanoformulation would be determined in cultured cancer cells and if the results are positive,nude mice transplanted with either drug-resistant or metastatic drug-resistant cancer cells,would be treated with the nanoformulation and monitored for efficacy and adverse *** the appropriate preclinical studies indicate this formulation is efficacious and safe,it is possible it could be evaluated in clinical trials.

关键词： N-myc downstream-regulated gene 2(NDRG2) cancer self-amplifying mRNA nanoparticle

Insights into the role of major bioactive dietary nutrients in lamb meat quality:a review

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Journal of Animal Science and Biotechnology 2022年第4期13卷 951-966页

作者： JavierÁlvarez-rodríguez Olaia Urrutia sandra Lobón Guillermo Ripoll Juan Ramón Bertolín Margalida Joy Departament de Ciència Animal Universitat de Lleida25198 LleidaSpain Departamento de Agronomía Biotecnología y AlimentaciónIS-FOOD InstituteEscuela Técnica Superior de Ingeniería Agronómica y BiocienciasUniversidad Pública de NavarraPamplonaSpain Centro de Investigación y Tecnología Agroalimentaria de Aragón(CITA) Avda.Montañana 93050059 ZaragozaSpain Instituto Agroalimentario de Aragón–IA2(CITA-Universidad de Zaragoza) Avda.Miguel Servet17750013 ZaragozaSpain.

Feed supplementation withα-linolenic acid(ALA)and linoleic acid(LA)increases their content in muscle,ALA increases n-3 polyunsaturated fatty acids and decrease n-6/n-3 ratio in muscle,and LA increases rumenic ***,high LA supplementation may have negative effects on lambs’lipid oxidative stability of *** the sources of ALA and LA are fed as fresh forage,the negative effects are counterbalanced by the presence of other bioactive compounds,as vitamin E(mainlyα-tocopherol)and polyphenols,which delay the lipid oxidation in *** is a wide consensus on the capability of vitamin E delaying lipid oxidation on lamb meat,and its feed content should be adjusted to the length of supplementation.A high dietary inclusion of proanthocyanidins,phenolic compounds and terpenes reduce the lipid oxidation in muscle and may improve the shelf life of meat,probably as a result of a combined effect with dietary vitamin ***,the recommended dietary inclusion levels depend on the polyphenol type and concentration and antioxidant capacity of the feedstuffs,which cannot be compared easily because no routine analytical grading methods are yet *** phenolic compounds content in dietary ingredients/supplements for lambs are reported,no specific association with animal physiology responses may be established.

关键词： Fatty acid Forage Oilseed Polyphenol Vitamin E

Exploring the effects of dietary inulin in rainbow trout fed a high‑starch,100%plant‑based diet

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Journal of Animal Science and Biotechnology 2024年第2期15卷 713-732页

作者： Raphaël Defaix Jep Lokesh Laura Frohn Mickael Le Bechec Thierry Pigot Vincent Veron Anne Surget sandra Biasutti Frederic Terrier Sandrine Skiba-Cassy Jerome Roy Stephane Panserat Karine Ricaud Universite de Pau Et Des Pays de L’Adour E2S UPPAINRAENUMEASaint‑Pee‑Sur‑NivelleFrance Universite de Pau Et Des Pays de L’Adour E2S UPPACNRSIMT Mines AlesIPREMPauFrance Universite de Pau Et Des Pays de L’Adour E2S UPPAIUT des Pays de l’AdourDepartement Genie BiologiqueMont de MarsanFrance.

Background High dietary carbohydrates can spare protein in rainbow trout(Oncorhynchus mykiss)but may affect growth and ***,a prebiotic,could have nutritional and metabolic effects,along with anti-inflammatory properties in teleosts,improving growth and *** tested this hypothesis in rainbow trout by feeding them a 100%plant-based diet,which is a viable alternative to fishmeal and fish oil in aquaculture *** a two-factor design,we examined the impact of inulin(2%)as well as the variation in the carbohydrates(CHO)/plant protein ratio on rainbow *** assessed the influence of these factors on zootechnical parameters,plasma metabolites,gut microbiota,production of short-chain fatty acids and lactic acid,as well as the expression of free-fatty acid receptor genes in the mid-intestine,intermediary liver metabolism,and immune markers in a 12-week feeding *** The use of 2%inulin did not significantly change the fish intestinal microbiota,but interestingly,the high CHO/protein ratio group showed a change in intestinal microbiota and in particular the beta diversity,with 21 bacterial genera affected,including Ralstonia,Bacillus,and 11 lactic-acid producing *** were higher levels of butyric,and valeric acid in groups fed with high CHO/protein diet but not with *** high CHO/protein group showed a decrease in the expression of pro-inflammatory cytokines(il1b,il8,and tnfa)in liver and a lower expression of the genes coding for tight-junction proteins in mid-intestine(tjp1a and tjp3).However,the 2%inulin did not modify the expression of plasma immune ***,inulin induced a negative effect on rainbow trout growth performance irrespective of the dietary *** With a 100%plant-based diet,inclusion of high levels of carbohydrates could be a promising way for fish nutrition in aquaculture through a protein sparing effect whereas the supplementation of 2%inulin does not appear to improve the use of CHO wh

关键词： Aquaculture Fish nutrition Gut microbiota Immune markers Intermediary metabolism Inulin Prebiotic Rainbow trout Short-chain fatty acids

The effect of Laves phases and nano-precipitates on the electrochemical corrosion resistance of Mg-Al-Ca alloys under alkaline conditions

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Journal of Magnesium and Alloys 2024年第6期12卷 2447-2461页

作者： Markus Felten Veronika Chaineux Siyuan Zhang Ali Tehranchi Tilmann Hickel Christina Scheu Joshua Spille Marta Lipińska-Chwałek Joachim Mayer Benjamin Berkels Marcus Hans Imke Greving Silja Flenner sandra Sefa Daniela Zander Chair of Corrosion and Corrosion Protection RWTH Aachen UniversityAachen 52072 Germany Max-Planck-Institut für Eisenforschung GmbH Düsseldorf 40237 Germany Central Facility for Electron Microscopy RWTH Aachen UniversityAachen 52074 Germany Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons Forschungszentrum Jülich GmbHJülich 52428Germany Mathematical Image and Signal Processing Aachen Institute for Advanced Study in Computational Engineering ScienceRWTH Aachen UniversityAachen 52062 Germany Materials Chemistry RWTH Aachen UniversityAachen 52074 Germany Institute of Materials Physics Helmholtz-Zentrum HereonGeesthacht 21502 Germany

The electrochemical corrosion mechanisms of Mg alloys were extensively studied in previous investigations of different chemical com-positions,modified surface states and various electrolyte ***,recent research focused on the active state of Mg dissolution,leading to unresolved effects of secondary phases adjacent to a stableα-solid solution passive *** present study investigates the fundamental electrochemical corrosion mechanisms of three different Laves phases with varying phase morphologies and phase fractions in the passive state of Mg-Al-Ca *** microstructure was characterized by(transmission-)electron microscopy and synchrotron-based transmission X-ray *** electrochemical corrosion resistance was determined with a standard three-electrode setup and advanced in-situ flow cell measurements.A new electrochemical activity sequence(C15>C36>α-Mg>C14)was obtained,as a result of a stable passive layer formation on theα-solid ***,nm-scale Mg-rich precipitates were identified within the Laves phases,which tend to inhibit the corrosion kinetics.

关键词： Laves phase STEM Magnesium Corrosion Passive layer