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第十届全国小麦基因组学及分子育种大会

作者： Etienne Paux Fran?ois Balfourier Sophie Bouchet sandra robert Romain De Oliveira Hélène Rimbert Jonathan Kitt Frédéric Choulet International Wheat Genome Sequencing Consortium BreedWheat Consortium

Since its domestication in the Fertile Crescent～8,000 to 10,000 years ago,wheat has undergone a complex history of spread,adaptation and *** get better insights into the wheat phylogeography and genetic diversity,we describe allele distribution through time using a set of 4,506 landraces and cultivars originating from105 different countries genotyped with a high-density SNP *** the genetic structure of landraces is collinear to ancient human migration roads,we observe a reshuffling through time,related to breeding programs,with the apparition of new alleles enriched with structural variations that may be the signature of introgressions from wild relatives after 1960.

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Uncoupling protein 2 deficiency reduces proliferative capacity of murine pancreatic stellate cells

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Hepatobiliary & Pancreatic Diseases International 2016年第6期15卷 647-654页

作者： Sarah Muller sandra Maria Klingbeil Andreea Sandica robert Jaster Department of Medicine II Division of Gastroen-terologyRostock University Medical CenterE.-Heydemann-Str.618057 RostockGermany

BACKGROUND： Uncoupling protein 2 （UCP2） has been suggested to inhibit mitochondrial production of reactive oxygen species （ROS） by decreasing the mitochondrial membrane potential. Experimental acute pancreatitis is associated with increased UCP2 expression, whereas UCP2 deficiency retards regeneration of aged mice from acute pancreatitis. Here, we have addressed biological and molecular functions of UCP2 in pancreatic stellate cells （PSCs）, which are involved in pancreatic wound repair and fibrogenesis. METHODS： PSCs were isolated from 12 months old （aged） UCP2^-/- mice and animals of the wild-type （WT） strain C57BL/6. Proliferation and cell death were assessed by em- ploying trypan blue staining and a 5-bromo-2＇-deoxyuridine incorporation assay. Intracellular fat droplets were visualized by oil red O staining. Levels of mRNA were determined by RT-PCR, while protein expression was analyzed by immunoblotting and immunofluorescence analysis. Intracellular ROS levels were measured with 2＇,7＇-dichlorofluorescin diacetate. Expression of senescence-associated β-galactosidase （SA β-Gal） was used as a surrogate marker of cellular senescence. RESULTS： PSCs derived from UCP2^-/- mice proliferated at a lower rate than cells from WT mice. In agreement with this observation, the UCP2 inhibitor genipin displayed dose- dependent inhibitory effects on WT PSC growth. Interestingly, ROS levels in PSCs did not differ between the two strains, and PSCs derived from UCP2^-/- mice did not senesce faster than those from corresponding WT cells. PSCs from UCP2^-/- mice and WT animals were also indistinguishable with respect to the activation-dependent loss of intracellular fat droplets, expression of the activation marker α-smooth muscle actin, type I collagen and the autocrine/paracrine mediators interleukin-6 and transforming growth factor-I~ 1. CONCLUSIONS： A reduced proliferative capacity of PSC from aged UCP2^-/- mice may contribute to the retarded regeneration after acute pancreatitis.

关键词： pancreatitis proliferation stellate cell biology uncoupling protein 2

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Covalent linkage of sulfated hyaluronan to the collagen scaffold Mucograft® enhances scaffold stability and reduces proinflammatory macrophage activation in vivo

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Bioactive Materials 2022年第2期7卷 420-434页

作者： Sarah Al-Maawi sandra Rother Norbert Halfter Karen M.Fiebig Juliane Moritz Stephanie Moeller Matthias Schnabelrauch Charles James Kirkpatrick robert Sader Hans-Peter Wiesmann Dieter Scharnweber Vera Hintze Shahram Ghanaati Clinic for Maxillofacial and Plastic Surgery Goethe UniversityFrankfurt Am MainGermany Institute of Materials Science Max Bergmann Center of BiomaterialsTU DresdenBudapester Str.2701069DresdenGermany Biomaterials Department INNOVENT e.V.Prüssingstr.27B07745JenaGermany Department of Cellular and Molecular Medicine Glycobiology Research and Training CenterUniversity of CaliforniaSan DiegoLa JollaCAUSA

Sulfated glycosaminoglycans(sGAG)show interaction with biological mediator *** collagen-based biomaterials are widely used in clinics,their combination with high-sulfated hyaluronan(sHA3)is *** study aims to functionalize a collagen-based scaffold(Mucograft®)with sHA3 via electrostatic(sHA3/PBS)or covalent binding to collagen fibrils(sHA3+EDC/NHS).Crosslinking without sHA3 was used as a control(EDC/NHS Ctrl).The properties of the sHA3-functionalized materials were *** vitro growth factor and cytokine release after culturing with liquid platelet-rich fibrin was performed by means of *** cellular reaction to the biomaterials was analyzed in a subcutaneous rat *** study revealed that covalent linking of sHA3 to collagen allowed only a marginal release of sHA3 over 28 days in contrast to electrostatically bound ***3+EDC/NHS scaffolds showed reduced vascular endothelial growth factor(VEGF),transforming growth factor beta 1(TGF-β1)and enhanced interleukin-8(IL-8)and epithelial growth factor(EGF)release in vitro compared to the other *** sHA3/PBS and EDC/NHS Ctrl scaffolds showed a high proinflammatory reaction(M1:CD-68+/CCR7+)and induced multinucleated giant cell(MNGC)formation in *** sHA3+EDC/NHS scaffolds reduced the proinflammatory macrophage M1 response and did not induce MNGC formation during the 30 ***3+EDC/NHS scaffolds had a stable structure in vivo and showed sufficient integration into the implantation region after 30 days,whereas EDC/NHS Ctrl scaffolds underwent marked disintegration and lost their initial *** summary,functionalized collagen(sHA3+EDC/NHS)modulates the inflammatory response and is a promising biomaterial as a stable scaffold for full-thickness skin regeneration in the future.

关键词： Sulfated hyaluronan Collagen Wound healing Cellular reaction Multinucleated giant cells

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Agenesis of the dorsal pancreas

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World Journal of Gastroenterology 2009年第3期15卷 376-377页

作者： Wolfgang J Schnedl Claudia Piswanger-Soelkner sandra J Wallner robert Krause Rainer W Lipp Practice for General Internal Medicine Hauptstrasse 5A-8940 LiezenAustria Department of Internal Medicine Medical UniversityAuenbruggerplatz 15A-8036 GrazAustria Institute of Pathophysiology Center for Molecular MedicineHeinrichstrasse 31aA-8010 GrazAustria

During the last 100 years in medical literature,there are only 54 reports,including the report of Pasaoglu et al(World J Gastroenterol 2008;14:2915-2916),with clinical descriptions of agenesis of the dorsal pancreas in *** of the dorsal pancreas,a rare congenital pancreatic malformation,is associated with some other medical conditions such as hyperglycemia,abdominal pain,pancreatitis and a few other *** approximately 50% of reported patients with this congenital malformation,hyperglycemia was *** of hyperglycemia and diabetes mellitus in all patients with agenesis of the dorsal pancreas including description of fasting blood glucose,oral glucose tolerance test,glycated hemoglobin and medical treatment would be a future *** autosomal dominant transmission has been suggested in single families,more family studies including imaging technologies with demonstration of the pancreatic duct system are needed for evaluation of this *** this letter to the editor,we aim to increase available information for the better understanding of this rare disease.

关键词：背部胰腺发育不全葡萄糖不耐性腹部疼痛胰腺炎

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Appliced Numerical Methods for Engineers 影印

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丛书名：时代教育·国外高校优秀教材精选

2004年

作者： (美) robert J.Schilling sandra L.Harris

本书着重介绍了解决工程实践中的各种有用的数值方法，还介绍了求解这些问题的数学软件（MATLABH和C语言）的计算机程序和结果。

ISBN: (数字)7111140109

ISBN: (纸本)7111140109

本书着重介绍了解决工程实践中的各种有用的数值方法，还介绍了求解这些问题的数学软件（MATLABH和C语言）的计算机程序和结果。

关键词： C语言

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Fundamentals of digital signal processing using MATLAB =数字信号处理基础 MATLAB实现

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2005年

作者： Schilling robert J.(robert Joseph) 1947-robert J. Schilling sandra L. Harris. Harris sandra L. 1947-

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Applied Numerical Methods for Engineers

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2000年

作者： robert J. Schilling sandra L. Harris.

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Primary and secondary prevention of colorectal cancer: An evidence- based review

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Family Medicine and Community Health 2017年第1期5卷 78-84页

作者： sandra J.Gonzalez Maria C.Mejia de Grubb robert S.Levine Department of Family and Community Medicine Baylor College of MedicineHoustonTXUSA

Colorectal cancer (CRC) is a common cancer that affects one in three men and one in four women worldwide. Late-stage detection is associated with significantly lower 5-year survival rates. Although it is well established that CRC mortality rates have decreased in the past several decades, adoption of routine screening continues to lag behind screening for other common cancers such as cervical and breast cancer. The decrease in overall rates has been attributed, in part, to improved primary and secondary prevention efforts, including smoking prevention and cessation programs, nutritional counseling, and the use of evidence-based screening protocols, as well as access to better treatment. Despite the increased screening rates, it is estimated that at least one-third of eligible people do not receive appropriate screening. The objective of this review is to describe the current epidemiology of CRC and to demonstrate effective primary and secondary prevention strategies for the primary care provider.

关键词： Colorectal cancer adenocarcinoma modifiable risk factors primary prevention secondary prevention primary care

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A pediatrician-friendly review of three common behavioral health screeners in pediatric practice: Findings and recommendations

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Pediatric Investigation 2021年第1期5卷 58-64页

作者： sandra Trafalis Courtney Giannini Jeremy Joves Saige Portera Hannah Toyama Anika Mehta Krista Basile robert D.Friedberg Center for the Study and Treatment of Anxious Youth Palo Alto UniversityPalo AltoCAUSA

Behavioral health concerns are surging in pediatric ***,integrated behavioral/medical health clinics are growing and child psychiatrists/psychologists are increasingly embedded in these care settings to help shoulder the clinical *** screening of behavioral health problems in primary care facilities enables early identification and ***,deciding on sound,efficient,and scalable screening measures is sometimes ***,this article presents a clinician-friendly review of three common instruments useful in screening pediatric behavioral health concerns including anxiety,depression,and conduct *** findings and clinical applications of the Pediatric Symptom Checklist-17(PSC-17),the Patient Health Questionnaire-9(PHQ-9),and the Screen for Child Anxiety Related Emotional Disorders(SCARED)are ***,clinical implications and recommendations for practicing pediatricians and child psychiatrists are offered.

关键词： Pediatricians Behavioral health Screeners

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Comprehensive evaluation of the metabolic effects of insect meal from Tenebrio molitor *** growing pigs by transcriptomics, metabolomics and lipidomics

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Journal of Animal Science and Biotechnology 2020年第2期11卷 527-544页

作者： sandra Meyer Denise K.Gessner Maria S.Braune Theresa Friedhoff Erika Most Marcus Höring Gerhard Liebisch Holger Zorn Klaus Eder robert Ringseis Institute of Animal Nutrition and Nutrition Physiology Justus Liebig University GiessenHeinrich-Buff-Ring 26-3235392 GiessenGiessenGermany Institute of Clinical Chemistry and Laboratory Medicine University Hospital of RegensburgFranz-Josef-Strauss-Allee 1193053 RegensburgGermany Institute of Food Chemistry and Food Biotechnology Justus Liebig University GiessenHeinrich-Buff-Ring 1735392 GiessenGiessenGermany Fraunhofer Institute for Molecular Biology and Applied Ecology Winchester Str.235394 GiessenGiessenGermany

Background:The hypothesis was tested that insect meal(IM)as protein source influences intermediary metabolism of growing *** test this,30 male,5-week-old crossbred pigs were randomly assigned to 3 groups of 10 pigs each with similar body weights(BW)and fed isonitrogenous diets either without(CON)or with 5%IM(IM5)or 10%IM(IM10)from Tenebrio molitor *** 4 weeks and key metabolic tissues(liver,muscle,plasma)were analyzed using ***:Most performance parameters did not differ across the groups,whereas ileal digestibilities of most amino acids were 6.7 to 15.6%-units lower in IM10 than in CON(P<0.05).Transcriptomics of liver and skeletal muscle revealed a total of 166 and 198,respectively,transcripts differentially expressed between IM10 and CON(P<0.05).Plasma metabolomics revealed higher concentrations of alanine,citrulline,glutamate,proline,serine,tyrosine and valine and a lower concentration of asparagine in IM10 than in CON(P<0.05).Only one out of fourteen quantifiable amino acid metabolites,namely methionine sulfoxide(MetS),in plasma was elevated by 45%and 71%in IM5 and IM10,respectively,compared to CON(P<0.05).Plasma concentrations of both,major carnitine/acylcarnitine species and bile acids were not different across *** of liver and plasma demonstrated no differences in the concentrations of triacylglycerols,cholesterol and the main phospholipids,lysophospholipids and sphingolipids between *** percentages of all individual phosphatidylcholine(PC)and phosphatidylethanolamine(PE)species in the liver showed no differences between groups,except those with 6 double bonds(PC 38:6,PC 40:6,PE 38:6,PE 40:6),which were markedly lower in IM10 than in CON(P<0.05).In line with this,the percentage of C22:6n-3 in hepatic total lipids was lower in IM10 than in the other groups(P<0.05).Conclusions:Comprehensive analyzes of the transcriptome,lipidome and metabolome of key metabolic tissues indicate that partial or complete replacement o

关键词： Animal nutrition Insect meal Lipidome Liver Metabolism Metabolome Pigs Plasma Skeletal muscle Transcriptome

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