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Analysis of Mortality Rates of the 5 Most Frequent Primary Cancer Sites in Brazil between 1979 and 2015 for Both Sexes

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Journal of Pharmacy and Pharmacology 2019年第2期7卷 61-68页

作者： Luiz Carlos de Araujo Souza Hugo Oliveira de Figueiredo Cavalcanti Vinicius Carvalhedo Cunha sandra lucia branco mendes coutinho Undergraduates of Medicine in the University Center of Brasilia(UniCEUB)and Researchers in the Department of Cytopathology and Pathological Anatomy of the Base Institute of the Federal District(NUCAP-IHBDF) Hospital Medical Sector Sul-Asa SulBrasilia 70330-150Brazil Resident Physician in Anatomical Pathology of the Federal District Base Institute(NUCAP-IHBDF) Hospital Medical Sector Sul-Asa SulBrasilia 70330-150Brazil Physician Anatomopathologist and Head of the Department of Cytopathology and Anatomical Pathology of the Federal District Base Institute(NUCAP-IHBDF) Hospital Medical Sector Sul-Asa SulBrasilia 70330-150Brazil

Introduction:Global estimates determined that there would be 14.1 million new cases of cancer and 8.2 million deaths from ***:To determine the adjusted mortality rates of the 5 most frequent primary sites of cancer and the mortality rates of the 5 most frequent primary in Brazil,between 1979 and ***:Epidemiological study between 1979 and 2015 based on data obtained from the Online Atlas of Mortality provided by the National Cancer Institute of Brazil(INCA)using information on cancer deaths obtained within the System of Information on Mortality(SIM)of Brazil Ministry of ***:When analyzing the mortality rate of the 5 most frequent primary sites by type of cancer from 1979 to 2015 for both sexes,we show that in the year 2015 the cancers with the highest rates are:bronchi and lungs,breast,stomach,prostate and unknown primary location.A total of 527,980 deaths from bronchial and lung neoplasms were recorded,304,546 deaths from breast cancer were recorded,407,611 deaths from stomach cancer were recorded,268,061 deaths from prostate cancer were recorded,and 257,357 deaths due to neoplasia of unknown primary location were *** we analyze the world standard rate and Brazil’s standard rate for mortality,we show that Brazil has higher values for the 5 most frequent primary sites by type of ***:The epidemiological study of these values aims to determine what are the main descriptors and characteristics to determine preventive measures against the increase of this disease.

关键词： Cancer bronchi breast stomach prostate unknown primary location Brazil INCA

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Antibody-Cytokeratin Marker 34βE12 in Prostate Cancer Detection

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Journal of Pharmacy and Pharmacology 2019年第4期7卷 187-197页

作者： Luiz Carlos de Araújo Souza Vinícius Carvalhêdo Cunha Hugo Oliveira de Figueiredo Cavalcanti Joao Ricardo Alves sandra Lúcia branco mendes coutinho Undergraduates of Medicine in the University Center of Brasilia(UniCEUB)and Researchers in the Department of Cytopathology and Pathological Anatomy of the Base Institute of the Federal District(NUCAP-IHBDF) Hospital Medical Sector Sul-Asa SulBrasilia 70330-150Brazil Resident Physician in Anatomical Pathology of the Federal District Base Institute(NUCAP-IHBDF) Hospital Medical Sector SulAsa SulBrasilia 70330-150Brazil Urologist Physician of the Clinical Body of the Federal District Base Institute and Urocentro(IHBDF) Hospital Medical Sector Sul-Asa SulBrasilia 70330-150Brazil Physician Anatomopathologist and Head of the Department of Cytopathology and Anatomical Pathology of the Federal District Base Institute(NUCAP-IHBDF) Hospital Medical Sector Sul-Asa SulBrasilia 70330-150Brazil

Introduction:The histological diagnosis of prostate cancer is commonly based on morphological *** presence of malignant tissue mixed with benign tissue,or the presence of carcinoma that mimics benignity may generate difficulty in the diagnostic ***,the application of immunohistochemistry contributes its diagnostic ***:To evaluate the 34βE12 marker in the detection of adenocarcinoma(ADn),atypical small acinar proliferation(ASAp),regular prostatic tissue(RPT)and regular prostatic tissue alternated by atrophy spotlights(RPTa)in transrectal biopsy guided by ultrasonography of patients with suspected prostate ***:Analysis of 34 patients who underwent ultrasound-guided transrectal biopsy with subsequent analysis by H&E staining and 34βE12 labeling for elucidation of neoplasms or diseased tissues with doubtful ***:The marker 34βE12 showed negativity in 100%of the neoplasms ADn,positivity in 100%of the benign prostatic tissues(RPT and RPTa);the patients with ASAp presented positivity(20%)and negativity(80%).The chi-square test(χ2)showed that there is an association(χ2=29.55 and p<0.0001)between the groups,that is,the 34βE12 marker has a significant value(p<0.0001)in the elucidation of patients with prostatic neoplasia and benign prostatic *** and Conclusion:With the early screening of prostate cancer in the modern era,pathologists have become increasingly challenged to diagnose small outbreaks of cancer when only a few atypical glands are present in transrectal biopsy-guided *** 34βE12 marker becomes an important tool in elucidating diagnoses such as ADn and ASAp.

关键词： Antibody-cytokeratin marker 34βE12 adenocarcinoma(ADn) atypical small acinar proliferation(ASAp) regular prostatic tissue(RPT) regular prostatic tissue alternated by atrophy spotlights(RPTa)

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Diagnostic Value between 1984 and 2018 of Transrectal Biopsy Guided by Ultrasonography after Radical Prostatectomy

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Journal of Pharmacy and Pharmacology 2019年第8期7卷 459-472页

作者： Luiz Carlos de Araújo Souza Vinícius Carvalhêdo Cunha Hugo Oliveira de Figueiredo Cavalcanti Joao Ricardo Alves Grimar de Oliveira Paula sandra Lúcia branco mendes coutinho Undergraduates of Medicine in the University Center of Brasilia (UniCEUB) Physician Anatomopathologist by Hospital Base of the Federal District (HBDF) Physician Urologist of the Clinical Body of the Hospital Base of the District Federal and Urocentro (HBDF) Physician Urologist by Hospital Base of the Federal District (HBDF) Physician Anatomopathologist and Head of the Department of Cytopathology and Anatomical Pathology of the Hospital Base of the Federal District (NUCAP-HBDF)

Objectives—to determine correlation between GSs(Gleason scores)on needle biopsy and RP(radical prostatectomy),evaluating diagnostic tests on biopsy and RP within the last years,between 1984 and ***—analysis of 100 patients,diagnosed with PCa(prostate cancer)needle biopsy using 18-gauge needle,who underwent RP with lymphadenectomy and for which preoperative and postoperative GSs were *** group analysis used three categorization schemes for differentiation:mild,moderate and poor for the whole group and we determined SE(sensitivity),SP(specificity),PVPR(positive predictive value),negative predictive value and ***—we found that 42%of the patients had no changes between GS on biopsy and prostatectomy,while 20%were overgraded and 38%undergraded by needle *** of+1 point in GS(32%)or-1 point(17%)was the most *** patients were classified as moderately differentiated by biopsies(78 and 35%in scheme 1 and 2 or 3,respectively),while 43%of patients received an intermediate differentiation *** accuracy varied from 44 to 76%for the analysis of all three ***—there are differences in correlation between GS on biopsy and on surgical specimen,and Gleason’s graduation also depends on the experience of the *** have shown that sextant biopsies using 18-gauge and a same group of pathologists showed acceptable concordance values(42%)between the GS on biopsy and prostatectomy.

关键词： PCa transrectal biopsy guided by ultrasonography RP PSA(prostate specific antigen)

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