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Total plasma homocysteine and methylenetetrahydrofolate reductase C677T polymorphism in patients with colorectal carcinoma

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World Journal of Gastroenterology 2006年第38期12卷 6128-6132页

作者： sandra Battistelli Aurelio Vittoria Massimo Stefanoni Camilla Bing Franco Roviello Dipartimento di chirurgia e Specialità chirurgiche Università degli Studi Policlinico Le Scotte Viale Bracci Siena 53100 Italy Dipartimento di Medicina Clinica e Scienze Immunologiche Università degli Studi Policlinico Le Scotte Viale Bracci Siena 53100 Italy Dipartimento di Medicina e chirurgia d’ Urgenza e di Accettazione Ospedale Civile di Gorizia Italy Dipartimento di Patologia Umana ed Oncologia U.O. Chirurgia Oncologica Università degli Studi Policlinico Le Scotte Viale Bracci Siena 53100 Italy

AIM: To investigate the behaviour of total plasma homocysteine (tHcy) and its most common genetic determinant defect, the methylenetetrahydrofolate reductase C677T (C677TMTHFR) polymorphism in patients with early stage colorectal carcinoma. METHODS: tHcy was quantified by Abbott IMx immunoassay; screening for C677TMTHFR substitution was performed by PCR and restriction analysis. RESULTS: The frequency of the C/T and T/T genotypes of the C677TMTHFR gene polymorphism did not differ between the groups. The mean tHcy was statistically higher in cancer patients than in control subjects carrying the same C/C or C/T genotype, whereas there was no difference in the T/T homozygous carriers of the two groups. tHcy was significantly higher in the T/T homozygous carriers than in C/C and C/T genotype carriers. CONCLUSION: The statistically significant increase of tHcy observed in C/C and C/T genotype carriers among our cancer patients is related to substrate consumption dependent on the tumor cell proliferation rate, whereas the tHcy increase observed in T/T genotype carriers of both groups probably depends on the enzymatic deficit of the homocysteine conversion to methionine and/or on the folate deficiency.

关键词： Homocysteine Colorectal cancer Methylenet etrahydrofolate reductase C677T polymorphism

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Parkinson's Disease:A Multisystem Disorder

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Neuroscience Bulletin 2023年第1期39卷 113-124页

作者： Helena Nunes Costa Ana Raquel Esteves Nuno Empadinhas sandra Morais Cardoso CNC–Center for Neuroscience and Cell Biology and CIBB–Center for Innovative Biomedicine and Biotechnology University of Coimbra3004-504CoimbraPortugal IIIUC–Institute for Interdisciplinary Research University of Coimbra3004-504CoimbraPortugal Faculty of Medicine University of Coimbra3004-504CoimbraPortugal

The way sporadic Parkinson's disease(PD)is perceived has undergone drastic changes in recent *** a long time,PD was considered a brain disease characterized by motor disturbances;however,the identification of several risk factors and the hypothesis that PD has a gastrointestinal onset have shed additional ***,after recognition of prodromal non-motor symptoms and the pathological processes driving their evolution,there is a greater understanding of the involvement of other organ *** this reason,PD is increasingly seen as a multiorgan and multisystemic pathology that arises from the interaction of susceptible genetic factors with a challenging environment during aging-related decline.

关键词： Parkinson's disease Gut microbiome Intestinal barrier α-Synuclein Blood-brain barrier

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Critical review of strategies for CO_2 delivery to large-scale microalgae cultures

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chinese Journal of chemical Engineering 2018年第11期26卷 2219-2228页

作者： Qi Zheng Xiaoyin Xu Gregory J.O.Martin sandra E.Kentish Peter Cook Centre for CCS Research Department of Chemical EngineeringThe University of Melbourne Algal Processing Group Department of Chemical EngineeringThe University of Melbourne

Microalgae have great, yet relatively untapped potential as a highly productive crop for the production of animal and aquaculture feed, biofuels, and nutraceutical products. Compared to conventional terrestrial crops they have a very fast growth rate and can be produced on non-arable land. During microalgae cultivation, carbon dioxide(CO_2) is supplied as the carbon source for photosynthesising microalgae. There are a number of potential CO_2 supplies including air, flue gas and purified CO_2. In addition, several strategies have been applied to the delivery of CO_2 to microalgae production systems, including directly bubbling CO_2-rich gas, microbubbles, porous membrane spargers and non-porous membrane contactors. This article provides a comparative analysis of the different CO_2 supply and delivery strategies and how they relate to each other.

关键词： Bubble Carbon dioxide Flue gas Bioreactors

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CLONING AND SEQUENCE ANALYSIS OF TWO SATELLITE RNAs FROM CUCUMBER MOSAIC VIRUS P1 ISOLATE

CLONING AND SEQUENCE ANALYSIS OF TWO SATELLITE RNAs FROM CUC...

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作者： sandra Perez Alvarez 浙江大学

学位级别：硕士

Cucumber mosaic virus （CMV） is a type member of the genus Cucumovirus. CMV have divided genomes consisting of three positive single-strands RNAs and a subgenomic RNA 4, which is generated by transcription from RNA 3 and serves as messenger RNA for the viral capsid protein. Some isolates of CMV contain abundant amounts of a small RNA （satellite RNA）, which is dependent on viral genomic RNA for its replication and spread, and has no appreciable nucleotide sequence similarity with the viral RNA. CMV can infect over 800 species of plants and is an economically important pathogen of field-grown vegetables in many areas of the world. In this study, the original cucumber mosaic virus （CMV） PI isolate has been caused very mild symptoms on many plant species, after serial passages of inoculation in 5 years, it was found that CMV P1 caused moderate symptoms on several tobacco cultivars and tomato. The dsRNA purification product were used for electrophoresis in agarose gel and the result show that the amount of satellite RNA is much higher than genomic RNAs and subgenomic RNA. Primers were synthesized based on reported CMV satellite RNA sequences, and a specific band of approximately 350 bases in length was found. In cloning and screening we found more than 20 white clones and only two were selected for sequence analysis. CMV PI sat-1 was 100% homology with a sequence reported in 1995, and the other one （CMV PI sat-2） was a new satellite. CMV P1 sat-1 is a mild satellite with about 335nt and CMV PI sat-2 is a new satellite （necrotic satellite） with 394nt, it is not a mutation from CMV P1 sat-1 because there are several deletions. The two satellites shared about 90% sequence homology. The two sequenced satellite RNAs have at least one open reading frame （ORF）. CMV P1 sat-1 share an ORF starting at nucleotide 11 and terminating at nucleotide 169. CMV P1 sat-2 has an ORF starting at residue 369 and terminating at residue 394, a second one s

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Impact of Colonization on Language Policy in Cameroon

Impact of Colonization on Language Policy in Cameroon

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作者： Ngueguo sandra Pamela 湖南大学

学位级别：硕士

喀麦隆的语言政策受到了殖民化的巨大影响。这种影响至今依然存在。喀麦隆的官方语言,英语和法语,是殖民化的遗留产物。喀麦隆作为一个多语言国家,有250多种地方语言和2种通用语。即喀麦隆洋泾浜英语和英法混合语言(Camfranglais)。除... 详细信息

喀麦隆的语言政策受到了殖民化的巨大影响。这种影响至今依然存在。喀麦隆的官方语言,英语和法语,是殖民化的遗留产物。喀麦隆作为一个多语言国家,有250多种地方语言和2种通用语。即喀麦隆洋泾浜英语和英法混合语言(Camfranglais)。除官方双语外,其他语言都被归入第二计划,使得文化传承受到影响,许多语言正走向消亡。本研究采用定量研究方法,采用在线问卷调查的方式,调查了喀麦隆英语区和法语区的受访者112人,就殖民化对语言政策的影响和对当地和官方语言未来的发展看法,问卷共设26个问题。本研究通过谷歌平台进行问卷调查,以便喀麦隆受访者参与。结果显示,殖民化对喀麦隆语言政策的影响既有正面的,也有负面的。我们发现,在官方的外国双语氛围中,年轻人在学校或家里通过这些语言接触到更多的外国文化,更倾向于外国文化,致使当地的多语制形同虚设。我们还发现,由外国语言和当地语言结合而成的混合语言在喀麦隆获得了很大发展,特别是在年轻人中间,尽管这些语言还没有被正式获得官方语言政策的确定和支持。受殖民主义的影响,喀麦隆的语言氛围存在冲突,官方双语很大程度上主导了当地的多语制,忽视了当地语言,导致文化逐渐消亡。殖民化对喀麦隆语言政策最严重的影响是该国当前所谓的英语危机或安巴索尼亚战争。本研究表明,由于殖民主义对喀麦隆语言政策的长期影响,实施可持续的语言政策迫在眉睫。本研究对于保护喀麦隆当地语言、避免语言消亡从而促进国家文化和民族的团结统一具有重要的意义。

关键词：殖民化喀麦隆语言政策地方语言官方语言

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Maintenance Management of Public Hospital Building Case Study:University Teaching Hospital,Enugu,Nigeria

Maintenance Management of Public Hospital Building Case Stud...

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作者： Mgbachi chinagolum sandra 湖南大学

学位级别：硕士

这项研究检查了尼日利亚埃努古的尼日利亚大学教学医院使用的维护管理实践,并确定了医疗保健部门维护管理人员所必需的技能。分析中总共使用了155份问卷:22份来自大楼的维修人员,50份来自医院的医生和护士,13份来自医院的行政人员和管... 详细信息

这项研究检查了尼日利亚埃努古的尼日利亚大学教学医院使用的维护管理实践,并确定了医疗保健部门维护管理人员所必需的技能。分析中总共使用了155份问卷:22份来自大楼的维修人员,50份来自医院的医生和护士,13份来自医院的行政人员和管理人员,70份来自医院的病人。该调查仅包括尼日利亚埃努古州的两所大学教学医院(基于分层随机选择技术):尼日利亚大学教学医院和埃努古公立医院大楼。为了进一步了解管理公共建筑物维修的公认做法,我们亦进行了文献回顾。研究人员使用了一种被称为有意抽样的抽样技术来选择研究的主要来源。频率表、平均值和标准偏差是用于检查数据的描述性统计的一些输出。屋顶、地板和天花板状况不佳,以及布线不当,是在物理检查中发现的最常见问题。研究发现,医院维修部门既缺乏必要的人员配备,也缺乏有效管理医院维修的必要经验。大多数到这个公共卫生中心就诊的病人从未接受过如何充分利用就诊的培训。本文还讨论了公立医院维修管理人员在完成维修任务时应具备的技能。还确定了阻碍人们参与最佳预防保健活动的因素。该报告建议,与其根据个人关系来预约,组织应该检查他们未来的维修部门主管是否符合研究中关于维修经理态度的成功标准。管理层应该对员工进行适当的培训,使他们能够充分利用空间并提供优质的服务。

关键词：大学教学医院维修管理维修经理尼日利亚维修实践

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New insights into renal lipid dysmetabolism in diabetic kidney disease

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World Journal of Diabetes 2021年第5期12卷 524-540页

作者： Alla Mitrofanova George Burke sandra Merscher Alessia Fornoni Peggy and Harold Katz Family Drug Discovery Center University of MiamiMiller School of MedicineMiamiFL 33136United States Katz Family Division of Nephrology and Hypertension Department of MedicineUniversity of MiamiMiller School of MedicineMiamiFL 33136United States Department of Surgery University of MiamiMiller School of MedicineMiamiFL 33136United States Diabetes Research Institute University of MiamiMiller School of MedicineMiamiFL 33136United States

Lipid dysmetabolism is one of the main features of diabetes mellitus and manifests by dyslipidemia as well as the ectopic accumulation of lipids in various tissues and organs,including the *** suggests that impaired cholesterol metabolism,increased lipid uptake or synthesis,increased fatty acid oxidation,lipid droplet accumulation and an imbalance in biologically active sphingolipids(such as ceramide,ceramide-1-phosphate and sphingosine-1-phosphate)contribute to the development of diabetic kidney disease(DKD).Currently,the literature suggests that both quality and quantity of lipids are associated with DKD and contribute to increased reactive oxygen species production,oxidative stress,inflammation,or cell ***,control of renal lipid dysmetabolism is a very important therapeutic goal,which needs to be *** article will review some of the recent advances leading to a better understanding of the mechanisms of dyslipidemia and the role of particular lipids and sphingolipids in DKD.

关键词： Diabetes Lipids Free fatty acids ATP-binding cassette transporters sub-class A Sterol-O-acyltransferase 1 CD36 Sphingolipids Sphingomyelin phosphodiesterase acid-like 3b Diabetic kidney disease

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Early Warning Smartphone Diagnostics for Water Security and Analysis Using Real-Time pH Mapping

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Photonic Sensors 2015年第4期5卷 289-297页

作者： Md. Arafat HOSSAIN John CANNING sandra AST Peter J. RUTLEDGE Abbas JAMALIPOUR interdisciplinary Photonics Laboratories (iPL) School of Chemistry The University of Sydney NSW 2006 Australia School of chemistry The University of Sydney NSW 2006 Australia Wireless Networking Group (WING) School of Electrical and Information Engineering The University of Sydney NSW2006 Australia

Early detection of environmental disruption, unintentional or otherwise, is increasingly desired to ensure hazard minimization in many settings. Here, using a field-portable, smartphone fluorimeter to assess water quality based on the pH response of a designer probe, a map of pH of public tap water sites has been obtained. A custom designed Android application digitally processed and mapped the results utilizing the global positioning system （GPS） service of the smartphone. The map generated indicates no disruption in pH for all sites measured, and all the data are assessed to fall inside the upper limit of local government regulations, consistent with authority reported measurements. This implementation demonstrates a new security concept： network environmental forensics utilizing the potential of novel smartgrid analysis with wireless sensors for the detection of potential disruption to water quality at any point in the city. This concept is applicable across all smartgrid strategies within the next generation of the Internet of Things and can be extended on national and global scales to address a range of target analytes, both chemical and biological.

关键词： Lab-in-a-phone Intemet of Things optical sensing and sensor smartphone sensor photonic sensor fluorescence water security

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Radiological diagnosis and staging of hilar cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2013年第7期5卷 115-126页

作者： Carlos Valls sandra Ruiz Laura Martinez David Leiva Department of Radiology Bellvitge University HospitalBarcelona 08907Spain

Hilar cholangiocarcinoma is a rare malignant tumor arising from the epithelium of the bile *** is still the only chance of potentially curative treatment in patients with perihilar ***,radical resection requires aggressive surgical strategies that should be tailored optimally according to the location,size and vascular invasion of the *** diagnosis and staging of these tumors is therefore critical for optimal treatment planning and for determining a *** computed tomography(MDCT),magnetic resonance imaging(MRI) and MR cholangiography are useful tools,both to diagnose and stage hilar *** imaging techniques allow accurate detection of the level of obstruction and the longitudinal and radial spread of the *** addition,high-resolution MDCT and MR provide specific radiographic features to determine vascular involvement of anatomic structures,such as the hepatic artery or the portal vein,which are critical to decide the surgical ***,radiological staging allows detection of patients with distant metastasis in the liver or peritoneum who will not benefit from a surgical approach.

关键词： cholangiocarcinoma Radiological staging Magnetic resonance imaging Multidetector computed tomography Hepatic resection

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changes of the liver metabolome following an intravenous lipopolysaccharide injection in Holstein cows supplemented with dietary carnitine

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Journal of Animal Science and Biotechnology 2023年第1期14卷 188-199页

作者： Wei Xu sandra Grindler Akos Kenez Sven Danicke Jana Frahm Korinna Huber Beijing Research Center of Intelligent Equipment for Agriculture Beijing 100097China. Department of Biosystems Biosystems Technology ClusterCampus GeelKleinhoefstraat 42440 Geel LeuvenKUBelgium. Institute of Animal Science Faculty of Agricultural SciencesUniversity of Hohenheim70599 StuttgartGermany. Department of Infectious Diseases and Public Health City University of Hong KongBlock 14/FTo Yuen Building31 To Yuen StreetKowloonHong Kong SARChina. Institute of Animal Nutrition Federal Research Institute for Animal Health(Friedrich-Loeffler-Institut)38116 BrunswickGermany.

Background:Carnitine facilitates the flux of long-chain fatty acids for hepatic mitochondrial beta-oxidation,which acts to ameliorate the negative energy balance commonly affecting high-yielding dairy *** triggered by lipopolysaccharide(LPS)load can however pose a challenge to the metabolic integrity via the expression of pro-inflammatory mediators,leading to immune system activation and respective metabolic *** effect of enhanced carnitine availability on hepatic metabolome profiles during an inflammatory challenge has not yet been determined in dairy ***,Holstein cows were supplemented with 25 g/d rumen-protected carnitine from 42d prepartum until 126 d postpartum(n=16)or assigned to the control group with no supplementation during the same period(n=14).We biopsied the liver of the cows before(100 d postpartum)and after(112 d postpartum)an intravenous injection of 0.5μg/kg *** samples were subjected to a targeted metabolomics analysis using the AbsoluteIDQ p180 Kit(Biocrates Life Sciences AG,Innsbruck,Austria).Results:Multivariate statistical analyses revealed that hepatic metabolome profiles changed in relation to both the carnitine supplementation and the LPS *** the metabolite profiles on 100 d,carnitine increased the concentration of short-and long-chain acyl-carnitines,which may be explained by an enhanced mitochondrial fatty acid shuttle and hence greater energy *** LPS injection affected hepatic metabolite profiles only in the carnitine supplemented group,particularly altering the concentration of biogenic ***:Our results point to interactions between an acute hepatic inflammatory response and biogenic amine metabolism,depending on energy availability.

关键词： Acyl-carnitines Inflammatory response Lipid metabolism Liver metabolome Mitochondrial function

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