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Maintenance Management of Public Hospital Building Case Study:University Teaching Hospital,Enugu,Nigeria

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Maintenance Management of Public Hospital Building Case Stud...

作者： Mgbachi Chinagolum sandra 湖南大学

学位级别：硕士

这项研究检查了尼日利亚埃努古的尼日利亚大学教学医院使用的维护管理实践,并确定了医疗保健部门维护管理人员所必需的技能。分析中总共使用了155份问卷:22份来自大楼的维修人员,50份来自医院的医生和护士,13份来自医院的行政人员和管... 详细信息

这项研究检查了尼日利亚埃努古的尼日利亚大学教学医院使用的维护管理实践,并确定了医疗保健部门维护管理人员所必需的技能。分析中总共使用了155份问卷:22份来自大楼的维修人员,50份来自医院的医生和护士,13份来自医院的行政人员和管理人员,70份来自医院的病人。该调查仅包括尼日利亚埃努古州的两所大学教学医院(基于分层随机选择技术):尼日利亚大学教学医院和埃努古公立医院大楼。为了进一步了解管理公共建筑物维修的公认做法,我们亦进行了文献回顾。研究人员使用了一种被称为有意抽样的抽样技术来选择研究的主要来源。频率表、平均值和标准偏差是用于检查数据的描述性统计的一些输出。屋顶、地板和天花板状况不佳,以及布线不当,是在物理检查中发现的最常见问题。研究发现,医院维修部门既缺乏必要的人员配备,也缺乏有效管理医院维修的必要经验。大多数到这个公共卫生中心就诊的病人从未接受过如何充分利用就诊的培训。本文还讨论了公立医院维修管理人员在完成维修任务时应具备的技能。还确定了阻碍人们参与最佳预防保健活动的因素。该报告建议,与其根据个人关系来预约,组织应该检查他们未来的维修部门主管是否符合研究中关于维修经理态度的成功标准。管理层应该对员工进行适当的培训,使他们能够充分利用空间并提供优质的服务。

关键词：大学教学医院维修管理维修经理尼日利亚维修实践

New insights into renal lipid dysmetabolism in diabetic kidney disease

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World Journal of Diabetes 2021年第5期12卷 524-540页

作者： Alla Mitrofanova George Burke sandra Merscher Alessia Fornoni Peggy and Harold Katz Family Drug Discovery Center University of MiamiMiller School of MedicineMiamiFL 33136United States Katz Family Division of Nephrology and Hypertension Department of MedicineUniversity of MiamiMiller School of MedicineMiamiFL 33136United States Department of Surgery University of MiamiMiller School of MedicineMiamiFL 33136United States Diabetes Research Institute University of MiamiMiller School of MedicineMiamiFL 33136United States

Lipid dysmetabolism is one of the main features of diabetes mellitus and manifests by dyslipidemia as well as the ectopic accumulation of lipids in various tissues and organs,including the *** suggests that impaired cholesterol metabolism,increased lipid uptake or synthesis,increased fatty acid oxidation,lipid droplet accumulation and an imbalance in biologically active sphingolipids(such as ceramide,ceramide-1-phosphate and sphingosine-1-phosphate)contribute to the development of diabetic kidney disease(DKD).Currently,the literature suggests that both quality and quantity of lipids are associated with DKD and contribute to increased reactive oxygen species production,oxidative stress,inflammation,or cell ***,control of renal lipid dysmetabolism is a very important therapeutic goal,which needs to be *** article will review some of the recent advances leading to a better understanding of the mechanisms of dyslipidemia and the role of particular lipids and sphingolipids in DKD.

关键词： Diabetes Lipids Free fatty acids ATP-binding cassette transporters sub-class A Sterol-O-acyltransferase 1 CD36 Sphingolipids Sphingomyelin phosphodiesterase acid-like 3b Diabetic kidney disease

Early Warning Smartphone Diagnostics for Water Security and Analysis Using Real-Time pH Mapping

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Photonic Sensors 2015年第4期5卷 289-297页

作者： Md. Arafat HOSSAIN John CANNING sandra AST Peter J. RUTLEDGE Abbas JAMALIPOUR interdisciplinary Photonics Laboratories (iPL) School of Chemistry The University of Sydney NSW 2006 Australia School of Chemistry The University of Sydney NSW 2006 Australia Wireless Networking Group (WING) School of Electrical and Information Engineering The University of Sydney NSW2006 Australia

Early detection of environmental disruption, unintentional or otherwise, is increasingly desired to ensure hazard minimization in many settings. Here, using a field-portable, smartphone fluorimeter to assess water quality based on the pH response of a designer probe, a map of pH of public tap water sites has been obtained. A custom designed Android application digitally processed and mapped the results utilizing the global positioning system （GPS） service of the smartphone. The map generated indicates no disruption in pH for all sites measured, and all the data are assessed to fall inside the upper limit of local government regulations, consistent with authority reported measurements. This implementation demonstrates a new security concept： network environmental forensics utilizing the potential of novel smartgrid analysis with wireless sensors for the detection of potential disruption to water quality at any point in the city. This concept is applicable across all smartgrid strategies within the next generation of the Internet of Things and can be extended on national and global scales to address a range of target analytes, both chemical and biological.

关键词： Lab-in-a-phone Intemet of Things optical sensing and sensor smartphone sensor photonic sensor fluorescence water security

Radiological diagnosis and staging of hilar cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2013年第7期5卷 115-126页

作者： Carlos Valls sandra Ruiz Laura Martinez David Leiva Department of Radiology Bellvitge University HospitalBarcelona 08907Spain

Hilar cholangiocarcinoma is a rare malignant tumor arising from the epithelium of the bile *** is still the only chance of potentially curative treatment in patients with perihilar ***,radical resection requires aggressive surgical strategies that should be tailored optimally according to the location,size and vascular invasion of the *** diagnosis and staging of these tumors is therefore critical for optimal treatment planning and for determining a *** computed tomography(MDCT),magnetic resonance imaging(MRI) and MR cholangiography are useful tools,both to diagnose and stage hilar *** imaging techniques allow accurate detection of the level of obstruction and the longitudinal and radial spread of the *** addition,high-resolution MDCT and MR provide specific radiographic features to determine vascular involvement of anatomic structures,such as the hepatic artery or the portal vein,which are critical to decide the surgical ***,radiological staging allows detection of patients with distant metastasis in the liver or peritoneum who will not benefit from a surgical approach.

关键词： Cholangiocarcinoma Radiological staging Magnetic resonance imaging Multidetector computed tomography Hepatic resection

Changes of the liver metabolome following an intravenous lipopolysaccharide injection in Holstein cows supplemented with dietary carnitine

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Journal of Animal Science and Biotechnology 2023年第1期14卷 188-199页

作者： Wei Xu sandra Grindler Akos Kenez Sven Danicke Jana Frahm Korinna Huber Beijing Research Center of Intelligent Equipment for Agriculture Beijing 100097China. Department of Biosystems Biosystems Technology ClusterCampus GeelKleinhoefstraat 42440 Geel LeuvenKUBelgium. Institute of Animal Science Faculty of Agricultural SciencesUniversity of Hohenheim70599 StuttgartGermany. Department of Infectious Diseases and Public Health City University of Hong KongBlock 14/FTo Yuen Building31 To Yuen StreetKowloonHong Kong SARChina. Institute of Animal Nutrition Federal Research Institute for Animal Health(Friedrich-Loeffler-Institut)38116 BrunswickGermany.

Background:Carnitine facilitates the flux of long-chain fatty acids for hepatic mitochondrial beta-oxidation,which acts to ameliorate the negative energy balance commonly affecting high-yielding dairy *** triggered by lipopolysaccharide(LPS)load can however pose a challenge to the metabolic integrity via the expression of pro-inflammatory mediators,leading to immune system activation and respective metabolic *** effect of enhanced carnitine availability on hepatic metabolome profiles during an inflammatory challenge has not yet been determined in dairy ***,Holstein cows were supplemented with 25 g/d rumen-protected carnitine from 42d prepartum until 126 d postpartum(n=16)or assigned to the control group with no supplementation during the same period(n=14).We biopsied the liver of the cows before(100 d postpartum)and after(112 d postpartum)an intravenous injection of 0.5μg/kg *** samples were subjected to a targeted metabolomics analysis using the AbsoluteIDQ p180 Kit(Biocrates Life Sciences AG,Innsbruck,Austria).Results:Multivariate statistical analyses revealed that hepatic metabolome profiles changed in relation to both the carnitine supplementation and the LPS *** the metabolite profiles on 100 d,carnitine increased the concentration of short-and long-chain acyl-carnitines,which may be explained by an enhanced mitochondrial fatty acid shuttle and hence greater energy *** LPS injection affected hepatic metabolite profiles only in the carnitine supplemented group,particularly altering the concentration of biogenic ***:Our results point to interactions between an acute hepatic inflammatory response and biogenic amine metabolism,depending on energy availability.

关键词： Acyl-carnitines Inflammatory response Lipid metabolism Liver metabolome Mitochondrial function

In vivo evaluation of riboflavin receptor targeted fluorescent USPIO in mice with prostate cancer xenografts

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Nano Research 2016年第5期9卷 1319-1333页

作者： Jabadurai Jayapaul Susanne Ares Matt Bunker Marek Weiler sandra Rutherford Peter Comba Fabian Kiessling Institute for Experimental Molecular Imaging RWTH Aachen University Pauwelsstrasse 30 Aachen 52074 Germany Anorganisch-Chemisches Institut Universit#t Heidelberg Im Neuenheimer Feld 270 Heidelberg 59120 Germany Molecular Imaging Group Department of Structural Biology Leibniz Institut fur Molekulare Pharmakologie (FMP) Robert-Rossle-Str. 10 Berlin 13125 Germany AstraZeneca Pharmaceutical Development Charter Way Macclesfield Cheshire SK10 2NA UK Molecular Profiles Ltd. 8 Orchard Place Nottingham Business Park Nottingham NG8 6PX UK

Riboflavin （Rf） receptors bind and translocate Rf and its phosphorylated forms （e.g. flavin mononucleotide, FMN） into cells where they mediate various cellular metabolic pathways. Previously, we showed that FMN-coated ultrasmall superparamagnetic iron oxide （FLUSPIO） nanoparticles are suitable for labeling metabolically active cancer and endothelial cells in vitro. In this study, we focused on the in vivo application of FLUSPIO using prostate cancer xenografts. Size, charge, and chemical composition of FLUSPIO were evaluated. We explored the in vitro specificity of FLUSPIO for its cellular receptors using magnetic resonance imaging （MRI） and Prussian blue staining. Competitive binding experiments were performed in vivo by injecting free FMN in excess. Bio-distribution of FLUSPIO was determined by estimating iron content in organs and tumors using a colorimetric assay. AFM analysis and zeta potential measurements revealed a particulate morphology approximately 20-40 nm in size and a negative zeta potential （-24.23±0.15 mV） in water. X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry data confirmed FMN present on the USPIO nanoparticle surface. FLUSPIO uptake in prostate cancer cells and human umbilical vein endothelial cells was significantly higher than that of control USPIO, while addition of excess of free FMN reduced accumulation. Similarly, in vivo MRI and histology showed specific FLUSPIO uptake by prostate cancer cells, tumor endothelial cells, and tumor-associated macrophages. Besides prominent tumor accumulation, FLUSPIO accumulated in the liver, spleen, lung, and skin. Hence, our data strengthen our hypothesis that targeting riboflavin receptors is an efficient approach to accumulate nanomedicines in tumors opening perspectives for the development of diagnostic and therapeutic systems.

关键词： flavin mononucleotide iron oxide nanoparticles magnetic resonance imaging molecular imaging riboflavin carrier protein riboflavin transporters

Eating practices during pregnancy:perceptions of select Maasai women in Northern Tanzania

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Global Health Research and Policy 2017年第1期2卷 292-300页

作者： Jessica Lennox Pammla Petrucka sandra Bassendowski Graduate Student College of NursingUniversity of SaskatchewanSaskatoonCanada College of Nursing University of SaskatchewanSaskatoonCanada

Background:Globally,pregnant women are challenged to meet sufficient and necessary dietary intake in order to improve maternal and neonatal *** challenges are amplified in traditional communities,such as the Maasai,where the historical and cultural practices may further curtail,or impact on this dyad’s potential *** research is intended to enhance understanding of Maasai women’s pregnancy and nutrition traditions as well as their ***:Interviews with 12 pregnant Maasai women,all originally from the(Ngorongoro Conservation Area Authority NCAA)area and have spent most or all of their adult lives in the NCAA,sought to answer two research questions:how do these women describe their current dietary pattern and what do they believe is the role of nutrition during ***:Interpretive description methodology was used to reveal five themes:(1)Eating less food makes baby come easier,(2)Not producing food means more dependence,(3)Working hard harms my baby,(4)Knowing what is needed for a good pregnancy and(5)Preferring our traditional ways for pregnancy and ***:There is an imperative to address nutrition throughout the perinatal period within the Maasai population and the women recognize how important nutrition is for them and their *** to incorporate cultural values and practices must be embedded in programmes/services to achieve success and *** is important for future prenatal programming with the Maasai in northern Tanzania and other vulnerable groups of pregnant women to build on the women’s knowledge of what leads to good pregnancy outcomes.

关键词： Prenatal care Maternal nutrition Maasai Tanzania Interpretive description Pregnancy

Genetic testing vs microforceps biopsy in pancreatic cysts:Systematic review and meta-analysis

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World Journal of Gastroenterology 2019年第26期25卷 3450-3467页

作者： sandra Faias Luisa Pereira Angelo Luis Paula Chaves Marilia Cravo Department of Gastroenterology Instituto Portugues de Oncologia de Lisboa de Francisco GentilEPELisboa 1099-023Portugal Faculdade de Ciencias da Seude Universidade da Beira InteriorCovilha 200-506Portugal GRUBI-Grupo de Revisoes Sistematicas Universidade da Beira InteriorCovilha 6200-506Portugal Centro de Matemática e Aplicacoes(CMA-UBI) Universidade da Beira InteriorCovilha 6200-506Portugal Centro de Investigacao em Ciencias da Saude(CICS-UBI) Universidade da Beira InteriorCovilha 6200-506Portugal Department of Pathology Instituto Portugues de Oncologia de Lisboa de Francisco GentilEPELisboa 1099-023Portugal Department of Gastroenterology Hospital Beatriz AngeloLoures 2674-514Portugal Faculdade de Medicina Universidade de LisboaLisboa 1099-023Portugal

BACKGROUND Carcinoembryonic antigen(CEA)and cytology in pancreatic cystic fluid are suboptimal for evaluation of pancreatic cystic *** testing and microforceps biopsy are promising tools for pre-operative diagnostic improvement but comparative performance of both methods is *** To compare the accuracy of genetic testing and microforceps biopsy in pancreatic cysts referred for *** We performed a literature search in Medline,Scopus,and Web of Science for studies evaluating genetic testing of cystic fluid and microforceps biopsy of pancreatic cysts,with endoscopic ultrasound with fine-needle aspiration(EUSFNA)prior to surgery and surgical pathology as reference standard for *** evaluated the diagnostic accuracy for:1-benign cysts;2-mucinous low-risk cysts;3-high-risk cysts,and the diagnostic yield and rate of correctly identified cysts with microforceps biopsy and molecular *** also assessed publication bias,heterogeneity,and study *** Eight studies,including 1206 patients,of which 203(17%)referred for surgery who met the inclusion criteria were analyzed in the systematic review,and seven studies were included in the *** testing and microforceps biopsies were identical for diagnosis of benign *** analysis was superior for diagnosis of both low and high-risk mucinous cysts,with sensitivities of 0.89(95%CI:0.79-0.95)and 0.57(95%CI:0.42-0.71),specificities of 0.88(95%CI:0.75-0.95)and 0.88(95%CI:0.80-0.93)and AUC of 0.9555 and 0.92,*** diagnostic yield was higher in microforceps biopsies than in genetic analysis(0.73 vs 0.54,respectively)but the rates of correctly identified cysts were identical(0.73 with 95%CI:0.62-0.82 vs 0.71 with 95%CI:0.49-0.86,respectively).CONCLUSION Genetic testing and microforceps biopsies are useful second tests,with identical results in benign pancreatic *** analysis performs better for low-and high-risk cysts but has lower diagnos

关键词： Pancreatic cysts Endoscopic ultrasound Endoscopic ultrasound with fineneedle aspiration Genetic testing Microforceps biopsy Molecular analysis KRAS Carcinoembryonic antigen Cytology

UDP-glucuronosyltransferases mediate coffee-associated reduction of liver fibrosis in bile duct ligated humanized transgenic UGT1A mice

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Hepatobiliary Surgery and Nutrition 2021年第6期10卷 766-781页

作者： Steffen Landerer sandra Kalthoff Christian P.Strassburg Department of Internal Medicine I University Hospital BonnVenusberg-Campus 1BonnGermany

Background:Coffee consumption has been shown to reduce the risk of liver fibrosis and is capable of inducing human UDP-glucuronosyltransferase(UGT)1A ***1A enzymes act as indirect antioxidants catalyzing the elimination of reactive metabolites,which in turn are potent initiators of profibrotic *** aim of this study was to analyze the role of UGT1A genes as effectors of the protective properties of coffee in bile duct ligation(BDL)induced liver ***:Fourteen days BDL with and without coffee pre-and co-treatment was performed in htgUGT1A-WT and htgUGT1A-SNP *** UGT1A mRNA expression levels,serum bilirubin and aminotransferase activities were *** fibrosis was assessed by collagen deposition,computational analysis of Sirius red tissue staining and expression of profibrotic marker *** stress was measured by hepatic peroxidase concentrations and immunofluorescence ***:UGT1A transcription was differentially activated in the livers of htgUGT1A-WT mice after BDL,in contrast to a reduced or absent induction in the presence of ***-treated(coffee+BDL)htgUGT1A-WT-mice showed significantly increased UGT1A expression and protein levels and a considerably higher induction compared to water drinking WT mice(BDL),whereas in co-treated htgUGT1A-SNP mice absolute expression levels remained below those observed in htgUGT1A-WT *** deposition,oxidative stress and the expression of profibrotic markers inversely correlated with UGT1A expression levels in htgUGT1A-WT and SNP mice after BDL and coffee+BDL ***:Coffee exerts hepatoprotective and antioxidative effects via activation of UGT1A *** hepatic fibrosis as a result of coffee-mediated UGT1A induction during cholestasis was detected,while the protective action of coffee was lower in a common low-function UGT1A SNP haplotype present in 10%of the Caucasian *** study suggests that coffee consumption might

关键词： Glucuronidation cholestasis liver fibrosis coffee oxidative stress