检索结果-南通市图书馆

Human Endogenous Retrovirus Type W Envelope from Multiple Sclerosis Demyelinating Lesions Shows Unique Solubility and Antigenic Characteristics

引用

Virologica Sinica 2021年第5期36卷 1006-1026页

作者： Benjamin Charvet Justine Pierquin Joanna Brunel Rianne Gorter Christophe Que´tard Branka Horvat sandra amor Jacques Portoukalian Herve´Perron GeNeuro Innovation Lyon 69008France CIRI International Center for Infectiology ResearchINSERM U1111CNRS UMR5308University of LyonENS LyonFrance Universite´Claude Bernard Lyon 1 Lyon 69000France Department of Pathology Amsterdam UMCLocation VUMC1007 MB AmsterdamThe Netherlands ProteinSimple Abingdon OX143NBUK Centre for Neuroscience and Trauma Blizard InstituteBarts and London School of Medicine and DentistryQueen Mary University of LondonLondon E12ATUK

In multiple sclerosis(MS),human endogenous retrovirus W family(HERV-W)envelope protein,pHERV-W ENV,limits remyelination and induces microglia-mediated *** better understand its role,we examined the soluble pHERV-W antigen from MS brain lesions detected by specific ***-chemical and antigenic characteristics confirmed differences between pHERV-W ENV and ***-W ENV monomers and trimers remained associated with membranes,while hexamers self-assembled from monomers into a soluble macrostructure involving sulfatides in MS *** hexamers are stabilized by internal hydrophobic bonds and external hydrophilic ***-W studies in MS also suggest that this diffusible antigen may correspond to a previously described highmolecular-weight neurotoxic factor secreted by MS B-cells and thus represents a major agonist in MS *** methods are now needed to identify encoding HERV provirus(es)in affected cells *** properties and origin of MS brain pHERV-W ENV soluble antigen will allow a better understanding of the role of HERVs in MS *** present results anyhow pave the way to an accurate detection of the different forms of pHERV-W ENV antigen with appropriate conditions that remained unseen until now.

关键词： Multiple sclerosis(MS) Brain Antigen HERV-W Envelope Endogenous retrovirus MSRV-ENV Syncytin Demyelination Lipids Glycolipids Sulfatides Oligomer Hexamer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Assessment of food supplementation and surveillance as techniques to reduce damage caused by black capuchin monkeys Sapajus nigritus to forest plantations

引用

Current Zoology 2014年第5期60卷 581-590页

作者： sandra Bos MIKICH Laboratory of Ecology (Laborat6rio de Ecologia) Embrapa Florestas Caixa Postal 319 CEP 83411-000 Colombo PR Brazil Black Capuchin Monkey Program (Programa Macaco-prego) National Fund for the Control of Forest Pests (Fundo Nacional de Controle de Pragas Florestais) Dieter Liebsch Environmental Consulting (Dieter Liebsch Consultoria Ambiental) Curitiba PR Brazil dieterliebsch@yahoo.com.br

Black capuchin monkeys Sapajus nigritus are among several mammalian species that damage forest plantations, pri- marily plantations of pine trees （Pinus spp.） in South Brazil. Management practices to reduce these damages include supplemen- tary food offerings and plantation surveillance. To assess the efficiency of these techniques, four treatments were evaluated： feeding （F, with supplementary bananas and maize）, surveillance （S, in situ, wherein men patrolled the plantations, deterring the monkeys）, feeding ＋ surveillance （FS） and control （no procedures）（C）. The efficiency assessment of each treatment involved the number of recorded primate sightings in the treatments with the presence of guards （S and FS） and a damage inventory of the outskirts of the experimental points immediately before and after the experiment. These data were complemented by a simulta- neous study of the availability of fruit, the primary item in the diet of this primate species, in the remnant native forest in the study area. Most sightings of S. nigritus occurred early in the morning, and in general, sightings were inversely proportional to the availability of native fruits. This trend was most evident in treatment FS, most likely due to the presence of food. Treatments F and FS exhibited higher percentages of damage, indicating that these are inefficient management techniques. Treatment S exhi- bited the lowest damage rate, but at a high cost, making this technique difficult to apply over large expanses. The development of other management techniques, such as environmental enrichment and the use of deterrents, is recommended to minimize the damage caused by capuchins in forest plantations [Current Zoology 60 （5）： 581-590, 2014].

关键词： Cebus Damage control Wildlife management Pinus Food provisioning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pork Meat Quality of Preto Alentejano and Commercial Largewhite Landrace Cross

引用

Journal of Integrative Agriculture 2013年第11期12卷 1961-1971页

作者： Alfredo Teixeira sandra Rodrigues Veterinary and Animal Reserch Centre (CECAV) Agrarian School of Polytechnic Institute of BraganaCampus Sta Apolónia Apt.1172Bragan a 5301-855Portugal Mountain Research Centre(CIMO) Agrarian School of Polytechnic Institute of BraganaCampus Sta Apolónia Apt.1172Bragan a 5301-855Portugal

This work aimed to evaluate the physical-chemical characteristics of pork from a local breed （Portuguese black pork called Preto Alentejano） and a commercial breed. Sixteen animals were used, 4 females and 4 males from each breed. Animals had 80-100 kg of live weight. The longissimus muscle between the 5th thoracic vertebra and the 10th lumbar vertebra was used in the analysis. Samples were analysed for protein, fat, pigments, ashes, dry mater, water-holding capacity, and texture. Results of fat and pigments contents indicate signiifcant （P〈0.05 and P〈0.01） differences for all treatments. For protein, ashes, dry mater, water-holding capacity and texture, no signiifcant differences were found for sex. In the analysis of fatty acids composition, ten were detected, being the main ones C16：0, C18：0, C16：1, C18：1, C18：2. There was a predominance of monounsaturated fatty acids （MUFA）, followed by saturated （SFA） and polyunsaturated （PUFA）. Differences were signiifcant for sex （P〈0.01） and breed （P〈0.01）. Preto Alentejano breed and females presented the higher percentages of SFA （P〈0.01） and MUFA （P〈0.001） fatty acids. Differences between breeds might be due to breed production system and feed differences.

关键词： breed sex pork meat quality

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Catalytic domain of PDC-E2 contains epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis

引用

World Journal of Gastroenterology 2010年第8期16卷 973-981页

作者： sandra Braun Christoph Berg sandra Buck Michael Gregor Reinhild Klein Department of Internal Medicine University of Tuebingen Department of Internal Medicine University of Tuebingen

AIM:To search for further immunodominant peptides of the pyruvate dehydrogenase complex E2-component (PDC-E2) recognized by antimitochondrial antibodies (AMA) in primary biliary cirrhosis (PBC). METHODS:Sera from 95 patients with PBC were tested by enzyme-linked immunosorbent assay against 33 synthetic overlapping peptides (25 amino acids; aa) covering the entire length of the E2-subunit of PDC-E2. Furthermore,the inner lipoyl peptide 167-184 was used in an unlip oylated and a lipoylated form as well as coupled to ovalbumin. Sera from 11 AMA negative/ANA posit ive PBC patients,63 patients with other liver disorders and 22 healthy blood donors served as ***:Of the 95 PBC-sera,74% reacted with the peptide 475-499 and 58% with the pept ide 407-431 located within the catalytic domain of PDC-E2. Patients with other disorders or healthy controls were positive in only up to 18%. Antibodies to the unlipoylatedand lip oylated pept ide 167-184 within the inner lipoyl domain were found in only 5% and 11% of the PBC sera,respectively; using ovalbumin-coupled peptides,the incidence increased up to 57% (unlipoylated form). CONCLUSION:Peptides within the catalytic site of PDC-E2 rather than the previously reported lipoyl binding peptide 167-184 may represent major immunodomin ant epitopes recognized by AMA in PBC.

关键词： Anti-M2 Epitope mapping E2-subunit Pyruvate dehydrogenase complex Inner lipoyl domain Active site Catalytic domain Primary biliary cirrhosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE

引用

世界最新医学信息文摘 2017年第30期 281-281页

作者： Marloes van Zwam Ruth Huizinga Marie-José Melief Annet F.Wierenga-Wolf Marjan van Meurs Jane S.Voerman Knut P.H.Biber Hendrikus W G.M.Boddeke Uta E.H?pken Christian Meisel Andreas Meisel Ingo Bechmann Rogier Q.Hintzen Bert A.'t Hart sandra amor Jon D.Laman Leonie A.Boven

Drainage of central nervous system(CNS) antigens to the brain-draining cervical lymph nodes(CLN) is likely crucial in the initiation and control of autoimmune responses during multiple sclerosis(MS).We demonstrate neuronal antigens within CLN of MS *** monkeys and mice with experimental autoimmune encephalomyelitis(EAE) and in mouse models with non-inflammatory CNS damage,the type and extent of CNS damage was associated with the frequencies of CNS antigens within the cervical lymph *** addition,CNS antigens drained to the spinal-cord-draining lumbar lymph *** human MS CLN,neuronal antigens were present in pro-inflammatory antigen-presenting cells(APC),whereas the majority of myelincontaining cells were *** may reflect a different origin of the cells or different drainage ***,neuronal antigen-containing cells in human CLN did not express the lymph node homing receptor CCR7,whereas myelin antigen-containing cells in situ and in vitro ***,CLN from EAE-affected CCR7-deficient mice contained equal amounts of myelin and neuronal antigens as wild-type *** conclude that the type and frequencies of CNS antigens within the CLN are determined by the type and extent of CNS ***,the presence of myelin and neuronal antigens in functionally distinct APC populations within MS CLN suggests that differential immune responses can be evoked.

关键词： Neuroinflammation Immune regulation Autoreactive Tcells Tolerance Chemokines Cytokines

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Hyper-chaos encryption using convolutional masking and model free unmasking

引用

Chinese Physics B 2014年第5期23卷 161-166页

作者：齐国元 sandra Bazebo Matondo Department of Electrical Engineerin Tshwane University of Technology Pretoria

In this paper, during the masking process the encrypted message is convolved and embedded into a Qi hyper-chaotic system characterizing a high disorder degree. The masking scheme was tested using both Qi hyper-chaos and Lorenz chaos and indicated that Qi hyper-chaos based masking can resist attacks of the filtering and power spectrum analysis, while the Lorenz based scheme fails for high amplitude data. To unmask the message at the receiving end, two methods are proposed. In the first method, a model-free synchronizer, i.e. a multivariable higher-order differential feedback controller between the transmitter and receiver is employed to de-convolve the message embedded in the receiving signal. In the second method, no synchronization is required since the message is de-convolved using the information of the estimated derivative.

关键词： Qi hyper-chaos masking high-order differentiator chaos-based encryption

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Compaction analysis and optimisation of convex-faced pharmaceutical tablets using numerical techniques

引用

Particuology 2019年第6期17卷 10-21页

作者： Ahmad Baroutaji sandra Lenihan Keith Bryan School of Engineering Faculty of Science and EngineeringUniversity of WolverhamptonTelfordUK School of Mechanical Electrical and Process EngineeringCork Institute of TechnologyCorkIreland

Capping failure,edge chipping,and non-uniform mechanical properties of convex-faced pharmaceutical tablets are common problems in the pharma *** this paper,the finite element method(FEM)and design of experiment techniques are used to determine the optimal shape of convex-faced(CF)pharmaceutical tablet which has more uniform mechanical properties and less capping and chipping *** effects of different geometrical parameters and friction on the compaction responses of convex-faced pharmaceutical tablets were first identified and *** FEM model of the tabletting process was generated using the implicit code ABAQUS and validated against experimental *** surface methodology was used to establish the relationship between the design variables,represented by the geometrical parameters and friction coefficient,and compaction responses of interest including residual die pressure,relative density variation within a tablet,and relative shear stress at the edge of a tablet.A statistical-based optimisation approach was then used to optimise the shape of CF *** obtained results demonstrated how the geometrical parameters and friction coefficient of CF pharmaceutical tablets strongly affect their compaction behaviour and quality.

关键词： Capping failure Edge chipping Tabletting FEM Optimisation Residual radial pressure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE

引用

世界最新医学信息文摘 2016年第11期 8-8页

作者： Marloes van Zwam Ruth Huizinga Marie-José Melief Annet F.Wierenga-Wolf Marjan van Meurs Jane S.Voerman Knut P.H.Biber Hendrikus W.G.M.Boddeke Uta E.H?pken Christian Meisel Andreas Meisel Ingo Bechmann Rogier Q.Hintzen Bert A.‘t Hart sandra amor Jon D.Laman Leonie A.Boven

Drainage of central nervous system(CNS) antigens to the brain-draining cervical lymph nodes(CLN) is likely crucial in the initiation and control of autoimmune responses during multiple sclerosis(MS). We demonstrate neuronal antigens within CLN of MS patients. In monkeys and mice with experimental autoimmune encephalomyelitis(EAE) and in mouse models with non-inflammatory CNS damage, the type and extent of CNS damage was associated with the frequencies of CNS antigens within the cervical lymph nodes. In addition, CNS antigens drained to the spinal-cord-draining lumbar lymph nodes. In human MS CLN, neuronal antigens were present in pro-inflammatory antigen-presenting cells(APC), whereas the majority of myelincontaining cells were anti-inflammatory. This may reflect a different origin of the cells or different drainage mechanisms. Indeed, neuronal antigen-containing cells in human CLN did not express the lymph node homing receptor CCR7, whereas myelin antigen-containing cells in situ and in vitro did. Nevertheless, CLN from EAE-affected CCR7-deficient mice contained equal amounts of myelin and neuronal antigens as wild-type mice. We conclude that the type and frequencies of CNS antigens within the CLN are determined by the type and extent of CNS damage. Furthermore, the presence of myelin and neuronal antigens in functionally distinct APC populations within MS CLN suggests that differential immune responses can be evoked.

关键词： Neuroinflammation Immune regulation Autoreactive Tcells Tolerance Chemokines Cytokines

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Measurements of Laminar Burning Velocities of Alternative Fuels:Application in Transport and Aerospace

引用

Journal of Thermal Science 2023年第2期32卷 503-512页

作者： RICHTER sandra BRAUN-UNKHOFF Marina NAUMANN Clemens German Aerospace Center(DLR) Institute of Combustion TechnologyDepartment of Chemical Kinetics and AnalyticsStuttgart 70569Germany

The laminar burning velocity belongs to the fundamental combustion properties of fuels being a measure for their heat release,flame length,as well as reactivity and combustion stability,and thus,may impact the design of burners and combustion ***,these experimental data are needed for the validation and optimization within the construction and development of detailed chemical kinetic reaction *** this study,an overview of the different applications of fuel characterization regarding the specific area of interest(road transport,aviation,and aerospace)will be *** on the application,effects of different molecular characteristics on the laminar burning velocity are evaluated:the presence of oxygen atoms and the grade of branching in a specific fuel molecule as well as the difference in the type of a chemical bond,here,single and double *** of alternative fuels being discussed in the present study are:(Ⅰ)oxymethylene ether(OMEn)in the field of road transport;(Ⅱ)a paraffinic Alcohol-to-Jet fuel as sustainable aviation fuel;and(Ⅲ)mixtures of ethane or ethene with nitrous oxide as green propellants for rocket propulsion applications.

关键词： laminar burning velocity alternative sustainable fuels road transport aviation fuels green propellants

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fruit availability, frugivore satiation and seed removal in 2 primate-dispersed tree species

引用

Integrative Zoology 2011年第3期6卷 178-194页

作者： sandra RATIARISON Pierre-Michel FORGET Department of Ecology and Management of Biodiversity Museum of Natural History Museum(MNHN)BrunoyFrance and oological Society of London LibrevilleGabon

During a mast-fruiting event we investigated spatial variability in fruit availability,consumption,and seed removal at two sympatric tree species,Manilkara bidentata and ***(Sapotaceae)at Nouragues Natural Reserve,French *** addressed the question of how Manilkara density and fruits at the community level might be major causes of variability in feeding assemblages between tree *** thus explored how the frugivore assemblages differed between forest patches with contrasting relative Manilkara density and fruiting *** the daytime,Alouatta seniculus was more often observed in *** crowns at Petit Plateau(PP)with the greatest density of Manilkara *** the lowest fruit diversity and availability,whereas Cebus apella and Saguinus midas were more often observed in *** crowns at both Grand Plateau(GP),with a lowest density of *** and overall greater fruit supply,and ***,nearly 53%and 15%of the *** seed crop at GP and PP,respectively,and about 47%of the *** seed crop were removed,otherwise either spit out or defecated beneath trees,or dropped in ***-bodied primates concentrated fallen seeds beneath parent trees while large-bodied primate species removed and dispersed more seeds away from ***,among the latter,satiated *** wasted seeds under conspecific trees at *** in feeding assemblages,seed removal rates and fates possibly reflected interactions with extra-generic fruit species at the community level,according to feeding choice,habitat preferences and ranging patterns of primate species.

关键词： frugivores masting primates satiation seed dispersal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：