Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE

作     者：Marloes van Zwam Ruth Huizinga Marie-José Melief Annet F.Wierenga-Wolf Marjan van Meurs Jane S.Voerman Knut P.H.Biber Hendrikus W.G.M.Boddeke Uta E.H?pken Christian Meisel Andreas Meisel Ingo Bechmann Rogier Q.Hintzen Bert A.‘t Hart Sandra Amor Jon D.Laman Leonie A.Boven 

出 版 物：《世界最新医学信息文摘》 (World Latest Medicine Information)

年 卷 期：2016年第11期

页      面：8-8页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Neuroinflammation Immune regulation Autoreactive Tcells Tolerance Chemokines Cytokines 

摘      要：Drainage of central nervous system(CNS) antigens to the brain-draining cervical lymph nodes(CLN) is likely crucial in the initiation and control of autoimmune responses during multiple sclerosis(MS). We demonstrate neuronal antigens within CLN of MS patients. In monkeys and mice with experimental autoimmune encephalomyelitis(EAE) and in mouse models with non-inflammatory CNS damage, the type and extent of CNS damage was associated with the frequencies of CNS antigens within the cervical lymph nodes. In addition, CNS antigens drained to the spinal-cord-draining lumbar lymph nodes. In human MS CLN, neuronal antigens were present in pro-inflammatory antigen-presenting cells(APC), whereas the majority of myelincontaining cells were anti-inflammatory. This may reflect a different origin of the cells or different drainage mechanisms. Indeed, neuronal antigen-containing cells in human CLN did not express the lymph node homing receptor CCR7, whereas myelin antigen-containing cells in situ and in vitro did. Nevertheless, CLN from EAE-affected CCR7-deficient mice contained equal amounts of myelin and neuronal antigens as wild-type mice. We conclude that the type and frequencies of CNS antigens within the CLN are determined by the type and extent of CNS damage. Furthermore, the presence of myelin and neuronal antigens in functionally distinct APC populations within MS CLN suggests that differential immune responses can be evoked.