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Compaction analysis and optimisation of convex-faced pharmaceutical tablets using numerical techniques

Particuology 2019年第6期17卷 10-21页

作者： Ahmad Baroutaji sandra lenihan Keith Bryan School of Engineering Faculty of Science and EngineeringUniversity of WolverhamptonTelfordUK School of Mechanical Electrical and Process EngineeringCork Institute of TechnologyCorkIreland

Capping failure,edge chipping,and non-uniform mechanical properties of convex-faced pharmaceutical tablets are common problems in the pharma *** this paper,the finite element method(FEM)and design of experiment techniques are used to determine the optimal shape of convex-faced(CF)pharmaceutical tablet which has more uniform mechanical properties and less capping and chipping *** effects of different geometrical parameters and friction on the compaction responses of convex-faced pharmaceutical tablets were first identified and *** FEM model of the tabletting process was generated using the implicit code ABAQUS and validated against experimental *** surface methodology was used to establish the relationship between the design variables,represented by the geometrical parameters and friction coefficient,and compaction responses of interest including residual die pressure,relative density variation within a tablet,and relative shear stress at the edge of a tablet.A statistical-based optimisation approach was then used to optimise the shape of CF *** obtained results demonstrated how the geometrical parameters and friction coefficient of CF pharmaceutical tablets strongly affect their compaction behaviour and quality.

关键词： Capping failure Edge chipping Tabletting FEM Optimisation Residual radial pressure

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A combination of density-based clustering method and DEM to numerically investigate the breakage of bonded pharmaceutical granules in the ball milling process

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Particuology 2021年第5期19卷 153-168页

作者： Alexander Krok Peter Peciar Kieran Coffey Keith Bryan sandra lenihan Department of Process Energy and Transport EngineeringMunster Technological UniversityBishopstownCork T12 P928Ireland Department of Mechanical Biomedical and Manufacturing EngineeringMunster Technological UniversityBishopstownCork T12 P928Ireland Pfizer Newbridge LittleconnellNewbridgeCo.Kildare W12 HX57Ireland Institute of Process Engineering Faculty of Mechanical EngineeringSlovak University of TechnologyNam.Slobody 1781231 BratislavaSlovakia

Ball milling is widely used in industry to mill particulate *** primary purpose of this process is to attain an appropriate product size with the least possible energy *** process is also extensively utilised in pharmaceuticals for the comminution of the excipients or ***,for ball mill,little is known concerning the mechanism of size *** prediction approaches are not deemed useful to provide significant insights into the operation or facilitate radical step changes in ***,the discrete element method(DEM)as a computational modelling approach has been used in this *** previous research,DEM has been applied to simulate breaking behaviour through the impact energy of all ball collisions as the driving force for ***,the nature of pharmaceutical material fragmentation during ball milling is more *** functional equations which link broken media and applied energy do not consider the collision of particulate media of different shapes or collisions of particulate media(such as granules)with balls and rotating mill *** could have a significant impact on ***,this paper aimed to investigate the fragmentation of bounded particles into DEM granules of different shape/size during the ball milling process.A systematic study was undertaken to explore the effect of milling speed on breakage ***,in this study,a combination of a density-based clustering method and discrete element method was employed to numerically investigate the number and size of the fragments generated during the ball milling process over *** was discovered that the collisions of the ball increased proportionally with rotation speed until reaching the critical rotation ***,results illustrate that with an increase of rotation speed,the mill power increased *** caratacting motion of mill material together with balls was identified as the most

关键词： Ball milling Granular pharmaceutical lactose Density-based clustering Discrete element method Breakage Mill rotation speed ABAQUS

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