A combination of density-based clustering method and DEM to numerically investigate the breakage of bonded pharmaceutical granules in the ball milling process
作者机构：Department of ProcessEnergy and Transport EngineeringMunster Technological UniversityBishopstownCork T12 P928Ireland Department of MechanicalBiomedical and Manufacturing EngineeringMunster Technological UniversityBishopstownCork T12 P928Ireland Pfizer NewbridgeLittleconnellNewbridgeCo.Kildare W12 HX57Ireland Institute of Process EngineeringFaculty of Mechanical EngineeringSlovak University of TechnologyNam.Slobody 1781231 BratislavaSlovakia
出 版 物：《Particuology》 (颗粒学报（英文版）)
年 卷 期：2021年第19卷第5期
页 面：153-168页
核心收录：
学科分类：081901[工学-采矿工程] 0819[工学-矿业工程] 08[工学]
基 金：supported by the Career-FIT Fellowships funded through European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No.713654 supported by ACCORD(ITMS project code:313021X329),funded through the European Regional Development Fund
主 题：Ball milling Granular pharmaceutical lactose Density-based clustering Discrete element method Breakage Mill rotation speed ABAQUS
摘 要：Ball milling is widely used in industry to mill particulate *** primary purpose of this process is to attain an appropriate product size with the least possible energy *** process is also extensively utilised in pharmaceuticals for the comminution of the excipients or ***,for ball mill,little is known concerning the mechanism of size *** prediction approaches are not deemed useful to provide significant insights into the operation or facilitate radical step changes in ***,the discrete element method(DEM)as a computational modelling approach has been used in this *** previous research,DEM has been applied to simulate breaking behaviour through the impact energy of all ball collisions as the driving force for ***,the nature of pharmaceutical material fragmentation during ball milling is more *** functional equations which link broken media and applied energy do not consider the collision of particulate media of different shapes or collisions of particulate media(such as granules)with balls and rotating mill *** could have a significant impact on ***,this paper aimed to investigate the fragmentation of bounded particles into DEM granules of different shape/size during the ball milling process.A systematic study was undertaken to explore the effect of milling speed on breakage ***,in this study,a combination of a density-based clustering method and discrete element method was employed to numerically investigate the number and size of the fragments generated during the ball milling process over *** was discovered that the collisions of the ball increased proportionally with rotation speed until reaching the critical rotation ***,results illustrate that with an increase of rotation speed,the mill power increased *** caratacting motion of mill material together with balls was identified as the most
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