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Reducing unnecessary crossmatching for hip fracture patients by accounting for preoperative hemoglobin concentration

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World Journal of Orthopedics 2021年第5期12卷 292-300页

作者： Raj M Amin Varun Puvanesarajah Yash P Chaudhry Matthew J Best sandesh s rao steven M Frank Erik A Hasenboehler Department of Orthopaedic surgery Stanford University Medical CenterStanfordCA 94305United States Department of Orthopaedic surgery Johns Hopkins School of MedicineBaltimoreMD 21205United States Department of Orthopaedic surgery Philadelphia College of Osteopathic MedicinePhiladelphiaPA 19122United States Department of Orthopaedic surgery Massachusetts General HospitalBostonMD 02114United States Department of Anesthesiology Critical Care MedicineBaltimoreMD 21205United States Department of Orthopaedics Johns Hopkins School of MedicineBaltimoreMD 21205United States

BACKGROUND Maximum surgical blood order schedules were designed to eliminate unnecessary preoperative crossmatching prior to surgery in order to conserve blood bank *** protocols recommend type and cross of 2 red blood cell(RBC)units for patients undergoing surgery for treatment of hip *** hemoglobin has been identified as the strongest predictor of inpatient transfusion,but current maximum surgical blood order schedules do not consider preoperative hemoglobin values to determine the number of RBC units to prepare prior to *** To determine the preoperative hemoglobin level resulting in the optimal 2:1 crossmatch-to-transfusion(C:T)ratio in hip fracture surgery *** In 2015 a patient blood management(PBM)program was implemented at our institution mandating a single unit-per-occurrence transfusion policy and a restrictive transfusion threshold ofsymptomatic patients andse with refractory symptomatic anemia or history of coronary artery *** identified all hip fracture patients between 2013 and 2017 and compared the preoperative hemoglobin which would predict a 2:1 C:T ratio in the pre PBM and post PBM *** profiling and sensitivity analysis were performed with statistical significance set at Ps who underwent hip fracture surgery between 2013 and 2017 were identified,291 in the post PBM *** requirements in the post PBM cohort were lower(51%vs 33%,Ps transfused per patient was 1.15 in the pre PBM cohort,compared to 0.66 in the post PBM cohort(Psfusion probability of 50%)was predicted by a preoperative hemoglobin of 12.3 g/dL[area under the curve(AUC)0.78(95%confidence interval(CI),0.72-0.83),sensitivity 0.66]in the pre PBM cohort and 10.7 g/dL[AUC 0.78(95%CI,0.73-0.83),sensitivity 0.88]in the post PBM cohort.A

关键词： Hip fracture Transfusion Blood conservation Hemoglobin Type and cross Maximum surgical blood order schedule

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Passive activity enhances residual control ability in patients with complete spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2337-2347页

作者： Yanqing Xiao Mingming Gao Zejia He Jia Zheng Hongming Bai Jia-sheng rao Guiyun song Wei song Xiaoguang Li Beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The state Key Laboratory of Virtual Reality Technology and systems Beihang UniversityBeijingChina Department of Rehabilitation Engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task

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Crimean-Congo hemorrhagic fever:Pathogenesis,transmission and public health challenges

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World Journal of Virology 2025年第1期14卷 63-72页

作者： sita Kumari Karanam Kandra Nagvishnu Praveen Kumar Uppala sandhya Edhi srinivasa rao Varri Department of Pharmaceutical Biotechnology Maharajah’s College of PharmacyVizianagaram 535002Andhra PradeshIndia Department of Pharmacology Santhiram Medical College and General HospitalNandyal 518501Andhra PradeshIndia Department of Pharmacology Santhiram Medical College and General HospitalNandyal 518501Andhra PradeshIndia Department of Pharmaceutical AnalysisMaharajah's College of PharmacyVizianagaram 535002Andhra PradeshIndia

The dangerous Crimean-Congo hemorrhagic fever virus(CCHFV),an encapsulated negative-sense RNA virus of the family Nairoviridae,is transmitted from person to person via *** a case fatality rate between 10%to 40%,the most common ways that the disease may spread to humans are via tick bites or coming into touch with infected animals'blood or ***,the transfer of bodily fluids between individuals is another potential route of *** is a wide range of symptoms experienced by patients throughout each stage,from myalgia and fever to extreme bruising and excess *** management measures include minimising the spread of ticks from one species to another and from people to animals via the use of protective clothing,repellents,and proper animal *** order to prevent the spread of illness,healthcare workers must adhere to stringent *** the lack of an authorised vaccine,the main components of treatment now consist of preventative measures and supportive care,which may include the antiviral medicine *** still don't know very much about the virus's mechanisms,even though advances in molecular virology and animal models have improved our understanding of the pathogenesis of CCHFV.A critical need for vaccination that is both safe and effective,as well as for quick diagnosis and efficient treatments to lessen the disease's impact in areas where it is most *** steps towards lowering Crimean-Congo hemorrhagic fever mortality and morbidity rates were to anticipatethe future availability of immunoglobulin products.

关键词： Crimean-congo haemorrhagic fever Tick-borne illness Immunoglobulins Viral hemorrhagic fever Antiviral therapy

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali song Luojia Wu Wei Wan Xiuqin rao Yue Lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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Controversies in fecal incontinence

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World Journal of Gastroenterology 2025年第3期31卷 113-119页

作者： Andreia Albuquerque satish s C rao school of Medicine and Biomedical sciences Fernando Pessoa UniversityGondomar 4420-096PortoPortugal Precancerous Lesions and Early Cancer Management Research Group RIsE@CI-IPO(Health Research Network) Portuguese Oncology Institute of PortoPorto 4200-072Portugal Division of Gastroenterology and Hepatology Department of Internal MedicineAugusta UniversityAugustaGA 30912United States

Fecal incontinence is a common condition that can significantly impact patients’quality of *** anal sphincter injury and anorectal surgeries are common *** ultrasound and anorectal manometry are important diagnostic tools for evaluating *** are various treatment options,including diet,lifestyle modifications,drugs,biofeedback therapy,tibial and sacral nerve neuromodulation therapy,and *** this editorial,we will discuss current controversies and novel approaches to fecal *** for asymptomatic anal sphincter defects after obstetric anal sphincter injury and in patients with inflammatory bowel disease is not generally recommended,but may be helpful in selected *** Garg incontinence score is a new score that includes the assessment of solid,liquid,flatus,mucous,stress and urge fecal *** tests such as translumbosacral anorectal magnetic stimulation and novel therapies such as translumbosacral neuromodulation therapy are promising diagnostic and treatment options,for both fecal incontinence and *** biofeedback therapy can overcome some limitations of the office-based *** muscle-derived cell implantation of the external anal sphincter has been further studied as a possible treatment *** neuromodulation may be useful in scleroderma,congenital fecal incontinence and inflammatory bowel disease but merits further study.

关键词： Fecal incontinence Endoanal ultrasound Anal sphincter defects Biofeedback Neuropathy sacral neuromodulation

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The Role of Vanadia for the selective Oxidation of Benzyl Alcohol over Heteropolymolybdate supported on Alumina

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催化学报 2011年第11期32卷 1719-1726页

作者： Pasupulet siva Nageswara rao Kasanneni Tirumala Venkateswara rao Potharaju s. sAI PRAsAD Nakka LINGAIAH Catalysis Laboratory Inorganic and Physical Chemistty Division Indian Institute of Chemical Technology Hyderabad 500 607 lndia

A series of 12-molybdophosphoric acid (MPA) supported on V2O5 dispersed γ-Al2O3 catalysts with different vanadia loadings were prepared by impregnation and characterized by N2 adsorption-desorption, X-ray diffraction, temperature-programmed reduction, in situ laser Raman spectroscopy, UV-Vis diffused reflectance spectroscopy, scanning electron microscopy, and temperature-programmed desorption of NH3 techniques. Their catalytic activities were evaluated for the vapor phase aerobic oxidation of benzyl alcohol. The catalysts exhibited high catalytic activity and the conversion of benzyl alcohol depended on the vanadia content while the catalyst with 15 wt% V2O5 content showed optimum activity. The characterization results suggest the presence of well-dispersed V2O5 and partially disintegrated Keggin ions of MPA on the support. In situ Raman studies showed a reduced Mo(IV) species when the catalysts were calcined at high temperatures. The high oxidation activity of the catalysts is related to the synergistic effect between MPA and V2O5.

关键词： molybdophosphoric acid vanadia alumina oxidation benzyl alcohol

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Assessment of soil microbial and enzyme activity in the rhizosphere zone under different land use/cover of a semiarid region, India

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Ecological Processes 2021年第1期10卷 225-236页

作者： Archana Meena K.s.rao Department of Botany University of RajasthanJaipurRajasthan 302004India. Natural Resource Management Laboratory Department of BotanyUniversity of DelhiNorth CampusDelhi 110007India.

Background:Land use/cover and management practices are widely known to influence soil organic matter(sOM)quality and *** present study investigated the effect of different land use,i.e.,forests *** forest cover(MFC),Prosopis juliflora(sw.)DC-dominated forest cover(PFC),and cultivated sites *** field(AF),vegetable field(VF),respectively,on soil parameter,microbial activity,and enzymes involved in soil nutrient cycle in a semiarid region of ***:The results showed a significant reduction(Psoil carbon(sC),soil nitrogen(sN)content(~30–80%)and consequently the soil microbial biomass carbon(sMBC)(~70–80%),soil basal respiration(sBR),soil substrate-induced respiration(ssIR),and soil enzyme activities(β-glucosidase,acid phosphatase,and dehydrogenase)under cultivated sites in comparison with forest ***’s correlation showed that a positive correlation of sC with sMBC,sBR,ssIR(Ps(i.e.,β-glucosidase,dehydrogenase)(PsC in regulating microbial and enzymatic ***,a positive correlation of soil moisture with urease activity(Ps found suggesting it as a significant abiotic factor for soil biological ***,based on the PCA analysis,we observed the clustering of sMBC/sC ratio and qCO_(2) nearby ***:Our study suggests that soil microbial parameters(sMBC,sBR,ssIR,sMBC/sC,qCO_(2))and enzyme activity are key indicators of soil health and *** use/cover alters the sOM content and soil microbial *** management strategies focusing on the conservation of natural forest and minimizing the land disturbances will be effective in preventing soil carbon flux as CO_(2) and maintaining the sC stock.

关键词： Land use changes soil microbes soil enzymes semiarid ecosystems Land management practices

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Lactobionic Acid as a New synergist in Combination with Phosphonate-Zn(Ⅱ)system for Corrosion Inhibition of Carbon steel

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Journal of Materials science & Technology 2014年第1期30卷 77-89页

作者： s.srinivasa rao B.V.Appa rao s.Roopas Kiran B.sreedhar Department of Chemistry V.R.Siddhartha Engineering College(Autonomous) Department of Chemistry National Institute of Technology Warangal(NITW) INFN Sezione di Padova Inorganic & Physical Chemistry Division Indian Institute of Chemical Technology(IICT)

studies on lactobionic acid introduced as a synergist in the presence of phosphonobutane-1,2,4-tricarboxylic acid （PBTC） and zinc ions for corrosion control of carbon steel in aqueous environment are presented. The investigations revealed that lactobionic acid （LBA） acts as an excellent synergist in corrosion inhibition. Optimum concentrations of all the three components of the ternary formulation are established by gravimetric studies. Potentiodynamic polarization studies indicate that the new ternary system is a mixed inhibitor. Impedance studies show that a protective film is formed on the metal surface in the presence of the inhibitor formulation. The film is found to exhibit its protective nature even at higher temperatures up to 60 ~C. Analysis of the protective film by X-ray photoelectron spectroscopy （XPs） and reflection absorption Fourier transform infrared （FTIR） spectroscopy infers the presence of Zn（OH）2, oxides and hydroxides of iron and the inhibitor molecules in the surface film probably in the form of a complex, [Zn（II）-PBTC-LBA]. The morphological studies by scanning electron microscopy （sEM） and the topographical studies by atomic force microscopy （AFM） also indicate the presence of protective film on the metal surface. A plausible mechanism of corrosion inhibition is proposed.

关键词： Corrosion inhibitor Carbon steel synergism X-ray photoelectron spectroscopy Electrochemical impedance spectroscopy

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Dolochar as a reductant in the reduction roasting of iron ore slimes

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International Journal of Minerals,Metallurgy and Materials 2017年第12期24卷 1341-1351页

作者： swagat s. Rath Danda srinivas rao Institute of Minerals and Materials Technology Council of Scientific&Industrial ResearchBhubaneswar 751013India

The present investigation examines the viability of dolochar, a sponge iron industry waste material, as a reductant in the reduction roasting of iron ore slimes, which are another waste generated by iron ore beneficiation plants. Under statistically determined optimum conditions, which include a temperature of 900°C, a reductant-to-feed mass ratio of 0.35, and a reduction time of 30–45 min, the roasted mass, after being subjected to low-intensity magnetic separation, yielded an iron ore concentrate of approximately 64 wt% Fe at a mass recovery of approximately 71% from the feed iron ore slime assaying 56.2 wt% Fe. X-ray diffraction analyses indicated that the magnetic products contain magnetite and hematite as the major phases, whereas the nonmagnetic fractions contain quartz and hematite.

关键词： iron ore slime reduction roasting dolochar reductant magnetic separation

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Thermoluminescence study of rare earth ion (Dy^(3+)) doped LiF:Mg crystals grown by EFG technique

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Journal of Rare Earths 2012年第7期30卷 641-646页

作者： Pooja seth shruti Aggarwal s M rao University school of Basic and Applied science Guru Gobind Singh Indraprastha University Department of Physics Punjabi University

This work describes investigation of radiation dosimetry characteristics of magnesium （Mg） doped lithium fluoride （LiF） crystals co-doped with different concentrations of dysprosium （Dy）. These crystals were grown by edge defined film fed crystal growth （EFG） tech- nique. Thermoluminescence （TL） measurements were made on as grown （AG） and annealed （AN） crystals after they were irradiated with a gamma dose of 15 Gy. The influence and advantage of optimized Dy^3＋ concentration in enhancing the thermoluminescence （TL） properties of LiF：Mg samples were discussed. The normalized peak height of the annealed crystals was nearly 3 times that of the as grown crystals for the particular concentration samples irradiated with Co6~ gamma source showed linearity up to 10 Gy. Thermoluminescence signal observed over a period of one month showed negligible fading. Thermoluminescence glow curve structure of optimized phosphor remained stable for higher doses of gamma rays of 103 Gy. Glow curve was analyzed using computer glow curve deconvolution （CGCD） method and trapping parame- ters were calculated.

关键词： thermoluminescenea rare earth ions annealing edge defined film fed growth technique

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