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Neural Regeneration Research 2021年第4期16卷 700-706页

作者： Piyush Bhardwaj don Kulasiri Sandhya Samarasinghe Centre of Advanced Computational Solutions(C-fACS) Lincoln UniversityChristchurchNew Zealand Department of Molecular Biosciences Lincoln UniversityChristchurchNew Zealand

The axon initial segment(AIS)region is crucial for action potential initiation due to the presence of high-density AIS protein voltage-gated sodium channels(Nav).Nav channels comprise several serine residues responsible for the recruitment of Nav channels into the structure of AIS through interactions with ankyrin-G(AnkG).In this study,a series of computational experiments are performed to understand the role of AIS proteins casein kinase 2 and AnkG on Nav channel recruitment into the *** computational simulation results using Virtual cell software indicate that Nav channels with all serine sites available for phosphorylation bind to AnkG with strong *** the low initial concentration of AnkG and casein kinase 2,the concentration of Nav channels reduces significantly,suggesting the importance of casein kinase 2 and AnkG in the recruitment of Nav channels.

关键词： Alzheimer’s disease ankyrin-G axon initial segment casein kinase-2 microtubules voltage-gated potassium channel voltage-gated sodium channel

Functional repertoire of protein kinases and phosphatases in synaptic plasticity and associated neurological disorders

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Neural Regeneration Research 2021年第6期16卷 1150-1157页

作者： Raheel Khan don Kulasiri Sandhya Samarasinghe Centre for Advanced Computational Solutions(C-fACS) Lincoln UniversityChristchurchNew Zealand Department of Molecular Biosciences Lincoln UniversityChristchurchNew Zealand

Protein phosphorylation and dephosphorylation are two essential and vital cellular mechanisms that regulate many receptors and enzymes through kinases and ***^2+- dependent kinases and phosphatases are responsible for controlling neuronal processing;balance is achieved through *** molecular mechanisms of learning and memory,kinases generally modulate positively while phosphatases modulate *** review outlines some of the critical physiological and structural aspects of kinases and phosphatases involved in maintaining postsynaptic structural *** also explores the link between neuronal disorders and the deregulation of phosphatases and kinases.

关键词： Alzheimer’s disease autism spectrum disorder CaMKII calcineurin longterm depression long-term potentiation protein kinase A protein phosphatase 1 protein dephosphorylation protein phosphorylation

Therapeutic Profile and Prognostic Factors of Patients Suffering from Upper Digestive Bleeding at Sikasso Regional Hospital

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Open Journal of Gastroenterology 2024年第9期14卷 300-312页

作者： Oumar Traoré Abdoul Salam Diarra Dramane Touré Tawfiq Abu Amadou Boubeye Maïga Kadiatou Cissé Saïdon Touré Mohomedine Touré Aboudou Dolo Youana Koné Madou Traoré Mamadou Togo Kalba Péliaba Mamadou Samaké Hamadoun Sangho Service of Internal Medicine Regional Hospital Sikasso Mali National Center for Scientific and Technological Research Bamako Mali Department of Pediatric Health Referral Center of Kalaban Coro Koulikoro Mali Private Practice for Family and Emergency Medicine Casablanca Morocco Service of Nephrology Regional Hospital Sikasso Mali Department of Infectious Disease Regional Hospital Sikasso Mali Service de Mdecine Interne CHU Gabriel Tour Bamako Mali Service dHpato-Gastro-Entrologie CHU Gabriel Tour Bamako Mali Department of Public Health Faculty of Medicine and Odontostomatology University of Sciences Techniques and Technologies of Bamako Bamako Mali

Introduction: Upper digestive hemorrhage is one of the main digestive emergencies and remains a major cause of morbidity and mortality in Mali. The aim of this study was to describe the therapeutic profile and outcome of patients suffering from upper digestive haemorrhage. Methodology: This was a prospective study carried out in the internal medicine department of the Sikasso Regional Hospital from August 2022 to July 2023. All adult patients presenting with upper digestive haemorrhage and having given their consent, were included. Data were analyzed using SPSS version 21 software. Results: Sixty-three patients were enrolled. The mean age was 49.7 ± 18.99 years, with a male-female sex ratio of 2.2. Ruptured esophageal varices (37.5%) and peptic ulcer (25%) were the main etiologies. Pharmacological treatment was dominated by proton pump inhibitors (85.7%). Hemostasis endoscopy accounted for 3.17%. The evolution was marked by hemorrhagic arrest (69.84%), recurrence of hemorrhage (11.11%) and death (19.04%), the main cause of which was hemorrhagic shock (58.3%). We found no statistically significant relationship between prognosis and etiologies (P = 0.11), and length of hospital stay (P = 0.18). Conclusion: Hemostasis endoscopy remains a challenge for Sikasso Hospital. A holistic strategy of communication and community awareness-raising, combined with adequate technical facilities, will help to improve patient care and outcomes.

关键词： Digestive Hemorrhage Digestive Endoscopy Treatment Outcome

Detection of Alzheimer’s disease onset using MRI and PET neuroimaging:longitudinal data analysis and machine learning

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Neural Regeneration Research 2023年第10期18卷 2134-2140页

作者： Iroshan Aberathne don Kulasiri Sandhya Samarasinghe Centre for Advanced Computational Solutions(C-fACS) Lincoln UniversityChristchurchNew Zealand

The scientists are dedicated to studying the detection of Alzheimer’s disease onset to find a cure, or at the very least, medication that can slow the progression of the disease. This article explores the effectiveness of longitudinal data analysis, artificial intelligence, and machine learning approaches based on magnetic resonance imaging and positron emission tomography neuroimaging modalities for progression estimation and the detection of Alzheimer’s disease onset. The significance of feature extraction in highly complex neuroimaging data, identification of vulnerable brain regions, and the determination of the threshold values for plaques, tangles, and neurodegeneration of these regions will extensively be evaluated. Developing automated methods to improve the aforementioned research areas would enable specialists to determine the progression of the disease and find the link between the biomarkers and more accurate detection of Alzheimer’s disease onset.

关键词： deep learning image processing linear mixed effect model neuroimaging neuroimaging data sources onset of Alzheimer’s disease detection pattern recognition

Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes

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Cancer Innovation 2024年第3期3卷 81-94页

作者： Sahil Seth Runzhe Chen Yang Liu Junya Fujimoto Lingzhi Hong Alexandre Reuben Susan Varghese Carmen Behrens Tina McDowell Luisa Solis Soto Cara Haymaker Annikka Weissferdt Neda Kalhor Jia Wu Xiuning Le Natalie I Vokes Chao Cheng John V.Heymach don L.Gibbons P.Andrew Futreal Ignacio IWistuba Humam Kadara Jianhua Zhang Cesar Moran Jianjun Zhang Department of Genomic Medicine The University of Texas MD Anderson Cancer CenterHoustonTexasUSA TRACTION The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Graduate School of Biomedical Sciences The University of Texas MD Anderson and the University of Texas Health Science CenterHoustonTexasUSA Department of Thoracic/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Medicine Baylor College of MedicineHoustonTexasUSA

Background:Pulmonary sarcomatoid carcinoma(PSC)is a rare and aggressive subtype of non-small cell lung cancer(NSCLC),characterized by the presence of epithelial and sarcoma-like *** molecular and immune landscape of PSC has not been well ***:Multiomics profiling of 21 pairs of PSCs with matched normal lung tissues was performed through targeted high-depth DNA panel,whole-exome,and RNA *** describe molecular and immune features that define subgroups of PSC with disparate genomic and immunogenic features as well as distinct clinical ***:In total,27 canonical cancer gene mutations were identified,with TP53 the most frequently mutated gene,followed by ***,most TP53 and KRAS mutations were earlier genomic events mapped to the trunks of the tumors,suggesting branching evolution in most PSC *** identified two distinct molecular subtypes of PSC,driven primarily by immune infiltration and *** Immune High(IM-H)subtype was associated with superior survival,highlighting the impact of immune infiltration on the biological and clinical features of localized ***:We provided detailed insight into the mutational landscape of PSC and identified two molecular subtypes associated with ***-H tumors were associated with favorable recurrence-free survival and overall survival,highlighting the importance of tumor immune infiltration in the biological and clinical features of PSCs.

关键词： genomic immune pulmonary sarcomatoid carcinoma survival

An adaptive directional MAC protocol for ad hoc networks using directional antennas

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Science China(Information Sciences) 2012年第6期55卷 1360-1371页

作者： TOWSLEY don LIO Pietro Deptartment of Computer Science University of MassachusettsAmherst 01003USA

A directional antenna can bring benefits in terms of power consumption,spatial reuse,*** exploit the advantage of directional antennas and improve the transmission throughput highest,this paper proposes an adaptive directional MAC protocol(ADMAC).By varying the transmission strategy according to the usage of the channel,nodes can send RTS and CTS packets omni-directionally or ***,this paper proposes a calculation method of virtual carrier sensing with collision *** the method,ADMAC protocol makes more pairs of nodes transmit and receive data simultaneously without interferences than other MAC protocols for directional *** paper compares the simultaneous delivering nodes and network throughput of ADMAC with DMAC,DVCS and SDMAC under different experiment *** simulation results show that the throughput of ADMAC is higher than the throughput of DMAC,DVCS and SDMAC protocols.

关键词： medium access control directional MAC directional antennas MANETs

A modified version of free orbit-dimension of von Neumann algebras

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Science China Mathematics 2011年第11期54卷 2329-2346页

作者： HADWIN don LI WeiHua Mathematics Department University of New Hampshire Durham NH 03824 USA Science and Mathematics Department Columbia College Chicago Chicago IL 60605 USA

Based on the notion of free orbit-dimension of Hadwin-Shen (2007) we introduce a new invariant for finite von Neumann algebras with arbitrarily large generating sets and acting on Hilbert spaces of arbitrary dimension. We show that this invariant is independent of the generating set, and we extend results in Hadwin-Shen (2007) to this larger class of algebras.

关键词： von Neumann algebras free entropy dimension free orbit dimension

Endoscopic ultrasound-guided portal pressure gradient identifies patients with previously undiagnosed clinically significant portal hypertension

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Portal Hypertension & Cirrhosis 2024年第2期3卷 67-74页

作者： Jerome C.Edelson Scott F.D.Edelson John G.Quiles Cyrus V.Edelson Eric M.Montminy Christian L.Horn John P.Magulick don C.Rockey Department of Gastroenterology and Hepatology Brooke Army Medical CenterFort Sam HoustonTexasUSA Department of Medicine Uniformed Services University of the Health SciencesBethesdaMarylandUSA Department of Medicine Brooke Army Medical CenterFort Sam HoustonTexasUSA John H.Stroger Jr.Hospital of Cook County ChicagoIllinoisUSA Digestive Disease Research Center Medical University of South CarolinaCharlestonSouth CarolinaUSA

Aims:Portal hypertension(PH)is a complication of cirrhosis that leads to hepatic *** the portal pressure gradient(PPG)provides valuable information for disease assessment,staging,and *** this study,we aimed to report the utilization of endoscopic ultrasound(EUS)-guided PPG(EUS-PPG)measurements in a real-world ***:This retrospective analysis included patients at a tertiary care center who underwent EUS-PPG between February 2021 and May *** most common indication was to establish or exclude the diagnosis of cirrhosis,followed by an assessment of surgical risk in the setting of suspected *** demographic and clinical data were collected,and statistical analysis was performed using the Student's t ***:Eighteen patients underwent *** success was achieved in 17 of the 18 *** complications were *** mean scores of Child-Pugh,Model for End-Stage Liver Disease-Sodium,and Fibrosis-4 scores were 5.1±0.5,9.0±3.0,and 3.7±4.5,*** the 18 patients,two presented with esophageal varices and six with portal hypertensive *** mean PPG was 5.8±4.5 mmHg,and five patients exhibited clinically significant PH(CSPH).Of the 18 patients,15 underwent concurrent EUS-liver biopsy,which was 100%successful and provided diagnostic histology for all *** PPG data led to changes in the clinical management of 17 ***:EUS-PPG is safe and technically *** Child-Pugh score did not correlate well with the presence of CSPH;however,PPG measurements resulted in changes in the management of almost all *** studies correlating EUS-PPG with other assessments of liver diseases are required.

关键词： EUS portal hypertension portal pressure gradient

A mathematical model of synaptotagmin 7 revealing functional importance of short-term synaptic plasticity

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Neural Regeneration Research 2019年第4期14卷 621-631页

作者： Yao He don Kulasiri Jingyi Liang Center for Advanced Computational Solutions (C-fACS) Lincoln UniversityChristchurch New Zealand

Synaptotagmin 7(Syt7), a presynaptic calcium sensor, has a significant role in the facilitation in shortterm synaptic plasticity: Syt7 knock out mice show a significant reduction in the facilitation. The functional importance of short-term synaptic plasticity such as facilitation is not well understood. In this study, we attempt to investigate the potential functional relationship between the short-term synaptic plasticity and postsynaptic response by developing a mathematical model that captures the responses of both wild-type and Syt7 knock-out mice. We then studied the model behaviours of wild-type and Syt7 knock-out mice in response to multiple input action potentials. These behaviors could establish functional importance of short-term plasticity in regulating the postsynaptic response and related synaptic properties. In agreement with previous modeling studies, we show that release sites are governed by non-uniform release probabilities of neurotransmitters. The structure of non-uniform release of neurotransmitters makes shortterm synaptic plasticity to act as a high-pass filter. We also propose that Syt7 may be a modulator for the long-term changes of postsynaptic response that helps to train the target frequency of the filter. We have developed a mathematical model of short-term plasticity which explains the experimental data.

关键词： synapse short-term plasticity short-term facilitation and depression mathematical model low-frequency stimulation high-frequency stimulation

Dynamical interactions of dark energy and dark matter:Yang-Mills condensate and QCD axions

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Chinese Physics C 2018年第7期42卷 103-112页

作者： Andrea Addazi Pietro donà Antonino Marcianò Department of Physics&Center for Field Theory and Particle Physics Fudan University200433 ShanghaiChina Institute for Gravitation and the Cosmos&Physics Department Penn StateUniversity ParkPA 16802USA

We analyze a model of cold axion dark matter weakly coupled with a dark gluon condensate, reproducing dark energy. We first review how to recover the dark energy behavior using the functional renormalization group approach, and ground our study in the properties of the effective Lagrangian, to be determined non-perturbatively. Then, within the context of GSM×SU（2）D×U（1）PQ, we consider Yang-Mills condensate （YMC） interactions with QCD axions. We predict a transfer of dark energy density into dark matter density, that can be tested in the next generation of experiments dedicated to dark energy measurements. We obtain new bounds on the interactions between the Yang-Mills condensate and axion dark matter from Planck data：the new physics interaction scale related to the axion/gluon condensate mixing is constrained to be higher than the 106 GeV energy scale.

关键词： dark matter dark energy axion peccei-quinn