检索结果-南通市图书馆

Elucidating the molecular basis of ATP-induced cell death in breast cancer: Construction of a robust prognostic model

引用

World Journal of Clinical Oncology 2024年第2期15卷 208-242页

作者： Hao-Ling Zhang sandai doblin Zhong-Wen Zhang Zhi-Jing Song Babu Dinesh Yasser Tabana DahhamSabbar Saad Mowaffaq Adam Ahmed Adam Yong Wang Wei Wang Hao-Long Zhang Sen Wu Rui Zhao Barakat Khaled Department of Biomedical Sciences Advanced Medical and Dental InstituteUniversiti Sains MalaysiaPenang 13200Malaysia School of Public Health Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Clinical College of Chinese Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Faculty of Pharmacy and Pharmaceutical Sciences University of AlbertaEdmonton AB T6G 2E1Canada Department of Science University of Technology and Applied Sciences RustaqRustaq 10 P.C.329Oman Department of Chemistry and Biochemistry San Diego State UniversitySan DiegoCA 92182United States Department of Pathology Center Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina College of Acupuncture-moxibustion and Tuina Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Universiti Sains Malaysia Advanced Medical and Dental InstitutePenang 13200Malaysia Department of Biomedical Science Universiti Sains MalaysiaPenang 13200Malaysia

BACKGROUND Breast cancer is a multifaceted and formidable disease with profound public health *** demise mechanisms play a pivotal role in breast cancer pathogenesis,with ATP-triggered cell death attracting mounting interest for its unique specificity and potential therapeutic *** To investigate the impact of ATP-induced cell death(AICD)on breast cancer,enhancing our understanding of its *** The foundational genes orchestrating AICD mechanisms were extracted from the literature,underpinning the establishment of a prognostic ***,a microRNA(miRNA)prognostic model was constructed that mirrored the gene-based prognostic *** between high-and low-risk cohorts within mRNA and miRNA characteristic models were scrutinized,with the aim of delineating common influence mechanisms,substantiated through enrichment analysis and immune infiltration *** The mRNA prognostic model in this study encompassed four specific mRNAs:P2X purinoceptor 4,pannexin 1,caspase 7,and cyclin *** miRNA prognostic model integrated four pivotal miRNAs:hsa-miR-615-3p,hsa-miR-519b-3p,hsa-miR-342-3p,and hsa-miR-324-3p.B cells,CD4+T cells,CD8+T cells,endothelial cells,and macrophages exhibited inverse correlations with risk scores across all breast cancer ***,Kyoto Encyclopedia of Genes and Genomes analysis revealed that genes differentially expressed in response to mRNA risk scores significantly enriched 25 signaling pathways,while miRNA risk scores significantly enriched 29 signaling pathways,with 16 pathways being jointly *** Of paramount significance,distinct mRNA and miRNA signature models were devised tailored to AICD,both potentially autonomous prognostic *** study's elucidation of the molecular underpinnings of AICD in breast cancer enhances the arsenal of potential therapeutic tools,offering an unparalleled window for innovative ***,this paper revea

关键词： ATP-induced cell death mRNA miRNA Prognostic model Breast cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anticancer effect of Psidium guajava(Guava) leaf extracts against colorectal cancer through inhibition of angiogenesis

引用

Asian Pacific Journal of Tropical Biomedicine 2020年第7期10卷 293-307页

作者： Bronwyn Lok doblin sandai Hussein M.Baharetha Mansoureh Nazari V Muhammad Asif Chu Shan Tan AMS Abdul Majid EMAN Laboratory Discipline of PharmacologySchool of Pharmaceutical SciencesUniversiti Sains MalaysiaPenangMalaysia Infectomics Cluster Advance Medical and Dental InstituteUniversiti Sains MalaysiaPenangMalaysia Department of Pharmacy College of Medicine and Health SciencesHadhramout UniversityHadhramoutYemen Department of Pharmacology Faculty of Pharmaceutical SciencesGovernment College University FaisalabadFaisalabadPakistan Discipline of Pharmacology School of Pharmaceutical SciencesUniversiti Sains MalaysiaPenangMalaysia ACRF Department of Cancer Biology and Therapeutics John Curtin School of Medical ResearchAustralian National UniversityCanberraAustralia

Objective:To evaluate the anti-angiogenic and anticancer activities of Psidium guajava leaf extracts against angiogenesis-dependent colorectal ***:Three extracts were produced using distilled water,ethanol,and n-hexane as *** extracts were physically characterised through gas chromatography–mass spectrometry,ultraviolet–visible spectroscopy,and Fourier transform infrared *** antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl,total phenolic content,and total flavonoid content *** assess their anti-angiogenic activity,cell viability and rat aortic ring assays were conducted,while cell migration,tube formation,colony formation,and VEGF ELISA assays were conducted to elucidate their effects on different aspects of *** docking was used to assess the antiangiogenic potential of some possible compounds in the *** spheroid assay was used to assess the extracts’potential as a treatment for colorectal ***:The ethanol extract showed the best antioxidant *** distilled water and ethanol extracts exhibited more inhibitory activity against ***926 cell viability and aortic ring microvessel *** addition,the ethanol extract performed significantly better than the distilled water extract against cell migration and colony formation,and VEGF expression of the cells was suppressed by the ethanol *** the distilled water and ethanol extracts showed significant inhibitory effect on ***926 tube formation and tumour spheroids consisting of ***926 and HCT116 *** ethanol extract containedβ-caryophyllene andβ-elemene by phytochemical analysis and subsequent docking studies,which may contribute to its anti-angiogenic ***:The ethanol extract of Psidium guajava has potential in the treatment of colorectal cancer through the inhibition of angiogenesis.

关键词： Angiogenesis Antioxidant Colorectal cancer Psidium guajava VEGF

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Adenosine triphosphate induced cell death: Mechanisms and implications in cancer biology and therapy

引用

World Journal of Clinical Oncology 2023年第12期14卷 549-569页

作者： Hao-Ling Zhang doblin sandai Zhong-Wen Zhang Zhi-Jing Song Dinesh Babu Yasser Tabana Sabbar Saad Dahham Mowaffaq Adam Ahmed Adam Yong Wang Wei Wang Hao-Long Zhang Rui Zhao Khaled Barakat Mohammad Syamsul Reza Harun Siti Nurfatimah Mohd Shapudin Bronwyn Lok Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia School of Public Health Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Clinical College of Chinese Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Faculty of Pharmacy and Pharmaceutical Sciences University of AlbertaEdmonton AB T6G 2E1Canada Department of Science University of Technology and Applied Sciences RustaqRustaq 10 P.C.329Oman Department of Chemistry and Biochemistry San Diego State UniversitySan DiegoCA 92182United States Pathology Center Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina College of Acupuncture-Moxibustion and Tuina Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina

Adenosine triphosphate(ATP)induced cell death(AICD)is a critical cellular process that has garnered substantial scientific interest for its profound relevance to cancer biology and to therapeutic *** comprehensive review unveils the intricate web of AICD mechanisms and their intricate connections with cancer *** review offers a comprehensive framework for comprehending the multifaceted role of AICD in the context of *** is achieved by elucidating the dynamic interplay between systemic and cellular ATP homeostasis,deciphering the intricate mechanisms governing AICD,elucidating its intricate involvement in cancer signaling pathways,and scrutinizing validated key ***,the exploration of AICD as a potential avenue for cancer treatment underscores its essential role in shaping the future landscape of cancer therapeutics.

关键词： Adenosine triphosphate induced cell death Adenosine triphosphate homeostasis Mechanism Cancer signaling pathways Prognosis and clinical values Cancer treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The CELLULOSE-SYNTHASE LIKE C （CSLC） Family of Barley Includes Members that Are Integral Membrane Proteins Targeted to the Plasma Membrane

引用

Molecular Plant 2009年第5期2卷 1025-1039页

作者： Fenny M. Dwivany Dina Yulia Rachel A, Burton Neil J. Shirley Sarah M. Wilson Geoffrey B, Fincher Antony Bacic Ed Newbigin Monika S. doblin Plant Cell Biology Research Centre School of Botany. University of Melbourne Victoria 3010 Australia Australian Centre for Plant Functional Genomics School of Agriculture and Wine University of Adelaide South Australia 5064 Australia Australian Centre for Plant Functional Genomics School of Botany University of Melbourne Victoria 3010 Australia Present address: Department of Biology Institut Teknologi Bandung Bandung Indonesia Present address: Stem Cell and Cancer Institute Jh Jend. Ahmad Yani No.2 Pulo Mas Jakarta 13210 Indonesia

The CELLULOSE SYNTHASE-LIKE C （CSLC） family is an ancient lineage within the CELLULOSE SYNTHASE/CELLULOSE SYNTHASE-LIKE （CESA/CSL） polysaccharide synthase superfamily that is thought to have arisen before the divergence of mosses and vascular plants. As studies in the flowering plant Arabidopsis have suggested synthesis of the （1,4）-β-glucan backbone of xyloglucan （XyG）, a wall polysaccharide that tethers adjacent cellulose microfibrils to each other, as a probable function for the CSLCs, CSLC function was investigated in barley （Hordeum vulgate L.）, a species with low amounts of XyG in its walls. Four barley CSLCgenes were identified （designated HvCSLC1-4）. Phylogenetic analysis reveals three well supported clades of CSLCs in flowering plants, with barley having representatives in two of these clades. The four barley CSLCs were expressed in various tissues, with in situ PCR detecting transcripts in all cell types of the coleoptile and root, including cells with primary and secondary cell walls. Co-expression analysis showed that HvCSLC3 was coordinately expressed with putative XyG xylosyltransferase genes. Both immuno-EM and membrane fractionation showed that HvCSLC2 was located in the plasma membrane of barley suspension-cultured cells and was not in internal membranes such as endoplasmic reticulum or Golgi apparatus. Based on our current knowledge of the sub-cellular locations of polysaccharide synthesis, we conclude that the CSLC family probably contains more than one type of polysaccharide synthase.

关键词： Cellulose synthase-like family C plant cell wall biosynthesis xyloglucan cellulose glycosyltransferase

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Multi-omics Analyses of Barley Rootzones under Salinity Stress Reveal Two Distinctive Salt Tolerance Mechanisms

引用

Plant Communications 2020年第3期1卷 107-123页

作者： William Wing Ho Ho Camilla B.Hill Monika S.doblin Megan C.Shelden Allison van de Meene Thusitha Rupasinghe Antony Bacic Ute Roessner School of BioSciences The University of MelbourneParkvilleVIC 3010Australia School of Veterinary and Life Sciences Murdoch UniversityMurdochWA 6150Australia La Trobe Institute for Agriculture&Food Department of AnimalPlant and Soil ScienceLa Trobe UniversityBundooraVIC 3086Australia ARC Centre of Excellence in Plant Energy Biology School of AgricultureFood and WineUniversity of AdelaideGlen OsmondSA 5064Australia Metabolomics Australia The University of MelbourneParkvilleVIC 3010Australia

The mechanisms underlying rootzone-localized responses to salinity during early stages of barley development remain *** this study,we performed the analyses of multi-root-omes(transcriptomes,metabolomes,and lipidomes)of a domesticated barley cultivar(Clipper)and a landrace(Sahara)that maintain and restrict seedling root growth under salt stress,*** generalized linear models were designed to determine differentially expressed genes(DEGs)and abundant metabolites(DAMs)specific to salt treatments,genotypes,or rootzones(meristematic Z1,elongation Z2,and maturation Z3).Based on pathway over-representation of the DEGs and DAMs,phenylpropanoid biosynthesis is the most statistically enriched biological pathway among all salinity responses *** with histological evidence,an intense salt-induced lignin impregnation was found only at stelic cell wall of Clipper Z2,compared with a unique elevation of suberin deposition across Sahara *** suggests two differential salt-induced modulations of apoplastic flow between the *** on the global correlation network of the DEGs and DAMs,callose deposition that potentially adjusted symplastic flow in roots was almost independent of salinity in rootzones of Clipper,and was markedly decreased in *** together,we propose two distinctive salt tolerance mechanisms in Clipper(growth-sustaining)and Sahara(salt-shielding),providing important clues for improving crop plasticity to cope with deteriorating global soil salinization.

关键词： barley root transcriptomics metabolomics lipidomics omics integration salinity stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of UDP-Glucuronic Acid Decarboxylase in Xylan Biosynthesis in Arabidopsis

引用

Molecular Plant 2016年第8期9卷 1119-1131页

作者： Beiqing Kuang Xianhai Zhao Chun Zhou Wei Zeng Junli Ren Berit Ebert Cherie T. Beahan Xiaomei Deng Qingyin Zeng Gongke Zhou Monika S. doblin Joshua L. Heazlewood Antony Bacic Xiaoyang Chen Ai-Min Wu State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources South China Agricultural University Guangzhou 510642 China Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm College of Forestry and Landscape Architecture South China Agricultural University Guangzhou 510642 China ARC Centre of Excellence in Plant Cell Walls School of BioSciences The University of Melbourne ParkviHe VIC 3010 Australia State Key Laboratory of Pulp and Paper Engineering South China University of Technology Guangzhou 510640 China Institute of Botany The Chinese Academy of Science Beijing 100093 China Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 China Joint BioEnergy Institute and Physical Biosciences Division Lawrence Berkeley Nationa Laboratory Berkeley CA 94720 USA Guangdong Province Research Center of woody forage engineering technology Guangzhou 510642 China These authors have contributed equay to this article.

UDP-xylose （UDP-Xyl） is the Xyl donor used in the synthesis of major plant cell-wall polysaccharides such as xylan （as a backbone-chain monosaccharide） and xyloglucan （as a branching monosaccharide）. The biosynthesis of UDP-Xyl from UDP-glucuronic acid （UDP-GIcA） is irreversibly catalyzed by UDP- glucuronic acid decarboxylase （UXS）. Until now, little has been known about the physiological roles of UXS in plants. Here, we report that AtUXS1, AtUXS2, and AtUXS4 are located in the Golgi apparatus whereas AtUXS3, AtUXS5, and AtUXS6 are located in the cytosoh Although all six single AtUXS T-DNA mu- tants and the uxsl usx2 uxs4 triple mutant show no obvious phenotype, the uxs3 uxs5 uxs6 triple mutant has an irregular xylem phenotype. Monosaccharide analysis showed that Xyl levels decreased in uxs3 uxs5 uxs6 and linkage analysis confirmed that the xylan content in uxs3 xus5 uxs6 declined, indicating that UDP-Xyl from cytosol AtUXS participates in xylan synthesis. Gel-permeation chromatography showed that the molecular weight of non-cellulosic polysaccharides in the triple mutants, mainly composed of xylans, is lower than that in the wild type, suggesting an effect on the elongation of the xylan backbone. Upon saccharification treatment stems of the uxs3 uxs5 uxs6 triple mutants released monosaccharides with a higher efficiency than those of the wild type. Taken together, our results indicate that the cytosol UXS plays a more important role than the Golgi-localized UXS in xylan biosynthesis.

关键词： UDP-Xylose xylan UDP-Glucuronic acid decarboxylase localization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

透视图新技法

透视图新技法

引用

作者： J.·多布林(J. doblin)

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

蓝光通过MYC2/MYC4激活NST1调控拟南芥次生细胞壁合成

蓝光通过MYC2/MYC4激活NST1调控拟南芥次生细胞壁合成

引用

第七届长三角植物科学研讨会暨青年学术报告会

作者：张倩谢志张蕊徐鹏刘宏涛杨洪全 Monika S doblin Antony Bacic 李来庚中国科学院上海植物生理生态研究所中科院分子植物卓越中心植物遗传国家重点实验室中国科学院大学 Department of Genetics and Informatics Institute University of Alabama at Birmingham 复旦大学生命科学学院 ARC Centre of Excellence in Plant Cell Walls and La Trobe Institute for Agriculture and Food(LIAF) School of Life SciencesDepartment of AnimalPlant and Soil SciencesAgriBioLa Trobe University

次生细胞壁是高等植物细胞中一种重要的特征结构,发生次生细胞壁加厚的细胞主要包括维管组织中的导管细胞和纤维细胞,为植物生长发育提供机械支持等作用。光是植物生长发育过程中主要的能量来源,植物通过光受体感受外界光照变化并调节... 详细信息

次生细胞壁是高等植物细胞中一种重要的特征结构,发生次生细胞壁加厚的细胞主要包括维管组织中的导管细胞和纤维细胞,为植物生长发育提供机械支持等作用。光是植物生长发育过程中主要的能量来源,植物通过光受体感受外界光照变化并调节植物组织器官的发育以适应外界生长环境,一些研究发现植物次生细胞壁的加厚受到光照的影响,但其具体的分子机制目前还一无所知。本研究发现拟南芥蓝光受体CRY1参与蓝光调控次生细胞壁合成。cry1突变体相对于野生型拟南芥呈现出花序轴及纤维细胞长度增加的现象,而过表达CRY1(CRY1-OE)表现出相反的表型。同时,在蓝光下,cry1突变体的纤维细胞次生细胞壁变薄,而CRY1-OE则变厚,但导管细胞厚度在突变体和过表达植株中都没有明显变化。分析蓝光下cry1突变体的花序轴转录组发现NST1介导的次生细胞壁合成相关基因都发生了明显下调。酵母单杂交筛选及体内ChIP实验发现MYC2和MYC4都能直接结合NST1启动子并激活其表达。遗传学实验发现MYC2/MYC4位于CRY1下游,并且其表达量受蓝光诱导。观察发现myc2myc4双突的纤维细胞次生细胞壁厚度在蓝光下明显变薄,茎秆拉力、次生细胞壁木质素和纤维素含量下降,这些结果表明MYC2和MYC4共同参与蓝光调控纤维细胞次生细胞壁加厚。本研究证明CRY1介导的蓝光信号正调控纤维细胞次生细胞壁加厚,MYC2和MYC4响应蓝光信号并直接结合NST1启动子促进纤维细胞次生壁加厚。

关键词：次生细胞壁蓝光信号纤维细胞 CRY1 MYC2 拟南芥

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：