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A prospective randomized study to define the role of low dose continuous prophylactic antibiotics and anti-adherence agents in altering the microbial colonization related to indwelling double‐J stents

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Asian Journal of Urology 2021年第3期8卷 269-274页

作者： Kumar Madhavan sanchit rustagi Rahul Jena Uday Pratap Singh M.S.Ansari Aneesh Srivastava Rakesh Kapoor Sanjoy Kumar Sureka Department of Urology and Renal Transplantation SGPGIMSLucknowIndia

Objective:Despite conflicting evidence,it is common practice to use continuous antibiotic prophylaxis(CAP)in patients with indwelling double-J(DJ)*** extracts and d-mannose have been shown to prevent colonization of the urinary *** evaluated their role in this ***:We conducted a prospective randomized study to evaluate patients with indwelling DJ stents following urological *** were randomized into three *** A(n=46)received CAP(nitrofurantoin 100 mg once daily[OD]).Group B(n=48)received cranberry extract 300 mg and d-mannose 600 mg twice daily(BD).Group C(n=40)received no *** stents were removed between 15 days and 45 days after *** groups were compared in terms of colonization of stent and urine,stent related symptoms and febrile urinary tract infections(UTIs)during the period of indwelling stent and until 1 week after ***:In Group A,9(19.5%)patients had significant bacterial growth on the *** was 8(16.7%)in the Group B and 5(12.5%)in Group C(p-value:0.743).However,the culture positivity rate of urine specimens showed a significant difference(p-value:0.023)with Group B showing least colonization of urine compared to groups A and *** was no statistically significant difference in the frequency of stent related symptoms(p-value:0.242)or febrile UTIs(p-value:0.399)among the ***:Prophylactic agents have no role in altering bacterial growth on temporary indwelling DJ stent,stent related symptoms or febrile *** extract may reduce the colonization of urinary tract,but its clinical significance needs further evaluation.

关键词： Antibiotic Prophylaxis Stent Cranberry Infection

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Carbon nanotubes:Evaluation of toxicity at biointerfaces

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Journal of Pharmaceutical Analysis 2019年第5期9卷 293-300页

作者： Debashish Mohanta Soma Patnaik sanchit Sood Nilanjan Das Department of Biotechnology Manav Rachna International Institute of Research Studies Faridabad Haryana India Accendere KMS New Delhi India

Carbon nanotubes (CNTs) are a class of carbon allotropes with interesting properties that make them productive materials for usage in various disciplines of nanotechnology such as in electronics equipments, optics and therapeutics. They exhibit distinguished properties viz., strength, and high electrical and heat conductivity. Their uniqueness can be attributed due to the bonding pattern present between the atoms which are very strong and also exhibit high extreme aspect ratios. CNTs are classified as singlewalled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) on the basis of number of sidewalls present and the way they are arranged spatially. Application of CNTs to improve the performance of many products, especially in healthcare, has led to an occupational and public exposure to these nanomaterials. Hence, it becomes a major concern to analyze the issues pertaining to the toxicity of CNTs and find the best suitable ways to counter those challenges. This review summarizes the toxicity issues of CNTs in vitro and in vivo in different organ systems (bio interphases) of the body that result in cellular toxicity.

关键词： Bio interphases Carbon nanotubes (CNTs) In vivo toxicity In vitro toxicity

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Special Considerations in the Management of Autoimmune Hepatitis in COVID-19 Hotspots:A Review

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Journal of Clinical and Translational Hepatology 2021年第4期9卷 568-575页

作者： Deepak Madhu sanchit Sharma Ashish Agarwal Anoop Saraya Department of Gastroenterology Aster MIMS CalicutKeralaIndia Department of Gastroenterology Caritas HospitalKottayamKeralaIndia Department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew DelhiIndia Department of Gastroenterology All India Institute of Medical SciencesJodhpurRajasthanIndia

The ongoing coronavirus disease-2019(COVID-19)pandemic has necessitated special considerations in the management of *** way presence of pre-existing diseases or treatment for it predisposes to,alters course of,and changes the management of COVID-19,is of relevance and is being extensively *** hepatitis(AIH)is unique in that it is an autoimmune disease mandating treatment with immunosuppressive drugs,as well as a liver disease with potential for varying degrees of underlying *** use of immunosuppressive drugs could alter the risk of acquiring COVID-19,the clinical course and severity of COVID-19 and the degree of underlying liver fibrosis could alter the clinical outcomes of patients with *** this review,we try to summarize key areas relevant in understanding and improving the clinical care of patients with AIH in the current *** considerations required in the management of patients with AIH in COVID-19 hotspots have been outlined based on the current evidence.

关键词： Hepatitis Autoimmune Liver cirrhosis COVID-19 SARS-CoV-2 infection Immunosuppressive agents

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SANTA： Self-aligned nanotrench ablation via Joule heating for probing sub-20 nm devices

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Nano Research 2016年第10期9卷 2950-2959页

作者： Feng Xiong sanchit Deshmukh Sungduk Hong Yuan Dai Ashkan Behnam Feifei Lian Eric Pop Department of Electrical Engineering Stanford University Stanford CA 94305 USA Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign Urbana IL 6180 I USA

Manipulating materials at the nanometer scale is challenging, particularly if alignment with nanoscale electrodes is desired. Here, we describe a lithography-free, self-aligned nanotrench ablation （SANTA） technique to create nanoscale ＂trenches＂ in a polymer like poly（methyl methacrylate）（PMMA）. The nanotrenches are self-aligned with carbon nanotube （CNT） or graphene ribbon electrodes through a simple Joule heating process. Using simulations and experiments we investigated how the Joule power, ambient temperature, PMMA thickness, and substrate properties affect the spatial resolution of this technique. We achieved sub-20 nm nanotrenches, for the first time, by lowering the ambient temperature and reducing the PMMA thickness. We also demonstrated a functioning nanoscale resistive memory （RRAM） bit self- aligned with a CNT control device, achieved through the SANTA approach. This technique provides an elegant and inexpensive method to probe nanoscale devices using self-aligned electrodes, without the use of conventional alignment or lithography steps.

关键词： nanolithography carbon nanotubes graphene finite element self-aligned fabrication nanoscale thermal transport

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Staged management of giant traumatic abdominal wall defect: A rare case report

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Burns & Trauma 2013年第3期1卷 144-147页

作者： Somendra Bansal sanchit Jain Laxmi Narayan Meena Department of General Surgery Sawai Man Singh Medical College and Hospital Jaipur Rajasthan India

Blunt traumatic abdominal wall disruptions associated with evisceration (abdominal wall injury grade type Ⅵ) are very rare. We describe a case of large traumatic abdominal wall disruption with bowel evisceration and complete transection of jejunum and sigmoid colon that occurred after a 30-year-old male sustained run over injury to abdomen. Abdominal exploration and primary end to end jejuno-jejunal and colo-colic anastomosis were done. Staged management of giant abdominal wall defect was performed without any plastic reconstruction with good clinical outcome.

关键词： Abdominal wall disruption blunt trauma abdomen evisceration

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A neutronic experiment to support the design of an Indian TBM shield module for ITER

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Plasma Science and Technology 2019年第6期21卷 147-152页

作者： H L SWAMI M ABHANGI sanchit SHARMA S TIWARI A N MISTRY V VASAVA V MEHTA S VALA C DANANI V CHAUDHARI P CHAUDHURI Institute for Plasma Research Gandhinagar Gujarat 382428 India Homi Bhabha National Institute(HBNI) Anushaktinagar Mumbai 400094 India Pandit Deendayal Petroleum University Gandhinagar Gujarat 382007 India

A shield module is associated with an Indian Test Blanket Module (TBM) in ITER to limit the radiation doses in port inter-space *** shield module is made of stainless steel plates and water *** is identified as an important component for radiation protection because of its radiation exposure control *** radiation protection classification leads to more assurance of the component *** order to validate and verify the design of the shield module,a neutronic laboratory-scale experiment is designed and *** experiment is planned by considering the irradiation under a neutron source of 14 MeV and yields of 1010 n *** reference neutron spectrum of the ITER TBM shield module has been achieved through optimization of the neutron source spectrum by a combination of steel and lead *** neutron spectrum and flux are measured using a multiple foil activation technique and neutron dose-rate meter LB 6411 (He-3 proton recoil counter with polyethylene),*** neutronic design simulation is assessed using MCNP5 and FENDL 2.1 crosssection *** paper covers neutronic design,irradiation and the outcome of the experiment in detail.

关键词： TBM shield module neutronic experiment ITER MCNP neutron attenuation

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Self-Organized Fractal Seismicity and b-Value of Aftershocks of the 2015 Gorkha Earthquake, Nepal

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International Journal of Geosciences 2020年第8期11卷 562-579页

作者： sanchit Minocha Imtiyaz A. Parvez Indian Institute of Technology Roorkee (IITR) Roorkee India CSIR Fourth Paradigm Institute (Formerly CSIR C-MMACS) Bangalore India

The Gorkha Earthquake that occurred on 25th April 2015 was a long anticipated, low angle thrust-faulting shallow event in Central Nepal that devastated the mountainous southern rim of the High Himalayan range. The earthquake was felt throughout central and eastern Nepal, much of the Ganges River plain in northern India, and northwestern Bangladesh, as well as in the southern parts of the Plateau of Tibet and western Bhutan. Two large aftershocks, with magnitudes 6.6 and 6.7, occurred in the region within one day of the main event, and several dozen smaller aftershocks occurred in the region during the succeeding days. In this study, we have analyzed the 350 aftershocks of the 2015 Gorkha Earthquake of Mw 7.8 to understand the spatial and temporal distribution of b-value and the fractal correlation dimension. The b-value is found to be 0.833 ± 0.035 from the Gutenberg-Richter relation by the least squares method and 0.95 ± 0.05 by the maximum likelihood method, indicating high stress bearing source zone. The spatial and temporal correlation dimension is estimated to be 1.07 ± 0.028 and 0.395 ± 0.0027 respectively. Spatial correlation dimension suggests a heterogeneous distribution of earthquake epicenters over a linear structure in space, while the temporal correlation dimension suggests clustering of aftershock activity in the time domain. The spatial variation of the b-value reveals that the b-value is high in the vicinity of the mainshock which is due to the sudden release of stress energy in the form of seismic waves. The spatial distribution of correlation dimension further confirms a linear source in the source zone as it varies from 0.8-1.0 in most of the region. We have also studied the temporal variation of b-value and correlation dimension that shows positive correlation for about first 15 days, then a negative correlation for next 45 days and after that, a positive correlation. The positive correlation suggests that the probability of

关键词： Nepal Earthquake Gorkha Earthquake b-Value Fractal Dimension

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