A prospective randomized study to define the role of low dose continuous prophylactic antibiotics and anti-adherence agents in altering the microbial colonization related to indwelling double‐J stents

作     者：Kumar Madhavan Sanchit Rustagi Rahul Jena Uday Pratap Singh M.S.Ansari Aneesh Srivastava Rakesh Kapoor Sanjoy Kumar Sureka 

作者机构：Department of Urology and Renal TransplantationSGPGIMSLucknowIndia 

出 版 物：《Asian Journal of Urology》 (亚洲泌尿外科杂志（英文）)

年 卷 期：2021年第8卷第3期

页      面：269-274页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Antibiotic Prophylaxis Stent Cranberry Infection 

摘      要：Objective:Despite conflicting evidence,it is common practice to use continuous antibiotic prophylaxis(CAP)in patients with indwelling double-J(DJ)*** extracts and d-mannose have been shown to prevent colonization of the urinary *** evaluated their role in this ***:We conducted a prospective randomized study to evaluate patients with indwelling DJ stents following urological *** were randomized into three *** A(n=46)received CAP(nitrofurantoin 100 mg once daily[OD]).Group B(n=48)received cranberry extract 300 mg and d-mannose 600 mg twice daily(BD).Group C(n=40)received no *** stents were removed between 15 days and 45 days after *** groups were compared in terms of colonization of stent and urine,stent related symptoms and febrile urinary tract infections(UTIs)during the period of indwelling stent and until 1 week after ***:In Group A,9(19.5%)patients had significant bacterial growth on the *** was 8(16.7%)in the Group B and 5(12.5%)in Group C(p-value:0.743).However,the culture positivity rate of urine specimens showed a significant difference(p-value:0.023)with Group B showing least colonization of urine compared to groups A and *** was no statistically significant difference in the frequency of stent related symptoms(p-value:0.242)or febrile UTIs(p-value:0.399)among the ***:Prophylactic agents have no role in altering bacterial growth on temporary indwelling DJ stent,stent related symptoms or febrile *** extract may reduce the colonization of urinary tract,but its clinical significance needs further evaluation.