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Broccoli products supplemented beers provide a sustainable source of dietary sulforaphane

Food Bioscience 2023年第1期51卷 413-419页

作者： paola sanchez-bravo Angel Abellan Pedro JZapata Cristina García-Viguera Raúl Domínguez-Perles María Jose Gimenez Lab.Fitoquímica y Alimentos saludables(LabFAS) Centro de Edafología y Biología Apliada del Segura(CEBAS)-CSICUniversity Campus-2530100EspinardoMurciaSpain Department of Food Technology EPSOUniveristy Miguel HernandezCtra Beniel km 3.203312OrihuelaAlicanteSpain

Broccoli is a highly consumed vegetable due to its content of bioactive nutrients and non-nutrients,including glucosinolates and ***,the consumption of craft beer has been boosted by the seek for enhanced sensory and functional *** this frame,broccoli have been proven as an ingredient to develop healthy *** objective of the work was to evaluate alternative broccoli materials(sprouts and byproducts powder)to go further from previous results,in a way contributing to the sustainability and circularity of the agro-food chain using underexploited material to supplement beers,which could be a sustainable dietary source of bioactive sulforaphane(SFN).The results showed high concentrations of SFN in beers supplemented with broccoli sprouts and powder(5.00 and 2.54 mg/L,respectively,previous to bottling).These concentrations remained stable until bottling,where they were reduced by>50%.After 150 storage days,the concentrations of SFN were 1.08 and 0.30 mg/L in beers supplemented with sprouts and powder,*** sensory analysis revealed the positive attributes(colour,floral,fruity,and aftertaste as a result of the profile of volatile compounds)of beers developed using sprouts,and significant values of cooked vegetables,alcoholic,and earthy leather,which could be considered negative in *** latter negative tips are the ones offering sensory traits associated to ITC to broccoli-based ***,the addition of broccoli in the format of fresh sprouts is more appropriate according to the SFN content and sensory features,providing a functional alternative that could be appreciated by consumers.

关键词： Healthy foods Beverages Brassica Isothiocyanates UHPLC-ESI-MS/MS Sensory properties

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Low concentrations of atrazine,glyphosate,2,4-dichlorophenoxyacetic acid,and triadimefon exposures have diverse effects on Xenopus laevis organ morphogenesis

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Journal of Environmental Sciences 2010年第9期22卷 1305-1308页

作者： Jenny R.Lenkowski Gabriela sanchez-bravo Kelly A.McLaughlin Department of Biology Tufts University

Many chemicals are released into the environment, and chemical contamination has been suggested as a contributing factor to amphibian declines. To add to a growing body of knowledge about the impact of individual chemicals on non-target organisms, we examined the specificity of deformities induced by exposure to four pesticides （atrazine, 2,4-dichloropheoxyacetic acid （2,4-D）, triadimefon, and glyphosate） in the model amphibian species, Xenopus laevis. We focused on the period of organ morphogenesis, as it is frequently found to be particularly sensitive to chemical exposure yet also commonly overlooked. We found similar levels of intestine malformations and edemas, as well as disruption of skeletal muscle, in atrazine and triadimefon exposed tadpoles. The effects of 2,4-D were only apparent at the highest concentrations we examined; glyphosate did not induce dramatic malformations at the concentrations tested. While researchers have shown that it is important to understand how chemical mixtures affect non-target organisms, our results suggest that it is first crucial to determine how these chemicals act independently in order to be able to identify consequences of individual pesticide exposure.

关键词： amphibian pesticide organ morphogenesis teratogenesis toxicology Xenopus laevis

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One-Dimensionality, Reliability, Distribution, and Correlates of the Brief Interactive Optimism Scale among University Teachers

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Open Journal of Medical Psychology 2025年第1期14卷 41-70页

作者： José Moral de la Rubia Adrián Valle de la O Jesús Alfonso Beltran-sanchez School of Psychology Universidad Autnoma de Nuevo Len Monterrey Mexico School of Medicine and Health Sciences Tecnolgico de Monterrey Monterrey Mexico

The Brief Interactive Optimism Scale (BIOS-G), recently published, was developed to measure optimism based on the interactive personality styles theory in the general population of Mexican adults. It has been validated in both the general population in Mexico and other Latin American countries. This study aims to further consolidate the validity of the BIOS-G in a specific population. The objectives are to assess the psychometric properties of its items, validate its unidimensional structure, describe its distribution, verify its internal consistency, and examine its direct relationship with affective balance and positive affect, as well as its inverse relationship with emotional exhaustion and negative affect among Mexican university teachers. The BIOS-G, the CESQT emotional exhaustion subscale, and Scale of Positive and Negative Experience (SPANE) were administered to a non-probability sample of 213 Mexican university teachers. All items demonstrated discriminative power and internal consistency. The scale showed internal consistency (Green-Yang ordinal ω = 0.74 and McDonald ordinal ω = 0.88). The one-factor model presented good to acceptable fit to the data, with an average variance extracted of 0.65. Its distribution was negatively skewed and mesokurtic. The BIOS-G correlated directly with SPANE’s affective balance and positive emotional experiences and inversely with negative emotional experiences and emotional exhaustion, with moderate strengths of association. Its mean score was higher in men than in women and correlated positively with age. It is concluded that the BIOS-G demonstrates internal consistency and validity evidence among Mexican university teachers, and its use in this specific population is recommended.

关键词： Optimism Psychometric Properties Affective Balance Emotional Exhaustion University Teachers

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基于期刊耦合识别“无形学院”成员的新方法（英文）

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Journal of Data and Information Science 2025年第1期 101-131+236-237页

作者： Jose A.Garcia Rosa Rodriguez-sanchez J.Fdez-Valdivia Department of Computer Science and Artificial Intelligence CITIC-UGRUniversidad de Granada

研究目的：本文通过基于期刊耦合（即共享学术期刊）的作者聚类分析，识别具有相似科学兴趣与概念框架的研究者群体。其核心假设是：相较于从未在相同期刊发表论文的学者，共同发文于同一期刊的作者更可能共享相似的研究范式与学术关注... 详细信息

研究目的：本文通过基于期刊耦合（即共享学术期刊）的作者聚类分析，识别具有相似科学兴趣与概念框架的研究者群体。其核心假设是：相较于从未在相同期刊发表论文的学者，共同发文于同一期刊的作者更可能共享相似的研究范式与学术关注点，从而更可能隶属于同一“无形学院”（即在某一研究领域内具有重要贡献，并倾向于在相似期刊发表成果的作者群体）。研究设计/方法：以Web of Science核心合集中“信息科学与图书馆学（IS&LS）”领域的302位作者为案例，测试基于期刊耦合的作者分组方法，以识别该领域的“无形学院”。对于每位作者，我们检索其发表论文的所有学术期刊，并利用余弦相似度（包括一阶和二阶相似度）计算作者之间的相似性。研究发现：通过分析IS&LS领域作者的期刊耦合关系，我们识别出四个主要的“无形学院”：“信息系统”、“商业与信息管理”、“计量信息科学”和“图书馆学”；定义“无形学院”的期刊包括《Inform Syst Res》《Inform Syst J》《J Bus Res》《J Knowl Manage》《J Informetr》《Pro Int Conf Sci Inf》《Int J Geogr Inf Sci》《J Am Med Inform Assn》和《Learn Publ》；支撑IS&LS领域整体性的核心期刊包括《J Am Soc Inf Sci Tec/J Assoc Inf Sci Tech》《Scientometrics》《Inform Process Manag》《J Inf Sci》。研究局限性：实验设计为控制性验证，分析仅使用了学术期刊，未纳入专著、图书章节及会议论文。因此，研究结果可能无法全面代表整个学术交流生态。实践意义：本研究的结果对于IS&LS领域的学者具有重要参考价值。通过期刊发表概况和期刊耦合，我们提供了一种新的作者归类视角。此外，该方法可进一步扩展至其他学科领域的结构研究，对科学史学者和科学计量学研究者亦具有潜在价值。原创性/价值：本研究提出了一种基于期刊耦合的新方法，以识别最有可能属于同一“无形学院”的研究者，为科学合作网络研究提供了新的理论和实践工具。

关键词：作者期刊耦合聚类分析无形学院信息科学与图书馆学 Web of Science核心合集

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Dietary processed former foodstuffs for broilers:impacts on growth performance,digestibility,hematobiochemical profiles and liver gene abundance

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Journal of Animal Science and Biotechnology 2025年第1期16卷 364-376页

作者： Karthika Srikanthithasan Marta Gariglio Elena Diaz Vicuna Edoardo Fiorilla Barbara Miniscalco Valeria Zambotto Eleonora Erika Cappone Nadia Stoppani Dominga Soglia Federica Raspa Joana Nery Andrea Giorgino Roser Sala Andrés Luis Martínez Marínz Josefa Madrid sanchez Achille Schiavone Claudio Forte Department of Veterinary Sciences University of TurinGrugliascoItaly Animal Nutrition and Welfare Service(SNiBA) Department of Animal and Food SciencesUniversitat Autònoma de BarcelonaBarcelonaSpain Departamento de Producción Animal Universidad de CórdobaCórdobaSpain Department of Animal Production University of MurciaMurciaSpain

Background The present experiment aimed to evaluate the effects of commercially processed former foodstuffs(cFF)as dietary substitutes of corn,soybean meal and soybean oil on the growth performance,apparent total tract digestibil-ity(ATTD),hematobiochemical profiles,and liver gene abundance in broiler *** hundred one-day-old male ROSS-308 chicks were assigned to 4 dietary groups(5 replicates of ten birds per replicate)according to their average body weight(BW,38.0±0.11 g).All groups received a two-phase feeding program:starter,d 1–12 and grower,d 12–*** control group(cFF0)was fed a standard commercial feed based on corn,soybean meal and soybean *** other three groups received diets in which the feed based on corn,soybean meal,and soybean oil was partially replaced with cFF at a substitution level of 6.25%(cFF6.25),12.5%(cFF12.5)or 25%(cFF25)for the following 33 *** The growth performance data showed no differences in BW or average daily gain among groups,although the average daily feed intake decreased during the grower period(12–33 d)and over entire experimental period(1–33 d)in a linear manner as the cFF inclusion level rose(P=0.026),positively affecting the gain to feed ratio(P=0.001).The ATTD of dry matter of the cFF-fed groups were greater with respect to control group and increased throughout the experimental period,whereas the ATTD of ether extract linearly decreased with increasing levels of cFF-fed groups compared with control group and throughout the experimental period(P<0.05).Additionally,a lin-ear increase in the heterophil to lymphocyte ratio,serum cholesterol,triglycerides and alanine-aminotransferase were observed with increasing dietary levels of cFF(P<0.05);however,no differences were observed in lipoprotein lipase or sterol regulatory element binding transcription factor gene *** The results of this experiment demonstrate that it is possible to incorporate cFF into nutritionally balanced diets for broiler ch

关键词： Alternative feed Broiler chicken Digestibility Former foodstuff Gene abundance Growth performance

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IKKβ overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice

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International Journal of Oral Science 2020年第1期12卷 31-39页

作者： Angustias Page Ana bravo Cristian Suarez-Cabrera Raquel sanchez-Baltasar Marta Oteo Miguel Angel Morcillo MLlanos Casanova Jose CSegovia Manuel Navarro Angel Ramirez Molecular Oncology Unit.Centro de Investigaciones Energéticas Medioambientales y Tecnológicas(CIEMAT)MadridSpain Instituto de Investigación 12 de Octubre i+12 MadridSpain Centro de Investigación Biomédica en Red de Cáncer(CIBERONC) MadridSpain Department of Anatomy Animal Production and Veterinary Clinical SciencesLaboratory of Pathology Phenotyping of Genetically Engineered MiceFaculty of Veterinary MedicineUniversity of Santiago de CompostelaLugoSpain Biomedical Applications and Pharmacokinetics Unit Centro de Investigaciones EnergéticasMedioambientales y Tecnológicas(CIEMAT)MadridSpain Hematopoietic Innovative Therapies Division.Centro de Investigaciones Energéticas Medioambientales y Tecnológicas(CIEMAT).Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)MadridSpain Unidad Mixta de Terapias Avanzadas Fundación Instituto de Investigaciones Sanitarias Fundación Jiménez DíazMadridSpain

Odontogenic tumours are a heterogeneous group of lesions that develop in the oral cavity region and are characterized by the formation of tumoural structures that differentiate as teeth. Due to the diversity of their histopathological characteristics and clinical behaviour, the classification of these tumours is still under debate. Alterations in morphogenesis pathways such as the Hedgehog,MAPK and WNT/β-catenin pathways are implicated in the formation of odontogenic lesions, but the molecular bases of many of these lesions are still unknown. In this study, we used genetically modified mice to study the role of IKKβ(a fundamental regulator of NF-κB activity and many other proteins) in oral epithelial cells and odontogenic tissues. Transgenic mice overexpressing IKKβ in oral epithelial cells show a significant increase in immune cells in both the oral epithelia and oral submucosa. They also show changes in the expression of several proteins and mi RNAs that are important for cancer development. Interestingly, we found that overactivity of IKKβ in oral epithelia and odontogenic tissues, in conjunction with the loss of tumour suppressor proteins(p53, or p16 and p19), leads to the appearance of odontogenic tumours that can be classified as ameloblastic odontomas, sometimes accompanied by foci of secondary ameloblastic carcinomas. These tumours show NF-κB activation and increased β-catenin *** findings may help to elucidate the molecular determinants of odontogenic tumourigenesis and the role of IKKβ in the homoeostasis and tumoural transformation of oral and odontogenic epithelia.

关键词： IKKβ tumour suppressor

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Hierarchy: enhancing performances beyond limits

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National Science Review 2020年第11期7卷 1624-1625页

作者： Clément sanchez Chimie de la Matière Condensée de Paris UMR 7574 Collège de France CNRS UMPC Université Paris 06 Sorbonne University PSL Research University Chemistry of Ultra-Divided Matter at USIAS University of Strasbourg Institute for Advanced Study

Living organisms, for their survival and reproduction, have evolved to produce complex hierarchical three-dimensional structures ranging from nanometers to meters with extraordinary and unusual sets of properties. Over the last 20 years,hierarchically porous materials that replicate complex living structures have attracted intense attention from both the academic and industrial worlds.

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MEC-based architecture for interoperable and trustworthy internet of moving things

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Digital Communications and Networks 2023年第1期9卷 270-279页

作者： Jesus sanchez-Gomez Rafael Marin-Perez Ramon sanchez-Iborra Miguel Angel Zamora Department of Information and Communications Engineering University of MurciaMurciaSpain Odin Solutions S.L. MurciaSpain University Center of Defense San Javier Air Force BaseMurciaSpain

The expansion of the Internet of Moving Things(IoMT)leads to limitless and continuous working playgrounds exploited by highly dynamic end *** requires the adoption of multi-Radio Access Technologies(RATs)-based strategies to provide IoMT units with ubiquitous *** this end,the development of secure bootstrapping and authentication mechanisms is necessary to permit the secure operation of end *** the transmission and power limitations of these elements,current cryptographic solutions do not address these stringent *** that reason,in the study we present a Multi-Access Edge Computing(MEC)-based endto-end architecture that enables an efficient and secure authentication and key agreement between end devices and network servers over heterogeneous resource-limited networks such as the Low Power Wide Area Networks(LPWANs).Our proposal is based on the Authentication,Authorization,and Accounting(AAA)architecture and the recent Internet Engineering Task Force initiatives Static Context Header Compression and Low-Overhead *** results obtained from experimental tests reveal the validity of the proposal as it enables constrained IoMT devices to gain IPv6 connectivity as well as performs end-to-end secure authentication with notable reliability and controlled latency.

关键词： Internet of moving things LPWAN Authentication LO-CoAP-EAP SCHC

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Reactive oxygen species and antioxidant properties from mushrooms

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Synthetic and Systems Biotechnology 2017年第1期2卷 13-22页

作者： Carmen sanchez Laboratory of Biotechnology Research Centre for Biological SciencesUniversidad Autonoma de TlaxcalaIxtacuixtlaTlaxcalaCP.90062Mexico

Preventive medicine and food industry have shown an increased interest in the development of natural antioxidants,since those most commonly used synthetic antioxidants may have restricted use in *** could explain why there is currently much research on the antioxidant properties from natural products such as *** mushrooms have been reported to possess antioxidant properties,which enable them to neutralize free *** oxygen molecule is a free radical,which lead to the generation of the reactive oxygen species and can damage the *** damage caused by free radicals appears to be a major contributor to aging and degenerative *** antioxidant components are found in fruit bodies,mycelium and culture both,which include polysaccharides,tocopherols,phenolics,carotenoids,ergosterol and ascorbic acid among *** bodies or mycelium can be manipulated to produce active compounds in a relatively short period of time,which represent a significant advantage in antioxidant compounds extraction from *** compounds may be extracted to be used as functional additives or mushrooms can be incorporated into our food regime,representing an alternative source of food to prevent damage caused by oxidation in the human body.

关键词： Antioxidant Fruit body Mushroom Mycelium Reactive oxygen species

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Laplace plane and low inclination geosynchronous radar mission design

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Science China(Information Sciences) 2017年第6期60卷 62-71页

作者： Stephen HOBBS Joan Pau sanchez School of Aerospace Transport and Manufacturing Cranfield University

This study is inspired by the Laplace orbit plane property of requiring minimal station-keeping and therefore its potential use for long-term geosynchronous synthetic aperture radar(GEOSAR) imaging. A set of GEOSAR user requirements is presented and analysed to identify significant mission requirements. Imaging geometry and power demand are assessed as a function of relative satellite speed(which is determined largely by choice of orbit inclination). Estimates of the cost of station-keeping as a function of orbit inclination and right ascension are presented to compare the benefits of different orbit choices. The conclusion is that the Laplace plane(and more generally, orbits with inclinations up to 15°) are attractive choices for GEOSAR.

关键词： Laplace plane station-keeping geosynchronous inclination GEOSAR

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