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基于WGCNA探讨葛根素对呕吐毒素诱导C6细胞损伤的保护作用

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生物技术通报 2024年第9期40卷 301-310页

作者：赵海平刘林王昕璐岳鹏飞孔维军王蒙江西中医药大学中医学院南昌330004 北京市农林科学院质量标准与检测技术研究所北京100097 江西中医药大学现代中药制剂教育部重点实验室南昌330004

【目的】利用呕吐毒素(deoxynivalenol,DON)构建C6细胞损伤模型,分析葛根素(puerarin,PUE)对DON诱导C6细胞损伤的保护作用机制。【方法】通过RNA测序(RNA-seq)和加权基因共表达网络分析(weighted gene co-expression network analysis,WGCNA),挖掘与PUE缓解DON诱导C6细胞损伤最相关的关键模块和关键核心靶点基因,探究PUE缓解DON诱导的神经毒性作用的分子机制。【结果】PUE可以显著抑制DON诱导的C6细胞活力下降,对损伤的C6细胞形态有所恢复,可有效缓解DON诱导的C6细胞损伤。RNA-seq和WGCNA结果表明,Blue模块是与PUE缓解DON诱导C6细胞损伤表型最相关的关键模块,从中筛选出S100a11、Pdia3、Hsp90b1等基因是PUE发挥对DON诱导C6细胞损伤保护作用的关键核心基因。【结论】PUE可能是通过靶向关键核心基因参与内质网中的蛋白质加工途径从而缓解DON诱导的C6细胞损伤。

关键词：呕吐毒素葛根素加权基因共表达网络分析 C6细胞

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Aversatile β-cyclodextrin functionalized silver nanoparticle monolayer for capture of methyl orange from complex wastewater

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Chinese Chemical Letters 2020年第2期31卷 539-542页

作者： jun liu Cancan Zhang Shaoxuan Zhang Huajiang Yu Wei Xie Key Lab of Advanced Energy Materials Chemistry(Ministry of Education) Renewable Energy Conversion and Storage CenterCollege of ChemistryNankai UniversityTianjin 300071China College of Chemistry State Key Laboratory of Elemento-Organic ChemistryNankai UniversityTianjin 300071China

The toxic organic dye contaminants in wastewater are extremely harmful to the *** enhanced Raman scattering(SERS) is a technique with high sensitivity and chemical specificity which fulfills the requirements for monitoring dye contaminants in ***,as one of the common dye contaminants,methyl orange(MO) has very weak affinity to metallic surfaces and is difficult to be detected by SERS at low ***,a new type of SERS substrate with Ag nanoparticle monolayer functionalized by mono-6-deoxy-6-thio-β-cyclodextrin(β-CD-SH) was prepared to efficiently capture and detect MO in wastewater with a limit of detection of 5×10^(-7) mol/*** hydrophobic cavity of β-CD is responsible for the efficient trap and enrichment of MO on the Ag NPs surface,achieving a strong SERS signal of MO at low concentrations and at different pH *** study provides new insight into designing a well-performed adsorbent for the capture and detection of organic contaminants.

关键词： Dye contaminants Methyl orange SERS Cyclodextrin Wastewater

Selective hydroconversion of 2-methylfuran to pentanols on MWNT-supported Pt catalyst at ambient temperature

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Rare Metals 2022年第3期41卷 889-900页

作者： Ting Wang Bin Zhang Chao-Qun Yin jun Zhao Xiang liu Chuan Wang Institute of Advanced Synthesis School of Chemistry and Molecular EngineeringJiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjing 211816China Nanyang Environment and Water Research Institute(NEWRI) Nanyang Technological UniversitySingapore 637141Singapore

The selective hydrogenolysis of C–O bond in furfural and its derivatives provides a sustainable route for transforming biomass-derived feedstocks into valued chemicals. Currently, the development of efficient catalysts which can effectively cleavage C–O bond under mild conditions remains a critical challenge. The present work reports Pt catalysts supported on multi-walled carbon nanotubes (MWNT) which are active in 2-methylfuran (2-MF) hydrogenolysis to form pentanols in liquid phase under mild conditions. The impact of various catalyst supports, active metals and reaction conditions in terms of metal loadings, solvent, time, pressure, etc., were *** 5 wt%Pt/MWNT catalyst demonstrated an excellent activity and selectivity with 100%2-MF conversion and53%pentanols (POLs) yield under 1 MPa H;at an exceptional low temperature of 25℃. The reaction mechanism was studied combing both the reactivity tests and characterization results, and it is found that the better catalytic performances of Pt/MWNT were correlated closely to the size of Pt nanoparticles and their interactions with the underlying MWNT support. Accordingly, a reaction pathway involving the adsorption of 2-MF parallel to the Pt nanoparticles and its subsequently selective C–O hydrogenolysis was proposed. This work showcases a promising catalyst for room-temperature biofuel production.

关键词： 2-methylfuran(2-MF) C–O cleavage Pentanols Multi-walled carbon nanotubes(MWNT) Platinum

Wind erodibility indices of aeolian sandy soils impacted by different vegetation restoration:a case study from the Shannan valley of the Yarlung Zangbo River

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Journal of Mountain Science 2022年第10期19卷 2830-2845页

作者： ZHANG Bao-jun XIONG Dong-hong liu Lin TANG Yong-fa Key Laboratory of Mountain Hazards and Earth Surface Process Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China College of Water Conservancy and Hydropower Engineering Sichuan Agricultural UniversityYa'an 625014China

Controlling aeolian desertification is a key ecological target on the Tibetan Plateau,especially within the widespread river *** recovery can change the near-soil surface characteristics,which thus may influence wind erodibility of ***,these potential effects are not sufficiently evaluated for aeolian sandy *** study selected the Shannan valley of the Yarlung Zangbo River on the southern Tibetan Plateau as a case to investigate the variations in wind erodibility of aeolian sandy soils impacted by different vegetation restoration,since many ecological measures have been implemented in recent decades in the river *** vegetated sandy lands with different restoration types and ages and two bare sandy lands(as controls)were chosen as test *** vegetated sandy lands were covered by Artemisia wellbyi,Hedysarum scoparium,Sophora moorcroftiana,and Populus *** the similar restoration age of 10 *** Sophora moorcroftiana and Populus ***,two restoration ages of 6 and over 30 years were also selected *** erodibility was reflected by wind erodible fraction(EF),mean weight diameter of dry aggregates(MWD),capillary water capacity(CWC),soil cohesion(CS),and soil penetration resistance(PR)from different aspects.A comprehensive wind erodibility index(CWEI)was further produced by a weighted summation method to combine those five indices together and comprehensively quantify the effects of vegetation restoration on wind erodibility of aeolian sandy *** results showed that revegetation was efficient to reduce wind erodibility of aeolian sandy *** generally decreased,while MWD,CWC,CS,and PR increased after vegetation restoration on the aeolian sandy *** CWEI of vegetated sandy lands varied greatly from 0.850 to 0 under different restoration types and ages and decreased by 14.4%to 100%compared to the *** the four different restoration types,Populus *** the relatively minimum CWEI,fol

关键词： Wind erosion Soil erodibility Erodible fraction Vegetation type Ecological restoration Yarlung Zangbo River valley

On the Downshift of Wave Frequency for Bragg Resonance

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China Ocean Engineering 2022年第1期36卷 76-85页

作者： PENG Ji TAO Ai-feng FAN jun ZHENG Jin-hai liu Yu-ming Key Laboratory of Ministry of Education for Coastal Disaster and Protection Hohai UniversityNanjing 210098China Quality Supervision Department China Renewable Energy Engineering InstituteBeijing 100120China College of Harbor Coastal and Offshore EngineeringHohai UniversityNanjing 210098China Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridge 02139USA

For surface gravity waves propagating over a horizontal bottom that consists of a patch of sinusoidal ripples,strong wave reflection occurs under the Bragg resonance *** critical wave frequency,at which the peak reflection coefficient is obtained,has been observed in both physical experiments and direct numerical simulations to be downshifted from the well-known theoretical *** has long been speculated that the downshift may be attributed to higher-order rippled bottom and free-surface boundary effects,but the intrinsic mechanism remains *** a regular perturbation analysis,we derive the theoretical solution of frequency downshift due to third-order nonlinear effects of both bottom and free-surface *** is found that the bottom nonlinearity plays the dominant role in frequency downshift while the free-surface nonlinearity actually causes frequency *** frequency downshift/upshift has a quadratic dependence in the bottom/free-surface *** bottom leads to a larger frequency downshift relative to the monochromatic *** addition,direct numerical simulations based on the high-order spectral method are conducted to validate the present *** theoretical solution of frequency downshift compares well with the numerical simulations and available experimental data.

关键词： gravity surface wave Bragg resonance frequency downshift regular perturbation analysis

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双线圈与单线圈磁脉冲辅助微冲裁对比与分析

塑性工程学报 2024年第8期31卷 20-25页

作者：黄蔚君杨亮黄曾鑫刘大海陶毅晨周恺祝李豪南昌航空大学航空制造工程学院江西南昌330063 南昌航空大学工程训练中心江西南昌330063

为进一步研究磁脉冲辅助微冲裁工艺,提出使用双线圈替代单线圈的磁脉冲辅助微冲裁方法,采用对比试验的方式进行了成形孔宏观效果及冲裁断面质量分析,从而对双线圈与单线圈成形率与冲裁断面质量优劣进行了对比。结果表明,在成形孔的宏观... 详细信息

为进一步研究磁脉冲辅助微冲裁工艺,提出使用双线圈替代单线圈的磁脉冲辅助微冲裁方法,采用对比试验的方式进行了成形孔宏观效果及冲裁断面质量分析,从而对双线圈与单线圈成形率与冲裁断面质量优劣进行了对比。结果表明,在成形孔的宏观效果方面,双线圈的孔成形率远高于单线圈,双线圈的应用提高了磁脉冲辅助微冲裁的能量利用率。单线圈磁脉冲辅助微冲裁的冲裁断面光亮带占比最高仅有15.3%,而双线圈的冲裁断面光亮带占比最高高达59.6%,双线圈冲裁质量远优于单线圈。

关键词：磁脉冲辅助成形微冲裁双线圈断面质量

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船只对南京长江江豚的行为影响分析

水生生物学报 2024年第10期48卷 1672-1679页

作者：陈炳耀陈力文张俊游秋逸郝秀青刘杉南京师范大学生命科学学院南京210023 南京长江江豚省级自然保护区管理站南京210019

长江江豚(Neophocaena asiaeorientalis)仅分布于我国鄱阳湖、洞庭湖、长江中下游及支流中,繁忙的船只不可避免地对长江江豚产生影响。本课题组在2019—2023年对南京长江江豚开展了112d截线抽样船只监测,调查船只对长江江豚行为的影响... 详细信息

长江江豚(Neophocaena asiaeorientalis)仅分布于我国鄱阳湖、洞庭湖、长江中下游及支流中,繁忙的船只不可避免地对长江江豚产生影响。本课题组在2019—2023年对南京长江江豚开展了112d截线抽样船只监测,调查船只对长江江豚行为的影响。结果表明:船只的出现改变了长江江豚的行为类型,觅食行为比例由48%下降到33%,同时旅行行为比例由32%提高至43%;船只距离对长江江豚的反应有显著影响,300 m以上时江豚对船只的中立反应占95%,未发现逃离行为,但是随着距离的减少,逃离行为逐渐增加,在100 m内逃离反应比例接近30%;不同船只类型和集群规模对长江江豚的行为有一定影响,但不显著。综上,船只有无、船只距离对长江江豚的正常活动均有较大的影响,应加强重要栖息地航行船只的管理,限速或禁止靠近岸边行驶,最大限度地保护长江江豚。

关键词：船只航运集群大小逃离行为行为响应长江江豚

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Involvement of TRPC1 and Cyclin D1 in Human Pulmonary Artery Smooth Muscle Cells Proliferation Induced by Cigarette Smoke Extract

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Current Medical Science 2020年第6期40卷 1085-1091页

作者： Xun WANG Wen WANG Chan liu Xiao-jun WU Department of Respiratory and Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China

Cigarette smoking contributes to the development of pulmonary artery hypertension(PAH).As the basic pathological change of PAH,pulmonary vascular remodeling is considered to be related to the abnormal proliferation of pulmonary artery smooth muscle cells(PASMCs).However,the molecular mechanism underlying this process remains not exactly *** aim of this research was to study the molecular mechanism of PASMCs proliferation induced by *** PASMCs(HPASMCs)were divided into 6 groups:0%(control group),cigarette smoking extract(CSE)-treated groups at concentrations of 0.5%,1%,2%,5%,10%CSE *** proliferation was observed after 24 *** were divided into two groups:0(control group),0.5%CSE *** mRNA and protein expression levels of transient receptor potential channel 1(TRPC1)and cyclin D1 in HPASMCs after CSE treatment were respectively detected by RT-PCR and Western *** intracellular calcium ion concentration was measured by the calcium probe in each *** the negative control group and TRPC1-siRNA transfection group,the proliferation of HPASMCs and the expression of cyclin D1 mRNA and protein were *** were compared with one-way ANOVA(for multiple-group comparison)and independent t-test(for two-group comparison)followed by the least significant difference(LSD)test with the computer software SPSS *** was found that 0.5%and 1%CSE could promote the proliferation of HPASMCs(P<0.05),and the former was more effective than the latter(P<0.05),while 3%and above CSE had inhibitory effect on HPASMCs(P<0.05).The mRNA and protein expression levels of TRPC1 and cyclin D1 in 0.5%and 1%CSE groups were significantly higher than those in the control group(P<0.05),while those in 3%CSE group were significantly decreased(P<0.05).Moreover,the proliferation of HPASMCs and the expression of cyclin D1 mRNA and protein in TRPC1-siRNA transfection group were significantly reduced as compared with those in the negative control group(P<

关键词： cigarette smoke extract human pulmonary artery smooth muscle cells transient receptor potential channel 1 cyclin D1

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发酵食品的滋味特性及其形成机制研究进展

食品与发酵工业 2024年第10期50卷 388-396页

作者：覃芳丽邹宇晓王思远黎尔纳穆利霞李庆荣刘军仲恺农业工程学院轻工食品学院广东广州510225 广东省农业科学院蚕业与农产品加工研究所/广东省农产品加工重点实验室/农业农村部功能食品重点实验室广东广州510610 广东翔顺调味食品有限公司广东云浮527499

肉类、豆类、水产类和蔬菜类等原料经过自然的或人工接种的微生物发酵后,转变为滋味诱人但迥异于新鲜食材的发酵食品,从古至今一直广受世界各地消费者的喜爱。食品原料在发酵过程中形成的有机酸、氨基酸、多肽和糖类等是重要的呈味物质... 详细信息

肉类、豆类、水产类和蔬菜类等原料经过自然的或人工接种的微生物发酵后,转变为滋味诱人但迥异于新鲜食材的发酵食品,从古至今一直广受世界各地消费者的喜爱。食品原料在发酵过程中形成的有机酸、氨基酸、多肽和糖类等是重要的呈味物质,决定了发酵食品的滋味与风味。该文在广泛查阅文献的基础上,综述了发酵食品中酸、甜、苦、咸、鲜、厚等6种滋味特性及其形成机制的相关研究进展,并对传统发酵食品的未来研究方向进行展望,以期为优质发酵食品的风味品质调控提供参考。

关键词：发酵食品滋味特性形成机制研究进展