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In vitro antiplasmodial effect of ethanolic extracts of coastal medicinal plants along Palk Strait against Plasmodium falciparum

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Asian Pacific journal of Tropical Biomedicine 2012年第5期2卷 364-367页

作者： samuel jacob Inbaneson Sundaram Ravikumar Palavesam Suganthi Department of Oceanography and Coastal Area Studies School of Marine SciencesAlagappa University

Objective:To identify the possible anliplasmodial compounds from Achyranlhes aspera(A. aspera).Acalypha indica(***),jatropha glandulifera(***)and Phyllanlhus amarus(***).Methods:The ***,***,*** and *** were collected along Palk Strait and the extraction was carried out in *** filter sterilized extracts(100,50,25,12.5,6.25 and 3.125μg/mL) of leaf,stem,root and flower extracts of A aspera,A. indica,*** and *** were tested for anliplasmodial activity against Plasnuxlium *** potential extracts were also tested for their phytochemical ***: Of the selected plants species parts,the stem extract of *** showed excellent antiplasmodial activity(IC_(50)=43.81μg/mL) followed by stem extract of ***(IC_(50)= 49.14μg/mL).The stem extract of ***,leaf and root extracts of ***,leaf,root and seed extracts of j. glanduUfera and leaf and stem extracts of *** showed IC_(50),values between 50 and 100 μg/ *** analysis revealed that,significant antiplasmodial activity(Pjury to erythrocytes was also carried out and it showed that there were no morphological changes in erythrocytes by the elhanolic extract of all the tested plant *** in vitro antiplasmodial activity might be due to the presence of alkaloids,glycosides,***,saponins,triterpenoids,proteins, and lannins in the elhanolic extracts of tested ***:The elhanolic stem extracts of *** and *** possess lead compounds for the development of antiplasmodial drugs.

关键词： Antiplasmodial activity IC_(50) Medicinal plants Phytochemicals Plasmodium falciparum Achyranthes aspera Acalypha indica jatropha glandulifera Phyllanthus amarus

Point Mutation Analysis of <i>PMP</i>22 in Patients Referred for Hereditary Neuropathy with Liability to Pressure Palsies

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Open journal of Genetics 2014年第6期4卷 426-433页

作者： samuel B. Brown David j. Bunyan Wessex Regional Genetics Laboratory Salisbury District Hospital Salisbury UK Human Genetics Division Southampton University School of Medicine Southampton UK

A cohort of 404 patients referred for hereditary neuropathy with liability to pressure palsies was tested initially for the common PMP22 whole gene deletion. 94 whole gene deletions were detected, plus three partial gene deletions, and the remaining 307 patients were screened for PMP22 point mutations. Nine point mutations were identified (8.5% of all mutations), eight of which were in exon 5, suggesting a point mutation hotspot for individuals with this condition. Sequencing analysis of PMP22 exon 5 should therefore be included as a routine diagnostic test for gene deletion-negative patients.

关键词： Point Mutations PMP22 HNPP

Management of symptomatic neuromas:a narrative review of the most common surgical treatment modalities in amputees

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Plastic and Aesthetic Research 2022年第1期9卷 120-132页

作者： Sahand C.Eftekari Peter j.Nicksic Allison j.Seitz D’Andrea T.Donnelly Aaron M.Dingle samuel O.Poore Division of Plastic Surgery University of Wisconsin School of Medicine and Public HealthG5-347 Clinical Sciences CenterMadisonWI 53711USA

Symptomatic neuromas are an all-too-common complication following limb amputation or extremity trauma,leading to chronic and debilitating pain for *** resection of symptomatic neuromas has proven to be the superior method of intervention,but traditional methods of neuroma resection do not address the underlying pathophysiology leading to the formation of a future symptomatic neuroma and lead to high reoperation *** approaches employ the physiology of peripheral nerve injury to harness the regeneration of nerves to their *** review explores the underlying pathophysiology of neuroma formation and centralization of pain *** compares the traditional surgical approach for symptomatic neuroma resection and describes three novel surgical strategies that harness this pathophysiology of neuroma formation to their *** traditional resection of symptomatic neuromas is currently the standard of care for amputation patients,but new techniques including the regenerative peripheral nerve interface,targeted muscle reinnervation,and intraosseous transposition have shown promise in improving patient pain outcomes for postamputation pain and residual limb *** neuromas are a chronic and debilitating complication following amputation procedures and trauma,and the current standard of care does not address the underlying pathophysiology leading to the formation of the *** techniques are under development that may provide improved patient pain outcomes and a higher level of care for symptomatic neuroma resection.

关键词： Neuromas regenerative peripheral nerve interface targeted muscle reinnervation osseointegrated neural interface amputation

Model-guided design of a high performance and durability Ni nanofiber/ceria matrix solid oxide fuel cell electrode

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journal of Energy Chemistry 2021年第5期30卷 98-112页

作者： Mengzheng Ouyang Antonio Bertei samuel j.Cooper Yufei Wu Paul Boldrin Xinhua Liu Masashi Kishimoto Huizhi Wang Max Naylor Marlow jingyi Chen Xiaolong Chen Yuhua Xia Billy Wu Nigel P.Brandon Department of Earth Science and Engineering Imperial College LondonExhibicion RoadLondon SW72AZUnired Kingdom Department of Civil and Industrial Engineering(D1CI) University of PisaLargo Lucio Lazzarino256J22 PisaItaly Dyson School of Design Engineering Imperial College LondonExhibition RoadLondon SW72AZUnited Kingdom Department of Computing Imperial College LondonExhibition RoadLondon SW72AZUnited Kingdom School of Transportation Science and Engineering Beihang UniversityKejiyuan RdHaidianBeijing 100083China Department of Aeronautics and Astronautics Kyoto UniversityYoshidahonmachiSakyo WardKyotoKyoto Prefecture 606-8501Japang Department of Mechanical Engineering Imperial College LondonExhibition RoadLondon SW72AZUnited Kingdom Department of Chemistry University of CambridgeThe Old SchoolsTrinity LnCambridge CB21TNUnited Kingdom

Mixed ionic electronic conductors(MIECs)have attracted increasing attention as anode materials for solid oxide fuel cells(SOFCs)and they hold great promise for lowering the operation temperature of ***,there has been a lack of understanding of the performance-limiting factors and guidelines for rational design of composite metal-MIEC *** a newly-developed approach based on 3 D-tomography and electrochemical impedance spectroscopy,here for the first time we quantify the contribution of the dual-phase boundary(DPB)relative to the three-phase boundary(TPB)reaction pathway on real MIEC electrodes.A new design strategy is developed for Ni/gadolinium doped ceria(CGO)electrodes(a typical MIEC electrode)based on the quantitative analyses and a novel Ni/CGO fiber-matrix structure is proposed and fabricated by combining electrospinning and tape-casting methods using commercial *** only 11.5 vol%nickel,the designer Ni/CGO fiber-matrix electrode shows 32%and 67%lower polarization resistance than a nano-Ni impregnated CGO scaffold electrode and conventional cermet electrode *** results in this paper demonstrate quantitatively using real electrode structures that enhancing DPB and hydrogen kinetics are more efficient strategies to enhance electrode performance than simply increasing TPB.

关键词： Solid oxide fuel cells Electrospinning Electrochemical impedance spectroscopy Tomography 2-d model Ceria

The benefits of being dominant:health correlates of male social rank and age in a marmot

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Current Zoology 2022年第1期68卷 19-26页

作者： Kenta UCHIDA Rachel NG samuel A.VYDRO jennifer E.SMITH Daniel T.BLUMSTEIN Department of Ecology&Evolutionary Biology University of CaliforniaLos AngelesCA 90095-1606USA Department of Biology Mills CollegeOaklandCA 94613USA The Rocky Mountain Biological Laboratory Crested ButteCO 81224USA

The benefits of dominance may not come without costs,particularly for *** example,the“immunocompetence handicap hypothesis”states that males with enhanced mating success allocate resources to enhance reproductive output at a cost to their current health,whereas the“resource quality hypothesis”predicts that high-ranking males may benefit from increased reproduction and good *** the predictions from each have been well tested in captive animals and in a variety of highly social primates,fewer studies have been carried out in free-living,facultatively social *** adult male yellow-bellied marmots(Marmota flaviventer),we evaluated predictions of these hypotheses by examining the relationship between social rank and 2 health indicators—fecal glucocorticoid metabolite(FCM)levels,and neutrophil/lymphocyte(N/L)ratios—after accounting for variation explained by age,body mass,and *** found that higher-ranking males tended to have a lower N/L ratio(reflecting good health)than lower-ranking individuals,whereas FCM levels were not significantly related to *** addition,heavier male marmots had lower N/L ratios,whereas body mass was not associated with FCM *** also found that older adult males had lower FCM levels(reflecting less physiological stress)but higher N/L ratios than younger ***,we found that FCM levels decreased as the active season progressed and FCM levels were associated with the time of the ***,our results suggest that socially-dominant male marmots enjoyed better,not worse health in terms of lower N/L ratios.

关键词： immunocompetence handicap hypothesis life history trade-offs N/L ratio physiological stress resource quality hypothesis

A chromosome-level genome assembly reveals that a bipartite gene cluster formed via an inverted duplication controls monoterpenoid biosynthesis in Schizonepeta tenuifolia

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Molecular Plant 2023年第3期16卷 533-548页

作者： Chanchan Liu samuel j.Smit jingjie Dang Peina Zhou Grant T.Godden Zheng jiang Wukun Liu Licheng Liui Wei Lin jinao Duan Qinan Wu Benjamin R.Lichman School of Pharmacy Nanjing University of Chinese MedicineNanjingChina jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization Nanjing University of Chinese MedicineNanjingChina Centre for Novel Agricultural Products Department of BiologyUniversity of YorkYork YO105DDUK Florida Museum of Natural History University of FloridaGainesileFLUSA Department of Pathogen Biology School of Medicine and Holistic Integrative MedicineNanjing University of Chinese MedicineNanjngChina

Biosynthetic gene clusters(BGCs)are regions of a genome where genes involved in a biosynthetic pathway are in *** origin and evolution of plant BGCs as well as their role in specialized metabolism remain largely *** this study,we have assembled a chromosome-scale genome of japanese catnip(Schizonepeta tenuifolia)and discovered a BGC that contains multiple copies of genes involved in four adjacent steps in the biosynthesis of p-menthane *** BGC has an unprecedented bipartite structure,with mirrored biosynthetic regions separated by 260 *** bipartite BGC includes identical copies of a gene encoding an old yellow enzyme,a type of flavin-dependent *** vitro assays and virus-induced gene silencing revealed that this gene encodes the missing isopiperitenone *** enzyme evolved from a completely different enzyme family to isopiperitenone reductase from closely related Mentha spp.,indicating convergent evolution of this pathway *** analysis revealed that this bipartite BGC has emerged uniquely in the *** lineage and through insertion of pathway genes into a region rich in monoterpene *** cluster gained its bipartite structure via an inverted *** discovered bipartite BGC for p-menthane biosynthesis in *** has similarities to the recently described duplicated p-menthane biosynthesis gene pairs in the Mentha longifolia genome,providing an example of the convergent evolution of gene *** work expands our understanding of plant BGCs with respect to both form and evolution,and highlights the power of BGCs for gene discovery in plant biosynthetic pathways.

关键词： specialized metabolism monoterpenoids biosynthetic gene cluster Lamiaceae biosynthesis chromosomal inversion

Project management in practice

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Machine-learning-based head impact subtyping based on the spectral densities of the measurable head kinematics

2001年

作者： samuel j. Mantel

来源：畅想之星图书光盘版（南... 评论

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journal of Sport and Health Science 2023年第5期12卷 619-629,F0003页

作者： Xianghao Zhan Yiheng Li Yuzhe Liu Nicholas j.Cecchi samuel j.Raymond Zhou Zhou Hossein Vahid Alizadeh jesse Ruan Saeed Barbat Stephen Tiernan Olivier Gevaert Michael M.Zeineh Gerald A.Grant David B.Camarillo Department of Bioengineering Stanford UniversityStanfordCA 94305USA Department of Biomedical Data Science Stanford UniversityStanfordCA 94305USA Ford Motor Company 3001 Miller RdDearbornMI 48120USA Technological University Dublin DublinD07 EWV4Ireland Department of Radiology Stanford UniversityStanfordCA 94305USA Department of Neurosurgery Stanford UniversityStanfordCA 94305USA

Background:Traumatic brain injury can be caused by head impacts,but many brain injury risk estimation models are not equally accurate across the variety of impacts that patients may undergo,and the characteristics of different types of impacts are not well *** investigated the spectral characteristics of different head impact types with kinematics ***:Data were analyzed from 3262 head impacts from lab reconstruction,American football,mixed martial arts,and publicly available car crash data.A random forest classifier with spectral densities of linear acceleration and angular velocity was built to classify head impact types(e.g.,football,car crash,mixed martial arts).To test the classifier robustness,another 271 lab-reconstructed impacts were obtained from 5 other instrumented ***,with the classifier,type-specific,nearest-neighbor regression models were built for brain ***:The classifier reached a median accuracy of 96% over 1000 random partitions of training and test *** most important features in the classification included both low-and high-frequency features,both linear acceleration features and angular velocity *** head impact types had different distributions of spectral densities in low-and high-frequency ranges(e.g.,the spectral densities of mixed martial arts impacts were higher in the high-frequency range than in the low-frequency range).The type-specific regression showed a generally higher R2value than baseline models without ***:The machine-learning-based classifier enables a better understanding of the impact kinematics spectral density in different sports,and it can be applied to evaluate the quality of impact-simulation systems and on-field data augmentation.

关键词： Classification Contact sports Head impacts Impact kinematics Traumatic brain injuryTagedAPTARAEnd

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利用神经网络由测井数据确定岩性

国外油气勘探 1993年第1期 76-83页

作者： samuel j.Rogers 钱志良

我们已经研制了利用向后传播神经网络由测井数据自动确定岩性的计算机程序。与常规的串行计算机不同,神经网络是一种由节点(有时称为神经元、神经极或单元)和节点间的连接组成的计算系统。神经计算试图仿效哺乳动物的脑功能,从而模拟思... 详细信息

我们已经研制了利用向后传播神经网络由测井数据自动确定岩性的计算机程序。与常规的串行计算机不同,神经网络是一种由节点(有时称为神经元、神经极或单元)和节点间的连接组成的计算系统。神经计算试图仿效哺乳动物的脑功能,从而模拟思维过程。神经网络法与以前的模式识别法的不同之点在于它向范例"学习"的能力。与常规的统计模式识别法不同,这种新方法不需要复杂的数学运算和大量的统计数据。本文讨论了神经网络在地质学中模式识别问题方面的应用:依据测井数据确定岩性。神经网络由选定的测井数据确定岩性(石灰岩、白云岩、砂岩、页岩、砂质及白云质灰岩、砂质白云岩和泥质砂岩)所需的时间仅为一个有经验的测井分析家所需的一小部分。

关键词：神经网络测井数据岩性模式识别