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The Search for Putative Hits in Combating Leishmaniasis:The Contributions of Natural Products Over the Last Decade

Natural Products and Bioprospecting 2021年第5期11卷 489-544页

作者： Patrick O.Sakyi Richard k.Amewu Robert N.O.A.Devine Emahi Ismaila Whelton A.Miller samuel k.kwofie Department of Chemistry School of Physical and Mathematical SciencesCollege of Basic and Applied SciencesUniversity of GhanaP.O.BOX LG 56LegonAccraGhana Department of Chemical Sciences School of SciencesUniversity of Energy and Natural ResourcesBox 214SunyaniGhana Department of Medicine Loyola University Medical CenterMaywoodIL 60153USA Department of Molecular Pharmacology and Neuroscience Loyola University Medical CenterMaywoodIL 60153USA Department of Chemical and Biomolecular Engineering School of Engineering and Applied ScienceUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Biomedical Engineering School of Engineering SciencesCollege of Basic&Applied SciencesUniversity of GhanaPMB LG 77LegonAccraGhana Department of Biochemistry Cell and Molecular BiologyWest African Centre for Cell Biology of Infectious PathogensCollege of Basic and Applied SciencesUniversity of GhanaP.O.Box LG 54AccraGhana

Despite advancements in the areas of omics and chemoinformatics,potent novel biotherapeutic molecules with new modes of actions are needed for *** socioeconomic burden of leishmaniasis remains alarming in endemic ***,reports from existing endemic areas such as Nepal,Iran,Brazil,India,Sudan and Afghanistan,as well as newly affected countries such as Peru,Bolivia and Somalia indicate concerns of chemoresistance to the classical antimonial *** a result,effective antileishmanial agents which are safe and affordable are urgently *** products from both flora and fauna have contributed immensely to chemotherapeutics and serve as vital sources of new chemical *** review focuses on a systematic cross-sectional view of all characterized anti-leishmanial compounds from natural sources over the last ***,IC_(50)/EC_(50),cytotoxicity and suggested mechanisms of action of some of these natural products are *** natural product classification includes alkaloids,terpenes,terpenoids,and *** plethora of reported mechanisms involve calcium channel inhibition,immunomodulation and *** avail-able enriched data pertaining to bioactivity and mechanisms of natural products complement current efforts geared towards unraveling potent leishmanicides of therapeutic relevance.

关键词： Chemotherapeutics Chemoinformatics Natural products Cytotoxicity Leishmaniasis Phenotypic screening

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Analysis of Causes of Delay in Middle and High Income Self-Build Housing Projects (SBHPs) in Wa, Ghana

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Journal of Building Construction and Planning Research 2015年第4期3卷 171-179页

作者： samuel Owusu Afram Anthony Bangdome-Dery Genevieve Ekua Eghan Titus Ebenezer kwofie Department of Architecture College of Architecture and Planning Kwame Nkrumah University of Science and Technology (KNUST) Kumasi Ghana Building Technology & Estate Management Department Wa Polytechnic Wa Ghana

Self-build housing projects (SBHPs) among middle and high income developers are faced with many challenges that cause delay in the delivery time of the house(s). The focus of this paper is to analyse the factors that cause delay in SBHPs in order to identify the critical delay factors. Review of literature and expert input revealed 20 variables which were used in a structured questionnaire for data collection from owners, consultants and builders in Wa Municipality. Reliability test, t-test analysis and mean ranking were used in the data analysis. The results revealed that “Delay in obtaining permit from Local Authorities” was the first delay factor followed by “Poor site management and supervision”. The delay factor ranked least was “Inadequate cost estimation and related details” from consultants. The paper recommends that Government agencies that regulate physical development should intensify public education, particularly on responsibilities and obligations, especially among self-builders. The paper recommends further study into labour-related issues as well as communication and information management among participants and its impact on self-build project success.

关键词： Delays Self-Build Housing Projects Ghana

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