The Search for Putative Hits in Combating Leishmaniasis:The Contributions of Natural Products Over the Last Decade
作者机构：Department of ChemistrySchool of Physical and Mathematical SciencesCollege of Basic and Applied SciencesUniversity of GhanaP.O.BOX LG 56LegonAccraGhana Department of Chemical SciencesSchool of SciencesUniversity of Energy and Natural ResourcesBox 214SunyaniGhana Department of MedicineLoyola University Medical CenterMaywoodIL 60153USA Department of Molecular Pharmacology and NeuroscienceLoyola University Medical CenterMaywoodIL 60153USA Department of Chemical and Biomolecular EngineeringSchool of Engineering and Applied ScienceUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Biomedical EngineeringSchool of Engineering SciencesCollege of Basic&Applied SciencesUniversity of GhanaPMB LG 77LegonAccraGhana Department of BiochemistryCell and Molecular BiologyWest African Centre for Cell Biology of Infectious PathogensCollege of Basic and Applied SciencesUniversity of GhanaP.O.Box LG 54AccraGhana
出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)
年 卷 期：2021年第11卷第5期
页 面：489-544页
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100602[医学-中西医结合临床] 10[医学]
主 题：Chemotherapeutics Chemoinformatics Natural products Cytotoxicity Leishmaniasis Phenotypic screening
摘 要：Despite advancements in the areas of omics and chemoinformatics,potent novel biotherapeutic molecules with new modes of actions are needed for *** socioeconomic burden of leishmaniasis remains alarming in endemic ***,reports from existing endemic areas such as Nepal,Iran,Brazil,India,Sudan and Afghanistan,as well as newly affected countries such as Peru,Bolivia and Somalia indicate concerns of chemoresistance to the classical antimonial *** a result,effective antileishmanial agents which are safe and affordable are urgently *** products from both flora and fauna have contributed immensely to chemotherapeutics and serve as vital sources of new chemical *** review focuses on a systematic cross-sectional view of all characterized anti-leishmanial compounds from natural sources over the last ***,IC_(50)/EC_(50),cytotoxicity and suggested mechanisms of action of some of these natural products are *** natural product classification includes alkaloids,terpenes,terpenoids,and *** plethora of reported mechanisms involve calcium channel inhibition,immunomodulation and *** avail-able enriched data pertaining to bioactivity and mechanisms of natural products complement current efforts geared towards unraveling potent leishmanicides of therapeutic relevance.
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