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Extra-hepatic manifestations associated with hepatitis E virus infection:a comprehensive review of the literature

Gastroenterology Report 2016年第1期4卷 1-15,I0001页

作者： Fateh Bazerbachi samir haffar Sushil K Garg John R Lake Division of Gastroenterology and Hepatology University of MinnesotaMinneapolisMN 55455USA Department of Gastroenterology and Hepatology University of DamascusDamascusSyrian Arab Republic

Background and aims:Hepatitis E virus(HEV)infection is a significant public health problem that afflicts almost 20 million individuals annually and causes acute liver injury in 3.5 million,with approximately 56000 *** with other viral hepatitides,extra-hepatic manifestations could represent an important aspect of this *** spectrum of these manifestations is still *** pancreatitis and neurological,musculoskeletal,hematological,renal,and other immune-mediated manifestations have been *** aim of this article is to comprehensively review the published literature of extra-hepatic manifestations associated with HEV *** sources:We searched the PubMed database using the MeSH term“hepatitis E”and each of the extra-hepaticmanifestations associated with HEV *** language or date restrictions were set in these *** retrieving articles with non-A,non-B hepatitis were *** articles were identified through the reference lists of included ***:Several extra-hepatic manifestations associated with HEV infection have been *** temporal association between some extra-hepatic manifestations and HEV infection and the exclusion of other possible etiologies suggests that HEV infection could have caused some of *** to the available data,HEV infection appears to be strongly associated with acute pancreatitis,neurological disorders(with primarily dominant peripheral nerve involvement,most commonly manifested as Guillain-Barre´syndrome,followed by neuralgic amyotrophy),hematological diseases(hemolytic anemia due to glucose phosphate dehydrogenase deficiency,and severe thrombocytopenia),glomerulonephritis,and mixed *** data are needed to clarify whether an association exists with musculoskeletal or other immunemediated ***:HEV infection should be considered in patients with acute pancreatitis,Guillain-Barre´syndrome,neuralgic amyotrophy,hem

关键词： hepatitis E virus viral hepatitis extra-hepatic manifestations vaccine primary prevention

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Systematic review of mixed cryoglobulinemia associated with hepatitis E virus infection:association or causation?

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Gastroenterology Report 2017年第3期5卷 178-184,I0001页

作者： Fateh Bazerbachi Michael D.Leise Kymberly D.Watt MHassan Murad Larry J.Prokop samir haffar Division of Gastroenterology and Hepatology Mayo ClinicRochesterMNUSA Robert D.and Patricia E.Kern Center for the Science of Health Care Delivery Mayo ClinicRochesterMNUSA Library Public Services Mayo ClinicRochesterMNUSA Digestive Centre for Diagnosis and Treatment DamascusSyrian Arab Republic

Background and aim:Mixed cryoglobulinemia(MC)has been associated with several viral infections,and chronic hepatitis C is recognized as a major *** associated with hepatitis E virus(HEV)has been described and little is known about this rare *** aim of this study is to perform a systematic review of MC associated with HEV,and examine the presence of a causal ***:An experienced librarian conducted a search of databases from each database’s inception to 12 December 2016 based on a priori *** risk of bias was assessed,and Hill’s criteria were applied to determine ***:Five publications met inclusion criteria,with a total of 15 *** studies had low,one low to moderate and one moderate risk of *** age was 43 years,and all patients came from Western *** patients were immunocompetent,while 13 were immunosuppressed,post solid organ transplant and had chronic hepatitis *** involvement was observed in seven patients,mild to moderately severe cryoglobulinemic disease in one patient and severe cryoglobulinemic disease in three *** patient improved spontaneously,and another was treated with immunosuppressant reduction leading to viral *** patients treated with peg-interferon or ribavirin for 3 months achieved loss of cryoglobulinemia and end-of-treatment response,but sustained virologic response was reported and achieved in *** achieved loss of cryoglobulinemia in three *** case of chronic renal failure,three cases of end-stage renal disease and one death were *** of the nine Hill’s criteria were ***:MC has been described with HEV infection.A causal relationship between HEV infection and cryoglobulinemia is highly probable.

关键词： hepatitis E virus hepatitis virology mixed cryoglobulinemia systematic review

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Acute pancreatitis associated with intravenous administration of propofol:evaluation of causality in a systematic review of the literature

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Gastroenterology Report 2019年第1期7卷 13-23,I0001页

作者： samir haffar Ravinder Jeet Kaur Sushil Kumar Garg Joseph A.Hyder M.Hassan Murad Barham K.Abu Dayyeh Fateh Bazerbachi Digestive Center for Diagnosis&Treatment 29 Ayar StreetDamascusSyrian Arab Republic Division of Gastroenterology and Hepatology Mayo Clinic200 First Street SWRochesterMN 55905USA Division of Anesthesiology and Perioperative Medicine Mayo Clinic200 First Street SWRochesterMN 55905USA Division of Health Care Policy and Research Mayo Clinic200 First Street SWRochesterMN 55905USA

Acute pancreatitis(AP)associated with intravenous administration of propofol has been described with unknown causal *** therefore assessed this causality in a systematic *** databases were searched on 16 August 2017;studies were appraised and selected by two reviewers based on a priori *** causality was evaluated with the Naranjo scale and Badalov *** identified 18 studies from 11 countries with a total of 21 patients,and the majority had adequate methodological *** median age was 35 years(range,4–77)and 10(48%)were ***,propofol was administrated in 8 patients as sedative along with induction/maintenance of anesthesia in 13 patients;median dose was 200 mg,with intermediate latency(1–30 days)in 14(67%).Serum triglycerides were>1000 mg/dL in four *** AP was observed in four patients(19%).AP recurrence occurred in one out of two patients who underwent *** related to AP was 3/21(14%).Propofol was the probable cause of AP according to the Naranjo scale in 19 patients(89%).Propofol-induced AP has a probable causal relation and evidence supports Badalov class *** is not the only mechanism by which propofol illicit ***-induced AP was severe in 19%of patients with a mortality rate related to AP of 14%.Future research is needed to delineate whether this risk is higher if combined with other procedures that portend inherent risk of pancreatitis such as endoscopic retrograde cholangiopancreatography.

关键词： Acute pancreatitis drug-induced pancreatitis propofol systematic review

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End-stage renal disease is associated with increased post endoscopic retrograde cholangiopancreatography adverse events in hospitalized patients

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World Journal of Gastroenterology 2018年第41期24卷 4691-4697页

作者： Tarek Sawas Fateh Bazerbachi samir haffar Won K Cho Michael J Levy John A Martin Bret T Petersen Mark D Topazian Vinay Chandrasekhara Barham K Abu Dayyeh Division of Gastroenterology and Hepatology Mayo Clinic Department of Gastroenterology Digestive Center for Diagnosis and Treatment Division of Gastroenterology and Hepatology Georgetown University Medstar Washington Hospital Center

AIM To determine if end-stage renal disease (ESRD) is a risk factor for post endoscopic retrograde cholangio-pancreatography (ERCP) adverse events (AEs). METHODS We performed a retrospective cohort study using the Nationwide Inpatient Sample (NIS) 2011-2013. We identified adult patients who underwent ERCP using the International Classification of Diseases 9^(th) Revision (ICD-9-CM). Included patients were divided into three groups: ESRD, chronic kidney disease (CKD), and control. The primary outcome was post-ERCP AEs including pancreatitis, bleeding, and perforation determined based on specific ICD-9-CM codes. Secondary outcomes were length of hospital stay, in-hospital mortality, and admission cost. AEs and mortality were compared using multivariate logistic regression *** There were 492175 discharges that underwent ERCP during the 3 years. The ESRD and CKD groups contained 7347 and 39403 hospitalizations respectively, whereas the control group had 445424 hospitalizations. Post-ERCP pancreatitis (PEP) was significantly higher in the ESRD group (8.3%) compared to the control group (4.6%) with adjusted odd ratio (aOR) = 1.7 (95% CI: 1.4-2.1, ~aP < 0.001). ESRD was associated with significantly higher ERCP-related bleeding (5.1%) compared to the control group 1.5% (aOR = 1.86, 95%CI: 1.4-2.4, ~aP < 0.001). ESRD had increased hospital mortality 7.1% vs 1.15% in the control OR = 6.6 (95%CI: 5.3-8.2, ~aP < 0.001), longer hospital stay with adjusted mean difference (aMD) = 5.9 d (95% CI: 5.0-6.7 d, ~aP < 0.001) and higher hospitalization charges aMD = $+82064 (95%CI: $68221-$95906, ~aP < 0.001). CONCLUSION ESRD is a risk factor for post-ERCP AEs and is associated with higher hospital mortality. Careful selection and close monitoring is warranted to improve outcomes.

关键词： End-stage renal disease Nationwide Inpatient Sample Endoscopic retrograde cholangiopancreatography

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Volvulus of the ileal pouch-anal anastomosis:a meta-narrative systematic review of frequency,diagnosis,and treatment outcomes

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Gastroenterology Report 2019年第6期7卷 403-410,I0001页

作者： Muhammad Jawoosh samir haffar Parakkal Deepak Alyssa Meyers Amy L.Lightner David W.Larson Laura H.Raffals MHassan Murad Navtej Buttar Fateh Bazerbachi Division of Gastroenterology and Hepatology Dessau Municipal HospitalAuenweg 3806847 Dessau-RosslauGermany Digestive Center for Diagnosis and Treatment DamascusSyrian Arab Republic Division of Gastroenterology John T.Milliken Department of MedicineWashington University School of MedicineSt.LouisMOUSA Division of Gastroenterology and Hepatology Mayo ClinicRochesterMNUSA Department of Colorectal Surgery Cleveland ClinicClevelandOHUSA Division of Colon and Rectal Surgery Mayo ClinicRochesterMNUSA Robert D and Patricia E Kern Center for the Science of Health Care Delivery Mayo ClinicRochesterMNUSA Division of Gastroenterology Massachusetts General HospitalBostonMAUSA

Background:Proctocolectomy with ileal pouch–anal anastomosis(IPAA)is the surgical procedure of choice for medically refractory ulcerative colitis and familial adenomatous *** rare,a pouch volvulus can *** aimed to determine the frequency,presentation,and management approach of pouch volvulus in patients with ***:A systematic search of published literature was performed by a medical reference librarian on 10 August 2018 and two independent reviewers identified relevant publications,extracted data,and assessed the methodological quality based on a validated tool.A retrospective review of the Mayo Clinic electronic medical records identified one case of pouch volvulus between January 2008 and August ***:The frequency of pouch volvulus from one large published study reporting long-termoutcomes of IPAA was 0.18%(3/1,700).A total of 22 patients(18 ulcerative colitis)were included(median age 32 years,73%females).Median time to volvulus after IPAA was 36 months while median interval to volvulus diagnosis from symptom onset was 24 *** pain was the most commonly reported symptom(76%).The diagnosis was made primarily by abdominal computed tomography(13/17 patients,76%).Endoscopic treatment was successful in 1 of 11 patients(9%).Surgery was performed in 20 patients and pouch-pexy and pouch excision were the most frequent surgical operations.A redo IPAA was performed in five patients(25%).Conclusion:Pouch volvulus is a rare but serious complication of IPAA and should be suspected even in the absence of obstruction *** treatment often fails and surgery is effective when performed early.

关键词： familial adenomatous polyposis ulcerative colitis ileal pouch–anal anastomosis pouch volvulus systematic review

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Stabilization and Synchronization of Discrete-time Fractional Chaotic Systems with Non-identical Dimensions

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Acta Mathematicae Applicatae Sinica 2021年第3期37卷 523-538页

作者： samir BENDOUKHA Department of Electrical Engineering College of EngineeringYanbuTaibah UniversitySaudi Arabia

This paper investigates the stabilization and synchronization of two fractional chaotic maps proposed recently,namely the 2D fractional Hénon map and the 3D fractional generalized Hénon *** show that although these maps have non–identical dimensions,their synchronization is still *** proposed controllers are evaluated experimentally in the case of non–identical orders or time–varying *** methods are used to illustrate the results.

关键词： discrete chaos fractional discrete calculus Hénon based maps stabilization synchronization

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DUALITY OF GENERALIZED DUNKL-LIPSCHITZ SPACES

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Acta Mathematica Scientia 2017年第6期37卷 1567-1593页

作者： samir KALLEL Department of Mathematics Higher Institute of Computer Sciences and Mathematics of MonastirMonastir University5000 MonastirTunisia

Abstract The aim of this paper is to prove duality and reflexivity of generalized Lipschitz spaces ∧κα,p,q（R）, α ∈R and 1≤〈 p, q ≤∞, in the context of Dunkl harmonic analysis.

关键词： Dunkl operator duality Herz spaces heat transform Dunkl transform gen-eralized Dunkl-Lipschitz spaces

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The effects of exhaust air vent location on thermal comfort inside a residential building equipped with an evaporative cooling system

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Building Simulation 2021年第4期14卷 1063-1075页

作者： rmin Saraei samir Farid Moujaes Department of Mechanical Engineering College of EngineeringUniversity of Nevada Las VegasLas VegasNV89154USA

The location of exhaust air vents of an evaporative cooling system can have significant effects on providing thermal comfort and controlling humidity, temperature and air distribution in buildings. In the current study, four different strategies have been evaluated for exhaust air vent locations to provide the optimum thermal comfort inside a typical residential house. This study provides a numerical solution for temperature and relative humidity profiles in the residential house and within the living space in each room typically at a height of 1.8 m or less. By evaluating different exhaust air vent locations in a room, the best strategy(ies) to provide more appropriate thermal comfort condition and obtained and as a conclusion, the exhaust vents should be located on furthest wall away from the entrance of the room and in the middle. The results provided in the current study can eventually be applied in the design of evaporative cooler exhaust vent systems in residential buildings and lead to improve the performance of these systems.

关键词： thermal comfort CFD evaporative cooling system exhaust air vents

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Finite Elementθ-Schemes for the Acoustic Wave Equation

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Advances in Applied Mathematics and Mechanics 2011年第2期3卷 181-203页

作者： samir Karaa Department of Mathematics and Statistics Sultan Qaboos UniversityP.O.Box 36Al-Khod 123MuscatSultanate of Oman

In this paper,we investigate the stability and convergence of a family of implicit finite difference schemes in time and Galerkin finite element methods in space for the numerical solution of the acoustic wave *** schemes cover the classical explicit second-order leapfrog scheme and the fourth-order accurate scheme in time obtained by the modified equation *** derive general stability conditions for the family of implicit schemes covering some well-known CFL *** error estimates are *** sufficiently smooth solutions,we demonstrate that the maximal error in the L^(2)-norm error over a finite time interval converges optimally as O(h^(p+1)+∆t^(s)),where p denotes the polynomial degree,s=2 or 4,h the mesh size,and∆t the time step.

关键词： Finite element methods discontinuous Galerkin methods wave equation implicit methods energy method stability condition optimal error estimates

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Simulation and analysis of resin flow in injection machine screw

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第3期9卷 338-345页

作者： Ling-feng LI samir MEKID College of Mechanical and Energy Engineering Zhejiang University Hangzhou 310027 China School of Mechanical Aerospace and Civil Engineering University of Manchester Manchester UK

A method with simulation and analysis of the resin flow in a screw is presented to ease the control of some problems that may affect the efficiency and the quality of the product among existing screws in an injection machine. The physical model of a screw is established to represent the stress, the strain, the relationship between velocity and stress, and the temperature of the cells. In this paper, a working case is considered where the velocity and the temperature distributions at any section of the flow are obtained. The analysis of the computational results shows an ability to master various parameters depending on the specifications.

关键词： Screw Plasticity Velocity distribution Temperature distribution

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