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Role of adipose tissue grafting and adipose-derived stem cells in peripheral nerve surgery

Neural Regeneration Research 2022年第10期17卷 2179-2184页

作者： Tiam M.Saffari Sara Saffari Krishna S.Vyas samir Mardini Alexander Y.Shin Department of Orthopedic Surgery Division of Microvascular and Hand SurgeryMayo ClinicRochesterMNUSA Radboud University Medical Center Radboud Institute for Health SciencesDepartment of Plastic SurgeryNijmegenThe Netherlands Department of Surgery Division of Plastic and Reconstructive SurgeryMayo ClinicRochesterMNUSA

The application of autologous fat grafting in reconstructive surgery is commonly used to improve functional *** review aims to provide an overview of the scientific evidence on the biology of adipose tissue,the role of adipose-derived stem cells,and the indications of adipose tissue grafting in peripheral nerve *** tissue is easily accessible through the lower abdomen and inner ***-vascularized adipose tissue grafting does not support oxidative and ischemic stress,resulting in variable survival of adipocytes within the first 24 *** of adipose tissue with a stromal vascular fraction is purported to increase the number of adipose-derived stem cells and is postulated to augment the long-term stability of adipose tissue *** science nerve research suggests an increase in nerve regeneration and nerve revascularization,and a decrease in nerve fibrosis after the addition of adipose-derived stem cells or adipose *** clinical studies,the use of autologous lipofilling is mostly applied to secondary carpal tunnel release revisions with promising *** the use of adipose-derived stem cells in peripheral nerve reconstruction is relatively new,more studies are needed to explore safety and long-term effects on peripheral nerve *** Food and Drug Administration stipulates that adipose-derived stem cell transplantation should be minimally manipulated,enzyme-free,and used in the same surgical procedure,*** tissue grafts that contain native adipose-derived stem cells or stromal vascular *** research may be shifted towards the use of tissue-engineered adipose tissue to create a supportive microenvironment for autologous graft ***-ready alternatives could be enhanced with adipose-derived stem cells or growth factors and eliminate the need for adipose tissue harvest.

关键词： adipose tissue adipose-derived stem cells angiogenesis autologous fat grafting nerve injury nerve regeneration paracrine environment peripheral nerve reconstruction stem cell secretome tissue engineering

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Naringenin suppresses NLRP3 inflammasome activation via the mRNA-208a signaling pathway in isoproterenol-induced myocardial infarction

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Asian Pacific Journal of Tropical Biomedicine 2023年第10期13卷 443-450页

作者： Ayman Eldourghamy Toka Hossam Mohammed Abdalla Hussein Amal Abdel-Aziz samir A.El-masry Environmental Biotechnology Department Genetic Engineering and Biotechnology Research InstituteSadat UniversityEgypt Department of Medical Labs Faculty of Applied Medical Sciences TechnologyOctober 6 UniversityEgypt Department of Biotechnology Faculty of Applied Health Sciences TechnologyOctober 6 UniversityEgypt Molecular Biology Department Genetic Engineering and Biotechnology Research InstituteSadat UniversityEgypt

Objective:To investigate the cardioprotective effect of naringenin against isoproterenol(ISO)-induced cardiotoxicity in ***:Rats were divided into five groups:the normal group,the ISO group(85 mg/kg b.w.);the ISO+naringenin(50 mg/kg b.w.)group,the ISO+naringenin(100 mg/kg b.w.)group and the ISO+propranolol(10 mg/kg b.w.)*** creatine kinase-MB(CK-MB),cardiac troponin T,lactate dehydrogenase,brain natriuretic peptide(BNP),and IL-10,as well as cardiac transforming growth factor-β1(TGF-β1),vascular endothelial growth factor(VEGF)and malondialdehyde(MDA)were *** addition,NLRP3 and mRNA-208a expressions were evaluated by RT-PCR *** examination was also performed to assess cardiac ***:Naringenin treatment significantly decreased plasma lactate dehydrogenase,CK-MB,cardiac troponin T,BNP,and IL-10,as well as cardiac TGF-β1,VEGF,and MDA while increasing p-Akt and superoxide dismutase in ISO-administered *** also reduced NLRP3 and mRNA-208a gene expression ***,naringenin improved ISO-induced cardiac ***:Naringenin attenuates myocardial dysfunction in ISO-treated rats by decreasing oxidative stress and increasing cardiac endogenous antioxidant system,which may be modulated partly by improvement of NLRP3 and mRNA-208a gene expression.

关键词： Naringenin Isoproterenol Myocardial infarction Antioxidants NLRP3 mRNA-208a

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Dynamic track-soil interaction——calculations and measurements of slab and ballast tracks

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2021年第1期22卷 21-36页

作者： Lutz AUERSCH samir SAID Federal Institute of Material Research and Testing Berlin 12200Germany

The dynamic behaviour of slab and ballast tracks was investigated using measurements and *** impacts and train passages were analysed and measurements were made using geophones(velocity transducers)which had been time-integrated to *** calculations were carried out in the frequency-wavenumber domain for multi-beamon-continuous soil *** characteristics of the different tracks and track elements were established in theory and by *** frequency-dependent compliances(displacement transfer functions)showed clear rail-on-railpad resonances or highly damped track-soil *** to the rail and sleeper,the track slab had much lower *** slab track usually had the highest rail amplitudes due to soft *** passage yielded track displacements which were a superposition of the axle loads from the two neighbouring axles of a bogie and from the two bogies of two neighbouring *** global behaviour was characteristic of the track slab of the slab track,whereas the rails of the slab and the ballast tracks behaved more locally with only one bogie of *** measurements agreed very well with the theory of continuous soil in the case of the six measured slab tracks and acceptably well for the six measured ballast *** measurements allowed us to find appropriate model parameters and to check the *** example,the Winkler model of the soil was found to be less appropriate because it reacted more locally.

关键词： Slab track Ballast track Train passage Hammer impact Track-soil interaction

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DUALITY OF GENERALIZED DUNKL-LIPSCHITZ SPACES

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Acta Mathematica Scientia 2017年第6期37卷 1567-1593页

作者： samir KALLEL Department of Mathematics Higher Institute of Computer Sciences and Mathematics of MonastirMonastir University5000 MonastirTunisia

Abstract The aim of this paper is to prove duality and reflexivity of generalized Lipschitz spaces ∧κα,p,q（R）, α ∈R and 1≤〈 p, q ≤∞, in the context of Dunkl harmonic analysis.

关键词： Dunkl operator duality Herz spaces heat transform Dunkl transform gen-eralized Dunkl-Lipschitz spaces

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Incremental Learning Framework for Mining Big Data Stream

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Computers, Materials & Continua 2022年第5期71卷 2901-2921页

作者： Alaa Eisa Nora E.L-Rashidy Mohammad Dahman Alshehri Hazem M.El-bakry samir Abdelrazek Information Systems Department Faculty of Computers and InformationMansoura UniversityMansoura35516Egypt Machine Learning and Information Retrieval Department Faculty of Artificial IntelligenceKafrelsheikh UniversityKafr El-SheikhEgypt Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia

At this current time,data stream classification plays a key role in big data analytics due to its enormous *** of the existing classification methods used ensemble learning,which is trustworthy but these methods are not effective to face the issues of learning from imbalanced big data,it also supposes that all data are *** weakness of current methods is that it takes a long evaluation time when the target data stream contains a high number of *** main objective of this research is to develop a new method for incremental learning based on the proposed ant lion fuzzy-generative adversarial network *** proposed model is implemented in spark *** each data stream,the class output is computed at slave nodes by training a generative adversarial network with the back propagation error based on fuzzy bound *** method overcomes the limitations of existing methods as it can classify data streams that are slightly or completely unlabeled data and providing high scalability and *** results show that the proposed model outperforms stateof-the-art performance in terms of accuracy(0.861)precision(0.9328)and minimal MSE(0.0416).

关键词： Ant lion optimization(ALO) big data stream generative adversarial network(GAN) incremental learning renyi entropy

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The effects of exhaust air vent location on thermal comfort inside a residential building equipped with an evaporative cooling system

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Building Simulation 2021年第4期14卷 1063-1075页

作者： rmin Saraei samir Farid Moujaes Department of Mechanical Engineering College of EngineeringUniversity of Nevada Las VegasLas VegasNV89154USA

The location of exhaust air vents of an evaporative cooling system can have significant effects on providing thermal comfort and controlling humidity, temperature and air distribution in buildings. In the current study, four different strategies have been evaluated for exhaust air vent locations to provide the optimum thermal comfort inside a typical residential house. This study provides a numerical solution for temperature and relative humidity profiles in the residential house and within the living space in each room typically at a height of 1.8 m or less. By evaluating different exhaust air vent locations in a room, the best strategy(ies) to provide more appropriate thermal comfort condition and obtained and as a conclusion, the exhaust vents should be located on furthest wall away from the entrance of the room and in the middle. The results provided in the current study can eventually be applied in the design of evaporative cooler exhaust vent systems in residential buildings and lead to improve the performance of these systems.

关键词： thermal comfort CFD evaporative cooling system exhaust air vents

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Metamaterial-Based Compact Antenna with Defected Ground Structure for 5G and Beyond

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Computers, Materials & Continua 2022年第5期71卷 2383-2399页

作者： Md.Mushfiqur Rahman Md.Shabiul Islam Mohammad Tariqul Islam samir Salem Al-Bawri Wong Hin Yong Faculty of Engineering Multimedia UniversityPersiaran MultimediaCyberjaya63100SelangorMalaysia Department of Electrical Electronic and Systems EngineeringFaculty of Engineering and Built EnvironmentUniversiti Kebangsaan MalaysiaBangi43600Malaysia Space Science Centre Climate Change InstituteUniversiti Kebangsaan Malaysia(UKM)Bangi43600Malaysia

In this paper,a unit cell of a single-negative metamaterial structure loaded with a meander line and defected ground structure(DGS)is investigated as the principle radiating element of an *** unit cell antenna causes even or odd mode resonances similar to the unit cell structure depending on the orientation of the microstrip feed used to excite the unit ***,the orientation which gives low-frequency resonance is considered *** unit cell antenna is then loaded with a meander line which is parallel to the split bearing side and connects the other two sides orthogonal to the split bearing *** modified structure excites another mode of resonance at high frequency when a meander line defect is loaded on the metallic ground *** parameters of the meander line structure,the DGS shape,and the unit cell are optimized to place these two resonances at different frequencies with proper frequency intervals to enhance the ***,the feed is placed in an offset position for better impedance matching without affecting the bandwidth The compact dimension of the antenna is 0.25λL×0.23λL×0.02λL,whereλL is the free space wavelength with respect to the center frequency of the impedance *** proposed antenna is fabricated and *** results reveal that the modified design gives monopole like radiation patterns which achieves a fractional operating bandwidth of 26.6%,from 3.26 to 4.26 GHz for|S11|<−10 dB and a pick gain of 1.26 dBi is *** addition,the simulated and measured crosspolarization levels are both less than−15 dB in the horizontal plane.

关键词： Split ring resonator(SRR) meander line defected ground structure compact antenna bandwidth enhancement 5G technology

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Finite Elementθ-Schemes for the Acoustic Wave Equation

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Advances in Applied Mathematics and Mechanics 2011年第2期3卷 181-203页

作者： samir Karaa Department of Mathematics and Statistics Sultan Qaboos UniversityP.O.Box 36Al-Khod 123MuscatSultanate of Oman

In this paper,we investigate the stability and convergence of a family of implicit finite difference schemes in time and Galerkin finite element methods in space for the numerical solution of the acoustic wave *** schemes cover the classical explicit second-order leapfrog scheme and the fourth-order accurate scheme in time obtained by the modified equation *** derive general stability conditions for the family of implicit schemes covering some well-known CFL *** error estimates are *** sufficiently smooth solutions,we demonstrate that the maximal error in the L^(2)-norm error over a finite time interval converges optimally as O(h^(p+1)+∆t^(s)),where p denotes the polynomial degree,s=2 or 4,h the mesh size,and∆t the time step.

关键词： Finite element methods discontinuous Galerkin methods wave equation implicit methods energy method stability condition optimal error estimates

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Simulation and analysis of resin flow in injection machine screw

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第3期9卷 338-345页

作者： Ling-feng LI samir MEKID College of Mechanical and Energy Engineering Zhejiang University Hangzhou 310027 China School of Mechanical Aerospace and Civil Engineering University of Manchester Manchester UK

A method with simulation and analysis of the resin flow in a screw is presented to ease the control of some problems that may affect the efficiency and the quality of the product among existing screws in an injection machine. The physical model of a screw is established to represent the stress, the strain, the relationship between velocity and stress, and the temperature of the cells. In this paper, a working case is considered where the velocity and the temperature distributions at any section of the flow are obtained. The analysis of the computational results shows an ability to master various parameters depending on the specifications.

关键词：机械结构分析方法模拟技术温度

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Blepharis persica increases testosterone biosynthesis by modulating StAR and 3β-HSD expression in rat testicular tissues

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Asian pacific Journal of Reproduction 2022年第1期11卷 27-34,I0001-I0003页

作者： Nilesh Gaikar Nishit Patel samir Patel Priyal Patel Piyush Chudasama Manan Raval Department of Pharmacognosy Ramanbhai Patel College of PharmacyCharotar University of Science and TechnologyCHARUSAT CampusChangaGujaratIndia Department of Pharmaceutical Chemistry Ramanbhai Patel College of PharmacyCharotar University of Science and TechnologyCHARUSAT CampusChangaGujaratIndia Department of Pharmacology Ramanbhai Patel College of PharmacyCharotar University of Science and TechnologyCHARUSAT CampusChangaGujaratIndia Research Scientist R&D UnitSat-Kaival Hospital Pvt.LtdAnand388001 GujaratIndia

Objective:To evaluate the effect of methanolic extract and ethyl acetate fraction of methanol extract prepared from the seeds of Blepharis(B.)persica on testosterone biosynthesis and also to elucidate the underlying ***:Forty-eight male Wistar rats were divided into eight groups(n=6 per group).GroupⅠreceived 0.3%w/w gum acacia suspension *** served as the normal control ***Ⅱwas administered testosterone propionate in arachis oil *** the positive control ***ⅢtoⅣreceived *** methanolic extract *** doses of 50,100 and 200 mg/kg body ***ⅥtoⅦreceived *** ethyl acetate fraction *** doses of 50,100 and 200 mg/kg body *** testis was used for biochemical estimation and histological *** effects of methanolic extract and ethyl acetate fraction of *** on testicular testosterone,mRNA expression corresponding to steroidogenic acute regulatory protein(StAR)and 3β-hydroxysteroid dehydrogenase(3β-HSD)along with 3β-HSD enzyme assay were evaluated in testicular tissues and sperm *** acetate fraction of *** was subjected to column *** studies were performed using TM3 cell line at three dose levels(50,100,200μg/mL),each for methanolic extract,ethyl acetate fraction and 2-benzoxazolinone for evaluation of their comparative effect on testosterone ***:Ethyl acetate fraction and methanolic extract of *** could elevate the testicular testosterone content compared to the normal control *** treatment with methanolic extract and ethyl acetate fraction of *** increased the expression of mRNA corresponding to StAR by 6.7 fold and 10.6 fold,respectively,whereas the mRNA expression of 3β-HSD increased by 5.7 fold and 7.3 fold,***,fraction and extract treatment exhibited increased 3β-HSD activity in the testicular tissues and were found to elevate sperm concentration in seminal *** spermatogenic potential was further en

关键词： Blepharis persica Testosterone Spermatogenic Leydig cells 3β-hydroxysteroid dehydrogenase Steroidogenic acute regulatory protein mRNA expression TM3 cell line

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