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Deubiquitination in prostate cancer progression:role of USP22

Journal of Cancer Metastasis and Treatment 2020年第1期6卷 155-167页

作者： Nivedita Nag samikshan dutta Department of Microbiology Sister Nibedita Government General Degree College for GirlsKolkata 700027India Department of Biochemistry and Molecular Biology University of Nebraska Medical CenterOmahaNE 68198-5870USA

Prostate cancer(PCa)is the leading cause of cancer death in *** more therapeutic modalities available,the overall survival in PCa has increased significantly in recent *** with relapses after advanced secondgeneration anti-androgen therapy however,often show poor disease *** group of patients often die from cancer-related *** approaches have been taken to understand disease recurrence and to correlate the gene expression *** one such study,an 11-gene signature was identified to be associated with PCa recurrence and poor *** them,a specific deubiquitinase called ubiquitin-specific peptidase 22(USP22)was selectively and progressively overexpressed with PCa ***,it was shown to regulate androgen receptors and Myc,the two most important regulators of PCa ***,USP22 has been shown to be associated with the development of therapy resistant *** USP22 was also found to be therapeutically advantageous,especially in clinically challenging and advanced *** review provides an update of USP22 related functions and challenges associated with PCa research and explains why targeting this axis is beneficial for PCa relapse cases.

关键词： USP22 prostate cancer SAGA Deubiquitin

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Tumor-and osteoclast-derived NRP2 in prostate cancer bone metastases

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Bone Research 2021年第2期9卷 233-247页

作者： Navatha Shree Polavaram samikshan dutta Ridwan Islam Arup K.Bag Sohini Roy David Poitz Jeffrey Karnes Lorenz C.Hofbauer Manish Kohli Brian A.Costello Raffael Jimenez Surinder K.Batra Benjamin A.Teply Michael H.Muders Kaustubh Datta Department of Microbiology and Pathology University of Nebraska Medical CenterOmahaNEUSA Department of Biochemistry and Molecular Biology University of Nebraska Medical CenterOmahaNEUSA Institute for Clinical Chemistry University Hospital DresdenDresdenGermany Department of Urology Mayo ClinicRochesterMNUSA Center for Healthy Aging and Bone Lab Dresden Department of Medicine IIITechnische Universität DresdenDresdenGermany School of Medicine Division of OncologyHuntsman Cancer InstituteSalt Lake CityUTUSA Division of Anatomic Pathology Department of Pathology and Laboratory MedicineMayo ClinicRochesterMNUSA Internal Medicine Division of Oncology&HematologyUniversity of Nebraska Medical CenterOmahaNEUSA Rudolf-Becker Laboratory for Prostate Cancer Research Institute of PathologyUniversity of Bonn Medical CenterBonnGermany

Understanding the role of neuropilin 2(NRP2)in prostate cancer cells as well as in the bone microenvironment is pivotal in the development of an effective targeted therapy for the treatment of prostate cancer bone *** observed a significant upregulation of NRP2 in prostate cancer cells metastasized to ***,we report that targeting NRP2 in cancer cells can enhance taxane-based chemotherapy with a better therapeutic outcome in bone metastasis,implicating NRP2 as a promising therapeutic ***,osteoclasts present in the tumor microenvironment express NRP2,we have investigated the potential effect of targeting NRP2 in *** results revealed NRP2 negatively regulates osteoclast differentiation and function in the presence of prostate cancer cells that promotes mixed bone *** study further delineated the molecular mechanisms by which NRP2 regulates osteoclast ***,depletion of NRP2 in osteoclasts in vivo showed a decrease in the overall prostate tumor burden in the *** results therefore indicate that targeting NRP2 in prostate cancer cells as well as in the osteoclastic compartment can be beneficial in the treatment of prostate cancer bone metastasis.

关键词： metastasis chemotherapy treatment

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