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Journal of Agricultural Science and Technology(A) 2017年第8期7卷 546-551页

作者： Ilker Kepenekci Onur dura sami dura Department of Plant Protection Faculty of Agriculture Gaziosmanpasa University Tashciftlik Tokat 60250 Turkey Atatiirk Central Horticultural Research Institute Merkez Yalova 77100 Turkey ROTAM Lifesciences Kimyasal Tartm Tic. Ltd. Sti Pasaport lzmir 35210 Turkey

The aim of this study was to determine the nematicidal effects of some biopesticides againist root-knot nematodes （RKNs）（Meloidogyne incognita） on Bruno type kiwifruit seedlings. Research was conducted in the Atattirk Central Horticultural Research Institute （ACHRI, Yalova, Turkey） greenhouse during 2013-2014. Biopesticides observed in this study were： sesame oil （Devalone EC）, castor oil （Ricinus communis）, Myrothecium verrucaria （M. verrucaria strain AARC-0255, Inferno DF）, Glomus spp. （Endomycorrhizal fungi, Endo Roots Soluble SP） and Paecilomyces lilacinus （Entomopathogenic fungi, P. lilacinus strain PL1, Bionematon SL）. Nematicide Nemacur EC 400 （fenamiphos） was used as treated control （TC） and trials were set up as randomized parcel design （RPD） with seven characters and 10 replicates. Reproduction ratio was determined according to scale values in trial applications and second stage juvenile （J2） populations of M. incognita in soil. The results showed that the best nematicidal effects against RKNs were determined in castor oil （77.92% in 2013 and 73.61% in 2014） and P. lilacinus （61.03% in 2013 and 55.55% in 2014）.

关键词： Root-knot nematodes Meloidogyne incognita sesame oil castor oil Myrothecium verrucaria Glomus Paecilomyceslilacinus kiwifruit.

Single-cell Analysis of CAR-T Cell Activation Reveals A Mixed T_H1/T_H2 Response Independent of Differentiation

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Genomics, Proteomics & Bioinformatics 2019年第2期17卷 129-139页

作者： Iva Xhangolli Burak dura GeeHee Lee Dongjoo Kim Yang Xiao Rong Fan Department of Biomedical Engineering Yale University New Haven CT 06520 USA Yale Cancer Center Yale School of Medicine New Haven CT 06520 USA Yale Stem Cell Center Yale School of Medicine New Haven CT 06520

The activation mechanism of chimeric antigen receptor (CAR)-engineered T cells may differ substantially from T cells carrying native T cell receptor,but this difference remains poorly understood. We present the first comprehensive portrait of single-cell level transcriptional and cyto-kine signatures of anti-CD19/4-1BB/CD28/CD3ζ CAR-T cells upon antigen-specific stimulation. Both CD4+helper T (TH) cells and CD8+cytotoxic CAR-T cells are equally effective in directly killing target tumor cells and their cytotoxic activity is associated with the elevation of a range of TH1 and TH2 signature cytokines,e.g.,interferon γ,tumor necrotic factor α,interleukin 5 (IL5),and IL13,as confirmed by the expression of master transcription factor genes TBX21 and GATA3. However,rather than conforming to stringent TH1 or TH2 subtypes,single-cell analysis reveals that the predominant response is a highly mixed TH1/TH2 function in the same cell. The reg-ulatory T cell activity,although observed in a small fraction of activated cells,emerges from this hybrid TH1/TH2 population. Granulocyte-macrophage colony stimulating factor (GM-CSF) is pro-duced from the majority of cells regardless of the polarization states,further contrasting CAR-T to classic T cells. Surprisingly,the cytokine response is minimally associated with differentiation status,although all major differentiation subsets such as na?ve,central memory,effector memory,and effector are detected. All these suggest that the activation of CAR-engineered T cells is a canon-ical process that leads to a highly mixed response combining both type 1 and type 2 cytokines together with GM-CSF,supporting the notion that polyfunctional CAR-T cells correlate with objective response of patients in clinical trials. This work provides new insights into the mechanism of CAR activation and implies the necessity for cellular function assays to characterize the quality of CAR-T infusion products and monitor therapeutic responses in patients.

关键词： Single-cell transcriptomics Single-cell proteomics CAR-T T cell activation

DAMAGE TOLERANCE AND FATIGUE LIFE ESTIMATION FOR PIPE/ROD BAR STRUCTURE

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Transactions of Nanjing University of Aeronautics and Astronautics 2011年第2期28卷 169-175页

作者： dura Hari Bahadur 吴铁鹰吴志功南京航空航天大学能源与动力学院

The damage tolerance for pipe/rod bar in the auxiliary power units （APUs） support system is studied. The main objective is to study whether planes can safely land when the fatigue crack appears on the bar. Firstly, the stress intensity factors （K~） of two bar structures are computed, and the iso-stress intensity factor （iso-Kl） model is presented. The model uses the finite element model （FEM） instead of the parameters of material to com- pute the crack propagation. Then, the general relations between Kt vs crack size are obtained for different mate- rials, inner to outer diameter ratios （D^n/Dout） and external crack propagation angles （0）. Finally, the FEM anal- ysis results are input to the ANSYS parametric design language（ANSYS-APDL） software. And the fatigue life of damaged bar is estimated under the condition of loading spectrum.

关键词： fatigue crack propagation circumferential crack stress intensity factor pipe/rod bar

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惠普耳病：52例临床分析

世界医学杂志 1998年第4期2卷 27-36页

作者： dura.,DV 顾瑞金

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在高铜补牙汞齐中形成的Su6Sn5

国外锡工业 1996年第4期24卷 41-45页

作者： dura.,YC 黄浩

直接观察汞与炉内冷却的用作商业补牙汞齐合金Ｔｙｔｉｎ的反应来形成的产品，发现在大粒Ｃｕ３Ｓｎ５和基质Ａｇ－Ｓｎ－Ｃｕ相位的交界处有Ｃｕ６Ｓｎ５集结，它能与汞容易地反应。棒状Ｃｕ６Ｓｎ５晶体沿Ｃｕ３Ｓｎ表面向优先结晶方... 详细信息

直接观察汞与炉内冷却的用作商业补牙汞齐合金Ｔｙｔｉｎ的反应来形成的产品，发现在大粒Ｃｕ３Ｓｎ５和基质Ａｇ－Ｓｎ－Ｃｕ相位的交界处有Ｃｕ６Ｓｎ５集结，它能与汞容易地反应。棒状Ｃｕ６Ｓｎ５晶体沿Ｃｕ３Ｓｎ表面向优先结晶方向生长，Ｃｕ３Ｓｎ不能与汞反应。铜在三元补牙汞齐合金中的作用是防止锡－汞化合物形成，而优先析出Ｃｕ６Ｓｎ５，但这种反应产品须在Ｃｕ３Ｓｎ合金分布的情况下才会成长。

关键词：补牙汞齐合金铜 Cu6Sn5

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柑桔种质资源的组织培养保存

浙江柑桔 1993年第1期10卷 42-42页

作者： M.L.Marin.N.dura-Vila 邓崇岭唐艳

本研究目的是对柑桔种质资源组织培养保存技术的可能性进行评估。以幼龄(1～2年生)的凤梨甜橙(***(L)Osb.)为外植体的组织培养保存系统已被建立。包括二次培养:A、初培养:含芽的茎节段外植体,在附加有1mgBA/升,并含有BNS的培养基中培养... 详细信息

本研究目的是对柑桔种质资源组织培养保存技术的可能性进行评估。以幼龄(1～2年生)的凤梨甜橙(***(L)Osb.)为外植体的组织培养保存系统已被建立。包括二次培养:A、初培养:含芽的茎节段外植体,在附加有1mgBA/升,并含有BNS的培养基中培养(培养温度为26±1℃,相对湿度60j％,j光照时间每天16小时),生长出芽,转移到加有3mg NAA/升,并含有BNS的生根培养基中培养,生长出根,再转移到伸长培养基中培养,获得完整小植株。B。

关键词：组织培养种质资源茎节保存技术来檬培养温度尤力克遗传资源

<i>STAT</i>1 gene mutation is not implicated in upper aerodigestive cancers

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Open Journal of Gastroenterology 2012年第2期2卷 68-71页

作者： Polat dura Rene H. M. te Morsche Martin Lacko Mihai G. Netea Jos W. M. van der Meer Joost P. H. Drenth Wilbert H. M. Peters Department of Otorhinolaryngology Maastricht University Medical Center Maastricht the Netherlands Departments of Gastroenterology and Internal Medicine Radboud University Nijmegen Medical Center Nijmegen the Netherlands

Autosomal Dominant Chronic Mucocutaneous Candidiasis (AD-CMC) is characterized by defective T cell immunity, leading to fungal infections limited to mucosal surfaces. Recently it was discovered that mutations in the coiled-coil (CC) domain of STAT1 are the cause of AD-CMC. STAT1 deficiency has been implicated in experimental models of oesophageal cancer (EC) and head and neck carcinoma (HNC). Both carcinoma types are prevalent among CMC patients. Consequently, we postulated that the same mutation in the STAT1 gene triggering AD-CMC, could also be involved in oesophageal- or head and neck carcinogenesis. However we failed to identify the c.820C>T mutation in the STAT1 CC domain in 3 cohorts of Dutch Caucasian origin: being 351 EC patients, 325 HNC patients and 309 controls. Although it seems valuable to investigate the relationship between AD-CMC and upper aerodigestive neo- plasms, the c.820C>T mutation in the STAT1 gene does not seem implicated in EC and HNC aetiology.

关键词： STAT1 Signal Transducers and Activators of Transcription Chronic Mucocutaneous Candidiasis Genetic Mutation Esophageal Carcinoma Head and Neck Carcinoma

Spinal dural arteriovenous fistula:a comprehensive review of the history,classification systems,management,and prognosis

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Chinese Neurosurgical Journal 2024年第1期10卷 48-56页

作者： Ali Alkhaibary Ahoud Alharbi Nada Alnefaie Hajar Alammar Alshaymaa M.Arishy Noor Alghanim Yazeed M.Aldhfyan Arwa Albaiahy Yahya H.Khormi Wael Alshaya Saad AlQahatani Ahmed Aloraidi Ahmed Alkhani sami Khairy College of Medicine King Saud Bin Abdulaziz University for Health SciencesRiyadhSaudi Arabia King Abdullah International Medical Research Center RiyadhSaudi Arabia Division of Neurosurgery Department of SurgeryKing Abdulaziz Medical CityMinistry of National Guard-Health AffairsRiyadhSaudi Arabia Department of Neurosurgery National Neurosciences InstituteKing Fahad Medical CityRiyadhSaudi Arabia College of Medicine Jazan UniversityJazanSaudi Arabia Department of Neurosurgery King Faisal Specialist Hospital and Research CenterRiyadhSaudi Arabia Department of Surgery Faculty of MedicineJazan UniversityJazanSaudi Arabia

Spinal dural arteriovenous fistulas account for the majority of spinal vascular *** are typically located in the thoracolumbar region and are diagnosed in the middle-aged and elderly *** spinal dural arteriovenous fistulas have been postulated to be acquired,their exact development remains ***,the arteriovenous shunt is situated close to the spinal nerve root,inside the dura mater,where the blood from the radiculomeningeal artery and radicular vein *** history,there have been multiple classification systems of spinal arteriovenous shunts since *** were mainly based on the evolution of diagnostic studies as well as the treatment of these *** classification systems have undergone significant changes over the *** intracranial dural arteriovenous fistula,spinal dural arteriovenous fistula is progressive in *** neurological manifestations,due to venous congestion,tend to be insidious as well as *** include sensory deficits,such as paresthesia,bilateral and/or unilateral radicular pain affecting the lower limbs,and gait *** dural arteriovenous fistulas can be suspected on magnetic resonance imaging/magnetic resonance angiography and confirmed by digital subtraction angiography(DSA).The management includes surgery,endovascular therapy,and in selected cases,*** treatment goal of spinal dural arteriovenous fistula is to halt the progression of the *** prognosis depends on both the duration of symptoms as well as the clinical condition prior to *** present article comprehensively reviews the pathophysiology,changes in classification systems,natural history,clinical manifestations,radiological features,management,and prognosis.

关键词： Connection Endovascular Myelopathy Vascular

配种前后补饲对鄂尔多斯细毛羊生产性能及血清学的影响

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畜牧与兽医 2020年第7期52卷 28-33页

作者：谷英斯登丹巴孙海洲满都拉张崇志桑丹额尔德尼布拉格德德玛张春华斯庆毕力格董海娟内蒙古鄂尔多斯市农牧业科学研究院内蒙古鄂尔多斯017000 内蒙古自治区农牧业科学院动物营养与饲料研究所内蒙古呼和浩特010031 内蒙古鄂尔多斯市乌审旗农牧业局家畜改良工作站内蒙古鄂尔多斯017300

鄂尔多斯细毛羊为毛肉兼用型哺乳类动物,在当前羊肉和细羊毛短缺的现状下,本试验拟通过配种前后补饲提高营养水平来研究其对细毛羊生产性能和血清学的影响,解决细毛羊产羔率低的现状,同时提高细毛羊产肉产毛性能、降低成本、缓减市场对... 详细信息

鄂尔多斯细毛羊为毛肉兼用型哺乳类动物,在当前羊肉和细羊毛短缺的现状下,本试验拟通过配种前后补饲提高营养水平来研究其对细毛羊生产性能和血清学的影响,解决细毛羊产羔率低的现状,同时提高细毛羊产肉产毛性能、降低成本、缓减市场对细毛羊羊肉羊毛短缺的难题。结果显示:在配种前40 d至配种后15 d每日补充0.5 kg/只的精补料,通过改善能繁母羊营养状况,调节激素水平,从而促进排卵及保证受精卵的着床率,使得鄂尔多斯细毛羊的产羔率由126.92%提高到162.50%,提高了35.58个百分点,效果显著。同时,在配种前提高了雌二醇、促黄体生成素和孕酮激素的水平,但差异不显著(P>0.05)。通过配种前后加强营养,所产单胎羔羊初生重提高0.47 kg,能繁母羊产毛量提高0.26 kg,毛长提高0.25 cm。研究表明,配种前后通过补饲可提高鄂尔多细毛羊的产羔率及毛肉等生产性能。

关键词：鄂尔多斯细毛羊生产性能血清学