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Vagus nerve stimulation in intracerebral hemorrhage:the need for further research

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Neural Regeneration Research 2025年第11期20卷 3213-3214页

作者： sheharyar s.Baig ali N.ali Arshad Majid sheffield Institute for Translational Neuroscience Division of NeuroscienceThe University of SheffieldSheffieldUK

Vagus nerve stimulation(VNs)and stroke:stroke is the second leading cause of death and the third leading cause of disability worldwide(Baig et al.,2023).There have been significant paradigm shifts in the management of acute ischemic stroke through mechanical *** chronic ischemic stroke,invasive VNs paired with rehabilitation is associated with a significant increase in upper limb motor recovery and is FDA-approved(Baig et al.,2023).There are no treatments of similar efficacy in acute intracerebral hemorrhage(ICH)where several promising trials,e.g.,TICH-2,sTOP-AUsT,and TRAIGE did not show improvements in functional outcomes(Puy et al.,2023).

关键词： stimulation acute

Nanocellulose isolation characterization and applications:a journey from non-remedial to biomedical claims

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Bio-Design and Manufacturing 2019年第3期2卷 187-212页

作者： sania Naz Joham s.ali Muhammad Zia Department of Biotechnology Quaid-i-Azam University IslamabadIslamabadPakistan

Cellulose is a renewable,biodegradable,ecofriendly and sustainable *** market of nanocellulose is comprehensively very high due to its *** of nanocellulose from bacteria and plant results in different morphology and size of ***,mechanical strength,biofabrication,crystallinity,high surface area per unit mass,hydrophilicity,porosity,transparency and non-toxicity of bacterial cellulose make it more *** extravagant nanoscaled three-dimensional network of cellulosic structures possess extraordinary properties for biomedical application,evidencing its usage in skin therapy,cardiovascular implants,cartilage meniscus implants,tissue engineering,bone tissue and neural implants,wound care products,drug delivery agents,tablet modification,tissue engineered urinary conduits,and synthesis of artificial *** due to potential benefits associated with nanocellulose effective and efficient techniques are required for the isolation of nanocellulose that should be economical,ecofriendly and non-toxic.

关键词： Nanocellulose Plant and bacterial source Extraction Applications

Forced oscillations and stability analysis of a nonlinear micro-rotating shaft incorporating a non-classical theory

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Acta Mechanica sinica 2018年第5期34卷 970-982页

作者： s.ali Ghasabi Mohammadreza Arbabtafti Majid shahgholi Mechanical Engineering Faculty Shahid Rajaee Teacher Training UniversityTehranIran

In this paper,the stability and bifurcation analysis of symmetrical and asymmetrical micro-rotating shafts are investigated when the rotational speed is in the vicinity of the critical *** the help of Hamilton's principle,nonlinear equations of motion are derived based on non-classical theories such as the strain gradient *** the dynamic modeling,the geometric nonlinearities due to strains,and strain gradients are *** bifurcations and steady state solution are compared between the classical theory and the non-classical *** is observed that using a non-classical theory has considerable effect in the steady-state response and bifurcations of the *** a result,under the classical theory,the symmetrical shaft becomes completely stable in the least damping coefficient,while the asymmetrical shaft becomes completely stable in the highest damping *** the modified strain gradient theory,the symmetrical shaft becomes completely stable in the least total eccentricity,and under the classical theory the asymmetrical shaft becomes completely stable in the highest total ***,it is shown that by increasing the ratio of the radius of gyration per length scale parameter,the results of the non-classical theory approach those of the classical theory.

关键词： strain gradient theory Micro-rotating shaft stability Nonlinear oscillation Bifurcation Multiple scales method

structural and Mechanistic studies of γ-Fe2O3 Nanoparticle as Capecitabine Drug Nanocarrier

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Chinese Journal of structural Chemistry 2018年第3期37卷 375-382页

作者： ETEBARI Nasfin MORsali ali BEYRAMABADI s.ali Department of Chemistry Mashhad BranchIslamic Azad UniversityMashhadIran&Research Center for Animal Development Applied Biology Mashhad BranchIslamic Azad UniversitG Mashhad 917568Iran

Using density functional theory,noncovalent interactions and four mechanisms of covalent functionalization of capecitabine anticancer drug onto γ-Fe2O3 nanoparticles have been *** molecular descriptors of noncovalent configurations were *** was specified that binding of capecitabine onto γ-Fe2O3 nanoparticles is thermodynamically *** and the gap of energy between LUMO and HOMO of capecitabine are higher than the noncovalent configurations,showing the reactivity of capecitabine increases in the presence of γ-Fe2O3 *** can bond to γ-Fe2O3 nanoparticles through OH（k1 mechanism）,NH（k2 mechanism）,CO（k3 mechanism） and F（k4 mechanism） *** activation energies,activation enthalpies and activation Gibbs free energies of these reactions were *** was specified that the k1 and k2 mechanisms are under thermodynamic control and k3 and k4 under kinetic *** results could be generalized to other similar drugs.

关键词： γ-Fe2O3 nanoparticles capecitabine density functional theory noncovalent and covalent functionalization mechanism

Microtechnology-based methods for organoid models

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Microsystems & Nanoengineering 2020年第1期6卷 381-393页

作者： Vanessa Velasco s.ali shariati Rahim Esfandyarpour Biochemistry Department Stanford UniversityPalo AltoCAUSA Department of Biomolecular Engineering Institute for the Biology of Stem CellsUniversity of CaliforniaSanta CruzCAUSA Department of Electrical Engineering University of CaliforniaIrvineCAUSA Department of Biomedical Engineering University of California IrvineIrvineCAUSA Henry samueli school of Engineering University of CaliforniaIrvineCAUSA

Innovations in biomaterials and stem cell technology have allowed for the emergence of novel three-dimensional(3D)tissue-like structures known as organoids and *** a result,compared to conventional 2D cell culture and animal models,these complex 3D structures have improved the accuracy and facilitated in vitro investigations of human diseases,human development,and personalized medical *** to the rapid progress of this field,numerous spheroid and organoid production methodologies have been ***,many of the current spheroid and organoid production techniques are limited by complexity,throughput,and *** and microscale platforms(e.g.,microfluidics and microprinting)have shown promise to address some of the current limitations in both organoid and spheroid *** and microfluidic devices have been shown to improve nutrient delivery and exchange and have allowed for the arrayed production of size-controlled culture areas that yield more uniform organoids and spheroids for a higher throughput at a lower *** this review,we discuss the most recent production methods,challenges currently faced in organoid and spheroid production,and microfabricated and microfluidic applications for improving spheroid and organoid ***,we focus on how microfabrication methods and devices such as lithography,microcontact printing,and microfluidic delivery systems can advance organoid and spheroid applications in medicine.

关键词： printing culture biomaterials

MARIE:One-stage Object Detection Mechanism for Real-Time Identifying of Firearms

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Computer Modeling in Engineering & sciences 2025年第1期142卷 279-298页

作者： Diana Abi-Nader Hassan Harb ali Jaber ali Mansour Christophe Osswald Nour Mostafa Chamseddine Zaki Computer science Department Faculty of SciencesLebanese UniversityBeirut146404Lebanon College of Engineering and Technology American University of the Middle EastEgaila54200Kuwait Lab-sTICC CNRS UMR 6285ENSTA-BretagneBrest29200France

security and safety remain paramount concerns for both governments and individuals *** today’s context,the frequency of crimes and terrorist attacks is alarmingly increasing,becoming increasingly intolerable to ***,there is a pressing need for swift identification of potential threats to preemptively alert law enforcement and security forces,thereby preventing potential attacks or violent *** advancements in big data analytics and deep learning have significantly enhanced the capabilities of computer vision in object detection,particularly in identifying *** paper introduces a novel automatic firearm detection surveillance system,utilizing a one-stage detection approach named MARIE(Mechanism for Realtime Identification of Firearms).MARIE incorporates the single shot Multibox Detector(ssD)model,which has been specifically optimized to balance the speed-accuracy trade-off critical in firearm detection *** ssD model was further refined by integrating MobileNetV2 and InceptionV2 architectures for superior feature extraction *** experimental results demonstrate that this modified ssD configuration provides highly satisfactory performance,surpassing existing methods trained on the same dataset in terms of the critical speedaccuracy *** these innovations,MARIE sets a new standard in surveillance technology,offering a robust solution to enhance public safety effectively.

关键词： Firearm and gun detection single shot multi-box detector deep learning one-stage detector MobileNet inception convolutional neural network

Newtonian heating in stagnation point flow of Burgers fluid

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Applied Mathematics and Mechanics(English Edition) 2015年第1期36卷 61-68页

作者： T.HAYAT s.ali M.AWAIs M.s.ALHUTHali Department of Mathematics Quaid-i-Azam University Nonlinear Analysis and Applied Mathematics (NAAM) Research Group Faculty of Science King Abdulaziz University Faculty of Engineering sciences Ghulam Ishaq Khan Institute of Engineering Sciences and Technology Department of Mathematics COMSATS Institute of Information Technology

The Newtonian heating effects in the stagnation point flow of a Burgers fluid are addressed in this paper. The boundary layer flow problems are stated in the spatial domain from zero to infinity. The solution expressions for the velocity and the temperature are obtained and examined for the influential variables. The tabulated values show comparison with the previous results. It is observed that the obtained results are in good agreement with the existing results in limiting sense.

关键词： Burgers fluid Newtonian heating series solutions

Analytical determination of non-local parameter value to investigate the axial buckling of nanoshells affected by the passing nanofluids and their velocities considering various modified cylindrical shell theories

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Chinese Physics B 2023年第4期32卷 511-528页

作者： soheil Oveissi Aazam Ghassemi Mehdi salehi s.ali Eftekhari saeed Ziaei-Rad Department of Mechanical Engineering Najafabad BranchIslamic Azad UniversityNajafabadIran Department of Mechanical Engineering Khomeinishahr BranchIslamic Azad UniversityKhomeinishahrIran Department of Mechanical Engineering Isfahan University of TechnologyIsfahan 84156-83111Iran

We analytically determine the nonlocal parameter value to achieve a more accurate axial-buckling response of carbon nanoshells conveying nanofluids. To this end, the four plates/shells' classical theories of Love, Fl ¨ugge, Donnell, and sanders are generalized using Eringen's nonlocal elasticity theory. By combining these theories in cylindrical coordinates,a modified motion equation is presented to investigate the buckling behavior of the nanofluid-nanostructure-interaction problem. Herein, in addition to the small-scale effect of the structure and the passing fluid on the critical buckling strain,we discuss the effects of nanoflow velocity, fluid density(nano-liquid/nano-gas), half-wave numbers, aspect ratio, and nanoshell flexural rigidity. The analytical approach is used to discretize and solve the obtained relations to study the mentioned cases.

关键词： buckling nonlocal cylindrical shell model anofluid-nanostructure interaction carbon nanotubes

The phytochemical, biological, and medicinal attributes of phytoecdysteroids: An updated review

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Acta Pharmaceutica sinica B 2021年第7期11卷 1740-1766页

作者： Niranjan Das siddhartha Kumar Mishra Anusha Bishayee Eunüs s.ali Anupam Bishayee Department of Chemistry Iswar Chandra Vidyasagar CollegeBelonia-799155TripuraIndia Cancer Biology Laboratory Department of ZoologySchool of Biological SciencesDr.Harisingh Gour Central UniversitySagar-470003Madhya PradeshIndia Pine View school OspreyFL 34229USA Department of Biochemistry and Molecular Genetics Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611USA Lake Erie College of Osteopathic Medicine BradentonFL 34211USA

The phytoecdysteroids(PEs)comprise a large group of biologically-active plant steroids,which have structures similar to those of insect-molting *** are distributed in plants as secondary metabolites that offer protection against phytophagus(plant-eating)*** insects consume the plants containing these chemicals,they promptly molt and undergo metabolic destruction;the insects eventually ***,ecdysteroids are a group of polyhydroxylated ketosteroids that are structurally similar to *** carbon skeleton of ecdysteroids is termed as cyclopentanoperhydro-phenanthrene with aβ-side chain at *** essential characteristics of ecdysteroids are a cis-(5β-H)junction of rings A and B,a 7-en-6-one chromophore,and a trans(14α-OH)junction of rings C and *** only synthesize PEs from mevalonic acid in the mevalonate pathway of the plant cell using acetyl-CoA as a precursor;the most common PE is *** far,over 400 PEs have been identified and reported,and a compilation of 166 PEs originating from 1998 has been previously *** the present review,we have summarized 212 new PEs reported between 1999 and *** have also critically analyzed the biological,pharmacological,and medicinal properties of PEs to understand the full impact of these phytoconstituents in health and disease.

关键词： Phytoecdysteroids secondary metabolites Antioxidant Anti-inflammatory Antimicrobial Antidiabetic Anticancer activity