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Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

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Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： Holly Flyger samantha J.Holdsworth Alistair J.Gunn Laura Bennet Hamid Abbasi Mātai Medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&Medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia

Piling up multidecker pyrgos[n]cages as antibacterial materials

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Science China Materials 2025年第1期 314-316页

作者： Miguel A.Liuzzi-Vaamonde Jackson B.Lancaster samantha A.Mason Yuanning Feng Department of Chemistry and Biochemistry The University of Oklahoma

The development of antibiotics is regarded as one of the most significant scientific advances in modern medicine. Before the commercialization of antibiotics, infectious diseases were catastrophic throughout history [1]. Penicillin was used to treat serious infections in the 1940s, but unfortunately, with the introduction of antibiotics came the emergence of antibiotic resistance [2,3]. Evolved and adapted methicillin-resistant Staphylococcus aureus (MRSA) strains are presently impacting community and healthcare systems across the globe [4].

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A Grain of Dust Falling Through a Sierpinski Gasket

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Acta Mathematica Sinica,English Series 2007年第6期23卷 1095-1108页

作者： samantha LEORATO Enzo ORSINGHER Dipartimento di Statistica Probabilitd e Statistiche ApplicateUniversity of Rome "La Sapienza"P.le A.Moro5-00185 RomaItaly

In this paper we analyze the downward random motion of a particle in a vertical, bounded, Sierpinski gasket G, where at each layer either absorption or delays are considered. In the case of motion with absorption the explicit distribution of the position of the descending particle in the pre-gasket Gn is obtained and the limiting case of the Sierpinski gasket discussed. For the delayed downward motion we derive a representation of the random time needed to arrive at the base of Gn in terms of independent binomial random variables （containing the contribution of delays at different layers with different geometrical structures）.

关键词： Binomial random variables fractals Hausdorff dimension random walks self-similarity

Investigating unsafe behaviours in traffic conflict situations:An observational study in Nigeria

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第5期6卷 482-492页

作者： Chinebuli Uzondu samantha Jamson Frank Lai Institute for Transport Studies University of Leeds Leeds LS2 9JT UK Department of Transport Management Technology Federal University of Technology Owerri Owerri Nigeria

Although road users are aware of the possible risks of engaging in unsafe behaviours while driving,they continue to do *** behaviours often contribute to traffic incidents and crashes involving them and other road *** study set out to analyse the effect of road user type,location and time of day on unsafe driving behaviours observed in traffic conflict *** were collected by road side observation at three different locations in the eastern part of Nigeria using the traffic conflict technique(TCT).This approach was adopted to overcome the inherent problems associated with reliable,inadequate and accessible crash data in *** total 946 traffic conflicts were observed and statistical testing showed that drivers were involved in one or more unsafe behaviours prior to these *** all unsafe behaviours observed,the incorrect use of indicators(13.3%) and tailgating(11.3%) were found to be the most prevalent,while road user type,location and time of day were found to be statistically associated with passenger scouting and other unsafe *** drivers were significantly more likely to engage in unsafe behaviours than vehicle *** are also more likely to engage in unsafe behaviours on straight ***,a greater number of these unsafe behaviours were observed during the peak *** is recommended that better road infrastructure,more effective regulations and enforcement,and proper road safety education could help improve traffic safety in Nigeria.

关键词： Unsafe behaviour Traffic conflict Traffic safety Crash data

Automated location correction and spot height generation for named summits in the coterminous United States

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International Journal of Digital Earth 2020年第12期13卷 1570-1584页

作者： samantha T.Arundel Gaurav Sinha U.S.Geological Survey Center of Excellence for Geospatial Information ScienceRollaMOUSA Department of Geography Ohio UniversityAthensOHUSA

Spot elevations published on historical *** Survey topographic maps were established as needed to enhance information imparted by the quadrangle’s *** addition to other features,labels were routinely placed on mountain *** some elevations were established through field survey triangulation,many were computed during photogrammetric ***,Global Navigation Satellite System(GNSS)receivers have replaced expensive triangulation ***,since GNSS measurements require visiting the feature location,a national dataset containing high-accuracy spot elevations has not yet been ***,modern *** maps are devoid of mountain peak or other spot ***,topographic map users continue to demand the display of spot ***,a pilot study was conducted to evaluate the feasibility of automatically generating elevation values at named *** using available elevation *** devised method uses an uphill stepping technique to find the most likely highest point in subsequently higher-resolution elevation *** elevation values are compared to other published *** from 196 summits indicate that values derived from lidar are generally higher,whereas those populated from the one-third arcsecond USGS Seamless 3DEP elevation dataset are generally lower.A thorough understanding of these relationships require the evaluation of more points.

关键词： Spot height summits 3D elevation program geographic names

Photo-activated microtubule targeting drugs: Advancing therapies for colorectal cancer

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World Journal of Gastroenterology 2024年第26期30卷 3257-3260页

作者： Naresh Singh samantha Sharma Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202United States

Over the years immunotherapy has demonstrably improved the field of cancer ***,achieving long-term survival for colorectal cancer(CRC)patients remains a significant unmet *** immunotherapies incor-porating targeted drugs like MEK or multi-kinase inhibitors have offered some palliative ***,substantial gaps remain in the current therapeutic armamentarium for *** recent years,there has been a surge of interest in exploring novel treatment strategies,including the application of light-activated drugs in conjunction with optical *** approach holds promise for achie-ving localized and targeted delivery of cytotoxic agents,such as microtubule-targeting drugs,directly to cancerous cells within the colon.

Sizing up feature descriptors for macromolecular machine learning with polymeric biomaterials

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npj Computational Materials 2023年第1期9卷 1287-1296页

作者： samantha Stuart Jeffrey Watchorn Frank X.Gu Institute of Biomedical Engineering University of TorontoTorontoOntarioCanada Department of Chemical Engineering and Applied Chemistry University of TorontoTorontoOntarioCanada

It has proved challenging to represent the behavior of polymeric macromolecules as machine learning features for biomaterial interaction *** are several approaches to this representation,yet no consensus for a universal representational framework,in part due to the sensitivity of biomacromolecular interactions to polymer *** help navigate the process of feature engineering,we provide an overview of popular classes of data representations for polymeric biomaterial machine learning while discussing their merits and ***,increasing the accessibility of polymeric biomaterial feature engineering knowledge will contribute to the goal of accelerating clinical translation from biomaterials discovery.

关键词： properties prediction biomaterials

A novel two-way method for dynamically coupling a hydrodynamic model with a discrete element model(DEM)

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Journal of Hydrodynamics 2018年第5期30卷 966-969页

作者： Yan Xiong Qiuhua Liang samantha Mahaffey Mohamed Rouainia Gang Wang State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China School of Architecture Building and Civil EngineeringLoughborough UniversityLoughboroughUK School of Engineering Newcastle UniversityNewcastle upon TyneEnglandUK

The effect of floating objects has so far been little considered for hazard risk assessment and structure design, despite being an important factor causing structural damage in flood-prone and coastal areas. In this work, a novel two-way method is proposed to fully couple a shock-capturing hydrodynamic model with a discrete element model （DEM） for simulation of complex debris-enriched flow hydrodynamics. After being validated against an idealized analytical test, the new coupled model is used to reproduce flume experiments of floating debris driven by dam-break waves. The numerical results agree satisfactorily with the experimental measurements, demonstrating the model＇s capability and efficiency in simulating complex fluid-debris interactions induced by violent shallow flows.

关键词： Coupled model, discrete element model (DEM) extreme hydraulic conditions floating debris shallow water equations Godunov-type finite volume method

Functional perspectives on tropical tree demography and forest dynamics

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Ecological Processes 2019年第1期8卷 1-11页

作者： samantha J.Worthy Nathan G.Swenson Department of Biology University of MarylandCollege ParkMD 20742USA

Disentangling the processes that drive population,community and whole forest structure and dynamics is a *** becomes a grand challenge in the tropics where there are a large number of species,small population sizes,less research infrastructure,and a relatively smaller number of researchers compared to the temperate *** this grand challenge,we argue,requires detailed knowledge of the functioning of individuals and *** this end,researchers frequently employ plant functional traits to study tree populations and ***,we review this approach by first providing a basic background regarding the major trait axes generally of *** then discuss how these axes may be or have been applied from ecosystem to community and population *** doing so,we highlight where the functional trait research program has failed in tropical tree ecology and where it can be improved or ***,we provide a perspective regarding how functional trait and emerging‘omics approaches can be integrated to address large questions facing the *** intention throughout is to provide an entryway into this literature for an early career researcher rather than a comprehensive review of all possible studies that have taken place in tropical forests.

关键词： Demographic rate Functional diversity Functional trait Transcriptome Tropical forest Tropical rain forest