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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Shin Jung Tae-Young Jung In-Young Kim Kyung-Sub Moon sam-suk kang Brain Tumor Research Laboratory Department of NeurosurgeryBrain Tumor ＆ Gamma Knife CenterChonnam National University Hwasun Hospital ＆ Medical School

Object:Although bone invasion and hyperostosis are common phenomena in patients with intracranial meningiomas,the basic pathomechanism is not fully *** on an immunohistochemical study of surgically-resected samples with hyperostosis,we postulate a possible mechanism of hyperostosis in patients with intracranial *** and Methods:Forty-six meningiomas were evaluated in this ***-six meningiomas associated with hyperostosis specimens served as the study group and 20 meningiomas without any bony changes served as controls.A histologic examination showed benign meningiomas in 42 samples and atypical meningiomas in 4 *** immunohistochemical staining technique was used to detect the expression of matrix metalloproteinase（MMP）-2,-9,and-13,membrane type（MT）1-MMP),estrogen receptor（ER）,and progesterone receptor（PR） in the main tumor and hyperostotic portions of the studied ***:In the non-hyperostosis group,expression of MMP-13,MT1-MMP,and ER was significantly less than in the main tumor portion of the hyperostotic meningiomas,while there was no difference in the expression of MMP-2 and-9 and PR in the main tumor between the non-hyperostosis and hyperostosis *** the hyperostosis group,the immunoreactivity of MMP-2 in the hyperostotic portion revealed a higher pattern of expression than the main tumor（p＜0.002）.The expression of MMP-9,MT1-MMP,ER,and PR had relatively positive immunoreactivity in the main tumor portion（P＜0.05）.Conclusions:High expression of MMP-13 and MT1-MMP in the tumor portion of hyperostosis of meningiomas might contribute to the initiation of *** MMP-2 in hyperostotic lesions may change the physiologic circumstance of skull bone,thus playing an important role in the formation of hyperostosis.

关键词： Meningioma Hyperostosis Immunohistochemisty(IHC) Matrix metalloproteinase(MMP)-2 MMP-9 MMP-13 membrane type(MT)1-MMP) estrogen receptor(ER) and progesterone receptor(PR)

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Immunohistochemical profiles of dural tail in intracranial meningiomas

Immunohistochemical profiles of dural tail in intracranial m...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

OBJECT:The dural tail was first described as a thin,tapering rim of dural enhancement,in continuity with meningiomas on enhanced T1-weighted magnetic resonance（MR） *** the exact nature of the tail pathology is still *** we would like to investigate the immunohistochemical characteristics of dural tail in intracranial *** and METHODS:Twenty-two patients with meningioma undergoing MRI imaging showed dural *** immunohistochemical（IHC） staining,expression of EMA,Vimentin,Ki-67,CD34 and vascular endothelial growth factor（VEGF） were evaluated between tumor mass and dural tail of meningioma.H＆E and Masson’s Trichrome staining were also ***:Sixteen of 22 cases（72.7%） show dural tail involved by tumor *** staining showed Vimentin and EMA intensively expressed in tumour mass,ki-67 expression nearly negative in both tumour mass and dural tail,CD34 overexpressed in duarl tail,VEGF overexpressed in tumour cells which invade to dural ***’s Trichrome staining clearly showed components of tumor,tail and dural ***:Our study showed most of dural tail involved by tumor cells（72.7%）,different immunohistochemical staining of CD34,and VEGF profiles obtained between tumour mass and dural tail.

关键词： Dural tail sign Meningioma Immunohistochemisty(IHC) CD34 Vascular endothelial growth factor(VEGF) Ki-67 EMA Vimentin

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PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha Lee Kyoungho suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

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Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： Jae-Hong Kim Ruqayya Afridi Il-Sung Jang Maan Gee Lee Kyoungho suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

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Study on wear behavior of plasma electrolytic oxidation coatings on aluminum alloy

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Rare Metals 2006年第Z2期25卷 141-145页

作者： kang suk-Bong LEE Jung-Moo Department of Materials Engineering Korean Institute of Machinery & Materials Gyeongnam 641831 Korea

Thick and hard ceramic coatings were fabricated on A356 aluminum alloy by using plasma electrolytic oxidation(PEO) technique. The microstructure and phase composition of the PEO coatings were examined by using SEM and XRD method. It is found that the PEO coatings are mainly composed of crystalline α-Al2O3 and mullite. The dry sliding wear test of PEO coatings were carried out on a ring-on-ring wear machine. Results shows that there is hardly no wear loss of polished PEO coatings while the wear rate of uncoated aluminum alloy is 4.3×10-5 mm3·(N·m)-1 at a speed of 0.52 m·s-1 and a load of 40 N.

关键词： aluminum alloy plasma electrolytic oxidation ceramic coating wear

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Microstructure comparison of ZK60 alloy under casting,twin roll casting and hot compression

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Transactions of Nonferrous Metals Society of China 2010年第5期20卷 763-768页

作者：王守仁王敏 kang suk-bong CHO Jae-hyung School of Mechanical Engineering University of Ji'nan School of Materials Science and Engineering Shandong University Korea Institute of Materials Science 66 Sangnam-dongChangwon 641010Korea

The microstructures of ZK60 alloy under conventional direct as-casting (DC),twin roll casting (TRC) and twin roll casting followed by hot compression (TRC-HC) were analyzed by optical morphology (OM),electron backscatter diffraction (EBSD) and X-ray diffraction (XRD).The deformation condition of hot compression is 350 ℃,0.1 s?*** microstructural evolution under TRC-HC deformation followed by annealing at different temperatures and time was *** results show that TRC provides more modified microstructure compared with *** are found in TRC processing;dynamic recrystallization (DRX),shear bands and twins are found in TRC-HC.A short annealing time has little effect on hardness,while during a long time annealing,it is found that low annealing temperatures increase the micro-hardness and high temperature decreases it.

关键词： microstructural evolution anneal dynamic recrystallization static recrystallization twin-roll casting hot compression magnesium alloy ZK60

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Addition of cerium and yttrium to ferritic steel weld metal to improve hydrogen trapping efficiency

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International Journal of Minerals,Metallurgy and Materials 2017年第4期24卷 415-422页

作者： Sung Jin Kim kang Mook Ryu Min-suk Oh Department of Advanced Materials Engineering Sunchon National University Jungang-ro Suncheon 540-742 Republic of Korea POSCO Steel Solution Marketing Division Geidong-Dong Pohang 790-704 Republic of Korea Automotive Components & Materials R&D Group Korea Institute of Industrial Technology 6 Cheomdan-gwagiro 208 beon-gil Gwangju 61012 Republic of Korea

The applicability of Ce and Y as promising candidate elements to form irreversible traps in weld metal was investigated by thermal desorption spectroscopy(TDS) with gas chromatography(GC). The precise nature of the precipitate particles newly formed in the weld metal by the addition of Ce and Y to a certain alloy system was characterized. Moreover,the hydrogen trapping efficiency expressed as the reduction of the diffusible hydrogen in the weld metal was analyzed. The results showed that the addition of Ce and/or Y to this alloy system led to the formation of a mixed type of(Ce,Ti)-based oxide,(Y,Ni)-based carbide,or(Ce,Y,Ti)-based oxide particles. Because of the high activation energy of the mixed type of particles(≥ 150 k J/mol),the trapping efficiency for hydrogen was considered to be sufficiently high to effectively reduce the diffusible hydrogen content.

关键词： hydrogen trapping weld rare earth metals cerium yttrium activation energy

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In-situ electrochemical functionalization of carbon materials for high-performance Li–O2 batteries

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Journal of Energy Chemistry 2020年第9期29卷 7-13,I0001页

作者： Jungwon kang Jin Min Kim Do Youb Kim Jungdon suk Jaekook Kim Dong Wook Kim Yongku kang Department of Advanced Materials Science and Engineering Mokpo National University61 dorim-ri1666 Yeongsan-roCheonggye-myeonMuan-gunJeonnamSouth Korea Center for Advanced Battery Materials Advanced Materials DivisionKorea Research Institute of Chemical Technology(KRICT)141 Gajeong-RoYuseong-GuDaejeon 305-600South Korea Department of Materials Science and Engineering Chonnam National University300 Yongbong-dongBukguGwangju 500-757South Korea

The development of effective synthetic routes is important to manifest proper nature of specific ***-situ electrochemical functionalization possesses great advantages over conventional routes,especially facile way and leading to reaching elaborate sites of functional ***,we demonstrate the preparation of functionalized carbons by in-situ electrochemical reduction in an argon atmosphere for application in low-cost,environmentally benign,and high-performance oxygen-electrodes for non-aqueous Li-O2 batteries.A Li-O2 battery with functionalized carbon shows a high discharge capacity(100 times that of pristine carbon),high power and cycling *** outstanding performance is attributed to the high O2 affinity of the functionalized carbon surface that facilitates the formation of soluble and diffusible superoxide intermediates by the reduction of the remaining O2 competing with surface growth for Li2O2 formation.

关键词： Lithium-oxygen battery High areal capacity Functionalization of carbon Electrochemistry

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Reliable high temperature, high humidity flexible thin film encapsulation using Al2O3/MgO nanolaminates for flexible OLEDs

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Nano Research 2020年第10期13卷 2716-2725页

作者： Ki suk kang So Yeong Jeong Eun Gyo Jeong Kyung Cheol Choi School of Eetrical Enginerng Korea Advanced lstute of Sciencp and Tchcnoloy(KAIST) 291 Daehak roYuscong guDaejeon 34141Republic of Korea Department of Clothing and Textiles Chormam National University77 Yongbong.roBuk guGwangjiu 61186Republic of Korea

Since most organic materials are very sensitive to moisture and oxygen, organic light emitting diodes (OLEDs) require an encapsulation layer to protect the active layer from these gases. Since light, flexible and portable OLEDs are being employed in more diverse climates and environmental conditions, the OLED encapsulation layer must retain robust mechanical properties and stability in high temperature/high humidity conditions. Al2O3 films have demonstrated excellent barrier performance, but they readily hydrolyze when exposed to prolonged harsh environments. In this study, we fabricated a thin film encapsulation (TFE) film that was resistant to hydrolysis, using Al2O3/MgO (AM) nanolaminates. MgO has superior resistance to harsh environments, and the aluminate phase generated by the chemical reaction of Al2O3 and MgO provided excellent barrier performance, even after storage in harsh conditions. A multi-barrier fabricated using the AM nanolaminate showed excellent barrier performance, close to the level required by OLEDs. It did not significantly deteriorate even after a bending test of 1,000 iterations at 0.63% strain. After 1,000 cycle of bending, the electrical properties of the passivated OLEDs were not significantly degraded at shelf-lifetime test where the fabricated device was stored for 50 days in a harsh environment of 60℃, 90% relative humidity. The multi-barrier shows the best performance compared to previous studies on flexible encapsulation that can be used in harsh environments.

关键词： thin film encapsulation nanolaminate structure Al2O3 MgO flexible organic light emitting diode(OLED)

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Effects of casting speed on microstructure and segregation of electromagnetically stirred Aluminum alloy in continuous casting process

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Rare Metals 2006年第Z2期25卷 118-123页

作者： LEE Dock-Young kang suk-Won CHO Duck-Ho KIM Ki-Bae Division of Materials Korea Institute of Science and Technology P.O. Box 131 Cheongryang Seoul 130-650 Korea Department of Applied Materials Engineering Hanbat National University Daejeon 305-719 Korea

Recently, a semi-solid metal processing has been acknowledged as a cost-effective technique to be able to manufacture high quality product for the transportation industry. In this study a hypo-eutectic Al alloy was fabricated by means of an electromagnetic stirrer in continuous casting process and the microstructural change during solidification due to a fluid flow by electromagnetic stirring was examined. Due to the forced fluid flow during solidification a dendritic phase of primary α phase of Al alloy was turned into a globular phase, which can make the Al alloy get a thixotropic behavior in the semi-solid region. In order to establish the quantitative relationship between microstructure and the process parameters, the morphology shape, a silicon distribution and a size of primary α phase were observed according to casting speed in continuous casting machine. The primary α phase was turned into the degenerate dendrites approaching a spherical configuration with increasing casting speed. The fine-grained and equiaxed microstructure appeared at higher casting speed. A segregation behavior of Si element was declined with increasing casting speed and a very uniform distribution of Si element was observed on the billet at a casting speed of 600 mm·min-1. A thickness of the solidifying shell of the billet was shortened with increasing the casting speed.

关键词： semi-solid slurry electromagnetic stirring casting speed segregation Al alloy

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