Possible Role of MMPs in Hyperostosis of Intracranial Meningiomas
作者单位：Brain Tumor Research LaboratoryDepartment of NeurosurgeryBrain Tumor ＆ Gamma Knife CenterChonnam National University Hwasun Hospital ＆ Medical School
会议名称：《中国抗癌协会神经肿瘤专业委员会第八届学术会议》
会议日期：2011年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：Meningioma Hyperostosis Immunohistochemisty(IHC) Matrix metalloproteinase(MMP)-2 MMP-9 MMP-13 membrane type(MT)1-MMP) estrogen receptor(ER) and progesterone receptor(PR)
摘 要：Object:Although bone invasion and hyperostosis are common phenomena in patients with intracranial meningiomas,the basic pathomechanism is not fully *** on an immunohistochemical study of surgically-resected samples with hyperostosis,we postulate a possible mechanism of hyperostosis in patients with intracranial *** and Methods:Forty-six meningiomas were evaluated in this ***-six meningiomas associated with hyperostosis specimens served as the study group and 20 meningiomas without any bony changes served as controls.A histologic examination showed benign meningiomas in 42 samples and atypical meningiomas in 4 *** immunohistochemical staining technique was used to detect the expression of matrix metalloproteinase（MMP）-2,-9,and-13,membrane type（MT）1-MMP),estrogen receptor（ER）,and progesterone receptor（PR） in the main tumor and hyperostotic portions of the studied ***:In the non-hyperostosis group,expression of MMP-13,MT1-MMP,and ER was significantly less than in the main tumor portion of the hyperostotic meningiomas,while there was no difference in the expression of MMP-2 and-9 and PR in the main tumor between the non-hyperostosis and hyperostosis *** the hyperostosis group,the immunoreactivity of MMP-2 in the hyperostotic portion revealed a higher pattern of expression than the main tumor（p0.002）.The expression of MMP-9,MT1-MMP,ER,and PR had relatively positive immunoreactivity in the main tumor portion（P0.05）.Conclusions:High expression of MMP-13 and MT1-MMP in the tumor portion of hyperostosis of meningiomas might contribute to the initiation of *** MMP-2 in hyperostotic lesions may change the physiologic circumstance of skull bone,thus playing an important role in the formation of hyperostosis.