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Alkaline activation of endogenous latent TGFβ1 by an injectable hydrogel directs cell homing for in situ complex tissue regeneration

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Bioactive Materials 2022年第9期7卷 316-329页

作者： Sainan Wang Yuting Niu Peipei Jia Zheting Liao Weimin Guo Rodrigo Cotrim Chaves Khanh-Hoa Tran-Ba Ling He Hanying Bai sam sia Laura J.Kaufman Xiaoyan Wang Yongsheng Zhou Yanmei Dong Jeremy J.Mao Department of Cariology and Endodontology Peking University School and Hospital of StomatologyBeijing100081China Department of Prosthodontics Peking University School and Hospital of StomatologyBeijing100081China Center for Craniofacial Regeneration Columbia UniversityNew YorkNY10032USA Department of Biomedical Engineering Columbia UniversityNew YorkNY10027USA Department of Chemistry Columbia UniversityNew YorkNY10027USA

Utilization of the body’s regenerative potential for tissue repair is known as in situ tissue ***,the use of exogenous growth factors requires delicate control of the dose and delivery strategies and may be accompanied by safety,efficacy and cost *** this study,we developed,for the first time,a biomaterial-based strategy to activate endogenous transforming growth factor beta 1(TGFβ1)under alkaline conditions for effective in situ tissue *** demonstrated that alkaline-activated TGFβ1 from blood serum,bone marrow fluids and soaking solutions of meniscus and tooth dentin was capable of increasing cell recruitment and early differentiation,implying its broad ***,we engineered an injectable hydrogel(MS-Gel)consisting of gelatin microspheres for loading strong alkaline substances and a modified gelatin matrix for hydrogel click *** vitro models showed that alkaline MS-Gel controllably and sustainably activated endogenous TGFβ1 from tooth dentin for robust bone marrow stem cell *** importantly,infusion of in vivo porcine prepared root canals with alkaline MS-Gel promoted significant pulp-dentin regeneration with neurovascular stroma and mineralized tissue by endogenous proliferative ***,this work offers a new bench-to-beside translation strategy using biomaterial-activated endogenous biomolecules to achieve in situ tissue regeneration without the need for cell or protein delivery.

关键词： Endogenous TGFβ1 Injectable alkaline hydrogel Cell homing Pulp-dentin complex In situ tissue regeneration

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Use of Essential Oils of the Genus Citrus as Biocidal Agents

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American Journal of Plant Sciences 2014年第3期5卷 299-305页

作者： Marcos S.Gomes Maria das G.Cardoso Maurilio JSoares Luís R.Batista samísia M.F.Machado Milene A.Andrade Camila M.O.de Azeredo Juliana Maria Valério Resende Leonardo M.A.Rodrigues Department of Chemistry Federal University of LavrasLavrasBrazil Laboratory of Cell Biology Instituto Carlos Chagas/FiocruzCuritibaBrasil Department of Food Science Federal University of LavrasLavrasBrazil Department of Chemistry Federal University of SergipeSao CristóvãoBrazil

In this study, the essential oils extracted from the peels of Citrus aurantifolia, Citrus limon and Citrus sinensis were chemically characterized and quantified. These essential oils and their standards limonene, citral and limonene + citral were evaluated (at concentrations ranging from 500 to 3.91 mL·mL-1) regarding their anti-trypanosome, antifungal and antibacterial activities. The chemical identification and quantification (by GC/FID and GC/MS) displayed the limonene as the major component of the three essential oils. It did not verified anti-trypanosome activity for all treatments. Regarding antimicrobial activity, the results were satisfactory against Gram-negative bacteria (Staphylococcus aureus, Listeria. monocytogenes and Salmonella cholerasuis) and funghi (Aspergillus niger, A. flavus and A. carbonarius), except for the bacterium Pseudomonas aeruginosa, which showed no inhibition for any treatment used.

关键词： Volatile Essential Oil Trypanosoma cruzi Gram-Negative Bactéria Funghi Antimicrobial

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Refraction characteristics of phononic crystals

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Acta Mechanica Sinica 2015年第4期31卷 481-493页

作者： sia Nemat-Nasser Department of Mechanical and Aerospace Engineering University of California

Some of the most interesting refraction prop- erties of phononic crystals are revealed by examining the anti-plane shear waves in doubly periodic elastic composites with unit cells containing rectangular and/or elliptical multi- inclusions. The corresponding band structure, group velocity, and energy-flux vector are calculated using a powerful mixed variational method that accurately and efficiently yields all the field quantities over multiple frequency pass-bands. The background matrix and the inclusions can be anisotropic, each having distinct elastic moduli and mass densities. Equifrequency contours and energy-flux vectors are read- ily calculated as functions of the wave-vector components. By superimposing the energy-flux vectors on equifrequency contours in the plane of the wave-vector components, and supplementing this with a three-dimensional graph of the corresponding frequency surface, a wealth of information is extracted essentially at a glance. This way it is shown that a composite with even a simple square unit cell con- taining a central circular inclusion can display negative or positive energy and phase velocity refractions, or simply performs a harmonic vibration （standing wave）, depending on the frequency and the wave-vector. Moreover, that the same composite when interfaced with a suitable homoge- neous solid can display：（1） negative refraction with negative phase velocity refraction; （2） negative refraction with pos- itive phase velocity refraction; （3） positive refraction with negative phase velocity refraction; （4） positive refraction with positive phase velocity refraction; or even （5） completereflection with no energy transmission, depending on the fre- quency, and direction and the wavelength of the plane-wave that is incident from the homogeneous solid to the interface. For elliptical and rectangular inclusion geometries, analyti- cal expressions are given for the key calculation quantities. Expressions for displacement, velocity, linear m

关键词： Doubly periodic composites - Phononiccrystals Band structure Group and energy-flux vectors

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A Survey of VASNET Framework to Provide Infrastructure-Less Green IoTs Communications for Data Dissemination in Search and Rescue Operations

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Journal of Electronic Science and Technology 2016年第3期14卷 220-228页

作者： Mohamad Nazim Jambli Adnan Shahid Khan sia Chiu Shoon the Faculty of Computer Science and Information Technology Universiti Malaysia Sarawak94300 Kota SamarahanMalaysia

implementation of wireless technologies based on the vehicular ad hoc sensor network （VASNET） may provide support for the search and rescue （SAR） team to operate effectively in natural disaster events, such as landslide, earthquake, flooding, and tsunami. The operations of SAR team are very challenging in such events due to the possible damages of the existing telecommunication infrastructures. The existing deployment of the cellular communications infrastructure may be partially or completely destroyed after the occurrence of these natural disasters. Thus, the current VASNET infrastructure must be able to support the infrastructure-less network by integrating other green wireless technologies that can benefit the SAR team, which can indirectly save more human lives and reduce the number of casualties. Therefore, the integration of green Internet of things （loT） and VASNET is proposed to form a heterogeneous framework for data dissemination in SAR operations. In addition, this paper also discusses the existing lot framework in disaster scenarios with future research direction for IoT using on any aspect, especially related to the natural disaster scenarios.

关键词： Framework green Internet of things (loT) SAR operations vehicular ad hoc sensor network (VASNET).

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Discover and Unfold the Mystery of Chinese Medicine

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Chinese Medicine and Culture 2019年第2期2卷 93-94页

作者： Sng Kim sia Lin Xun Department of Postgraduate Program International Education CollegeShanghai University of Traditional Chinese MedicineShanghaiChina

This article shares my experience and journey in Chinese Medicine where I started back in 2014 in Malaysia for my bachelor's degree,and subsequently led me in continuing my postgraduate studies in Shanghai University ... 详细信息

关键词： China Chinese medicine experience sharing journey Malaysia

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Overview of milling techniques for improving the solubility of poorly water-soluble drugs

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Asian Journal of Pharmaceutical Sciences 2015年第4期10卷 255-274页

作者： Zhi Hui Loh Asim Kumar samanta Paul Wan sia Heng GEANUS Pharmaceutical Processing Research Laboratory Department of PharmacyNational University of Singapore18 Science Drive 4Singapore 117543Singapore Janssen India Department of PDMS-SMMD-ADJohnson&Johnson Ltd.Higi HouseOpp Ralli WolfLBS MargMulund(W)Mumbai 400080India

Milling involves the application of mechanical energy to physically break down coarse particles to finer ones and is regarded as a“topedown”approach in the production of fine *** drug particulates are especially desired in formulations designed for parenteral,respiratory and transdermal *** drugs after crystallization may have to be comminuted and this physical transformation is required to various extents,often to enhance processability or solubility especially for drugs with limited aqueous *** mechanisms by which milling enhances drug dissolution and solubility include alterations in the size,specific surface area and shape of the drug particles as well as millinginduced amorphization and/or structural disordering of the drug crystal(mechanochemical activation).Technology advancements in milling now enable the production of drug micro-and nano-particles on a commercial scale with relative *** review will provide a background on milling followed by the introduction of common milling techniques employed for the micronization and nanonization of *** information contained in the cited examples are further extracted and summarized for ease of reference by researchers keen on employing these techniques for drug solubility and bioavailability enhancement.

关键词： Drug solubility Fluid energy milling Ball milling Media milling High pressure homogenization Cryomilling

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The COVID-19 Pandemic:Global Asymmetries and Challenges for the Future of Health

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China CDC weekly 2021年第7期3卷 140-141页

作者： Nísia Trindade Lima Carlos Grabois Gadelha Oswaldo Cruz Foundation-Fiocruz

The coronavirus disease 2019(COVID-19)pandemic reveals economic,social,and environmental trends that have been present since the last two decades,and it is characterized as a new phenomenon that qualitatively alters contemporary global and national dilemmas—not only because it was caused by a hitherto unknown virus,but by the magnitude of the crisis and the transformations that shape the *** marks a disruptive and threatening historical period in the face of the foundations of modern sociability built during the post-war period.

关键词： COV demic contemporary

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Prevalence of intestinal parasites in selected vegetables at major public markets in Metro Manila,Philippines

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Asian Pacific Journal of Tropical Medicine 2009年第6期2卷 37-39页

作者： Malison Marilyn T sia Su Glenn L Pamantasan ng Lungsod ng Maynila ManilaPhilippines School of Environmental Science and Management University of the Philippines Los BanosLagunaPhilippines

Objective:This study aims to determine the prevalence of intestinal parasites infesting the vegetable foodstuffs and determine the parasitological profile of the vegetable foodstuffs ***:About 200 randomly sampled vegetable foodstuffs obtained from the vendors of the Balintawak and Divisoria public markets were examined for the occurrence of intestinal ***:A total of 119(59.5%) vegetable foodstuffs examined were tested *** most common parasite found was the Ascaris *** significant differences between the prevalence of intestinal parasites at the two public markets were found(P > 0.05).Conclusion: The vegetables can be a potential source of parasitic infection.

关键词： Parasite Vegetable Foodstuff Intestinal parasite Public market

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Development of Cloud Movement Prediction Method for Solar Photovoltaic System

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Journal of Harbin Institute of Technology(New Series) 2022年第1期29卷 64-69页

作者： Fei Lu siaw Yaw Yoong sia Mallikarachchi Dilshani Center for Advanced Electrical and Electronic Systems(CAEES) Faculty of EngineeringBuilt Environment and Information TechnologySEGi UniversityKota DamansaraPetaling Jaya 47810Malaysia

Variability of power generation due to the prevalence of cloud cover over solar photovoltaics(PV)power plants is a challenge faced by grid operators and independent system operators(ISOs)in the integration of solar energy into the *** forecasts generated through ground⁃based sky imaging systems are useful for short⁃term cloud motion ***,the cost of sky imaging systems currently available in industries is relatively ***,a ground⁃based camera system utilizing a simple webcam is proposed in this *** proposed method can produce predictions with high levels of *** were generated through video analysis using MATLAB for the computation of cloud motion *** image processing involved in the implementation of the proposed system is based on the detection of cloud regions in the form of a cluster of white pixels within individual frames and tracking their motion through comparison of subsequent *** study describes the techniques and processes used in the development of the proposed method,along with the evaluation of performance through analysis of the *** predictions were carried out over multiple time *** time horizons selected include 5,10,15,20,25,and 30 *** overall results computed showed promising accuracy levels above 94.60%,which makes it adequate for generating reliable forecasts.

关键词： forecast solar photovoltaic cloud cover MATLAB

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Hemodynamic analysis of intracranial aneurysms using phase-contrast magnetic resonance imaging and computational fluid dynamics

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Acta Mechanica Sinica 2017年第2期33卷 472-483页

作者： Xuemei Zhao Rui Li Yu Chen Sheau Fung sia Donghai Li Yu Zhang Aihua Liu Beijing Huaxin Hospital (First Affiliated Hospital of Tsinghua University) Beijing 100016 China Center for Biomedical Imaging Research Department of Biomedical Engineering Tsinghua University School of Medicine Beijing 100084 China Division of Neurosurgery Faculty of Medicine University of Malaya 50603 Kuala Lumpur Malaysia Medical Center Tsinghua University Beijing 100084 China Beijing Neurosurgical Institute Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Additional hemodynamic parameters are highly desirable in the clinical management of intracranial aneurysm rupture as static medical images cannot demonstrate the blood flow within aneurysms. There are two ways of obtaining the hemodynamic information-by phase-contrast magnetic resonance imaging (PCMRI) and computational fluid dynamics (CFD). In this paper, we compared PCMRI and CFD in the analysis of a stable patient's specific aneurysm. The results showed that PCMRI and CFD are in good agreement with each other. An additional CFD study of two stable and two ruptured aneurysms revealed that ruptured aneurysms have a higher statistical average blood velocity, wall shear stress, and oscillatory shear index (OSI) within the aneurysm sac compared to those of stable aneurysms. Furthermore, for ruptured aneurysms, the OSI divides the positive and negative wall shear stress divergence at the aneurysm sac.

关键词： PCMRI CFD WSSD OSI Aneurysm rupture

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