Overview of milling techniques for improving the solubility of poorly water-soluble drugs

作     者：Zhi Hui Loh Asim Kumar Samanta Paul Wan Sia Heng 

作者机构：GEANUS Pharmaceutical Processing Research LaboratoryDepartment of PharmacyNational University of Singapore18 Science Drive 4Singapore 117543Singapore Janssen IndiaDepartment of PDMS-SMMD-ADJohnson&Johnson Ltd.Higi HouseOpp Ralli WolfLBS MargMulund(W)Mumbai 400080India 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2015年第10卷第4期

页      面：255-274页

核心收录：

学科分类：0202[经济学-应用经济学] 02[经济学] 020205[经济学-产业经济学] 

主　　题：Drug solubility Fluid energy milling Ball milling Media milling High pressure homogenization Cryomilling 

摘      要：Milling involves the application of mechanical energy to physically break down coarse particles to finer ones and is regarded as a“topedownapproach in the production of fine *** drug particulates are especially desired in formulations designed for parenteral,respiratory and transdermal *** drugs after crystallization may have to be comminuted and this physical transformation is required to various extents,often to enhance processability or solubility especially for drugs with limited aqueous *** mechanisms by which milling enhances drug dissolution and solubility include alterations in the size,specific surface area and shape of the drug particles as well as millinginduced amorphization and/or structural disordering of the drug crystal(mechanochemical activation).Technology advancements in milling now enable the production of drug micro-and nano-particles on a commercial scale with relative *** review will provide a background on milling followed by the introduction of common milling techniques employed for the micronization and nanonization of *** information contained in the cited examples are further extracted and summarized for ease of reference by researchers keen on employing these techniques for drug solubility and bioavailability enhancement.