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超声引导下射频消融术治疗原发性肝癌的疗效及对患者免疫功能与预后的影响

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疑难病杂志 2019年第6期18卷 577-581页

作者：帕哈尔丁·白克热阿不拉江·阿不都克力木王海林黄伍奎依马木买买提江·阿布拉新疆医科大学第三临床医学院(附属肿瘤医院)介入诊疗科乌鲁木齐830011 新疆医科大学第三临床医学院(附属肿瘤医院)肝胆胰外科

目的探讨超声引导下射频消融术治疗原发性肝癌的疗效及对患者免疫功能与预后的影响,为其临床治疗提供参考。方法选择2015年6月—2017年12月新疆医科大学第三临床医学院收治的原发性肝癌患者90例作为研究对象,按照治疗方式不同分为对照... 详细信息

目的探讨超声引导下射频消融术治疗原发性肝癌的疗效及对患者免疫功能与预后的影响,为其临床治疗提供参考。方法选择2015年6月—2017年12月新疆医科大学第三临床医学院收治的原发性肝癌患者90例作为研究对象,按照治疗方式不同分为对照组和观察组,各45例。其中对照组给予经肝动脉栓塞化疗术治疗,观察组给予超声引导下射频消融术治疗。比较2组患者治疗的临床疗效、治疗前后的肝功能和免疫功能相关指标变化,以及随访1年的远期生存情况。结果观察组患者的治疗总有效率明显高于对照组(86.67%vs.62.22%,χ~2=7.067,P<0.01)。与治疗前相比,2组患者治疗后的血清TBil、DBil、ALT、AST、CD8^+、AFP水平均明显降低(P均<0.01),且观察组降低幅度大于对照组(t/P=6.031/0.000,7.436/0.000,6.855/0.000,5.238/<0.001,11.123/0.000,54.743/0.000);CD3^+、CD4^+、CD4^+/CD8^+及IgA、IgG、IgM水平均明显升高(P均<0.01),且观察组升高幅度大于对照组(t/P=5.640/0.000,2.771/0.000,2.756/0.007,6.989/0.000,9.116/0.000,8.418/0.000)。随访1年,观察组患者的无进展生存时间为(12.49±5.23)月,明显高于对照组的(8.46±4.52)月(P<0.05)。结论超声引导下射频消融术治疗原发性肝癌,可增强机体免疫力,减少肝功能损伤,提高肿瘤局部控制率以及无进展生存时间,具有一定的临床应用价值。

关键词：超声引导下射频消融术肝癌,原发性免疫功能肝功能预后

Plant Biosystems Design Research Roadmap 1.0

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BioDesign Research 2020年第1期2020卷 53-90页

作者： Xiaohan Yang June I.Medford Kasey Markel Patrick M.Shih Henrique C.De Paoli Cong T.Trinh Alistair J.McCormick Raphael Ployet Steven G.Hussey Alexander A.Myburg Poul Erik Jensen Md Mahmudul Hassan Jin Zhang Wellington Muchero Udaya C.Kalluri Hengfu Yin Renying Zhuo Paul E.abraham Jin-Gui Chen David J.Weston Yinong Yang Degao Liu Yi Li Jessy Labbe Bing Yang Jun Hyung Lee Robert W.Cottingham Stanton Martin Mengzhu Lu Timothy J.Tschaplinski Guoliang Yuan Haiwei Lu Priya Ranjan Julie C.Mitchell Stan D.Wullschleger Gerald A.Tuskan Biosciences Division Oak Ridge National LaboratoryOak RidgeTN 37831USA The Center for Bioenergy Innovation Oak Ridge National LaboratoryOak RidgeTN 37831USA Department of Biology Colorado State UniversityFort CollinsCO 80523USA Department of Plant Biology University of CaliforniaDavisDavisCAUSA Feedstocks Division Joint BioEnergy InstituteEmeryvilleCAUSA Department of Biodesign Biological Systems and Engineering DivisionLawrence Berkeley National LaboratoryBerkeleyCAUSA Department of Chemical and Biomolecular Engineering University of TennesseeKnoxvilleTN 37996USA SynthSys and Institute of Molecular Plant Sciences School of Biological SciencesUniversity of EdinburghEdinburgh EH93BFUK Department of Biochemistry Genetics and MicrobiologyForestry and Agricultural Biotechnology Institute(FABI)University of PretoriaPretoria 0002South Africa Department of Food Science University of CopenhagenRolighedsvej 26DK-1858FrederiksbergCopenhagenDenmark State Key Laboratory of Subtropical Silviculture School of Forestry and BiotechnologyZhejiang A&F UniversityHangzhouZhejiang 311300China State Key Laboratory of Tree Genetics and Breeding Research Institute of Subtropical ForestryChinese Academy of ForestryHangzhouZhejiang 311400China Department of Plant Pathology and Environmental Microbiology and the Huck Institute of the Life Sciences The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Genetics Cell Biology and DevelopmentCenter for Precision Plant Genomics and Center for Genome EngineeringUniversity of MinnesotaSaint PaulMN 55108USA Department of Plant Science and Landscape Architecture University of ConnecticutStorrsCT 06269USA Division of Plant Sciences Bond Life Sciences CenterUniversity of MissouriColumbiaMOUSA Donald Danforth Plant Science Center St.LouisMOUSA Environmental Sciences Division Oak Ridge National LaboratoryOak RidgeTN 37831USA

Human life intimately depends on plants for food,biomaterials,health,energy,and a sustainable *** plants have been genetically improved mostly through breeding,along with limited modification via genetic engineering,yet they are still not able to meet the ever-increasing needs,in terms of both quantity and quality,resulting from the rapid increase in world population and expected standards of living.A step change that may address these challenges would be to expand the potential of plants using biosystems design *** represents a shift in plant science research from relatively simple trial-and-error approaches to innovative strategies based on predictive models of biological *** biosystems design seeks to accelerate plant genetic improvement using genome editing and genetic circuit engineering or create novel plant systems through de novo synthesis of plant *** this perspective,we present a comprehensive roadmap of plant biosystems design covering theories,principles,and technical methods,along with potential applications in basic and applied plant biology *** highlight current challenges,future opportunities,and research priorities,along with a framework for international collaboration,towards rapid advancement of this emerging interdisciplinary area of ***,we discuss the importance of social responsibility in utilizing plant biosystems design and suggest strategies for improving public perception,trust,and acceptance.

关键词： Plant utilizing breeding

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專利侵權救濟規則完善研究

中国专利与商标 2018年第4期 77-91页

作者：張廣良陶鈞彭文毅陳勇李森中國人民大學法學院北京市高級人民法院知識産權庭北京知識産權法院北京市萬慧達律師事務所

无救济便无权利。对于作为无形财产权的专利权，充分而有效的救济尤为重要。在侵犯专利权救济方面，中国已取得了长足的进步。然而，不可否认的是侵权救济的某些规则仍有待于完善。本文结合中国现行法律规定和司法实践，梳理侵犯专利权... 详细信息

无救济便无权利。对于作为无形财产权的专利权，充分而有效的救济尤为重要。在侵犯专利权救济方面，中国已取得了长足的进步。然而，不可否认的是侵权救济的某些规则仍有待于完善。本文结合中国现行法律规定和司法实践，梳理侵犯专利权永久性禁令，的适用以及损害赔偿确定中存在的问题.

关键词：专利侵权救济专利权法律规定损害赔偿财产权永久性中国

临床试验数据共享声明国际医学期刊编辑委员会统一要求

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英国医学杂志中文版 2017年第7期20卷 365-366页

作者： Darren B Taichman Peush Sahni Larry Peiperl Christine Laine Astrid James Sung-Tae Hong abraham Haileamlak Laragh Gollogly Fiona Godlee Frank A Frizelle Fernando Florenzano Jeffrey M Drazen Howard Bauchner Christopher Baethge Deutsches Arzteblatt Joyce Backus 季媛媛不详中华医学杂志英文版编辑部

国际医学期刊编辑委员会（ICMJE）认为，由于临床试验参与者处于研究风险之中，我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月，ICMJE发表了1项关于临床试验数据共享的提案，旨在帮助创造共享去标识个体患者数... 详细信息

国际医学期刊编辑委员会（ICMJE）认为，由于临床试验参与者处于研究风险之中，我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月，ICMJE发表了1项关于临床试验数据共享的提案，旨在帮助创造共享去标识个体患者数据的常态化环境。迄今，应我们的反馈要求，ICMJE收到了很多来自个人和团体的意见。

关键词：临床试验数据数据共享期刊编辑工作

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临床试验数据共享声明

中国医院院长 2017年第16期13卷 27-28页

作者： Darren B Taichman Peush Sahni Anja Pinborg Larry Peiperl Christine Laine Astrid James Sung-Tae Hong abraham Haileamlak Laragh Gollogly Fiona Godlee Frank A Frizelle Fernando Florenzano Jeffrey M Drazen Howard Bauchner Christopher Baethge Joyce Backus 季媛媛

国际医学期刊编辑委员会（ICMJE）认为，由于临床试验参与者处于研究风险之中，我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月，ICMJE发表了一项关于临床试验数据共享的提案，旨在帮助创造共享去标识个体患者... 详细信息

国际医学期刊编辑委员会（ICMJE）认为，由于临床试验参与者处于研究风险之中，我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月，ICMJE发表了一项关于临床试验数据共享的提案，旨在帮助创造共享去标识个体患者数据的常态化环境。

关键词：数据共享临床试验国际医学期刊编辑委员会原始数据干预性

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阿梅格尔巴克/哥本山

城市环境设计 2019年第2期 172-183页

作者： Nanna Gyldholm M?ller Alberto Cumerlato Aleksander Wadas Alexander Codda Alexander Ejsing Alexandra Gustafsson Alina Tamosiunaite Armor Gutierrez Anders Hjortn?s Andreas Klok Pedersen Annette Jensen Ariel Wallner Ask Andersen Balaj IIulian Blake Smith Borko Nikolic Brygida Zawadzka Buster Christensen Chris Falla Chris Zhongtian Yuan Daniel Selensky Dennis Rasmussen Espen Vik Finn N?rkj?r Franck Fdida Gonzalo Castro Gül Ertekin George abraham Helen Chen Henrick Poulsen Henrik R?mer Kania Horia Spirescu Jakob Ohm Laursen Jelena Vucic Jeppe Ecklon Ji-young Yoon Jing Xu Joanna Jakubowska Johanna Nenander Kamilla Heskje Katarzyna Siedlecka Krzysztof Marciszewski Laura W?tte Liang Wang Lise Jessen Long Zuo Maciej Zawadzki Mads Enggaard Stidsen Marcelina Kolasinska Marcos Bano Maren Allen Mathias Bank Matti N?rgaard Michael Andersen Narisara Ladawal Schr?der Niklas A. Rasch Nynne Madsen ?ssur Nols? Pero Vukovic Richard Howis Ryohei Koike Se Hyeon Kim Simon Masson Sunming Lee Toni Mateu Xing Xiong Zoltan David Kalaszi Rasmus Hjortshoj 陈子钰

垃圾焚烧发电厂阿梅格尔巴克/哥本山位于工业区,多年来,该工业区已成为冒险者们的极限运动目的地。原始的工业设施为各种极限运动活动提供了场所,如缆绳滑水、卡丁车和攀岩等。阿梅格尔巴克/哥本山是该地区最重要的地标,其建筑亟须更新... 详细信息

垃圾焚烧发电厂阿梅格尔巴克/哥本山位于工业区,多年来,该工业区已成为冒险者们的极限运动目的地。原始的工业设施为各种极限运动活动提供了场所,如缆绳滑水、卡丁车和攀岩等。阿梅格尔巴克/哥本山是该地区最重要的地标,其建筑亟须更新。我们提出了一种新型的垃圾焚烧发电厂,这种工厂能产生经济、环保和社会效益。我们不将阿梅格尔巴克/哥本山视为一个孤立的对象,而是调动起建筑的

关键词：巴克本山

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iSchool中的数字人文

数字人文研究 2021年第3期1卷 93-112页

作者：约翰·A.沃尔什彼得·J.科布韦恩·德·弗雷默里科拉伊卡·戈卢布基赫·汉弗莱金贞贤约瑟夫·基普朗特刘英享西蒙·马奥尼吴三均克里斯·阿伦·苏拉特德·安德伍德王晓光陈怡(译) 美国印第安纳大学勒迪学院香港大学教育学院人类通讯、发展与信息科学学术组(CDIS) 香港大学人文学院韩国西江大学媒体艺术科学院瑞典林奈大学信息研究所联合国粮食及农业组织美国北得克萨斯州大学信息学院肯尼亚莫伊大学信息科学学院挪威奥斯陆城市大学图书情报档案系北京师范大学珠海分校数字出版与数字人文研究中心韩国成均馆大学图书馆与信息科学系美国普瑞特艺术学院信息学院美国伊利诺伊大学厄巴纳-香槟分校信息科学学院武汉大学信息管理学院、数字人文研究中心中国人民大学信息资源管理学院

作为交叉领域而广为人知的数字人文,正形式多样地呈现于iSchool的教学和研究活动中.在专门负责探索数字人文课程体系的iSchools组织委员会工作的基础上,当前的发现来自于一系列探讨iSchool(经常与其他部门和学科合作)的数字人文教学、... 详细信息

作为交叉领域而广为人知的数字人文,正形式多样地呈现于iSchool的教学和研究活动中.在专门负责探索数字人文课程体系的iSchools组织委员会工作的基础上,当前的发现来自于一系列探讨iSchool(经常与其他部门和学科合作)的数字人文教学、教育和研究之各方面的相关探讨.首先基于对iSchool项目的调研和一项对数字人文课程的在线调查,考察了iSchool中丰富多样的数字人文教育模式;通过分析各课程大纲与描述,详细探究了数字人文课程设置及体系.随后简要介绍了与iSchool合作进行数字人文研究项目或提供数字人文教育的学科部门.接着,通过分析相关职位的招聘广告探讨了数字人文职业.最后,围绕开展一项新的数字人文项目,就运营和行政层面上的挑战与机遇提供了一些观察.作为结果,最终呈现的是一份关于iSchool中数字人文发展现状的概览,可为设计与发展新的数字人文项目、学位和相关举措提供有益参考.

关键词：数字人文 iSchool 教育培养课程设置合作学科职业生涯

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基于辣椒基因组测序探究辣味在种群中的进化

辣椒杂志 2014年第2期12卷 40-50页

作者： Seungill Kim Minkyu Park Seon-In Yeom Yong-Min Kim Je Min Lee Hyun-Ah Lee Eunyoung Seo Jaeyoung Choi Kyeongchae Cheong Ki-Tae Kim Kyongyong Jung Gir-Won Lee Sang-Keun Oh Chungyun Bae Saet-Byul Kim Hye-Young Lee Shin-Young Kim Myung-Shin Kim Byoung-Cheorl Kang Yeong Deuk Jo Hee-Bum Yang Hee-Jin Jeong Won-Hee Kang Jin-Kyung Kwon Chanseok Shin Jae Yun Lim June Hyun Park Jin Hoe Huh June-Sik Kim Byung-Dong Kim Oded Cohen Ilan Paran Mi Chung Suh Saet Buyl Lee Yeon-Ki Kim Younhee Shin Seung-Jae Noh Junhyung Park Young sam Seo Suk-Yoon Kwon Hyun A Kim Jeong Mee Park Hyun-Jin Kim Sang-Bong Choi Paul W Bosland Gregory Reeves Sung-Hwan Jo Bong-Woo Lee Hyung-Taeg Cho Hee-Seung Choi Min-Soo Lee Yeisoo Yu Yang Do Choi Beom-Seok Park Allen van Deynze Hamid Ashrafi Theresa Hill Woo Taek Kim Hyun-Sook Pai Hee Kyung Ahn Inhwa Yeam James J Giovannoni Jocelyn K C Rose Iben Sφrensen Sang-Jik Lee Ryan W Kim Ik-Young Choi Beom-Soon Choi Jong-Sung Lim Yong-Hwan Lee Doil Choi 刘峰张西露 Department of Plant Science Seoul National University Plant Genomics and Breeding Institute Seoul National University Department of Agricultural Biotechnology Seoul National University Department of Bioinformatics and Life Science Soongsil University Vegetable Breeding Research Center Seoul National University Agricultural Research Organization Institute of Plant Science Volcani Center Bet DaganIsrael. Agricultural Research Organization Institute of Plant Science Volcani Center Bet DaganIsrael Department of Bioenergy Science and Technology Chonnam National University Genomics Genetics Institute GreenGene BioTech Inc. Codes Division Insilicogen Inc. Ginseng Resources Research Laboratory Korea Ginseng Corporation Korea Research Institute of Bioscience and Biotechnology Division of Bioscience and Bioinformatics Myongji University Department of Plant and Environmental Sciences New Mexico State University Chile Pepper Institute New Mexico State University Seeders Inc. Department of Biological Sciences Seoul National University Arizona Genomics Institute University of Arizona Agricultural Genome Center National Academy of Agricultural Science Rural Development Administration Seed Biotechnology Center University of California Davis Davis California USA Department of Systems Biology Yonsei University Department of Horticulture and Breeding Andong National University US Department of Agriculture-Agricultural Research Service Robert W. Holley Center Ithaca New York USA Boyce Thompson Institute for Plant Research Cornell University Ithaca New York USA Department of Plant Biology Cornell University Ithaca New York USA Biotechnology Institute Nongwoo Bio Yeoju Korea Genome Center University of California Davis Davis California USA National Instrumentation Center for Environmental Management Seoul National University Seoul Korea 湖南省蔬菜研究所

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表... 详细信息

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表明辣椒基因组大小约为番茄的4倍,辣椒基因组上存在大量gypsy转座子和花椰菜病毒家族元件的积累。结合转录组综合分析认为,辣椒素合成酶基因表达模式的改变及新功能化是导致辣椒素生物合成的原因,研究还发现辣椒与番茄在乙烯合成及果实成熟调控方面存在明显不同的分子模式。辣椒参考基因组的发布为辣椒营养品质和药用价值的改善提供了重要平台。

关键词：基因组测序辣椒素参考基因 Capsicum 转座子辣椒果实分子模式生物合成基因表达模式基因组大小

Abstracts from the 15th International Myopia Conference

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Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez Ann Nour Tobin Ansel Kathleen Abarr Luying Yan Keisha Roden David Troilo Chanyi Lu Miaozhen Pan Min Zheng Jia Qu Xiangtian Zhou Christine F. Wildsoet Fan Lu Jie Chen Jinhua Bao Liang Hu Qinmei Wang Zibing Jin Frances Rucker Stephanie Britton Stephan Hanowsky Molly Spatcher Hui-Ying Kuo Ching-Hsiu Ke I-Hsin Kuo Chien-Chun Peng Han-Yin Sun Ian G. Morgan Jeremy A. Guggenheim Rupal L. Shah Cathy Williams Jinglei Yang Peter S. Reinach Sen Zhang Wenfeng Sun Bo Liu Fen Li Xiaoqing Li Aihua Zhao Tianlu Chen Wei Jia Jun Jiang Haoran Wu Kazuo Tsubota Hiroko Ozawa Hidemasa Torii Shigemasa Takamizawa Toshihide Kurihara Kazuno Negishi Klaus Graef Daniel Rathbun Frank Schaeffel Ladan Ghodsi William K. Stell Machelle T. Pardue Ranjay Chakraborty Han na Park Curran S. Sidhu P. Michael Iuvone Michael J Collins Nethrajeith Srinvasalu Sally A. McFadden Paul N. Baird Pablo Artal Pauline Cho SW Cheung Pei-Chang Wu Quan V. Hoang Duk C. Lee Erica G. Landis Michael A. Bergen Curran Sidhu samer Hattar Richard A. Stone Ravi Metlapally Ruiqin Li Qinglin Xu Hong Zhong Chenglin Pan Weizhong Lan Xiaoning Li Ling Chen Zhikuan Yang Scott A. Read Seang-Mei Saw Shi-Jun Weng Xiao-Hua Wu Kang-Wei Qian Yun-Yun Li Guo-Zhong Xu Furong Huang Xiong-Li Yang Yong-Mei Zhong Earl L Smith, III Baskar Arumugam Li-Fang Hung Lisa A. Ostrin Klaus Trier Monica Jong Brien A. Holden Thomas Chuen Lam samantha Shan Bing Zuo Dennis Yan-yin Tse Jingfang Bian King-Kit Li Quan Liu Chi-ho To Timothy J. Gawne John T. Siegwart, Jr. Alexander H. Ward Thomas T. Norton Yan Zhang Yue Liu Carol Ho Eileen Phan abraham Hang Emily Eng Christine Wildsoet Department of Biological Sciences SUNY College of Optometry New York NY 10036 USA School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China Center for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medical University Wenzhou Zhejiang 325027 China Biomedical Science and Disease New England College of Optom Boston MA USA School of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Biochemistry and Molecular Biology Research School of Biology Australian National University Canberra Australia State Key Laboratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China School of Optometry & Vision Sciences Cardiff University Cardiff UK School of Social and Community Medicine University of Bristol Bristol UK School of and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China State Key Laboratory Cultivation Base and Key Laboratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China Department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic Research Institute University of Tuebingen 72076 Tuebingen Germany Bernstein Center for Computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reichardt Centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refractive changes that occur when eye growth decelerates in *** We measured peripheral refraction and on-axis vitreous chamber depth on a total of 53 marmosets;36 treated monocularly for 12 weeks 9 hrs/day(26 with-5 D contact lenses,10 with+5 D)and 17 untreated *** the 26 marmosets treated with-5 D,10 wore contact lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of recovery(R14).Eight had both contact lenses removed for 30 mins twice/day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the second four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated