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The moderating effect of physical activity on the relationship between bullying and mental health among sexual and gender minority youth

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journal of Sport and Health Science 2023年第1期12卷 106-115页

作者： sally j.kirklewski Ryan j.Watson Carolyn Lauckner Department of Health Promotion and Behavior University of GeorgiaAthensGA 30602USA Human Development and Family Sciences University of ConnecticutStorrsCT 06269 USA Department of Behavioral Science University of Kentucky College of MedicineUniversity of KentuckyLexingtonKY 40506USA

Background:Sexual and gender minority youth frequently experience bullying,which often contributes to higher depressive symptoms and lower *** that physical activity(PA)can mitigate depressive symptoms and improve self-esteem,we examined the moderating effect of PA on the relationship between bullying and mental health among sexual and gender minority ***:Data from the Lesbian,Gay,Bisexual,Transgender,and Queer National Teen Survey(n=9890)were *** regression analyses examined the influence of history and frequency of being bullied,PA,and the interaction of these variables on depressive symptoms and *** slopes analyses were used to probe significant ***:Results indicated the importance of accounting for bullying history when examining effects of PA on mental *** was negatively related to depression(t=-4.18,p<0.001)and positively related to self-esteem(t=12.11,p<0.001).Bullying frequency was positively related to depression(t=19.35,p<0.001)and negatively related to self-esteem(t=-12.46,p<0.001).There was a significant interaction between bullying frequency and PA for depression(t=4.45,p<0.001)and self-esteem(t=-4.69,p<0.001).Post hoc analyses suggested that the positive effects of PA on mental health may be limited to those not bullied because it had a negligible effect on those who were ***:Results suggest that sexual and gender minority youth exercise interventions aiming to improve mental health should first address bullying history;otherwise,their effectiveness may be limited to those who have been bullied.

关键词： Bullying Depression Exercise LGBTQ Self-esteem Youth

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Feruloylated Arabinoxylans Are Oxidatively Cross- Linked by Extracellular Maize Peroxidase but Not by Horseradish Peroxidase

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Molecular Plant 2009年第5期2卷 883-892页

作者： sally j. Burr Stephen C. Fry The Edinburgh Cell Wall Group Institute of Molecular Plant Sciences School of Biological Sciences The University of Edinburgh Daniel Rutherford Building The King's Buildings Edinburgh EH9 3JH UK Present address: Ecologie Microbienne/UMR CNRS 5557 USC INRA 1193 Universite Claude Bernard--Lyon 1 Batiment Gregor Mendel 16 rue Dubois F-69622 Villeurbanne Cedex France

Covalent cross-linking of soluble extracellular arabinoxylans in living maize cultures, which models the cross- linking of wall-bound arabinoxylans, is due to oxidation of feruloyl esters to oligoferuloyl esters and ethers. The oxidizing system responsible could be H2O2/peroxidase, O2/laccase, or reactive oxygen species acting non-enzymically, To distinguish these possibilities, we studied arabinoxylan cross-linking in vivo and in vitro. In living cultures, exogenous, soluble, extracellular, feruloylated [pentosyl-3H]arabinoxylans underwent cross-linking, beginning abruptly 8 d after sub-culture. Crosslinking was suppressed by iodide, an H2O2 scavenger, indicating dependence on endogenous H2O2. However, exogenous H2O2 did not cause precocious cross-linking, despite the constant presence of endogenous peroxidases, suggesting that younger cultures contained natural cross-linking inhibitors. Dialysed culture-filtrates cross-linked [^3H]arabinoxylans in vitro only if H2O2 was also added, indicating a peroxidase requirement. This cross-linking was highly ionic-strength-dependent. The peroxidases responsible were heat-labile, although relatively heat-stable peroxidases （assayed on o-dianisidine） were also present. Surprisingly, added horseradish peroxidase, even after heat-denaturation, blocked the arabinoxylancross-linking action of maize peroxidases, suggesting that the horseradish protein was a competing substrate for [^3H]arabinoxylan coupling. In conclusion, we show for the first time that cross-linking of extracellular arabinoxylan in living maize cultures is an action of apoplastic peroxidases, some of whose unusual properties we report.

关键词： Cell wall cross-links phenolics ferulate peroxidase soluble extracellular polysaccharides Zea mays L.

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Genotypes and viral variants in chronic hepatitis B: A review of epidemiology and clinical relevance

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World journal of Hepatology 2015年第3期7卷 289-303页

作者： Catherine MN Croagh Paul V Desmond sally j Bell Department of Gastroenterology St Vincent's Hospital

The Hepatitis B Virus(HBV) has a worldwide distribu-tion and is endemic in many populations. It is constantly evolving and 10 genotypic strains have been identified with varying prevalences in different geographic regions. Numerous stable mutations in the core gene and in the su-rface gene of the HBV have also been identified in untreated HBV populations. The genotypes and viral variants have been associated with certain clinical featu-res of HBV related liver disease and Hepatocellu-lar carcinoma. For example Genotype C is associated withlater hepatitis B e antigen(HBe Ag) seroconversion, and more advanced liver disease. Genotype A is associated with a greater risk of progression to chronicity in adu-lt acqu-ired HBV infections. Genotype D is particu-larly associated with the precore mu-tation and HBe Ag negative chronic hepatitis B(CHB). The genotypes prevalent in parts of West Africa, Central and Sou-th America, E, F and H respectively, are less well stu-died. Viral variants especially the Basal Core Promotor mutation is associated with increased risk of fibrosis and cancer of the liver. Althou-gh not cu-rrently part of rou-tine clinical care, evalu-ation of genotype and viral variants may provide u-sefu-l adju-nctive information in predicting risk abou-t liver related morbidity in patients with CHB.

关键词： Chronic hepatitis B Genotype Pre-core Basal core promotor Mutations

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The association between Tai Chi exercise and safe driving performance among older adults： An observational study

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journal of Sport and Health Science 2018年第1期7卷 83-94页

作者： sally Miller Ruth E.Taylor-Piliae School of Nursing Vanderbilt University Nashville TN 37240 USA College of Nursing The University of Arizona Tucson AZ 85721 USA

Background: Age-related cognitive and physical decline can impair safe driving performance. Tai Chi exercise benefits cognitive and physical function and may influence safe driving performance in older adults. The primary aim of this observational study was to compare cognitive processes and physical function related to safe driving performance among older adult Tai Chi practitioners to normative reference *** aims were to examine relationships between Tai Chi exercise habits, cognitive processes, and physical function related to safe driving performance and to explore potential predictors of safe driving ***: The Driving Health Inventory, the Driving Scenes Test, other driving-related cognitive and physical measures, and self-reported measures including the Mindful Attention Awareness Scale(MAAS) and the Vitality Plus Scale(VPS) were collected from current Tai Chi practitioners(n = 58; age 72.9 ± 5.9 years, mean ± SD) with median >3 years Tai Chi ***: Compared to normative reference values, participants performed better on numerous cognitive measures including the Driving Scenes Test(p < 0.001, d = 1.63), maze navigation(p = 0.017, d = 0.27), the Useful Field of View Test(p < 0.001, r = 0.15), and on physical measures including the Rapid Walk Test(p < 0.001, r = 0.20), and the Right Foot Tapping Test,(p < 0.001, r = 0.35). Participants scored higher than normative reference values on MAAS and VPS(p < 0.001, d = 0.75; p = 0.002, d = 0.38, respectively). Statistically significant correlations were found between several study measures. The digit span backward test was the strongest predictor of safe driving performance(β = 0.34,p = 0.009).Conclusion: Tai Chi exercise has the potential to impact cognitive processes and physical function related to safe driving performance. Further study using randomized controlled trials, structured Tai Chi exercise doses, and driving simulator or on-road driving performance as outcome measures

关键词： Automobile driving Driving performance Exercise Older adults Physical activity Tai Chi

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Portal vein thrombosis and arterioportal shunts:Effects on tumor response after chemoembolization of hepatocellular carcinoma

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World journal of Gastroenterology 2011年第10期17卷 1267-1275页

作者： Thomas j Vogl Nour-Eldin Nour-Eldin sally Emad-Eldin Nagy NN Naguib joerg Trojan Hans Ackermann Omar Abdelaziz Institute for Diagnostic and Interventional Radiology Johan Wolfgang Goethe University Hospital Diagnostic and Interventional Radiology Department Cairo University Hospital

AIM: To evaluate the effect of portal vein thrombosis and arterioportal shunts on local tumor response in advanced cases of unresectable hepatocellular carcinoma treated by transarterial chemoembolization. METHODS: A retrospective study included 39 patients (mean age: 66.4 years, range: 45-79 years, SD: 7) with unresectable hepatocellular carcinoma (HCC) who were treated with repetitive transarterial chemoembolization (TACE) in the period between March 2006 and October 2009. The effect of portal vein thrombosis (PVT) (in 19 out of 39 patients), the presence of arterioportal shunt (APS) (in 7 out of 39), the underlying liver pathology,Child-Pugh score, initial tumor volume, number of tumors and tumor margin definition on imaging were correlated with the local tumor response after TACE. The initial and end therapy local tumor responses were evaluated according to the response evaluation criteria in solid tumors (RECIST) and magnetic resonance imaging volumetric measurements. RESULTS: The treatment protocols were well tolerated by all patients with no major complications. Local tumor response for all patients according to RECIST criteria were partial response in one patient (2.6%), stable disease in 34 patients (87.1%), and progressive disease in 4 patients (10.2%). The MR volumetric measurements showed that the PVT, APS, underlying liver pathology and tumor margin definition were statistically significant prognostic factors for the local tumor response (P = 0.018, P = 0.008, P = 0.034 and P = 0.001, respectively). The overall 6-, 12- and 18-mo survival rates from the initial TACE were 79.5%, 37.5% and 21%, respectively. CONCLUSION: TACE may be exploited safely for palliative tumor control in patients with advanced unresectable HCC; however, tumor response is significantly affected by the presence or absence of PVT and APS.

关键词： Hepatocellular carcinoma Transarterialchemoembolization Portal Shunt Thrombosis

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VPOT:A Customizable Variant Prioritization Ordering Tool for Annotated Variants

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Genomics, Proteomics & Bioinformatics 2019年第5期17卷 540-545页

作者： Eddie Ip Gavin Chapman David Winlaw sally LDunwoodie Eleni Giannoulatou Victor Chang Cardiac Research Institute Sydney 2010Australia St Vincent’s Clinical School University of New South WalesSydney 2052Australia Heart Centre for Children The Children’s Hospital at WestmeadSydney 2145Australia Sydney Medical School University of SydneySydney 2050Australia School of Biotechnology and Biomolecular Sciences University of New South WalesSydney 2033Australia

Next-generation sequencing(NGS) technologies generate thousands to millions of genetic variants per *** of potential disease-causal variants is labor intensive as it relies on filtering using various annotation metrics and consideration of multiple pathogenicity prediction *** have developed VPOT(variant prioritization ordering tool),a python-based command line tool that allows researchers to create a single fully customizable pathogenicity ranking score from any number of annotation values,each with a user-defined *** use of VPOT can be informative when analyzing entire cohorts,as variants in a cohort can be *** also provides additional functions to allow variant filtering based on a candidate gene list or by affected status in a family *** outperforms similar tools in terms of efficacy,flexibility,scalability,and computational *** is freely available for public use at Git Hub(https://***/VCCRI/VPOT/).Documentation for installation along with a user tutorial,a default parameter file,and test data are provided.

关键词： Next-generation sequencing Pathogenicity predictions Variant prioritization Customizable ranking Genomic annotation

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Effect of Niobium on Transformations From Austenite to Ferrite in Low Carbon Steels

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journal of Iron and Steel Research International 2011年第S1期18卷 208-212页

作者： Parker sally Rose Andrew West Geoff Thomson Rachel Steel Metallurgy Department Tata Steel RD and TSwinden Technology CentreRotherhamS60 3ARUK Department of Materials Loughborough UniversityLoughboroughLE11 3TUUK

Niobium has an important effect on the transformation behaviour,grain size refinement and precipitation strengthening during hot rolling and subsequent cooling in low carbon steels,with even a low content of niobium having a strong effect on the transformation rate from austenite to ***,the effects of niobium on transformation behaviour have not been fully characterised and understood to *** paper examines in detail austenite grain growth as a function of austenitisation time in high strength low alloy (HSLA) steels with three different niobium contents,together with the effect of niobium on the isothermal transformation kinetics from austenite to ferrite as a function of *** is shown that austenite has the slowest grain growth rate in the steel with the highest niobium *** austenite grain sizes are consistent,the steel with the highest niobium content was found to have the slowest transformation rate from austenite to ferrite.

关键词： niobium transformation kinetics austenite grain growth low carbon steels

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Expression of Gli1 in the hedgehog signaling pathway and breast cancer recurrence

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Chinese journal of Cancer Research 2012年第4期24卷 257-258页

作者： Naoko Takebe sally Hunsberger Sherry X.Yang Cancer Therapy Evaluation Program Bioinformatics Research Branch National Clinical Target Validation Laboratory Division of Cancer Treatment and DiagnosisNational Cancer InstituteNational Institutes of HealthUSA

The hedgehog （Hh） signaling pathway plays an essential role in the embryonic development and homeostasis of diverse adult tissues, and its deregulation has been implicated in the tumorigenesis and metastasis of various malignancies including breast cancer. Aberrant activation of the Hh pathway includes the following mechanisms：（I） Hh ligand-independent mechanism - Loss of function mutations in the Hh receptor Patched 1 （PTCH1） or gain of function mutations in the Smoothened （SMO） lead to constitutive activation of this pathway; （II） Autocrine signaling- Ith ligand produced by tumor cells stimulates the Hh signaling in tumor cells; （III） Paracrine signaling - tumor cell produced-Hh ligand activates stromal and endothelial cells that produce growth factors in microenvironment for supporting tumor growth and survival; and （IV） Reverse paracrine signaling - Hh ligand produced by stromal cells support tumor growth and survival. Upon the pathway activation, the Gli transcription factors, effectors of the Hh signaling, activate or inhibit transcription by binding to their responsive genes and interacting with the transcriptional complex. The Gli transcription factor family includes Glil, Gli2, and Gli3 （1）. Glil is a transcriptional activator whose expression has been recognized as an activation state of the Hh signaling pathway, Gli2 is either an activator or repressor, and Gli3 is a strong repressor of transcriptional activities. To date, a ligand-dependent autocrine model of activating the Hh signaling has been described in breast cancer, and both an autocrine and paracrine mechanisms in colorectal cancer, pancreatic cancer and prostate cancer （2,3）. Notably, a ligand-independent mechanism （mutationsin PTCHI and SMO） of the signaling has been well demonstrated in basal cell carcinoma and medulloblastoma （4,5）.

关键词： cell Expression of Gli1 in the hedgehog signaling pathway and breast cancer recurrence

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Cyclophosphamide-associated enteritis: A rare association with severe enteritis

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World journal of Gastroenterology 2016年第39期22卷 8844-8848页

作者： Linda S Yang Karla Cameron Tim Papaluca Chamara Basnayake Louise jackett Penelope McKelvie David Goodman Barbara Demediuk sally j Bell Alexander j Thompson Department of Gastroenterology St. Vincent’s HospitalFitzroy Department of Pathology St. Vincent’s HospitalFitzroy Department of Nephrology St. Vincent’s HospitalFitzroy

Cyclophosphamide is a potent cytotoxic agent used in many clinical settings. The main risks of cyclophosphamide therapy include hematological disorders, infertility, hemorrhagic cystitis and malignancies. Gastrointestinal side effects reported to date are often non-specific and not severe. We present the first case of a fatal small bowel enteritis and pan-colitis which appears to be associated with cyclophosphamide. We aim to raise the readers' awareness of this significant adverse event to facilitate clinical suspicion and early recognition in potential future cases.

关键词： Enteritis Colitis Cyclophosphamide Small bowel Pan-colitis

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Cost-effectiveness of Crohn's disease post-operative care

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World journal of Gastroenterology 2016年第14期22卷 3860-3868页

作者： Emily K Wright Michael A Kamm Peter Dr Cruz Amy L Hamilton Kathryn j Ritchie sally j Bell Steven j Brown William R Connell Paul V Desmond Danny Liew Department of Gastroenterology St Vincent's Hospital University of Melbourne Fitzroy VIC 3065 Melbourne Australia Imperial College London SW7 2AZ United Kingdom Melbourne EpiCentre University of Melbourne and Melbourne Health Parkville VIC 3010 Melbourne Australia

AIM: To define the cost-effectiveness of strategies, including endoscopy and immunosuppression, to prevent endoscopic recurrence of Crohn’s disease following intestinal ***: In the “POCER” study patients undergoing intestinal resection were treated with post-operative drug therapy. Two thirds were randomized to active care (6 mo colonoscopy and drug intensification for endoscopic recurrence) and one third to drug therapy without early endoscopy. Colonoscopy at 18 mo and faecal calprotectin (FC) measurement were used to assess disease recurrence. Administrative data, chart review and patient questionnaires were collected prospectively over 18 ***: Sixty patients (active care n = 43, standard care n = 17) were included from one health service. Median total health care cost was $6440 per patient. Active care cost $4824 more than standard care over 18 mo. Medication accounted for 78% of total cost, of which 90% was for adalimumab. Median health care cost was higher for those with endoscopic recurrence compared to those in remission [$26347 (IQR 25045-27485) vs $2729 (IQR 1182-5215), P < 0.001]. FC to select patients for colonoscopy could reduce cost by $1010 per patient over 18 mo. Active care was associated with 18% decreased endoscopic recurrence, costing $861 for each recurrence ***: Post-operative management strategies are associated with high cost, primarily medication related. Calprotectin use reduces costs. The long term cost-benefit of these strategies remains to be evaluated.

关键词： Crohn’ s disease Post-operative Health economics Health care cost Biologics

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