Cyclophosphamide-associated enteritis: A rare association with severe enteritis

作     者：Linda S Yang Karla Cameron Tim Papaluca Chamara Basnayake Louise Jackett Penelope McKelvie David Goodman Barbara Demediuk Sally J Bell Alexander J Thompson 

作者机构：Department of Gastroenterology St. Vincent’s HospitalFitzroy Department of Pathology St. Vincent’s HospitalFitzroy Department of Nephrology St. Vincent’s HospitalFitzroy 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2016年第22卷第39期

页      面：8844-8848页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：肠炎 大肠炎 Cyclophosphamide 小肠 平底锅大肠炎 

摘      要：Cyclophosphamide is a potent cytotoxic agent used in many clinical settings. The main risks of cyclophosphamide therapy include hematological disorders, infertility, hemorrhagic cystitis and malignancies. Gastrointestinal side effects reported to date are often non-specific and not severe. We present the first case of a fatal small bowel enteritis and pan-colitis which appears to be associated with cyclophosphamide. We aim to raise the readers awareness of this significant adverse event to facilitate clinical suspicion and early recognition in potential future cases.