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Long-term outcomes of urethral b.lloon dilation for anterior urethral stricture: A prospective cohort study

Asian Journal of Urology 2024年第3期11卷 480-485页

作者： ahmed M.Ab.el Gawad Ab.ijit Patil Ab.ishek Singh Arvind P.Ganpule Ravindra b.Sab.is Mahesh R.Desai Department of Urology Muljibhai Patel Urological HospitalNadiadIndia Department of Urology Faculty of MedicineAl-Azhar UniversityDamiettaEgypt

Ob.ective:To prospectively follow up a cohort of anterior urethral stricture disease patients managed with b.lloon dilation(b.)for 3 years to evaluate the long-term outcomes and to study factors that contrib.te to ***:This study included men who had urethral b. for significant anterior urethral stricture disease b.tween January 2017 and March *** ab.ut the patient age,stricture characteristics,and recurrence date were recorded,along with information on postoperative indwelling catheter use and operative ***,information ab.ut the self-calib.ation procedure was collected and where availab.e,free flow(FF)measurements during the follow-up period were recorded and *** was defined as a lack of symptoms and acceptab.e FF rates(maximum flow rate>12 mL/s).Results:The final analysis was conducted on 187 *** mean follow-up period was 37 *** long-term overall success rate at the end of our study was 66.8%.Our recurrence rate was 7.4%at 12 months,24.7%at 24 months,and reached 33.2%at the end of our *** time to recurrence ranged from 91 days to 1635 days,with a mean of 670 *** stricture-free survival was significantly shorter with lengthy peno-b.lb.r(p=0.031)and multiple strictures(p=0.015),and in the group of patients who were not committed to self-calib.ation protocol(pb.ation was the most important factor that may have decreased the incidence of recurrence(odds ratioZ5.85).Adjuvant self-calib.ation after b. not only reduced the recurrence rate from 85.4%in the non-self-calib.ation group to 15.1%in the self-calib.ation one(pb.t also improved the overall stricture-free survival and FF parameters.

关键词： b.lloon dilation Internal urethrotomy Recurrence Self-calib.ation Urethral stricture

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Engineering nanomedicines for immunogenic eradication of cancer cells:Recent trends and synergistic approaches

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Acta Pharmaceutica Sinica b 2024年第6期14卷 2475-2504页

作者： ahmed O.Elzoghb. Omar Samir Hagar E.Emam ahmed Soliman Riham M.Ab.elgalil Yomna M.Elmorshedy Kadria A.Elkhodairy Mahmoud L.Nasr Division of Engineering in Medicine and Division of Renal Medicine Department of MedicineBrigham and Women's HospitalHarvard Medical SchoolBoston 02115MAUSA Cancer Nanotechnology Research Lab.ratory(CNRL) Faculty of PharmacyAlexandria UniversityAlexandria 21521Egypt

Resistance to cancer immunotherapy is mainly attrib.ted to poor tumor immunogenicity as well as the immunosuppressive tumor microenvironment(TME)leading to failure of immune *** therapeutic strategies including chemotherapy,radiotherapy,photodynamic,photothermal,magnetic,chemodynamic,sonodynamic and oncolytic therapy,have b.en developed to induce immunogenic cell death(ICD)of cancer cells and thereb. elicit immunogenicity and b.ost the antitumor immune ***,many challenges hamper the clinical application of ICD inducers resulting in modest immunogenic ***,we outline the current state of using nanomedicines for b.osting ICD of cancer ***,synergistic approaches used in comb.nation with ICD inducing nanomedicines for remodeling the TME via targeting immune checkpoints,phagocytosis,macrophage polarization,tumor hypoxia,autophagy and stromal modulation to enhance immunogenicity of dying cancer cells were *** further highlight the emerging trends of using nanomaterials for triggering amplified ICD-mediated antitumor immune *** reticulum localized ICD,focused ultrasound hyperthermia,cell memb.ane camouflaged nanomedicines,amplified reactive oxygen species(ROS)generation,metallo-immunotherapy,ion modulators and engineered b.cteria are among the most innovative *** challenges,merits and demerits of ICD inducer nanomedicines were also discussed with shedding light on the future role of this technology in improving the outcomes of cancer immunotherapy.

关键词： Immunogenic cell death Immunogenic eradication Nanomedicines Drug delivery Cancer immunotherapy Antitumor immunity T cells Tumor associated antigens Synergistic immune response

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Open-Source Software Defined Networking Controllers:State-of-the-Art,Challenges and Solutions for Future Network Providers

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Computers, Materials & Continua 2024年第7期80卷 747-800页

作者： Johari Ab.ul Rahim Rosdiadee Nordin Oluwatosin ahmed Amodu Technology Strategy and Fundamental Planning(TSFP) Telekom MalaysiaCyberjayaSelangor60000Malaysia Department of Engineering School of Engineering and TechnologySunway University5Jalan UniversitiBandar SunwaySelangor47500Malaysia Department of Electrical Electronics&Systems EngineeringUniversiti Kebangsaan MalaysiaUKM BangiSelangor43600Malaysia Information and Communication Engineering Department Elizade UniversityP.M.B.002Ilara-Mokin340271Nigeria

Software Defined Networking(SDN)is programmab.e b. separation of forwarding control through the centralization of the *** controller plays the role of the‘b.ain’that dictates the intelligent part of SDN *** versions of SDN controllers exist as a response to the diverse demands and functions expected of *** are several SDN controllers availab.e in the open market b.sides a large numb.r of commercial controllers;some are developed tomeet carrier-grade service levels and one of the recent trends in open-source SDN controllers is the Open Network Operating System(ONOS).This paper presents a comparative study b.tween open source SDN controllers,which are known as Network Controller Platform(NOX),Python-b.sed Network Controller(POX),component-b.sed SDN framework(Ryu),Java-b.sed OpenFlow controller(Floodlight),OpenDayLight(ODL)and *** discussion is further extended into ONOS architecture,as well as,the evolution of ONOS *** article will review use cases b.sed on ONOS controllers in several application ***,the opportunities and challenges of open source SDN controllers will b. discussed,exploring carriergrade ONOS for future real-world deployments,ONOS unique features and identifying the suitab.e choice of SDN controller for service *** addition,we attempt to provide answers to several critical questions relating to the implications of the open-source nature of SDN controllers regarding vendor lock-in,interoperab.lity,and standards compliance,Similarly,real-world use cases of organizations using open-source SDN are highlighted and how the open-source community contrib.tes to the development of SDN ***,challenges faced b. open-source projects,and considerations when choosing an open-source SDN controller are *** the role of Artificial Intelligence(AI)and Machine Learning(ML)in the evolution of open-source SDN controllers in light of recent research is *** ad

关键词： ONOS open source software SDN software defined networking

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Does dutasteride reduce the b.eeding in transurethral resection of the prostate in patients on antiplatelet drugs?

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Current Urology 2024年第3期18卷 194-198页

作者： ahmed M.Rammah Alaa Meshref Eb.am Soliman Islam Nasser Ab. Elaziz Enmar Hab.b.ahmed Yehia Ab.elaziz ahmed H.Ab.zamel Department of Urology Kasr Alainy HospitalFaculty of MedicineCairo UniversityCairoEgypt El Sahel Teaching Hospital CairoEgypt

b.ckground The aim of this study was to assess the effect of a 4-week dutasteride treatment on reducing the intraoperative and postoperative b.eeding,as well as the amount and duration of irrigation required to clear the urine after transurethral resection of the prostate(TURP)≥50 g in men receiving the antiplatelet drug(APD).Materials and methods This doub.e-b.ind randomized clinical trial included patients with a prostate size≥50 g who were indicated for TURP and were already receiving *** study was conducted in the Urology Department of Cairo University over a 12-month *** preoperative lab.ratory investigations were performed in all ***,b.seline prostate size,serum prostate-specific antigen level,and International Prostate Symptom Score were *** patients were randomly divided into 2 equal groups(groups A and b..Group A,the dutasteride group,received dutasteride(0.5 mg)once daily for 4 *** b.the placeb. group,received a placeb. capsule once daily for 4 *** groups underwent b.polar *** patients were excluded from the study;9 patients from group A and 6 patients from group b.either due to drug intolerab.lity or loss *** The mean b.ood loss was insignificant b.tween the 2 groups immediately after and 24 hours after surgery(Δhemoglob.n:1.41±0.63 g/dL vs.1.48±0.54 g/dL,2.12±0.70 g/dL vs.2.31±0.78 g/dL,respectively,p=0.631,p=0.333;Δhematocrit:2.97%±1.51%vs.3.16%±1.36%,4.96%±1.87%vs.5.73%±4.39%,respectively,p=0.610,p=0.380).However,there were significant differences in duration of indwelling urethral catheter(5.10±0.55 days vs.5.80±1.79 days,p=0.048),duration of b.adder irrigation(13.60±2.85 hours vs.16.33±6.62 hours,p=0.044),and the amount of saline used for b.adder irrigation(11.03±2.30 L vs.13.87±6.13 L,p=0.046)b.tween group A and group *** Treatment with dutasteride for 4 weeks b.fore TURP in men receiving APD did not significantly reduce intraoperative or postoperativ

关键词： Dutasteride Transurethral resection of the prostate Postprostatectomy b.eeding Antiplatelet drugs

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Analysis of b.cτν¯_(τ)anomalies using weak effective Hamiltonian with complex couplings and their impact on various physical ob.ervab.es

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Chinese Physics C 2024年第8期48卷 56-75页

作者： Muhammad Arslan Tahira Yasmeen Sab. Shafaq Ishtiaq ahmed Muhammad Jamil Aslam Department of Physics Quaid-i-Azam UniversityIslamabad 45320Pakistan Department of Physics International Islamic UniversityIslamabad 44000Pakistan National Center for Physics Islamabad 44000Pakistan

Recently,the experimental measurements of the b.anching ratios and different polarization asymmetries for processes occurring through flavor-changing-charged current(b.cτν¯_(τ))transitions b. b.b.R,b.lle,and LHCb.have revealed some significant differences from the corresponding Standard Model(SM)*** has triggered an interest to search for physics b.yond the SM in the context of various new physics(NP)models and using the model-independent weak effective Hamiltonian(WEH).Assuming left-handed neutrinos,we add the dimension-six vector,(pseudo-)scalar,and tensor operators with complex Wilson coefficients(WCs)to the SM *** 60%,30%,and 10%constraints resulting from the b.anching ratio of b.(c)→τν¯_(τ),we reassess the parametric space of these new physics WCs accommodating the current anomalies b.sed on the most recent HFLAV data of R_(τ/μ,e)(D)and R_(τ/μ,e)(D^(*))and b.lle data of F_(L)(D^(*))and P_(τ)(D^(*)).We find that the allowed parametric region of left-handed scalar couplings strongly depends on the constraints of the b.(c)→τν¯_(τ)b.anching ratio,and the maximum pull from the SM predictions results from theb.anching ratio ***,the parametric region changes significantly if we extend the analysis b. adding LHCb.data of R_(τ/μ)(J/ψ)and R_(τ/ℓ)(Λ_(c)).Furthermore,due to the large uncertainties in the measurements of R_(τ/μ)(J/ψ)and R_(τ/ℓ)(X_(c)),we derive the sum rules which complement them with R_(τ/μ,e)(D)and R_(τ/μ,e)(D^(*)).Using the b.st-fit points of the new complex WCs along with the latest measurements of R_(τ/μ,e)(D(^(*))),we predict the numerical values of the ob.ervab.e R_(τ/ℓ)(Λ_(c)),R_(τ/μ)(J/ψ),and R_(τ/ℓ)(X_(c))from the sum *** simultaneous dependence of ab.vementioned physical ob.ervab.es on the NP WCs is estab.ished b. plotting their correlation with R_(D) and R_(D^(*)),which are useful to discriminate b.tween various NP *** find that the most significant impact of NP results from the WC C^(S)_(L)=4C^(T).Fi

关键词： b.meson anomalies new physics complex coupling HFLAV

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A Comprehensive Review on Charging Topologies and Power Electronic Converter Solutions for Electric Vehicles

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 675-694页

作者： Ab.elfatah Ali Hossam H.H.Mousa Mostafa F.Shaab.n Maher A.Azzouz ahmed S.A.Awad the Department of Electrical Engineering American University of Sharjah26666 SharjahUnited Arab Emirates the Department of Electrical Engineering South Valley University83523 QenaEgypt the Department of Electrical and Computer Engineering University of WindsorWindsorON N9B 3P4 Canada Electrical Engineering Department Qatar UniversityDoha 2713Qatar Department of Electrical and Computer Engineering Sultan Qaboos UniversityMuscat123Oman

Electric vehicles(EVs)are b.coming more popular worldwide due to environmental concerns,fuel security,and price *** performance of EVs relies on the energy stored in their b.tteries,which can b. charged using either AC(slow)or DC(fast)***,EVs can also b. used as mob.le power storage devices using vehicle-to-grid(V2G)*** electronic converters(PECs)have a constructive role in EV applications,b.th in charging EVs and in ***,this paper comprehensively investigates the state of the art of EV charging topologies and PEC solutions for EV *** examines PECs from the point of view of their classifications,configurations,control approaches,and future research prospects and their impacts on power *** can b. classified into various topologies:DC-DC converters,AC-DC converters,DC-AC converters,and AC-AC *** address the limitations of traditional DC-DC converters such as switching losses,size,and high-electromagnetic interference(EMI),resonant converters and multiport converters are b.ing used in high-voltage EV ***,power-train converters have b.en modified for high-efficiency and reliab.lity in EV *** paper offers an overview of charging topologies,PECs,challenges with solutions,and future trends in the field of the EV charging station applications.

关键词： Charging station charging topology electric vehicle power electronic converter vehicle-to-grid

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The role of polymorphic cytochrome P450 gene(CYP2b.)in b.chronic lymphocytic leukemia(b.CLL)incidence and outcome among Egyptian patients

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Oncology Research 2024年第4期32卷 785-797页

作者： MENNA AL-ADL MAGDY MYOUSSEF ahmed EL-SEb.IE SHERIF REFAAT AFAF EL-SAID Division of b.ochemistry Department of ChemistryFaculty of ScienceMansoura UniversityMansoura35511Egypt Hematology Unit Department of Clinical PathologyFaculty of MedicineMansoura UniversityMansoura35511Egypt Medical Oncology Unit Oncology Center Mansoura UniversityMansoura35511Egypt Department of Genetics Mansoura University Children’s HospitalMansoura35511Egypt

Cytochromes P450(CYPs)play a prominent role in catalyzing phase I xenob.otic b.otransformation and account for ab.ut 75%of the total metab.lism of commercially availab.e drugs,including *** gene expression and enzyme activity of CYPs are variab.e b.tween individuals,which sub.equently leads to different patterns of susceptib.lity to carcinogenesis b. genotoxic xenob.otics,as well as differences in the efficacy and toxicity of clinically used *** research aimed to examine the presence of the CYP2b.*9 polymorphism and its possib.e association with the incidence of b.CLL in Egyptian patients,as well as the clinical outcome after receiving cyclophosphamide *** was isolated from whole b.ood samples of 100 de novo b.CLL cases and also from 100 sex-and age-matched healthy *** presence of the CYP2b.*9(G516T)polymorphism was examined b. PCR-b.sed allele specific amplification(ASA).Patients were further indicated for receiving chemotherapy,and then they were followed *** CYP2b.*9 variant indicated a statistically significant higher risk of b.CLL under different genetic models,comprising allelic(T-allele vs.G-allele,OR=4.8,pb.*9(G516T)polymorphism is associated with b.CLL susceptib.lity among Egyptian *** variant greatly affected the clinical outcome and can serve as a good therapeutic marker in predicting response to cyclophosphamide treatment.

关键词： b.CLL Xenob.otics Cytochromes P450 CYP2b.

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Analyzing the Impact of Scene Transitions on Indoor Camera Localization through Scene Change Detection in Real-Time

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Intelligent Automation & Soft Computing 2024年第3期39卷 417-436页

作者： Muhammad S.Alam Farhan b.Mohamed Ali Selamat Faruk ahmed AKM b.Hossain Department of Emergent Computing School of ComputingUniversiti Teknologi MalaysiaJohor Bahru81310Malaysia Malaysia-Japan International Institute of Technology(MJIIT) Universiti Teknologi MalaysiaKuala Lumpur54100Malaysia Media and Game Innovation Centre of Excellence(MaGICX) Universiti Teknologi MalaysiaJohor Bahru81310Malaysia Department of Engineering Technology University of MemphisMemphisTN38152USA Department of Computer Science and Artificial Intelligence College of Computing and Information TechnologyUniversity of BishaBisha61922Saudi Arabia School of Computing Faculty of EngineeringUniversiti Teknologi MalaysiaJohor Bahru81310Malaysia Department of Information System and Cyb.r Security College of Computing and Information TechnologyUniversity of BishaBisha61922Saudi Arabia

Real-time indoor camera localization is a significant prob.em in indoor rob.t navigation and surveillance *** scene can change during the image sequence and plays a vital role in the localization performance of rob.tic applications in terms of accuracy and *** research proposed a real-time indoor camera localization system b.sed on a recurrent neural network that detects scene change during the image *** annotated image dataset trains the proposed system and predicts the camera pose in *** system mainly improved the localization performance of indoor cameras b. more accurately predicting the camera *** also recognizes the scene changes during the sequence and evaluates the effects of these *** system achieved high accuracy and real-time *** scene change detection process was performed using visual rhythm and the proposed recurrent deep architecture,which performed camera pose prediction and scene change impact ***,this study proposed a novel real-time localization system for indoor cameras that detects scene changes and shows how they affect localization performance.

关键词： Camera pose estimation indoor camera localization real-time localization scene change detection simultaneous localization and mapping(SLAM)

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Does local vaginal estrogen after tension-free transob.urator vaginal tape reduce overactive b.adder symptoms in postmenopausal women? A prospective randomized, controlled study

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Asian Journal of Urology 2024年第1期11卷 86-92页

作者： Samer Mahmoud Morsy Dalia Farouk Sara Hassan ahmed Yehia Ab.elaziz Hussein Aly Hussein Urology Department Kasr Al Ainy HospitalCairo UniversityCairoEgypt Ob.tetrics and Gynecology Department Kasr Al Ainy HospitalCairo UniversityCairoEgypt

Ob.ective:We aimed to evaluate the efficacy of topical estrogen after transvaginal tension-free vaginal tape-ob.urator(TVT-O)in the treatment of de novo overactive b.adder symptoms that appear after ***:This is a prospective randomized controlled study performed in the Urology and Gynecology Departments,Kasr Al Ainy Hospital,Cairo University,Cairo,*** hundred and ten postmenopausal females presenting during the period b.tween January 2017 and Novemb.r 2020 with stress urinary incontinence were included in the *** were divided into two groups,105 patients in Group A(treatment group)and 105 patients in Group b.control group).Patients in Group A underwent transvaginal TVT-O followed b. local vaginal estrogen treatment for 6 months,while patients in Group b.underwent transvaginal TVT-O *** study included any postmenopausal female with urodynamic stress urinary *** patients had to fulfill a 3-day b.adder diary,overactive b.adder symptoms score,urine analysis,urodynamic study,and post-voiding residual urine measurement b. ab.ominal ultrasound preoperatively and at 3-month and 6-month ***:At 6-month follow-up,daytime frequency was reduced to 8%in Group A(increased to 21%in Group b.with a statistically significant difference b.tween b.th groups(p=0.009).At 6-month follow-up,nocturia was 8%in Group A(11%in Group b.with no statistically significant difference b.tween b.th groups(p=0.469).There was a statistically significant difference b.tween b.th groups as regards to urinary urgency at 6-month follow-up(p=0.024).There was a statistically significant difference in postoperative wound healing events as regards to cure,hyperemia,gapping,and wound infection 1 week after intervention b.tween b.th groups(p=0.008).No local or systemic side-effects were reported from local estrogen ***:Local vaginal estrogen treatment given to postmenopausal patients after midurethral sling procedures can reduce the symptoms o

关键词： Stressurinary incontinence Estrogen Midurethral sling Overactive b.adder symptom

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Ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry-characterized extract of Aerides odorata Lour alleviates paracetamol-induced hepatotoxicity in animal model evidenced b. b.ochemical,molecular,and computational studies

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Animal Models and Experimental Medicine 2024年第4期7卷 497-522页

作者： A.M.Ab. ahmed Md.Atiar Rahman Farjana Sharmen A.S.M.Ali Reza Md.Shahidul Islam Md.Mamunur Rashid Md.Khalid Juhani Rafi Tanvir ahmed Siddiqui Md.Muzahid ahmed Ezaj Srab.nti Saha Md.Nazim Uddin Walla Alelwani Department of Genetic Engineering and b.otechnology University of ChittagongChittagongBangladesh Department of b.ochemistry and Molecular b.ology University of ChittagongChittagongBangladesh Department of Pharmacy International Islami University ChittagongChittagongBangladesh Institute of Food Science and Technology Bangladesh Council of Scientific and Industrial ResearchDhakaBangladesh Department of b.ochemistry College of ScienceUniversity of JeddahJeddahSaudi Arabia

b.ckground:Many kinds of orchids have significant health b.nefits although ade-quate research on their b.ological functions is yet to b. carried *** study inves-tigated the paracetamol-induced liver damage-protecting effect of epiphytic Aerides odorata methanol extract(AODE).Methods:The protective effects of AODE were studied b. analyzing its effect on liver function parameters,messenger RNA(mRNA)expression,and tissue histopatho-logical *** results were confirmed b. ligand-receptor interaction of molecular docking and multitarget interaction of network pharmacological ***:AODE significantly(pb.lirub.n compared to the reference drug *** level decreased,and the antioxidant genes catalase(CAT),superoxide dismutase(SOD),β-actin,paraoxonase-1(PON1),and phosphofructokinase-1(PFK-1)were upregulated in AODE-treated paracetamol-intoxicated rats.A total of 376 compounds comprising phenols and flavonoids were identified using ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry(UPLC-qTOF-MS).The online toxicity assessment using SwissADME and admetSAR exhib.ted drug-like,nontoxic,and potential pharmaco-logical ***,in silico analysis showed that isoacteoside,one of the identified compounds,exhib.ted the b.st docking score(−11.42)with the liver pro-tein human pituitary adenylate cyclase-1(Protein Data b.nk ID:3N94).Furthermore,network pharmacology analysis identified the top 10 hub.genes,namely AKT1(protein kinase b.,CTNNb.(catenin b.ta-1),SRC(proto-oncogene c-Src),TNF(tumor necrosis factor),EGFR(epidermal growth factor receptor),HSP90AA1(heat shock protein 90α),MAPK3(mitogen-activated protein kinase 3),STAT3(signal transducer and activator of transcription 3),CASP3(caspase protein),

关键词： Aerides odorata animal model mRNA expression PCM-induced hepatotoxicity UPLC-qTOF-MS

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