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Impact of biliary complications on quality of life in live-donor liver transplant recipients

World Journal of Hepatology 2021年第10期13卷 1405-1416页

作者： Reginia Nabil Guirguis Ehab Hasan Nashaat Azza Emam Yassin Wesam ahmed Ibrahim Shereen A saleh Mohamed Bahaa Mahmoud El-Meteini Mohamed Fathy Hany Mansour Dabbous Iman Fawzy Montasser Manar Salah Ghada Abdelrahman Mohamed Department of Internal Medicine Gastroenterology and Hepatology UnitFaculty of MedicineAin Shams UniversityCairo 11591Egypt Department of General Surgery Faculty of MedicineAin Shams UniversityCairo 11591Egypt Department of Tropical Medicine Faculty of MedicineAin Shams UniversityCairo 11591Egypt

BACKGROUND Despite significant advancements in liver transplantation(LT)surgical procedures and perioperative care,post-LT biliary complications(BCs)remain a significant source of morbidity,mortality,and graft *** addition,data are conflicting regarding the health-related quality of life(HRQoL)of LT ***,the success of LT should be considered in terms of both the survival and recovery of *** To assess the impact of BCs on the HRQoL of live-donor LT recipients(LDLT-Rs).METHODS We retrospectively analysed data for 25 LDLT-Rs who developed BCs post-LT between January 2011 and December 2016 at our *** Short Form 12 version 2(SF 12v2)health survey was used to assess their *** also included 25 LDLT-Rs without any post-LT complications as a control *** The scores for HRQoL of LDLT-Rs who developed BCs were significantly higher than the norm-based scores in the domains of physical functioning(P=0.003),role-physical(P<0.001),bodily pain(P=0.003),general health(P=0.004),social functioning(P=0.005),role-emotional(P<0.001),and mental health(P<0.001).No significant difference between the two groups regarding vitality was detected(P=1.000).The LDLT-Rs with BCs had significantly lower scores than LDLT-Rs without BCs in all HRQoL domains(P<0.001)and the mental(P<0.001)and physical(P=0.0002)component summary *** The development of BCs in LDLT-Rs causes a lower range of improvement in HRQoL.

关键词： Live-donor liver transplantation Quality of life The Short Form 12 version 2 Cirrhosis Biliary complications Mental health

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Topical Application of Ascorbic Acid Solution as an Adjunctive Method of Periodontal Therapy among Wet Snuff Users after Prosthodontics Therapy

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Open Journal of Stomatology 2021年第3期11卷 119-132页

作者： Mohammed M. A. Abdullah Al-Abdaly Ali saleh Alghamdi Ahmad Hassan Alshehri Faris ahmed Abdullah Al Nasser Periodontics and Community Dental Sciences Department College of Dentistry King Khalid University Abha Saudi Arabia Ministry of Health King Khalid Hospital Alkhaldiyah Primary Health Care Center Tabuk Saudi Arabia Ministry of Health Al Qahmah Hospital Asir Saudi Arabia Ministry of Health Mnshabah Primary Health Care Center Jazan Saudi Arabia

Background: During several years, ascorbic acid (vitamin C) played a significant role in the health of periodontal tissues. The goals of prosthodontics management are to restore the missing teeth, provide the loss of teeth functions, and establish acceptable dental esthetics, and there are some evidences revealing the passive effects of snuff on the results of prosthodontics and periodontal treatment, so the present study is performed to evaluate the outcomes of topical application of ascorbic acid solution as an adjunctive method of periodontal therapy among wet sniff users after prosthodontics therapy. Methods: The clinical situation was evaluated in 150 moderate periodontitis patients after conventional periodontal and prosthodontics therapy. They were selected from outpatient clinics, college of dentistry, King Khalid University, and from some hospitals Ministry of Health in Tabuk, Jazan and Aseer regions. The study was conducted from September 2020 to December 2020. The time of post-treatment assessment was one year. The study was included 50 patients who don

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Prevalence and Predictors of Viral Hepatitis D Co-Infection in Chronic HbsAg Carriers

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Open Journal of Gastroenterology 2022年第9期12卷 213-220页

作者： Ali Mahamat Moussa Tahir Mahamat saleh Mayanna Habkreo Bessimbaye Nadlaou Adama ahmed Ngare Doffou Adjeka Stanislas Assi Constant Service de Medecine Interne & Gastroentérologie CHU La Référence Nationale N’Djamena Tchad Service de Medecine Interne CHU La Renaissance N’Djamena Tchad Service de Laboratoire CHU La Référence Nationale N’Djamena Tchad

The characteristics of viral hepatitis B and D co-infection are poorly documented in Chad. The aim of our study was to determine the prevalence of HBV/HDV co-infection and the characteristics of this co-infection. Materials and Methods: This was a retrospective study including all patients with chronic HBsAg carriers referred in our department from January 2014 to December 2018. Non-inclusion criteria were: absence of anti-HDV testing, presence of anti-viral hepatitis C or Human Immunodeficiency Virus antibodies or excessive alcohol consumption. The variables studied were age, sex, blood transaminase level, HBV DNA level, HDV RNA level, and liver fibrosis and activity score (Actitest Fibrotest). The prevalence of HDV and the characteristics of HDV/HBV co-infection were determined. Results: During the study period, 403 patients were seen in these two hospitals for chronic HBsAg carriage. Of these, 378 (75%) had performed the anti HDV assay. Anti-HDV antibodies were positive in 53 patients (14%). In multivariate analysis, HBV/HDV co-infected patients were less frequently HBeAg positive (5.4% vs. 28.1%;p = 0.0001), older (35 years vs. 32 years;p = 0.001), and more frequently had significant necrotic-inflammatory activity (3.9% vs. 3.2%;p = 0.031) compared with mono infected patients. Neither gender (76.9% male vs. 77.4% male;p = ns), nor viral load (median 530 IU/ml vs. 195 IU/ml;p = ns), nor significant liver fibrosis (35.1% vs. 47.1%;p = ns), nor transaminases (median 26 vs. 32 IU/ml) were different with mono infected patients. Conclusion: VHD is common in Chad. It is associated with increased hepatic necrotic-inflammatory activity.

关键词： Viral Hepatitis D (Anti VHD Ac) Prevalence Favouring Factors Necrotic-Inflammatory Activity Chad

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Smart Building Design to Improve the Energy Consumption at an Office Room

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Smart Grid and Renewable Energy 2022年第9期13卷 209-221页

作者： saleh Babaa Abdul Aziz Al Rawahi Angala Subramanian Abdullah Humaid Alshibli Shahid Khan Martin Khzouz Muneer ahmed Ibrahim Ashrafi Systems Engineering Department Military Technological College (Affiliated with University of Portsmouth UK) Muscat Oman

Buildings are becoming smarter as a result of a variety of advanced technologies that enable energy management, optimal space utilization, and smart surveillance for safety, among other things. Energy-efficient smart building ideas and execution are of great interest and top priority due to the building’s occupants’ misused and high-power consumption. This paper addresses the design and execution of an energy management system that includes a solar power system for generating power for the building’s needs and a PIR-based automation system for efficient power use. This project was carried out at the Military Technological College (MTC) in Muscat, in the system engineering department’s offices. This project seeks to generate power for the building’s energy needs using solar photovoltaic panels and reduce energy consumption within the office using a PIR-based automation system. The results demonstrate that after the breakeven point (the time it takes to recoup the initial investment), it can provide power to the building for another 17 years. The calculations and practical results presented in this study approve that the system is extremely helpful.

关键词： Smart Building Design Energy Consumption Solar Power Passive Infra Red Sensor

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Biliary complications in recipients of living donor liver transplantation:A single-centre study

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World Journal of Hepatology 2021年第12期13卷 2081-2103页

作者： Reginia Nabil Guirguis Ehab Hasan Nashaat Azza Emam Yassin Wesam ahmed Ibrahim Shereen A saleh Mohamed Bahaa Mahmoud El-Meteini Mohamed Fathy Hany Mansour Dabbous Iman Fawzy Montasser Manar Salah Ghada Abdelrahman Mohamed Gastroenterology and Hepatology Unit Department of Internal MedicineFaculty of MedicineAin Shams UniversityCairo 11591Egypt Department of General Surgery Faculty of MedicineAin Shams UniversityCairo 11591Egypt Department of Tropical Medicine Faculty of MedicineAin Shams UniversityCairo 11591Egypt

BACKGROUND Biliary complications(BCs)after liver transplantation(LT)remain a considerable cause of morbidity,mortality,increased cost,and graft *** To investigate the impact of BCs on chronic graft rejection,graft failure and *** From 2011 to 2016,215 adult recipients underwent right-lobe living-donor liver transplantation(RT-LDLT)at our *** excluded 46 recipients who met the exclusion criteria,and 169 recipients were included in the final ***’and recipients’demographic data,clinical data,operative details and postoperative course information were *** also reviewed the management and outcomes of *** were followed for at least 12 mo post-LT until December 2017 or graft or patient *** The overall incidence rate of BCs including biliary leakage,biliary infection and biliary stricture was 57.4%.Twenty-seven(16%)patients experienced chronic graft *** failure developed in 20(11.8%)patients.A total of 28(16.6%)deaths occurred during *** were a risk factor for the occurrence of chronic graft rejection and failure;however,mortality was determined by recurrent hepatitis C virus *** Biliary complications after RT-LDLT represent an independent risk factor for chronic graft rejection and graft failure;nonetheless,effective management of these complications can improve patient and graft survival.

关键词： Biliary complications Living donor liver transplantation Retrospective analysis Bile leak Biliary stricture Risk factors Mortality Graft rejection

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Immune microenvironment of medulloblastoma:The association between its molecular subgroups and potential targeted immunotherapeutic receptors

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World Journal of Clinical Oncology 2023年第3期14卷 117-130页

作者： Maher Kurdi Nasser Mulla Husam Malibary ahmed K Bamaga Motaz M Fadul Eyad Faizo Sahar Hakamy saleh Baeesa Department of Pathology Faculty of MedicineKing Abdulaziz UniversityRabigh 213733Saudi Arabia Neuromuscular Unit King Fahad Medical Research CenterKing Abdulaziz UniversityJeddah 213733Saudi Arabia Department of Internal Medicine Faculty of MedicineTaibah UniversityMedina 213733Saudi Arabia Department of Internal Medicine Faculty of MedicineKing Abdulaziz UniversityJeddah 213733Saudi Arabia Department of Paediatrics Faculty of MedicineKing Abdulaziz UniversityJeddah 213733Saudi Arabia Division of Neurosurgery Department of SurgeryFaculty of MedicineTabuk UniversityTabuk 213733Saudi Arabia Neurmuscular Unit Center of Excellence of Genomic MedicineJeddah 21423Saudi Arabia Department of Neuroscience King Faisal Specialist Hospital and Research CenterJeddahSaudi Arabia

Medulloblastoma(MB)is considered the commonest malignant brain tumor in *** treatments consisting of surgery,radiation,and chemotherapy have improved patients’***,the recurrence occurs in 30%of *** persistent mortality rates,the failure of current therapies to extend life expectancy,and the serious complications of non-targeted cytotoxic treatment indicate the need for more refined therapeutic *** MBs originating from the neurons of external granular layer line the outer surface of neocerebellum and responsible for the afferent and efferent ***,MBs have been segregated into four molecular subgroups:Wingless-activated(WNT-MB)(Group 1);Sonichedgehog-activated(SHH-MB)(Group 2);Group 3 and 4 *** molecular alterations follow specific gene mutations and disease-risk *** current treatment protocols and ongoing clinical trials against these molecular subgroups are still using common chemotherapeutic agents by which their efficacy have improved the progression-free survival but did not change the overall ***,the need to explore new therapies targeting specific receptors in MB microenvironment became *** immune microenvironment of MBs consists of distinctive cellular heterogeneities including immune cells and none-immune *** associate macrophage and tumour infiltrating lymphocyte are considered the main principal cells in tumour microenvironment,and their role are still under *** this review,we discuss the mechanism of interaction between MB cells and immune cells in the microenvironment,with an overview of the recent investigations and clinical trials.

关键词： Medulloblastoma Tumour microenvironment Tumour associated macrophages Tumour infiltrating lymphocyte Immunotherapies

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TQM in Higher Education:A Search for New Insight

TQM in Higher Education:A Search for New Insight

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作者： Abu saleh Md.Sohel-Uz-Zaman ahmed Imran Kabir Abu Rashed Osman School of Business and Economics United International University

The number of higher education institutions,particularly universities,both public and private,has been enormously increased in *** the significant growth in number,there is an increasing concern for quality education in these higher education *** order to address this concern,a number of scholars believe that Total Quality Management（TQM） can be an effective ***,there is a doubt to the extent to which it（TQM） will be applicable in higher education as it was originally developed for the manufacturing *** due course of evolution,TQM is now a well-accepted philosophy in service *** education is within the service sector,therefore,it can be assumed that it could play a vital role in assuring quality in higher *** prime objective of this paper is to assess the potentials of TQM in improving and assuring quality in higher education and to develop general guidelines by highlighting key issues for quality *** and information for this qualitative paper have been collected through literature search,policy document analysis,expert interview,and personal *** is expected that the findings of this study would be able to offer a thoughtful insight regarding the applicability of TQM in higher education in a developing country context like Bangladesh.

关键词： Total quality management Higher education Quality assurance

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The Patterns of Blood Groups and Its Association with Blood Donation in Saudi Arabia

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Open Journal of Preventive Medicine 2018年第9期8卷 291-300页

作者： Fahad A. Alateeq Thamer Z. Aldugieman Yousef Duhaim A. Al-Rashdi Abdul Rahman Ali A. Alsogair saleh Hadi Alharbi Ibrahim Bin ahmed Hussain Gadelkarim ahmed Faculty of Medicine Al Imam Mohammad Ibn Saud Islamic University Riyadh Kingdom of Saudi Arabia (KSA) College of Medicine University of Hail Hail Kingdom of Saudi Arabia (KSA)

Background: Blood groups system has key importance for transfusion safety and clinical practice. Therefore, the objective of the present study was to evaluate the distribution of ABO blood groups and its association with blood donation in Saudi Arabia. Methodology: In this study, we collected information regarding blood donation from 715 Saudi volunteers living in the city of Hail, Northern Saudi Arabia. Data about blood donation were obtained from 715 Saudi volunteers living in the city of Hail. Results: The majority of the study population was found with group B+ representing 174 participants, followed by A+, O+, AB+, B-ve, A-ve, AB-ve and O-ve, representing 165, 153, 47, 29, 20, 9, and 7 participants, in this order. Conclusion: The major blood group among Saudi population is group B+ followed by group A+ and O+. Individuals with rare blood groups were less likely to participate in blood donation programs, which necessitate the need for educational programs using motivating factors.

关键词： Blood Donation Donors Saudi Arabia Voluntary Donation ABO Group

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The Relevant Roles of Plastic and Orthopedic Surgery in Hand Salvage

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Modern Plastic Surgery 2018年第2期8卷 29-43页

作者： Bassam ahmed Almutlaq Mohammad M. Al-Qattan Majid Zannon Alturkstani Rakan Fraih Almuazzi Abdulkarim saleh Alkhateeb Ayman Talla Talla Muqbil Sayer Alshammari Hussain Gadelkarim ahmed College of Medicine University of Hail Hail KSA Division of Plastic Surgery Head of Research Centre College of Medicine King Saud University Riyadh KSA Batterjee Medical College Jeddah Saudi Arabia

Over the recent past few years, there is a huge innovation in plastic surgery and orthopedic surgery through implantation of new techniques, which enabled a great level of success in hand salvage. Conditions such as trauma, tumor, sepsis, or vascular disease, may necessitate hand salvage. The most frequent argument among surgeon from different subspecialties (orthopedics, plastics, trauma, and vascular surgery) are characterized by in what way each one can do his own part of the salvage operation, be it bony fixation, revascularization, or soft-tissue coverage, but none of them is sure whether it should be endeavored. What is necessary in such clinical situations is an interdisciplinary team attitude led by individual or groups of clinicians who are conversant not only with their identifiable subspecialized skills but also with those of their coworkers and the consequences accompanying the joined efforts at hand salvage. The perception of orthoplastic surgery is based on such an indication, where the integrated skills and techniques of the orthopedic surgeon and reconstructive microsurgeon are performed in recital to direct efforts concerning hand salvage or choose against it when it is not designated. The current article reviews the roles of orthopedic and plastic surgery and how this team can deal with the existing techniques to improve outcomes in hand salvage surgery.

关键词： Hand Salvage Plastic Surgery Orthopedic Surgery Hand Transplantation Prosthetic Fitting

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Neurocysticercosis:A case report and brief review

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Asian Pacific Journal of Tropical Medicine 2016年第1期9卷 98-100页

作者： Syed A.A.Rizvi Ayman M.saleh Hanns Frimpong Hussain M.Al Mohiy Jasmin ahmed Ronda D.Edwards Sultan S.ahmed College of Pharmacy Nora Southeastern University JAS Medical Management LLC Department of Basic Medical Sciences College of MedicineKing Saud Bin Abdulaziz University for Health SciencesNational Guard Health Affairs Radiological Sciences Department College of Applied Medical SciencesKing Khalid University Herbert Wertheim College of Medicine Florida International University School of Medicine Spartan Health Science University

Neurocysticercosis(NCC) is one of the seven neglected endemic zoonoses targeted by the World Health *** is considered a common infection of the nervous system caused by the Tanenia solium and is known to be the primary cause of preventable epilepsy in many developing *** is commonly resulted by the ingestion of Tanenia solium eggs after consuming undercooked pork,or contaminated *** parasite can grow in the brain and spinal cord within the nervous system,causing severe headache and seizures beside other pathological *** and international travel to endemic countries has made this disease common in the United *** can be diagnosed with computed tomography and magnetic resonance imaging of the *** treatment of the NCC including cysticidal drugs(eg.,albendazole and praziquantel),and neurosurgical procedure,depending upon a the situation.A patient of Asian origin came to our clinic with complaints of dizziness,headaches and episodes seizures for the past twelve years without proper *** computed tomography and magnetic resonance imaging scans indicated multilobulated cystic mass in the brain with the suspicion of neurocysticercosis.

关键词： Neurocysticercosis Tanenia solium Epilepsy Magnetic resonance imaging Computed Tomography

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