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Rumex dentatus could be a potent alternative to treatment of microbial infections and of breast cancer

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Journal of Traditional Chinese Medicine 2019年第6期39卷 772-779页

作者： Riffat Batool Ejaz Aziz Hina salahuddin Javed Iqbal Saira Tabassum tariq Mahmood University Institute of Biochemistry and Biotechnology Pir Mehr Ali Shah Arid Agriculture University RawalpindiRawalpindiPunjab 46000Pakistan Department of Botany Government Degree College KhanpurHaripur 22650Pakistan Department of Zoology University of OkaraOkara 56300Pakistan National University of Technology School of Applied Sciences and HumanitiesNational University of TechnologyIslamabad 42000Pakistan Department of Plant Sciences Faculty of Biological SciencesQuaid-i-Azam UniversityIslamabad 45320Pakistan

OBJECTIVE:To investigate the phytochemicals and in vitro antioxidant,antimicrobial and cytotoxic potential of Rumex dentatus(***)leaf ***:The total phenolics and flavonoids content of *** extracts were evaluated by the Folin-Ciocalteu and aluminum chloride colorimetric methods *** potential of studied plant extracts was assessed through 2,2-diphenyl-1-picrylhydrazyl radical scavenging capacity,total reducing power and total antioxidant ***,antibacterial and antifungal capacity was also evaluated by disc diffusion method against six clinically isolated multi-drug resistant bacterial strains as well as six fungal ***,cell cytotoxicity was also evaluated through3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide ***:Ethanol extract showed highest total phenolic[(38.9±1.5)μg gallic acid equivalent/mg]and total flavonoids[(17.2±1.9)μg quercetin equivalent/mg]*** assays indicated that ethanol and methanol extracts possess potent antioxidant ***,it was observed that ethanol and hexane extracts have the potential to inhibit most of the tested multi-drug resistant bacterial strains while methanol,chloroform and hexane extracts could inhibit the growth of pathogenic fungal strains *** all the studied extracts,ethanolic extract showed highest cytotoxicity against MCF-7 cell line then Hep-2 and DU-145 cell lines by MTT assay with lowest IC50 of 47.3μg/m ***:These results suggest that *** could be a potent alternative candidate for treatment of microbial infections and for breast cancer treatment.

关键词： Rumex Atioxidants Anti-infective agents Drug resistant,multiple Cytotoxins

A system of general nonlinear variational inclusions in Banach spaces

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Applied Mathematics and Mechanics(English Edition) 2015年第12期36卷 1663-1672页

作者： Xieping DING salahuddin College of Mathematics and Software Science Sichuan Normal University Department of Mathematics Jazan University

A new system of general nonlinear variational inclusions is introduced and studied in Banach spaces. An iterative algorithm is developed and analyzed by use of the resolvent operator techniques to find the approximate solutions of the system of general nonlinear variational inclusions involving different nonlinear operators in uniformly smooth Banach spaces.

关键词： system of general nonlinear variational inclusions strongly accretive mapping relaxed accretive mapping resolvent operator uniformly smooth Banach space

In vitro antioxidant and anti-cancer activities and phytochemical analysis of Commelina benghalensis L. root extracts

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Asian Pacific Journal of Tropical Biomedicine 2020年第9期10卷 417-425页

作者： Riffat Batool Ejaz Aziz Javed Iqbal Hina salahuddin Benny Kwong-Huat Tan Saira Tabassum tariq Mahmood University Institute of Biochemistry and Biotechnology PMAS-UAAR RawalpindiPakistan Department of Botany GDC KhanpurHaripur Pakistan Department of Plant Sciences Faculty of Biological SciencesQuaid-i-Azam UniversityIslamabad-45320Pakistan Department of Zoology University of OkaraOkaraPakistan Department of Pharmacology Yong Loo Lin School of MedicineNational University of SingaporeSingapore Department of Biotechnology Faculty of Biological SciencesQuaid-i-Azam UniversityIslamabad-45320Pakistan

Objective:To explore antioxidant potential,anti-cancer activity,and phytochemicals of Commelina benghalensis ***:The roots of Commelina benghalensis were extracted in different solvents(methanol,ethanol,benzene,chloroform,n-hexane)with a range of *** activity was evaluated by reducing power assay,DPPH radical scavenging activity and phosphomolybdenum method,cytotoxicity by MTT assay,apoptotic and cell cycle analysis by flow cytometry,migratory and invasive potential by wound scratch assay and invasion assay,respectively,functional groups analysis by FT-IR spectroscopy and phytochemicals by aluminum chloride colorimetric and FolinCiocalteu ***:The extracts showed worthy antioxidant *** chloroform extract demonstrated the most significant cytotoxic effect on MDA-MB-231(breast cancer)cell line,induced apoptosis and reduced migratory and invasive potential of MDA-MB-231 *** and ethanol extracts presented good yield of total phenolic and total flavonoid *** FTIR spectroscopic studies revealed different characteristic peak values with various functional compounds such as alkenes,alkanes,aliphatic amines,aromatics,alkyl halides,carboxylic acid,alcohols,ester,aldehydes and ***:The results demonstrate the potential use of Commelina benghalensis as a good antioxidant with significant anticancer effect.

关键词： Commelina benghalensis Anti-cancer Antioxidant FT-IR

Influence of site conditions on seismic design parameters for foundations as determined via nonlinear site response analysis

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Frontiers of Structural and Civil Engineering 2021年第1期15卷 275-303页

作者： Muhammad tariq A.CHAUDHARY Civil Engineering Department Kuwait UniversityKhalidya 13060Kuwait

Site conditions,including geotechnical properties and the geological setting,influence the near-surface response of strata subjected to seismic *** geotechnical parameters required for the design of foundations include mass density(ρ),damping ratio(β_(s)),shear wave velocity(V_(s)),and soil shear modulus(G_(s)).The values of the last three parameters are sensitive to the level of nonlinear strain induced in the strata due to seismic ground *** this study,the effect of variations in soil properties,such as plasticity index(PI),effective stress(σ′),over consolidation ratio(OCR),impedance contrast ratio(ICR)between the bedrock and the overlying strata,and depth of soil strata over bedrock(H),on seismic design parameters(β_(s),V_(s),and G_(s))was investigated for National Earthquake Hazards Reduction Program(NEHRP)site classes C and D,through 1D nonlinear seismic site response *** Morris one-at-a-time(OAT)sensitivity analysis indicated thatβ_(s),V_(s),and G_(s)were significantly influenced by variations in PI,while ICR affectedβ_(s)more than it affected V_(s)and G_(s).However,the influence of H on these parameters was less *** was also found that variations in soil properties influenced seismic design parameters in soil type D more significantly than in soil type *** relationships forβ_(s),V_(s),and G_(s)were derived based on the 1D seismic site response analysis and sensitivity analysis ***β_(s),V_(s),and G_(s)values obtained from the analysis were compared with the corresponding values in NEHRP to determine the similarities and differences between the two sets of *** need to incorporate PI and ICR in the metrics for determiningβ_(s),V_(s),and G_(s)for the seismic design of foundations was highlighted.

关键词： site effects 1D seismic site response analysis sensitivity analysis foundations shear wave velocity soil shear modulus

Microstructure,Tensile and Impact Toughness Properties of Friction Stir Welded Mild Steel

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Journal of Iron and Steel Research International 2010年第10期17卷 68-74页

作者： A K Lakshminarayanan V Balasubramanian M salahuddin Department of Manufacturing Engineering Annamalai University Clean Technology Division Ministry of Environment and Forests

Microstructure, tensile and impact toughness properties and fracture location of friction stir welded AISI 1018 mild steel were revealed. The AISI 1018 mild steel plates with thickness of 5 mm were friction stir welded by tungsten based alloy tool with tool rotational speed of 1 000 r/min and welding speed of 50 ram/rain. Tensile strength of stir zone is higher （8%） compared to that of the base metal. This may be due to the formation of finer grains in the weld nugget region under the stirring action of the rotating tool. The ductility and impact toughness of the joints are decreased compared to those of the base metal owing to the inclusion of tungsten particles in the weld region.

关键词： friction stir welding tensile property impact toughness mildsteel

Generalized Second Law of Thermodynamics in Wormhole Geometry with Logarithmic Correction

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Chinese Physics Letters 2011年第7期28卷 55-58页

作者： Faiz-ur-Rahman salahuddin M.Akbar Centre for Advanced Mathematics and Physics National University of Sciences and Technology(NUST)IslamabadPakistan

We construct various cases for validity of the generalized second law(GSL)of thermodynamics by assuming the logarithmic correction to the horizon entropy of an evolving *** is shown that the GSL is always respected fo... 详细信息

关键词： correction thermodynamics horizon

A comparison of IBC with 1997 UBC for modal response spectrum analysis in standard-occupancy buildings

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Earthquake Engineering and Engineering Vibration 2011年第1期10卷 99-113页

作者： tariq M. Nahhas Umm Al-Qura University

This paper presents a comparison of the seismic forces generated from a Modal Response Spectrum Analysis （MRSA） by applying the provisions of two building codes, the 1997 Uniform Building Code （UBC） and the 2000-2009 International Building Code （IBC）, to the most common ordinary residential buildings of standard occupancy. Considering IBC as the state of the art benchmark code, the primary concern is the safety of buildings designed using the UBC as compared to those designed using the IBC. A sample of four buildings with different layouts and heights was used for this comparison. Each of these buildings was assumed to be located at four different geographical sample locations arbitrarily selected to represent various earthquake zones on a seismic map of the USA, and was subjected to code-compliant response spectrum analyses for all sample locations and for five different soil types at each location. Response spectrum analysis was performed using the ETABS software package. For all the cases investigated, the UBC was found to be significantly more conservative than the IBC. The UBC design response spectra have higher spectral accelerations, and as a result, the response spectrum analysis provided a much higher base shear and moment in the structural members as compared to the IBC. The conclusion is that ordinary office and residential buildings designed using UBC 1997 are considered to be overdesigned, and therefore they are quite safe even according to the IBC provisions.

关键词： response spectrum analysis seismic forces multi-story buildings seismic design building codes IBC UBC

Role of macrophages and monocytes in hepatitis C virus infections

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World Journal of Gastroenterology 2014年第11期20卷 2777-2784页

作者： Dennis Revie Syed Zaki salahuddin Department of Biology California Lutheran UniversityThousand OaksCA 91360United States California Institute of Molecular Medicine VenturaCA 93003United States

A number of studies conducted over many years have shown that hepatitis C virus(HCV)can infect a variety of cell *** vivo infection of monocytes,macrophages,and dendritic cells by HCV has been frequently shown by a number of *** studies have demonstrated replication of HCV by detecting the presence of both negative genomic strands and a variety of non-structural HCV proteins in infected *** addition,analyses of genome sequences have also shown that different cell types can harbor different HCV *** have also done preliminary studies of which cellular genes are affected by HCV infection,but there have not yet been a sufficient number of these studies to understand the effects of infection on these *** of in vitro HCV replication have shown that monocytes,macrophages and dendritic cells can be infected by HCV from patient sera or *** studies suggest that entry and cellular locations may vary between different cell *** studies suggest that macrophages may preferentially allow HCV genotype 1 to replicate,but macrophages do not appear to select particular hypervariable ***,these studies agree with a model where monocytes and macrophages act as an amplification system,in which these cells are infected and show few cytopathic effects,but continuously produce *** allows them to produce virus over an extended time and allows its spread to other cell types.

关键词： Hepatitis C virus Macrophages Monocytes Dendritic cells Hepatitis C virus replication

Evaluation of line brattice length in an empty heading to improve air flow rate at the face using CFD

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International Journal of Mining Science and Technology 2017年第2期27卷 253-259页

作者： Feroze tariq Genc Bekir School of Mining Engineering University of the WitwatersrandJohannesburg 2050South Africa

The effectiveness of line brattice(LB) ventilation system depends on the associated system ***, the effect of these variables on the air flow rates close to the face of the heading is not extensively studied. In this paper, the effect of the LB length in relation to the LB-wall distance on the air flow rate reaching the face is analysed. Scenarios were developed using four LB lengths, two LB-wall distances and two heading depths. These scenarios were simulated with a validated CFD model. The air flow rates and patterns at various locations inside the heading were analysed. This helped to find the minimum LB-face distance that should be maintained for each LB-wall distance to maximise the air flow rate at the face. The minimum length when used will improve ventilation and reduce energy cost.

关键词： Coal mine ventilation Auxiliary ventilation Line brattice ventilation system Computational fluid dynamics