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Seroconversion of Hepatitis B Vaccine in Young Bangladeshi Children: A Tertiary Centre Experience

World Journal of Vaccines 2021年第2期11卷 7-18页

作者： salahuddin mahmud Jahida Gulshan Farhana Tasneem Syed Shafi Ahmed Department of Pediatric Gastroenterology Hepatology & Nutrition Bangladesh Institute of Child Health Dhaka Shishu(Children) Hospital Dhaka Bangladesh Institute of Statistical Research and Training University of Dhaka Dhaka Bangladesh Department of Pediatrics BIHS General Hospital Diabetic Association of Bangladesh Dhaka Bangladesh

Background: Hepatitis B virus (HBV) infection is one of the most important global health problems and active immunization is the single most important and effective preventive measure against HBV infection. Several studied show that HBV carrier rate is between 2% - 7% in Bangladesh. Bangladesh introduced hepatitis B vaccination in children through Expanded Program on Immunization (EPI) in 2005 that includes 3 doses which starts from six weeks after birth. Currently booster vaccination is not recommended any more. However, many studies on different countries observed a declined level of HBs-antibody over a period of 3 - 6 years that may even reach to non-protective levels. Objective: To evaluate the status of seroconversion and seroprotection along with non-responders of EPI vaccinated children against HBV and to measure their antibody levels in different age groups. Methods: A cross sectional descriptive study was done in the department of Pediatric Gastroenterology, Hepatology & Nutrition, Dhaka Shishu (Children) Hospital, Dhaka, Bangladesh on 120 cases of EPI vaccinated children enrolled from January-December 2019 while attending the inpatient department without any liver problem. The development of Anti-HBs titre greater than or equal to 10 mIU/mL is considered as protective immunity and any titre less than 10 mIU/mL as non-protective following HBV vaccination. Results: Age of the children was 1 - 12 years with mean age of 5.6 ± 1.7 years and male: female ratio was 1.1:1. Among the children, 56 (46.6%) were from 1 - 5 years age, 36 (30.1%) children from 6 - 10 years age group and 27 (23.3%) children from 11 - 12 years age group. Out of 120 children, presence of Anti-HBs protective titre was in 63 (52.5%) children and non-protective level in 57 (47.5%) children. Among protective level, 34 (60.7%) children were in 1 - 5 years age group, 18 (50.0%) children in 6 - 10 years age group and 11 (39.3%) c

关键词： Hepatitis B Virus Expanded Program on Immunization Immune Response Antibody Titre

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孟加拉国之变

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财新周刊 2024年第32期 12-13页

作者： Kazi salahuddin Razu(图) 视觉中国

当地时间2024年8月5日孟加拉国首都达卡,抗议者爬上“国父”谢赫·穆吉布·拉赫曼雕像,庆祝总理谢赫,哈西娜辞职。现年76岁的哈西娜是谢赫穆吉布。拉赫曼的长女,已经在该国持续掌政15年,今年1月才刚开启第五个总理任期,在孟加拉国因一... 详细信息

当地时间2024年8月5日孟加拉国首都达卡,抗议者爬上“国父”谢赫·穆吉布·拉赫曼雕像,庆祝总理谢赫,哈西娜辞职。现年76岁的哈西娜是谢赫穆吉布。拉赫曼的长女,已经在该国持续掌政15年,今年1月才刚开启第五个总理任期,在孟加拉国因一项争议性公务员配额制度点燃的群众抗议活动持续发酵了一个多月后一哈西娜在凶涌民意中仓促辞职下台流亡国外。随后,孟加拉国军方迅速介入肩势,宣布将成立临时政府接管政权。

关键词：抗议活动临时政府谢赫拉赫曼流亡国外配额制度孟加拉国公务员

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Efﬁciency and safety of sofosbuvir in Bangladeshi children with chronic hepatitis C virus

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iLIVER 2023年第3期2卷 146-150页

作者： salahuddin mahmud Jahida Gulshan MdBelayet Hossain Madhabi Baidya Rafia Rashid Farhana Tasneem Ahmed Rashidul Hasan Tanzila Farhana Mohammed Reaz Mobarak MdJahangir Alam Syed Shafi Ahmed Department of Pediatric Gastroenterology Hepatology&NutritionBangladesh Shishu Hospital&InstituteDhakaBangladesh Institute of Statistical Research and Training(ISRT) University of DhakaDhakaBangladesh Department of Pediatric Hematology&Oncology Bangladesh Shishu Hospital&InstituteDhakaBangladesh Department of Pediatric Gastroenterology Dr.M R Khan Shishu Hospital&Institute of Child HealthDhakaBangladesh Department of Pediatrics BIHS General HospitalDiabetic Association of BangladeshDhakaBangladesh Department of Epidemiology&Research Bangladesh Shishu Hospital&InstituteDhakaBangladesh Bangladesh Shishu Hospital&Institute DhakaBangladesh

Background and aims:Currently,treatment with oral direct-acting antivirals is recommended for all hepatitis C virus(HCV)-infected pediatric *** aim of this study was to evaluate the efficacy and safety of sofosbuvir and ribavirin combination ther apy for children and adolescents in Bangladesh who are living with chronic HCV in ***:An experimental study was performed from January 2021 to December *** polymerase chain reaction(PCR)-positive thalassemic children,who were 6–18 years of age,were enrolled by consecutive non-probability *** features were recorded,and investigations were *** patients were initially treated with sofosbuvir(200 mg for 6-to 11-year-olds and 400 mg for 12-to 18-year-olds)and ribavirin(10–15 mg/kg/day)and were assessed clinically on a four-weekly basis,along with liver-function *** total duration of therapy was 24 *** PCR was done at the end of treatment and 12 weeks after the completion of treatment to see the sustained virological ***:There were 26 cases in total,with a mean age of 9.26?2.82 years;14 were males(53.8%),and 12 females(46.2%).Twenty-five(96.15%)patients achieved a sustained virological response,and the end-of-treatment PCR was *** patient(3.85%)was a nonresponder even after 24 weeks of *** medication was well received,with only four patients(15.3%)reporting headaches that were reported ***:The combination of sofosbuvir and ribavirin is effective in treating chronic HCV infection and is not accompanied by any major negative side effects.

关键词： Hepatitis C virus Direct-acting antivirals Sofosbuvir Ribavirin

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Effect of Trimetazidine on Functional Capacity in Patient with Ischaemic Cardiomyopathy (TOFCAPI)

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International Journal of Clinical Medicine 2024年第2期15卷 55-67页

作者： Mohsin Ahmed Golam Morshed Mahmood Hasan Khan Md. Arifur Rahman Muhammed Aminur Razzaque Shariful Islam Sayeedur Rahman Khan Chowdhury Md. Kudrat-E-Khuda salahuddin Anis Shiblee Md. Habibur Rahman Department of Cardiology National Institute of Cardiovascular Diseases Dhaka Bangladesh Department of Cardiology Government Employee’s Hospital Dhaka Bangladesh Department of Cardiology Delta Hospital Ltd. Dhaka Bangladesh IPDI Foundation Dhaka Bangladesh

Objective: This study aimed to evaluate the efficacy of trimetazidine on exercise capacity via a six-minute walk test in patients with ischaemic cardiomyopathy and also evaluate the effect of trimetazidine on left ventricular function via echocardiography in the same population. Methods: This prospective observational study, conducted at the National Institute of Cardiovascular Diseases in Dhaka, Bangladesh, enrolled 200 patients with ischaemic cardiomyopathy and a depressed left ventricular ejection fraction (LVEF Results: In this study (n = 200) of ischaemic cardiomyopathy patients, the mean age was 58 years, with 76% of the patients being male. All study subjects received GDMT (Guideline-Directed Medical Therapy) for angina and heart failure. Those who received the modified released form of trimetazidine developed lesions during the 1st and 2nd follow-ups, during which the LVEF, LVIDd, and six-minute walk distance significantly improved (p Conclusion: The findings of the present study demonstrated that the addition of modified-release trimetazidine to GDMT can improve exercise capacity and left ventricular function in patients with ischaemic cardiomyopathy.

关键词： Bangladesh Heart Failure Exercise Capacity Trimetazidine Ischaemic Cardiomyopathy

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Dengue epidemiology and pathogenesis:images of the future viewed through a mirror of the past

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Virologica Sinica 2015年第5期30卷 326-343页

作者： Rashedul Islam Mohammed salahuddin Md.salahuddin Ayubi Tahmina Hossain Apurba Majumder Andrew W.Taylor-Robinson Abdullah mahmud-Al-Rafat Bio-Resources Technology and Industrial Biotechnology Laboratory Department of Biotechnology and Genetic EngineeringJahangirnagar University Biotechnology and Genetic Engineering Discipline Khulna University School of Medical & Applied Sciences Central Queensland University Research and Development (R&D) Department Incepta Vaccine Limited

Every year, millions of individuals throughout the world are seriously affected by dengue virus. The unavailability of a vaccine and of anti-viral drugs has made this mosquito-borne disease a serious health concern. Not only does dengue cause fatalities but it also has a profoundly negative economic impact. In recent decades, extensive research has been performed on epidemiology, vector biology, life cycle, pathogenesis, vaccine development and prevention. Although dengue research is still not at a stage to suggest definite hopes of a cure, encouraging significant advances have provided remarkable progress in the fight against infection. Recent developments indicate that both anti-viral drug and vaccine research should be pursued, in parallel with vector control programs.

关键词： dengue epidemiology pathogenesis dengue vaccine ve

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High efficiency CZTSSe solar cells enabled by dual Ag-passivation approach via aqueous solution process

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Journal of Energy Chemistry 2023年第2期77卷 239-246,I0007页

作者： Temujin Enkhbat Enkhjargal Enkhbayar Namuundari Otgontamir Md Hamim Sharif Md salahuddin Mina Seong Yeon Kim JunHo Kim Department of Physics Incheon National UniversityIncheon 22012Republic of Korea Research Center for Thin Film Solar Cells Daegu-Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea Global Energy Research Center for Carbon Neutrality Incheon National UniversityIncheon 22012Republic of Korea

Ag substitution in Cu_(2)ZnSn(S,Se)_(4)(CZTSSe)is a promising way to mitigate Cu/Zn related defects,electrostatic fluctuations and Shockley-Read-Hall(SRH)recombination ***,high performance ACZTSSe solar cells are generally demonstrated with more Ag amounts and strenuous fabrication processes,which are not ideal when using cheap constituent materials *** reduce the Ag amount(2%-3%),local Ag substitutions into CZTSSe at front(F),back(B)and dual front/back(FB)were *** results revealed that F-passivation effectively reduced the Cu/Zn related defects and further limits the interface/bulk recombination whereas B-passivation improved the grain growth at the back interface and further allows enhanced transport of charge *** employing the dual Agpassivation approach,the final ACZTSSe device parameters were significantly improved and remarkable power conversion efficiency(PCE)of 12.43%was achieved with eco-friendly aqueous solution process.

关键词： Ag-doped CZTSSe Dual surface passivation Defect passivation Aqueous spray deposition

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A system of general nonlinear variational inclusions in Banach spaces

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Applied Mathematics and Mechanics(English Edition) 2015年第12期36卷 1663-1672页

作者： Xieping DING salahuddin College of Mathematics and Software Science Sichuan Normal University Department of Mathematics Jazan University

A new system of general nonlinear variational inclusions is introduced and studied in Banach spaces. An iterative algorithm is developed and analyzed by use of the resolvent operator techniques to find the approximate solutions of the system of general nonlinear variational inclusions involving different nonlinear operators in uniformly smooth Banach spaces.

关键词： system of general nonlinear variational inclusions strongly accretive mapping relaxed accretive mapping resolvent operator uniformly smooth Banach space

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Microstructure,Tensile and Impact Toughness Properties of Friction Stir Welded Mild Steel

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Journal of Iron and Steel Research(International) 2010年第10期17卷 68-74页

作者： A K Lakshminarayanan V Balasubramanian M salahuddin Department of Manufacturing Engineering Annamalai University Clean Technology Division Ministry of Environment and Forests

Microstructure, tensile and impact toughness properties and fracture location of friction stir welded AISI 1018 mild steel were revealed. The AISI 1018 mild steel plates with thickness of 5 mm were friction stir welded by tungsten based alloy tool with tool rotational speed of 1 000 r/min and welding speed of 50 ram/rain. Tensile strength of stir zone is higher （8%） compared to that of the base metal. This may be due to the formation of finer grains in the weld nugget region under the stirring action of the rotating tool. The ductility and impact toughness of the joints are decreased compared to those of the base metal owing to the inclusion of tungsten particles in the weld region.

关键词： friction stir welding tensile property impact toughness mildsteel

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Generalized Second Law of Thermodynamics in Wormhole Geometry with Logarithmic Correction

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Chinese Physics Letters 2011年第7期28卷 55-58页

作者： Faiz-ur-Rahman salahuddin M.Akbar Centre for Advanced Mathematics and Physics National University of Sciences and Technology(NUST)IslamabadPakistan

We construct various cases for validity of the generalized second law(GSL)of thermodynamics by assuming the logarithmic correction to the horizon entropy of an evolving *** is shown that the GSL is always respected fo... 详细信息

关键词： correction thermodynamics horizon

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Structural and Functional Analysis of NS1 and NS2 Proteins of H1N1 Subtype

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Genomics, Proteomics & Bioinformatics 2010年第3期8卷 190-199页

作者： Parveen salahuddin Asad U.Khan Distributed Information Sub-Centre Interdisciplinary Biotechnology UnitAligarh Muslim University

Influenza A virus （H1N1）, a genetic reassortment of endemic strains of human, avian and swine flu, has crossed species barrier to human and apparently acquired the capability of human to human transmission. Some strains of H5N1 subtype are highly virulent because NS 1 protein inhibits antiviral interferon α/β production. Another protein NS2 mediates export of viral ribonucleoprotein from nucleus to the cytoplasm through export signal. In this paper, we have studied structure-function relationships of these proteins of H1N1 subtype and have determined the cause of their pathogenicity. Our results showed that non-conservative mutations slightly stabilized or destabilized structural domains of NS1 or NSI-dsRNA complex, hence slightly increased or decreased the function of NS 1 protein and consequently enhanced or reduced the pathogenicity of the H1N1 virus. NS2 protein of different strains carried non-conservative mutations in different domains, resulting in slight loss of function. These mutations slightly decreased the pathogenicity of the virus. Thus, the results confirm the structure-function relationships of these viral proteins.

关键词： influenza A virus H1N1 pathogenicity NS2 NS1

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