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World Journal of Gastroenterology 2009年第19期15卷 2372-2375页

作者： Naheed Akhtar Bader Faiyaz Zuberi Syed Riazul Hasan Raj Kumar salahuddin afsar Department of Medicine Dow University of Health SciencesKarachi 74000Pakistan

AIM： To determine the correlation of Adjusted Blood Requirement Index （ABRI） with the 7th day outcome in patients presenting with acute variceal ***： All patients presenting with acute variceal hemorrhage （AVH） were included. Patients with previous band ligation, sclerotherapy, gastrointestinal or hepatic malignancies were excluded. Patients were managed as per standard protocol for AVH with terlipressin and band ligation. ABRI scores were calculated using the formula outcome of alive or expired up to the 7th day after treatment. The correlation between ABRI and mortality was estimated and a receiver operative characteristic （ROC） curve was ***： A total of 113 patients （76 male; 37 female） were included. On assessment, 18 were in Child＇s Pugh Class A, 82 in Class B and 13 were in Class C. The median number of blood units transfused ± inter-quartile range was 3.0 ± 2.0. The median ± inter-quartile range for ABRI was 1.3 ± 1.1. The ROC curve of ABRI for expiry showed a significantly large area of 0.848 （P 〈 0.0001; 95% CI： 0.75-0.95）. A significant correlation of log transformation of ABRI with an outcome of mortality was present （P 〈 0.0001）.

关键词： Adjusted Blood Requirement Index Cirrhosis Mortality Portal hypertension Variceal hemorrhage

Sustained virological response based on rapid virological response in genotype-3 chronic hepatitis C treated with standard interferon in the Pakistani population

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World Journal of Gastroenterology 2008年第14期14卷 2218-2221页

作者： Bader Faiyaz Zuberi Faisal Faiyaz Zuberi Sajjad Ali Memon Muhammad Hafeez Qureshi Sheikh Zafar Ali salahuddin afsar Department of Medicine Dow University of Health Sciences Karachi 74000 Pakistan Nehal Hospital Malir Karachi 74900 Pakistan

AIM:To document the sustained virological response (SVR) in rapid virological responders (RVR) of genotype-3 chronic hepatitis C with standard interferon (SdIF). METHODS:Hepatitis C genotype-3 patients during the period July 2006 and June 2007 were included. Complete blood counts, prothrombin time, ALT, albumin, qualitative HCV RNA were done. SdIF and ribavirin were given for 4 wk and qualitative HCV RNA was repeated. Those testing negative were allocated to group-A while the rest were allocated to group-B. Treatment was continued a total of 16 and 24 wk for group A and B respectively. HCV RNA was repeated after 24 wk of treatment. End virological and sustained virological responses were compared by χ2 test. ROC of pretreatment age, ALT and albumin were plotted for failure to achieve SVR. RESULTS:Of 74 patients treated, RCV RNA after 16 wk of therapy became undetectable in 34 (45.9%) and was detectable in 40 (54.1%) and were allocated to groups A and B respectively. SVR was achieved in 58.8% and 27.8% in groups A and B respectively. SVR rates were significantly higher in patients who had RVR as compared to those who did not (P = 0.0;γ = 2). Both groups combined ETR and SVR were 70% and 33% respectively. ROC plots of pretreatment age, ALT and albumin for SVR showed only ALT to have a significantly large area under the ***:SVR rates were higher in patients who had RVR with SdIF and high pre treatment ALT values correlated to probability of having RVR.

关键词： Hepatitis C Sustained virological response Rapid virological responders Chronic hepatitis

A system of general nonlinear variational inclusions in Banach spaces

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Applied Mathematics and Mechanics(English Edition) 2015年第12期36卷 1663-1672页

作者： Xieping DING salahuddin College of Mathematics and Software Science Sichuan Normal University Department of Mathematics Jazan University

A new system of general nonlinear variational inclusions is introduced and studied in Banach spaces. An iterative algorithm is developed and analyzed by use of the resolvent operator techniques to find the approximate solutions of the system of general nonlinear variational inclusions involving different nonlinear operators in uniformly smooth Banach spaces.

关键词： system of general nonlinear variational inclusions strongly accretive mapping relaxed accretive mapping resolvent operator uniformly smooth Banach space

Microstructure,Tensile and Impact Toughness Properties of Friction Stir Welded Mild Steel

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Journal of Iron and Steel Research International 2010年第10期17卷 68-74页

作者： A K Lakshminarayanan V Balasubramanian M salahuddin Department of Manufacturing Engineering Annamalai University Clean Technology Division Ministry of Environment and Forests

Microstructure, tensile and impact toughness properties and fracture location of friction stir welded AISI 1018 mild steel were revealed. The AISI 1018 mild steel plates with thickness of 5 mm were friction stir welded by tungsten based alloy tool with tool rotational speed of 1 000 r/min and welding speed of 50 ram/rain. Tensile strength of stir zone is higher （8%） compared to that of the base metal. This may be due to the formation of finer grains in the weld nugget region under the stirring action of the rotating tool. The ductility and impact toughness of the joints are decreased compared to those of the base metal owing to the inclusion of tungsten particles in the weld region.

关键词： friction stir welding tensile property impact toughness mildsteel

Generalized Second Law of Thermodynamics in Wormhole Geometry with Logarithmic Correction

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Chinese Physics Letters 2011年第7期28卷 55-58页

作者： Faiz-ur-Rahman salahuddin M.Akbar Centre for Advanced Mathematics and Physics National University of Sciences and Technology(NUST)IslamabadPakistan

We construct various cases for validity of the generalized second law(GSL)of thermodynamics by assuming the logarithmic correction to the horizon entropy of an evolving *** is shown that the GSL is always respected fo... 详细信息

关键词： correction thermodynamics horizon

Role of macrophages and monocytes in hepatitis C virus infections

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World Journal of Gastroenterology 2014年第11期20卷 2777-2784页

作者： Dennis Revie Syed Zaki salahuddin Department of Biology California Lutheran UniversityThousand OaksCA 91360United States California Institute of Molecular Medicine VenturaCA 93003United States

A number of studies conducted over many years have shown that hepatitis C virus(HCV)can infect a variety of cell *** vivo infection of monocytes,macrophages,and dendritic cells by HCV has been frequently shown by a number of *** studies have demonstrated replication of HCV by detecting the presence of both negative genomic strands and a variety of non-structural HCV proteins in infected *** addition,analyses of genome sequences have also shown that different cell types can harbor different HCV *** have also done preliminary studies of which cellular genes are affected by HCV infection,but there have not yet been a sufficient number of these studies to understand the effects of infection on these *** of in vitro HCV replication have shown that monocytes,macrophages and dendritic cells can be infected by HCV from patient sera or *** studies suggest that entry and cellular locations may vary between different cell *** studies suggest that macrophages may preferentially allow HCV genotype 1 to replicate,but macrophages do not appear to select particular hypervariable ***,these studies agree with a model where monocytes and macrophages act as an amplification system,in which these cells are infected and show few cytopathic effects,but continuously produce *** allows them to produce virus over an extended time and allows its spread to other cell types.

关键词： Hepatitis C virus Macrophages Monocytes Dendritic cells Hepatitis C virus replication

Structural and Functional Analysis of NS1 and NS2 Proteins of H1N1 Subtype

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Genomics, Proteomics & Bioinformatics 2010年第3期8卷 190-199页

作者： Parveen salahuddin Asad U.Khan Distributed Information Sub-Centre Interdisciplinary Biotechnology UnitAligarh Muslim University

Influenza A virus （H1N1）, a genetic reassortment of endemic strains of human, avian and swine flu, has crossed species barrier to human and apparently acquired the capability of human to human transmission. Some strains of H5N1 subtype are highly virulent because NS 1 protein inhibits antiviral interferon α/β production. Another protein NS2 mediates export of viral ribonucleoprotein from nucleus to the cytoplasm through export signal. In this paper, we have studied structure-function relationships of these proteins of H1N1 subtype and have determined the cause of their pathogenicity. Our results showed that non-conservative mutations slightly stabilized or destabilized structural domains of NS1 or NSI-dsRNA complex, hence slightly increased or decreased the function of NS 1 protein and consequently enhanced or reduced the pathogenicity of the H1N1 virus. NS2 protein of different strains carried non-conservative mutations in different domains, resulting in slight loss of function. These mutations slightly decreased the pathogenicity of the virus. Thus, the results confirm the structure-function relationships of these viral proteins.

关键词： influenza A virus H1N1 pathogenicity NS2 NS1

Dengue epidemiology and pathogenesis:images of the future viewed through a mirror of the past

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Virologica Sinica 2015年第5期30卷 326-343页

作者： Rashedul Islam Mohammed salahuddin Md.salahuddin Ayubi Tahmina Hossain Apurba Majumder Andrew W.Taylor-Robinson Abdullah Mahmud-Al-Rafat Bio-Resources Technology and Industrial Biotechnology Laboratory Department of Biotechnology and Genetic EngineeringJahangirnagar University Biotechnology and Genetic Engineering Discipline Khulna University School of Medical & Applied Sciences Central Queensland University Research and Development (R&D) Department Incepta Vaccine Limited

Every year, millions of individuals throughout the world are seriously affected by dengue virus. The unavailability of a vaccine and of anti-viral drugs has made this mosquito-borne disease a serious health concern. Not only does dengue cause fatalities but it also has a profoundly negative economic impact. In recent decades, extensive research has been performed on epidemiology, vector biology, life cycle, pathogenesis, vaccine development and prevention. Although dengue research is still not at a stage to suggest definite hopes of a cure, encouraging significant advances have provided remarkable progress in the fight against infection. Recent developments indicate that both anti-viral drug and vaccine research should be pursued, in parallel with vector control programs.

关键词： dengue epidemiology pathogenesis dengue vaccine ve

Dirac R-matrix calculations of photoionization cross sections of Ni Ⅻ and atomic structure data of Ni 

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Chinese Physics B 2017年第2期26卷 127-140页

作者： R T Nazirt M A Bari M Bilal S Sardar M H Nasim M salahuddin Department of Physics and Applied Mathematics Pakistan Institute of Engineering and Applied Sciences Islamabad 45650 Pakista

We performed R-matrix calculations for photoionization cross sections of the two ground state configuration 3s^23p^5（~2P_（3/2,1/2）~o） levels and 12 excited states of Ni Ⅻ using relativistic Dirac Atomic R-matrix Codes（DARC） across the photon energy range between the ionizations thresholds of the corresponding states and well above the thresholds of the last level of the Ni XIII target ion. Generally, a good agreement is obtained between our results and the earlier theoretical photoionization cross sections. Moreover, we have used two independent fully relativistic GRASP and FAC codes to calculate fine-structure energy levels, wavelengths, oscillator strengths, transitions rates among the lowest 48 levels belonging to the configuration（3s^23p^4, 3s3p^5, 3p^6, 3s^23p^33d） in Ni XIII. Additionally, radiative lifetimes of all the excited states of Ni XIII are presented. Our results of the atomic structure of Ni XIII show good agreement with other theoretical and experimental results available in the literature. A good agreement is found between our calculated lifetimes and the experimental *** present results are useful for plasma diagnostic of fusion and astrophysical plasmas.

关键词： photoionization cross sections energy levels wavelengths lifetimes

Rumex dentatus could be a potent alternative to treatment of microbial infections and of breast cancer

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Journal of Traditional Chinese Medicine 2019年第6期39卷 772-779页

作者： Riffat Batool Ejaz Aziz Hina salahuddin Javed Iqbal Saira Tabassum Tariq Mahmood University Institute of Biochemistry and Biotechnology Pir Mehr Ali Shah Arid Agriculture University RawalpindiRawalpindiPunjab 46000Pakistan Department of Botany Government Degree College KhanpurHaripur 22650Pakistan Department of Zoology University of OkaraOkara 56300Pakistan National University of Technology School of Applied Sciences and HumanitiesNational University of TechnologyIslamabad 42000Pakistan Department of Plant Sciences Faculty of Biological SciencesQuaid-i-Azam UniversityIslamabad 45320Pakistan

OBJECTIVE:To investigate the phytochemicals and in vitro antioxidant,antimicrobial and cytotoxic potential of Rumex dentatus(***)leaf ***:The total phenolics and flavonoids content of *** extracts were evaluated by the Folin-Ciocalteu and aluminum chloride colorimetric methods *** potential of studied plant extracts was assessed through 2,2-diphenyl-1-picrylhydrazyl radical scavenging capacity,total reducing power and total antioxidant ***,antibacterial and antifungal capacity was also evaluated by disc diffusion method against six clinically isolated multi-drug resistant bacterial strains as well as six fungal ***,cell cytotoxicity was also evaluated through3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide ***:Ethanol extract showed highest total phenolic[(38.9±1.5)μg gallic acid equivalent/mg]and total flavonoids[(17.2±1.9)μg quercetin equivalent/mg]*** assays indicated that ethanol and methanol extracts possess potent antioxidant ***,it was observed that ethanol and hexane extracts have the potential to inhibit most of the tested multi-drug resistant bacterial strains while methanol,chloroform and hexane extracts could inhibit the growth of pathogenic fungal strains *** all the studied extracts,ethanolic extract showed highest cytotoxicity against MCF-7 cell line then Hep-2 and DU-145 cell lines by MTT assay with lowest IC50 of 47.3μg/m ***:These results suggest that *** could be a potent alternative candidate for treatment of microbial infections and for breast cancer treatment.

关键词： Rumex Atioxidants Anti-infective agents Drug resistant,multiple Cytotoxins