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Cytotoxic Effect of Propolis Nanoparticles on Ehrlich Ascites Carcinoma Bearing mice

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Advances in Nanoparticles 2019年第4期8卷 55-70页

作者： Jawharah A. Abdo Fahd m. Alsharif Nivin salah Om Ali Y. Elkhawaga Division of Biochemistry Department of Chemistry Faculty of Science Mansoura University Mansoura Egypt Department of Pharmaceutics and Industrial Pharmacy College of Pharmacy Al-Azhar University Assiut Egypt Department of Pharmaceutical Sciences College of Pharmacy University of Kentucky Lexington USA

Background and objective Previous studies have demonstrated the anti-cancer effects of propolis. However, its use is limited because of its poor bioavailability. In the present study, the major objective was to improve propolis bioavailability using a nanosuspension formulation. The cytotoxic effect of propolis nanosuspension (PRO-NS) on the Ehrlich ascites carcinoma (EAC) in female Swiss albino mice was investigated in comparison to the free propolis. materials and methods A propolis-loaded nanosuspension was formulated by applying solvent-antisolvent nano-precipitation technique. The prepared PRO-NS was characterized for average particle size, polydispersity index (PDI) and zeta potential. Also, the morphology of the nanosuspension particles was investigated using scanning electron microscopy (SEm). moreover, PRO-NS cytotoxicity was tested using EAC bearing mice. The anticancer activity of Pro-NS was assessed by studying tumor volume, life span, viable and non-viable cell count, antioxidant, biochemical estimations and proliferation of EAC cells. Results The results revealed that propolis nanoparticles were relatively spherical in shape with rough surface. The tumor bearing mice treated with PRO-NS showed increased life span and inhibited tumor growth and the proliferation of EAC cells in comparison to the free propolis (p Conclusions Our results indicate that PRO-NS has a strong inhibitory activity against growth of tumors in comparison to free propolis. The anti-tumor mechanism may be mediated by preventing oxidative damage, immune-stimulation and induction of apoptosis.

关键词： Propolis Nanosuspension Ehrlich Ascites Carcinoma Cells Cytotoxicity Immune-Stimulation Cell Cycle

Technological Characterization and Industrial Application of Tunisian Clays from makthar Area (Central Tunisia) in the Ceramic Industry

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Open Journal of Geology 2016年第7期6卷 626-639页

作者： Imed Ben salah moufida Ben m’Barek Jemai Ali Sdiri Najet Shimi Slim m.brouk Boughdiri Department of Geology University of Sciences of Bizerte Bizerte Tunisia National Engineering School of Sfax Sfax Tunisia Department of Geology University of Sciences of Tunis Tunis Tunisia

This study focused on the geochemical, mineralogical and technological characterization of clays in makthar area (Central of Tunisia) of Cretaceous-Paleogene. Its aims are to identify and promote use in the field of ceramics industry. The result of the mineralogical analysis of clays showed a dominance of illite with a percentage higher than 65%, of kaolinite and smectite with percentages of 15%. Geochemical analysis of the major elements of clay showed a SiO2 content exceeding 29% and a percentage of Al2O3 higher than 7.5%. The Fe2O3 percentage was ranging from 3% to 8%. The percentage of CaO was between 22.5% and 28% while that of K2O is 4%. The percentages of SO4, mgO and NaO2 were in very small fractions. Granulometric and microgranulometric analysis showed that the clay fraction (m) varies from 30% to 37%. The plasticity index showed the plasticity character of clays which presented a specific surface area ranging from 112 m2/g to 178 m2/g reflecting illite dominance. Drying behavior indicated that clay mixture had a drying shrinkage less than 7%, while the firing shrinkage didn’t exceed 2% giving the possibility of clay using in the ceramics field.

关键词： Clay mineral mineralogy Chemical and Physical Properties Ceramic Industry

The Value of Serum midKine as a marker of Hepatocellular Carcinoma on Top of Hepatitis C Virus Related Cirrhosis

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Journal of Biosciences and medicines 2022年第4期10卷 37-47页

作者： Ayman menessy Ehab Fouda salah Aref Ramy Agwa Internal medicine Department Faculty of Medicine Mansoura University Mansoura Egypt m. B. B. Ch Faculty of Medicine Mansoura University Mansoura Egypt Clinical Pathology Department Faculty of Medicine Mansoura University Mansoura Egypt

Background: Hepatocellular carcinoma (HCC) is characterized by the deficiency of specific symptoms in the early stages of the disease and a poor prognosis. Biomarkers that have the diagnostic ability to distinguish between inflammation, cirrhosis, and HCC are needed for early case detection. midKine (mK) is overexpressed in many malignancies, including hepatocellular carcinoma, gastric carcinoma, colon carcinoma, lung carcinoma, urinary bladder carcinoma and prostate carcinoma. Objective: The objective is to evaluate serum midKine as a marker of HCC in HCV-related liver cirrhosis. Patients and methods: This study included 50 patients with HCC (on top of hepatitis C virus-related cirrhosis), 20 cirrhotic patients due to chronic HCV infection, and 10 normal subjects as a control group. History, examination, and laboratory investigations were performed on all subjects in the three groups including mK and Alpha fetoprotein (AFP) serum levels. Results: Serum levels of AFP and mK were higher in the HCC group than in the other study groups (P Conclusion: midKine is a novel sensitive biomarker that could be used for early detection of HCC and has a high significance in differentiation between cirrhosis and HCC cases. midKine levels are correlated with HCC stages and sizes.

关键词： midKine Hepatocellular Carcinoma Alpha-Fetoprotein Chronic Hepatitis C

Some Equivalences and Dualities via Static modules

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Advances in Pure mathematics 2011年第6期1卷 359-362页

作者： salah Al-Nofayee Syed Khalid Nauman 不详

For a ring A, an extension ring B, a fixed right A-module m, the endomorphism ring D formed by m, the endomorphism ring E formed by , and the endomorphism ring F formed by HomA (B,m), we present equivalences and dualities between subcategories of B-modules which are finitely cogenerated injective as A-modules and E-modules and F-modules which are finitely generated projective as D-modules.

关键词： Static modules Finitely Cogenerated Injective modules Finitely Generated Projective modules

Dartos Fascio-myo-Cutaneous Flap for Penile Skin Loss: A Simple Flap with an Immense Potential

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Surgical Science 2014年第1期5卷 6-9页

作者： Adel m. Tolba Ahmed Abo-hashem Azab mohamed Aly Nasr Emad salah Plastic Surgery Unit General Surgery Department Zagazig University Zagazig Egypt

Introduction: Penile skin loss poses a particular challenge for reconstruction to the plastic surgeon. These defects, depending on their size, have been reconstructed using skin grafts or regional flap. Patients & methods: Ten patients with variable sized penile skin defects were included in this work. Scrotal fascio-myo-cutaneous (Dartos) flap was harvested and used for penile shaft resurfacing. Results: All harvested flaps were successful. None of them showed any ischemic manifestations. Discussion: Despite being a simple and robust flap, its use for resurfacing of moderate to extensive penile skin defects isn’t popular. We propose the use of Dartos flap as a good alternative for challenging moderate to extensive penile skin losses.

关键词： Scrotal Blood Supply Penile Skin Loss Penile Reconstruction

The Accuracy of Transabdominal Ultrasound in Detection of the Common Bile Duct Stone as Compared to Endoscopic Retrograde Cholangiopancreatography (with Literature Review)

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Open Journal of Gastroenterology 2016年第10期6卷 275-299页

作者： Taha Ahmed m. Alkarboly salah mohamad Fatih Hiwa Abubaker Hussein Talar m. Ali Heero Ismael Faraj Sulaimani School of medicine Kurdistan Centre for Gastroenterology & Hepatology (KCGH) Sulaimani Iraq

Introduction: Common bile duct stone (CBDS) is a common clinical problem that can cause serious complications, such as acute cholangitis and pancreatitis. It is important to have an accurate, safe, and reliable method for the definitive diagnosis of CBDS before proceeding to therapeutic endoscopic retrograde cholangiopancrea-tography (ERCP). Objective: To compare the accuracy of trans-abdominal ultra-sound (TAUS) as a diagnostic tool at our institution—Kurdistan Centre for Gastroen-terology & Hepatology (KCGH)—with invasive tool like ERCP in the diagnosis of bile duct stones, using specificity, sensitivity, and positive and negative predictive values. Patient and method: After obtaining ethical committee approval & informed consent from every patient. This was a prospective study conducted on 71 patients (24 male patients and 47 females patients) where suspected to have CBDS depending on history, clinical suspicion and blood tests. Their ages range between (2 - 88 years). Both TAUS and ERCP were performed. Final diagnosis was confirmed de-pending on ERCP as it served as a diagnostic standard in diagnosing CBDS. Result: In 71 patients suspected to have CBDS by TAUS, only 46 patients had stone (65%), and 55 patients had stone by ERCP (77%). In our result, sensitivity, specificity, pos-itive predictive value and negative predictive value for TAUS were 80%, 87.5%, 65.5% and 56%, respectively. Conclusion: TAUS can play an important role as an initial screening procedure for CBDS detection because of the various advantages like easy availability, cost effectiveness, no requirement of contrast material and lack of ionizing radiation but should done with other imaging modality to avoid se-rious complication of ERCP.

关键词： TAUS ERCP CBDS KCGH Sulaimani

Chemistry of the groundwater of the Eastern mitidjaBasin, Algeria

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Journal of Chemistry and Chemical Engineering 2019年第3期13卷 120-131页

作者： m.brouk Benziada Centre de Développement des Energies Renouvelables Route de l’Observatoire BP 62-Village Céleste16340 Bouzaréah AlgerAlgérie

In this article,we present the results of Eastern mitidja basin groundwater chemical analysis realized by the Algerian water laboratory at National Water Resources Agency(Algiers)in October-November *** try to show a synthetic cartography of some physic-chemical parameters in this area,the spatial quality evolution of groundwater and its irrigation *** groundwater of Eastern mitidja basin are bicarbonate-calcareous with magnesium by place *** mineralization of groundwaters is weak in the high stream and strong in downstream(proximity of the sea).The concentrations of nitrates remain below from the World Health Organization norms over the whole of basin *** mitidja basin groundwaters are not dangerous and can be used for irrigation.

关键词： Potability of groundwater water of agriculture mitidja Algeria

Outcome of Early Surgical Decompression in Traumatic Incomplete Spinal Cord Injury

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Open Journal of modern Neurosurgery 2020年第3期10卷 353-363页

作者： mohammed Ahmed Eissa Ahmed Elsharkawy Hieder Al-Shami Aya Ouf Ahmed m. salah El-Din Department of Neurosurgery Cairo University Cairo Egypt Department of Neurosurgery Al-Ahly Bank Hospital Cairo Egypt School of medicine Cairo University Cairo Egypt

Objectives: Central cord syndrome has been reported to occur with particular frequency among older persons with cervical spondylosis who sustain hyperextension neck injury. This study aims to determine the efficacy of early surgical decompression (within 24 hours) of traumatic central cord syndrome patients in comparison with conservative management for central cord syndrome to determine a line of management to these cases. methods: 60 patients suffering from acute traumatic central cord syndrome with various neurological deficits were divided into 2 groups, group A (conservatively managed) and group B (surgically managed). Patients in group B were operated upon within 24 hr. of trauma by posterior decompression. Clinical assessment of each patient on admission, discharge and 3 months follow-ups was done using the ASIA Impairment Scale, FIm, Ashworth scale, bladder function, and neuropathic pain symptoms. Results: Data collected from both groups showed, group A (the conservative group) consisted of 22 male (73.3%) and 8 female subjects (26.6%) with a mean age of 57.5 years while in group B (surgical group) the sample consisted of 20 male (66.6%) and 10 female subjects (33.3%) with a mean age of 58.6 years. There was an improvement in our study—according to ASIA and FIm scales—in 8 patients of 30 (26.6%) in the conservative group. In the surgical group, improvement in 16 patients (53.3%). Conclusions: Early surgical decompression with laminectomy and duroplasty can be considered a reliable modality in the management of traumatic CCS and can effectively reduce the secondary injury of the spinal cord and consequent deterioration with less hospital stay.

关键词： Central Cord Syndrome “CCS” Early Surgical Decompression Laminectomy Duroplasty

Quantitative Determination of Cd and Pb in Tissues and Organs of Chickens Raised in El-Jabel Alakhder Region—Libya

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Food and Nutrition Sciences 2013年第8期4卷 763-766页

作者： Ramadan E. Abdolgader Ramadan A. Hussain salah m. Hasan Agoub A. Agoub Department of Food Science and Technology Faculty of Agriculture Omar Almukhater University Bayda Libya.

This study was carried out to determine the concentration of Cd, and Pb in the tissues of thigh, breast, liver, heart, gizzard, neck and skin of chicken. All samples were collected in the summer of 2004 from three different commercial farms of chickens production located in different areas of EL-Jabal Alakhder region at Libya country (Gernada, EL-Abrak and Sousa). For comparison, the metals were also determined in the same tissues of the chickens which produced in the national station of poultry production at EL-Akhoria city. The metals in the chickens feed and in water for both drinking and cleaning inside the slaughter house were also determined. The results revealed that the highest concentrations of Cd were found in neck, liver and heart while the neck and skin tissues contained the highest level of Pb. However, the tissues of thigh and breast flesh had the lowest level of metals. The levels of Cd in the different tissues ranged from 0.008 to 0.227 ppm and from 0.093 to 2.391 ppm for Pb. The results revealed that the levels of Cd in neck from all farms, liver from both EL-Akhoria and Gernada farms. Levels of Pb in the neck and skin from all farms were exceeding the permitted limits according to some European regulations. The results also indicate that the high concentrations of Cd in some tissues were due to the effect of high levels of these metals in the feed of birds. However the drinking and cleaning water had no effects on the level of the metals in the different tissues.

关键词： Chicken Heavy metals Lead Cadmium