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Vanillylacetone attenuates cadmium chloride-induced hippocampal damage and memory loss through upregulation of nuclear factor erythroid 2-related factor 2 gene and protein expression

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Neural Regeneration Research 2024年第12期19卷 2750-2759页

作者： Fahaid H.A.L-Hashem salah O.Bashir Amal F.Dawood moutasem S.Aboonq Ismaeel Bin-Jaliah Abdulaiziz m.Al-Garni mohamed D.morsy Department of Physiology College of MedicineKing Khalid UniversityAbhaSaudi Arabia Department of Basic medical Sciences College of MedicinePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Physiology College of MedicineTaibah UniversityAl-Madinah Al-MunawwarahSaudi Arabia Department of medicine College of MedicineKing Khalid UniversityAbhaSaudi Arabia

memory loss and dementia are major public health concerns with a substantial economic *** stress has been shown to play a crucial role in the pathophysiology of hippocampal damage-induced memory *** investigate whether the antioxidant and anti-inflammatory compound vanillyla cetone(zingerone) can protect against hippocampal damage and memory loss induced by cadmium chloride(CdCl_(2)) administration in rats,we explo red the potential involvement of the nuclear factor erythroid 2-related factor 2(Nrf2) signaling pathway,which is known to modulate oxidative stress and *** healt hy male Wistar rats were divided into five groups:vehicle-treated(control),vanillylacetone,CdCl_(2),vanillylacetone+ CdCl_(2),vanillylacetone+ CdCl_(2)+ brusatol(a selective pharmacological N rf2inhibitor) *** effectively attenuated CdCl_(2)-induced damage in the dental gyrus of the hippocampus and improved the memory function assessed by the morris Water maze ***,vanillylacetone markedly decreased the hippocampal tissue levels of inflammatory biomarkers(interleukin-6,tumor necrosis factor-α,intracellular cell adhesive molecules) and apoptosis biomarkers(Bax and cleaved caspase-3).The control and CdCl_(2)-treated groups treated with va nillylacetone showed reduced generation of reactive oxygen species,decreased malondialdehyde levels,and increased superoxide dismutase and glutathione activities,along with significant elevation of nuclear Nrf2 mRNA and protein expression in hippocampal *** the protective effects of vanillylacetone we re substantially blocked by the co-administration of brusatol(a selective N rf2 inhibitor).Va nillylacetone mitigated hippocampal damage and memory loss induced by CdCl_(2),at least in part, by activating the nuclear transcription factor ***,vanillylacetone exerted its potent antioxidant and antiinflammatory actions.

关键词： hippocampus neuroprotective Nrf2 gene oxidative stress vanillylacetone

Evaluation of hybrid closed-loop insulin delivery system in type 1 diabetes in real-world clinical practice:One-year observational study

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World Journal of Diabetes 2024年第3期15卷 455-462页

作者： Ahmed Eldib Shilton Dhaver Karim Kibaa Astrid Atakov-Castillo Tareq salah marwa Al-Badri Abdelrahman Khater Ryan mcCarragher Omnia Elenani Elena Toschi Osama Hamdy Department of Clinical Behavioral&Outcomes ResearchJoslin Diabetes CenterBostonMA 02215United States Department of medicine Harvard Medical SchoolBostonMA 02115United States

BACKGROUND In 2016,the Food and Drug Administration approved the first hybrid closed-loop(HCL)insulin delivery system for adults with type 1 diabetes(T1D).There is limited information on the impact of using HCL systems on patient-reported outcomes(PROs)in patients with T1D in real-world clinical *** this independent study,we evaluated glycemic parameters and PROs over one year of continuous use of medtronic’s 670G HCL in real-world clinical *** To assess the effects of hybrid closed loop system on glycemic control and quality of life in adults with *** We evaluated 71 patients with T1D(mean age:45.5±12.1 years;59%females;body weight:83.8±18.7 kg,body mass index:28.7±5.6 kg/m2,A1C:7.6%±0.8%)who were treated with HCL at Joslin Clinic from 2017 to *** measured A1C and percent of glucose time-in-range(%TIR)at baseline and 12 *** measured percent time in auto mode(%TiAm)for the last two weeks preceding the final visit and assessed PROs through several validated quality-of-life surveys related to general health and diabetes *** At 12 mo,A1C decreased by 0.3%±0.1%(P=0.001)and%TIR increased by 8.1%±2.5%(P=0.002).The average%TiAm was only 64.3%±32.8%and was not associated with A1C,%TIR or ***,provided at baseline and at the end of the study,showed that the physical functioning submodule of 36Item Short-Form Health Survey increased significantly by 22.9%(Pmia fear survey/worry scale decreased significantly by 24.9%(Pm Areas In Diabetes reduced significantly by-17.2%(P=0.002).The emotional burden submodules of dietary diversity score reduced significantly by-44.7%(P=0.001).Furthermore,analysis of Clarke questionnaire showed no increase in awareness of hypoglycemic ***-5 showed no improvements in subject’s wellbeing among participants after starting the 670G HCL ***,analysis of Pittsburgh Sleep Quality Index showed no difference in sleep quality,sleep latency,or duration o

关键词： Artificial pancreas Continuous blood glucose monitor Type 1 diabetes Hybrid closed-loop insulin delivery Quality of life

CO oxidation and 4-nitrophenol reduction over ceria-promoted platinum nanoparticles impregnated with ZSm-5 zeolite

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Journal of Rare Earths 2022年第8期40卷 1247-1254页

作者： Zeinhom m.El-Bahy mohammed T.Alotaibi salah m.El-Bahy Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr City11884CairoEgypt Department of Chemistry Turabah University CollegeTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia

Active new ceria-promoted platinum supported on ZSm-5 catalysts were prepared and characterized by X-ray diffraction(XRD),Fourier transform infrared spectra(FTIR),transform electron microscopy(TEm),temperature programmed desorption(TPD),and FTIR of CO *** samples were prepared by the incipient wetness impregnation method and calcined at 500℃.The XRD patterns and FTIR spectra prove that the zeolite framework is kept unaltered after metal *** images prove the presence of Pt nanoparticles with particle size starting from 14 to 27 *** FTIR data suggest the formation of Pt-O-Ce ***-situ FTIR of CO adsorption over reduced samples proves the presence of Pt~0 only,and no Pt^(n+)-CO species are *** prepared catalysts were tested in both oxidation reaction(CO oxidation) in the gas phase and in reduction reaction(4-nitrophenol reduction) in the aqueous ***,CO oxidation by O_(2) results in the formation of a CO_(2) peak at 2347 cm^(-1) as the only CO oxidation product in the studied frequency *** intensity of the CO_(2) peak increases after the addition of Ce,and it is 4 times higher in Pt_(1) Ce_(0.5)ZSm-5 than that in the Ce-free *** to the FTIR data and previous reports,the increase in the catalytic activity may be due to the formation of Pt-O-Ce ***,Ce-promoted Pt_(1) ZSm5 also exhibits enhanced catalytic activity towards the reduction of 4-nitrophenol to 4-aminophenol by NaBH_(4) in the aqueous *** first-order rate constant of the reduction increases ≈13 times after incorporating equal ratios of Pt and Ce(Pt_(1) Ce_(1)ZSm-5),and the activation energy(E_(a)) decreases to 40% of that in the reaction over Pt_(1) ZSm-5.

关键词： 4-Nitrophenol CO oxidation TPD-CO Platinum-cerium ZSm-5 Rare earths

Unconstrained Hand Dorsal Veins Image Database and Recognition System

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Computers, materials & Continua 2022年第12期73卷 5063-5073页

作者： mustafa m.Al Rifaee mohammad m.Abdallah mosa I.salah Ayman m.Abdalla Faculty of Science and Information Technology Al-Zaytoonah University of JordanAmman11733Jordan Faculty of Architecture and Design Al-Zaytoonah University of JordanAmman11733Jordan

Hand veins can be used effectively in biometric recognition since they are internal organs that,in contrast to fingerprints,are robust under external environment effects such as dirt and paper ***,they form a complex rich shape that is unique,even in identical twins,and allows a high degree of ***,most currently employed hand-based biometric systems rely on hand-touch devices to capture images with the desired *** the start of the COVID-19 pandemic,most handbased biometric systems have become undesirable due to their possible impact on the spread of the ***,new contactless hand-based biometric recognition systems and databases are desired to keep up with the rising hygiene *** contribution of this research is the creation of a database for hand dorsal veins images obtained contact-free with a variation in capturing distance and rotation *** database consists of 1548 images collected from 86 participants whose ages ranged from 19 to 84 *** the other research contribution,a novel geometrical feature extraction method has been developed based on the Curvelet *** method is useful for extracting robust rotation invariance features from vein *** database attributes and the veins recognition results are analyzed to demonstrate their efficacy.

关键词： Biometric recognition contactless hand biometrics veins recognition Curvelet transform image segmentation feature extraction

Analysis and Characterization of Pore System and Grain Sizes of Carbonate Rocks from Southern Lebanon

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Journal of Earth Science 2023年第1期34卷 101-121页

作者： mohamed K.salah Hammad Tariq Janjuhah Josep Sanjuan Department of Geology American University of BeirutRiad El SolhBeirut11072020Lebanon Department of Geology Shaheed Benazir Bhutto UniversitySheringal KP10850Pakistan Department of Earth and Ocean Dynamics Faculty of Earth SciencesUniversity of BarcelonaBarcelona08028Spain

Carbonate rocks are common in many parts of the world, including the Eastern mediterranean, where they host significant groundwater supplies and are widely used as building and ornamental stones. The porosity of carbonate rocks plays a critical role in fluid storage and retrieval. The pore structure connectivity, in particular, controls many properties of geological formations, as well as the relationships between the properties of individual minerals and the bulk properties of the rock. To study the relationships between porosity, rock properties, pore structure, pore size, and their impact on reservoir characteristics, 46 carbonate rock samples were collected from four stratigraphic sections exposed near Sidon, South Lebanon. The studied carbonate rocks are related to marine deposits of different ages(e.g., Upper Cretaceous, Eocene, and Upper miocene). In order to understand the pore connectivity, the mICP(mercury injection capillary pressure) technique was conducted on ten representative samples. Results from the SEm analysis indicate the dominance of very fine and fine pore sizes, with various categories ranging in diameter from 0.1 to10 μm. The mICP data revealed that the pore throat radii vary widely from 0.001 to 1.4 μm, and that all samples are dominated by micropore throats. The grain size analysis indicated that the studied rocks have significant amounts of silt-and clay-size grains with respect to the coarser ‘sand-size’ particles, suggesting a high proportion of microporosity. Obtained results, such as the poorly-sorted nature of grains, high microporosity, and the high percentage of micropore throats, justify the observed low mean hydraulic radius, the high entry pressure, and the very low permeability of the studied samples. These results suggest that the carbonate rocks near Sidon(south of Lebanon) are possibly classified as non-reservoir facies.

关键词： petrophysics mercury injection capillary pressure(mICP) micrite microtexture microporosity platform carbonates southern Lebanon

微旋转切向双曲混合流体中悬浮混合纳米粒子的流变学

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Journal of Central South University 2023年第4期30卷 1231-1245页

作者： m.N.ABRAR salah UDDIN Kamran AKHTAR Department of Civil Engineering National University of Sciences and TechnologyBalochistan Campus QuettaQuetta 86000Pakistan National University of Sciences and Technology Islamabad 44000Pakistan

流体运动通过线性拉伸片而实现。本研究结合多种流动和热现象,如多孔介质、倾斜磁流体、焦耳热以及速度和热滑移因子,用数值方法研究了切向双曲混合纳米流体通过多孔薄片的微旋转效应。得到的数学公式是一组非线性耦合偏微分方程。为了... 详细信息

流体运动通过线性拉伸片而实现。本研究结合多种流动和热现象,如多孔介质、倾斜磁流体、焦耳热以及速度和热滑移因子,用数值方法研究了切向双曲混合纳米流体通过多孔薄片的微旋转效应。得到的数学公式是一组非线性耦合偏微分方程。为了得到近似解,引入了相似性变量。利用Runge-Kutta-Fehlberg 45 (RKF-45)和射门技术,得到主导微分方程的数值解。用图示法表示相关参数的物理意义。为了验证数值结果,与已经发表的数据进行比较。假设流体的流速随Weissenberg数和渗透率的增加而减小,流体的角速度随表面条件参数的增加而明显著加快。表面摩擦因数随Weissenberg数的增加而有效减小,随大的速度滑移参数的增大而增大。结果证实,较高的银和铜纳米颗粒体积分数具有提高流动流体导热率的潜力。混合纳米流体可广泛应用在工程中,比如核冷却、海水淡化、机加工、制冷、热交换器、太阳能集热器和发动机冷却等。此外,在微旋转切向双曲流体中混入纳米流体可提高系统的热能力,可将其应用于依赖热传递的机械系统。

关键词：微极性流体混合纳米流体切向双曲流体多孔介质滑移因子倾斜磁流体

The Effect of Atrial Septal Defect Closure on Cardiac Volumetric Changes in Adults, Transcatheter Versus Surgical Closure, a Pilot Cardiac magnetic Resonance Study

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Congenital Heart Disease 2023年第6期18卷 679-691页

作者： Amr mansour Noha m.Gamal Alaa m.Nady Amr Ibraheem Dalia m.salah Khaled m.El-maghraby Cardiology Department Congenital and Structural Heart Disease UnitAin Shams University HospitalsFaculty of MedicineAin Shams UniversityCairoEgypt Cardiology Department Faculty of MedicineAssuit UniversityAssuitEgypt Cardiothoracic Surgery Department Faculty of MedicineAssuit UniversityAssuitEgypt Anesthesia Department Faculty of MedicineAssuit UniversityAssuitEgypt

Background:Closure of an atrial septal defect(ASD)reduces right-side heart volumes by abolishing shunting with simultaneous improvement of the left ventricle(LV)ﬁlling and functions due to ventricular interdependence,thereby improving ***,studies conducted on atrial volume changes after ASD closure are *** magnetic resonance(CmR)is considered as the gold standard method for measuring cardiac volume and ***:We aimed to study the effect of transcatheter and surgical closure of secundum ASD on cardiac volumes and systolic functions as well as the fate of tricuspid regurgitation(TR),using CmR ***:We prospectively enrolled 30 adult patients with isolated secundum ASD who were referred to ASD *** evaluation of cardiac chambers indexed volumes,systolic function,myocardial mass index,and tricuspid regurgitant fraction were done at before and 6 months after ***:RV volumes decreased in both groups when compared to baseline(p-value 0.001),the device group had more reduction in volumes and more improvement in RV function after closure(p-value 0.001)when compared to the surgical *** changes in the RV mass index were insigniﬁcant between both groups(p-value 0.31).Functional TR improved to the same extent in both *** ventricular end diastolic volume index(LVEDVI)and LV mass index increased sig-niﬁcantly in both groups when compared to baseline in both groups but with no difference between groups p-value 0.01),left ventricular end systolic volume index(LVESVI)changes were insigniﬁ*** systolic function improved in patients who underwent device closure only(63.53±3.85 vs.67.13±4.34,p-value 0.01).There was a signiﬁcant reduction in right atrial(RA)volumes and an insigniﬁcant decrease in left atrial(LA)volumes,with no difference between ***:Transcatheter and surgical secundum ASD closure resulted in volumetric changes in some cardiac chambers with better improvement in bi-ventricular

关键词： Atrial septal defect closure cardiac volumetric changes functional tricuspid regurgitation cardiac CmR

Characterization of catechol 1,2-dioxygenase from cell extracts of Sphingomonas xenophaga QYY

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Science China Chemistry 2009年第5期52卷 615-620页

作者： m.salah Uddin Department of Genetics and Breeding University of RajshahiRajshahi-6205 Bangladesh

Sphingomonas xenophaga QYY, capable of growing significantly on more than ten kinds of aromatic compounds as sole carbon source, was used to study characterization of catechol 1,2-dioxygenase (C12O) in cell extracts. Characterization of the crude C12O showed that the maximum activity was obtained at 40-70℃ and pH 7.8-8.8. metal ions had different influences on the activity of crude C12O. It was suggested that strain QYY possessed an inducible and ferric-dependent C12O. Kinetic studies showed that the value of Vmax and Km was 0.25 μmol catechol/L/mg protein/min and 52.85 μmol/L, respectively. In addition, the partial purification of C12O was achieved by a HiTrap Q Sepharose column chromatography.

关键词： catechol 1 2-dioxygenase cell extracts characterization Sphingomonas xenophaga

Volatility spillovers,structural breaks and uncertainty in technology sector markets

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Financial Innovation 2023年第1期9卷 2908-2938页

作者： Linn Arnell Emma Engström Gazi salah Uddin mdBokhtiar Hasan Sang Hoon Kang Landshypotek Bank StockholmSweden Department of management and Engineering Linköping UniversityLinköpingSweden Department of Finance and Banking Islamic UniversityKushtia 7003Bangladesh School of Business Pusan National UniversityBusanRepublic of Korea

This study uses the dynamic conditional correlation to investigate how technology subsector stocks interact with financial assets in the face of economic and financial *** results suggest that structural breaks have diverse effects on financial asset connectedness and that the level of bond linkage increases when the trend *** see a growing co-movement between the technology sector and major financial assets when uncertainty is ***,our findings indicate that the connectedness response varies depending on the type of uncertainty shock.

关键词： Technology sector Diversification Dynamic conditional correlation Uncertainty Structural breaks