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The Notch-Hes pathway in mammalian neural development

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Cell Research 1999年第3期9卷 179-188页

作者： KAGEYAMA RYOICHIRO TOSHIYUKI OHTSUKA(Institute for Virus Research, Kyoto University, sakyo-ku,Kyoto 606-8507 Japan) Institute for Virus Research Kyoto University Sakyo-ku Japan

A wide variety of neurons and gIial cells differentiatefrom common precursor cells in the developing nervoussystem. During this process, Notch-mediated cell-cell in-teraction is essential for maintenance of dividing cells andsubsequellt generation of cell type diversity. Activation ofNotch inhibits cellular differentiation, and abnormality ofthe Notch pathway leads to premature neuronal differenti-ation, the lack of some cell types, and severe defects of tis-sue morphogenesis. Recent data demonstrate that Notchfails to inhibit cellular differentiation in the absence of thebHLH genes Hes1 and He5, which functionally afitago-nize the neuronal bHLH genes such as theh1- These re-sults indicate that the two Hes genes are essential effecorsfor the Notch pathway and that neuronal differentiation iscontrolled by the pathway "Notch-+He1/Hs5,Mish1".

关键词： bHLH Hes lateral inhibition neuron Notch

Effects of excitation frequency on detection accuracy of orthogonal wavelet decomposition for structural health monitoring

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Earthquake Engineering and Engineering Vibration 2004年第1期3卷 101-106页

作者： Raul J.Alonso Mohammad Noori Soheil Saadat Arata MasudaDepartment of Mechanical and System Engineering Kyoto Institute of Technology Matsugasaki sakyo-ku Mechanical Engineering & Eleetro Optical Systems-MS 368 1362 Brass Mill Road Department of Mechanical & Aerospace Engineering North Carolina State University

Accurate estimation of stiffness loss is a challenging problem in structural health *** this studyorthogonal wavelet decomposition is used for identifying the stiffness loss in a single degree of freedom *** effects of excitation frequency on accuracy of damage detection is *** show that pseudo-aliaseffects caused by the orthogonal wavelet decomposition(OWD),affect damage *** is demonstrated that theproposed approach is sunable for damage detection when the excitation frequency is relatively *** study shows how apriori knowledge about the signal and ability to control the sampling frequency can enhance damage detectability.

关键词： wavelet analysis damage detection structural health monitoring

Genetic Algorithms Development for MultiobjectiveDesign Optimization of Compressor Cascade

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Journal of Thermal Science 1999年第3期8卷 158-165页

作者： Jun LI(Venture Laboratory, Graduate School, Kyoto institute of Technology, Matsugasaki, sakyo-ku, Kyoto606-8585, Japan)Koji Morinishi Nobuyuki Satofuka(Department of Mechanical and System Engineering, Kyoto Institute of Technology, Matsugasaki,sakyo-ku, Venture Laboratory Graduate School Kyoto Institute of Technology Kyoto Japan Department of Mechanical and System Engineering Kyoto Institute of Technology Kyoto Japan

INTRODUCTIONTurbomaChinery,especiallycompressorcascade,******... 详细信息

INTRODUCTIONTurbomaChinery,especiallycompressorcascade,******...

关键词：空气压缩机优化设计遗传算法

Micro-Raman Spectroscopy for Stress Evaluation of 3C-SiC Epitaxially Grown on Si Substrate by Hot Wall CVD

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材料热处理学报 2004年第5B期25卷 803-806页

作者： ZHUWen-liang ZHUJi-liang PEZZOTTIGiuseppe CeramicPhysicsLaboratory＆ResearchInstituteforNanoscience RINKyotoInstituteofTechnologySakyo-kuMatsugasaki606-8585KyotoJapan DepartmentofElectronicsandInformationScience KyotoInstituteofTechnologySakyo-kuMatsugasaki606-8585KyotoJapan

A series of cubic SiC single crystals were heteroepitaxially grown by the hot-wall chemical vapor deposition (CVD) using a HMDS-C3H8-H2 system on 2 inch silicon substrates with the orientations of (100), (111), (110) and (211), respectively. Even though an initial carbonization was carried out to reduce the large lattice mismatch, residual stress could not be completely relieved, partly also due to the difference of their thermal expansion coefficients. Raman scattering studies for the specimens were performed to estimate the internal stress in the SiC epilayer and the substrate. Raman spectra were mapped out on the sample surface as well as on the cross section using an automated x-y stage with a spatial resolution capable of 100 nm. For all the samples, two Raman peaks corresponding to the transverse optical (TO) and longitudinal optical (LO) phonon modes were observed, even though the intensity varied with the polarization configurations. In the SiC epilayers, tensile stresses decrease away from the interface, while compressive stresses exist in the substrate, with the magnitudes dependent on the growth orientation. The lattice strains were discussed in terms of the elastic deformation theory for the comparison.

关键词：显微喇曼光谱学应力测定 3C-SiC 热壁CVD 外延生长

NOVEL X-RAY ANALYSIS METHODS

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NOVEL X-RAY ANALYSIS METHODS

IMPROVEMENT　IN　THE　YIELD　OF　DIMETHYL　ETHER　FROM　SYNTHESIS　GAS　UNDER　CONCENTRATION　PERIODIC　OPERATION

全国第六届X射线荧光光谱学术报告会与X射线光谱分析研讨...

作者： Jun Kawai (Department of Materials Science and Engineering, Kyoto University, sakyo-ku, Kyoto 606-85011 Japan)

＜正＞I will present several X-ray analysis techniques developed, applied, or tested in the present author’s laboratory, as follws. 1. X-ray absorption using electric battery py roelectric X-ray generator. 2. X-ray f...

关键词：

来源： cnki会议评论

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Chinese Journal of Catalysis 1996年第2期17卷 95-96页

作者： Li Jinlu Zhang Xuegong (State Keg Laboratory of C1 Chemical Technology, Tsinghua University, Beijing 100084)Tomoyuki Inui (Division of Energy and Hydrocarbon Chemistry, Graduate School of Engineering,Kyoto University, sakyo-ku, Kyoto 606-01, Japan) State Key Laboratory of C Chemical Technology Tsinghua University Beijing 100084 Division of Energy and Hydrocarbon Chemistry Graduate School of Engineering Kyoto University Sakyo-ku Kyoto 606-01 Japan

ＩＭＰＲＯＶＥＭＥＮＴＩＮＴＨＥＹＩＥＬＤＯＦＤＩＭＥＴＨＹＬＥＴＨＥＲＦＲＯＭＳＹＮＴＨＥＳＩＳＧＡＳＵＮＤＥＲＣＯＮＣＥＮＴＲＡＴＩＯＮＰＥＲＩＯＤＩＣＯＰＥＲＡＴＩＯＮ￥ＬｉＪｉｎｌｕ；ＺｈａｎｇＸｕｅｇｏｎｇ... 详细信息

ＩＭＰＲＯＶＥＭＥＮＴＩＮＴＨＥＹＩＥＬＤＯＦＤＩＭＥＴＨＹＬＥＴＨＥＲＦＲＯＭＳＹＮＴＨＥＳＩＳＧＡＳＵＮＤＥＲＣＯＮＣＥＮＴＲＡＴＩＯＮＰＥＲＩＯＤＩＣＯＰＥＲＡＴＩＯＮ￥ＬｉＪｉｎｌｕ；ＺｈａｎｇＸｕｅｇｏｎｇ（ＳｔａｔｅＫｅｇＬａｂｏｒａｔｏ...

关键词： imethyl ether synthesis gas concentration periodic operation Cu/Zn/Al catalyst

PREPARATION　OF　THE　CATALYST　FOR　DIRECT　SYNTHESIS　OF　DIMETHYL　ETHER　FROM　SYNTHESIS　GAS　BY　BIHYDROLYSIS　PRECIPITATION

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Chinese Journal of Catalysis 1996年第2期17卷 93-94页

作者： Li Jinlu Zhang Xuegong (State Key Laboratory of C1 Chemical Technology, Tsinghua University, Beijing 100084)Tomoyuki Inui (Division of Energy and Hydrocarbon Chemislry, Graduate School of Engineering,Kyoto University, sakyo-ku, Kyoto 606-01, Japan) State Key Laboratory of C Chemical Technology Tsinghua University Beijing 100084 Division of Energy and Hydrocarbon Chemistry Graduate School of Engineering Kyoto University Sakyo-ku Kyoto 606-01 Japan

ＰＲＥＰＡＲＡＴＩＯＮＯＦＴＨＥＣＡＴＡＬＹＳＴＦＯＲＤＩＲＥＣＴＳＹＮＴＨＥＳＩＳＯＦＤＩＭＥＴＨＹＬＥＴＨＥＲＦＲＯＭＳＹＮＴＨＥＳＩＳＧＡＳＢＹＢＩＨＹＤＲＯＬＹＳＩＳＰＲＥＣＩＰＩＴＡＴＩＯＮ￥ＬｉＪｉｎｌｕ... 详细信息

ＰＲＥＰＡＲＡＴＩＯＮＯＦＴＨＥＣＡＴＡＬＹＳＴＦＯＲＤＩＲＥＣＴＳＹＮＴＨＥＳＩＳＯＦＤＩＭＥＴＨＹＬＥＴＨＥＲＦＲＯＭＳＹＮＴＨＥＳＩＳＧＡＳＢＹＢＩＨＹＤＲＯＬＹＳＩＳＰＲＥＣＩＰＩＴＡＴＩＯＮ￥ＬｉＪｉｎｌｕ；ＺｈａｎｇＸｕｅｇｏｎｇ（Ｓｔａ...

关键词： dimethyl ether synthesis gas Cu/Zn/Al catalyst bihydrolysisprecipitation

EPIGENETIC NATURE OF RADIATION CARCINOGENESIS AT LOW DOSES

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Chinese Medical Journal 1994年第6期 7-12页

作者： T. Sugahara and M. WatanabeHealth Research Foundation. Pasteur Building 5F. 103-5 Tanaka Monzencho. sakyo-ku. Kyoto 606. JapanFaculty of Pharmaceutical Sciences. Nagasaki University. 1-14 Bunkyo-machi, Nagasaki 852, Japan

The present paradigm of radiation-induced carcinogenesis has been based on somatic mutation theory initiating a mutation in somatic cells derived from DNA damage by ionizing radiation. A non-threshold linear model has been assumed from high doses to low doses. As an alternative to this, we are proposing a new model that epigenetic changes induced by low dose irradiation may be a first step of carcinogenesis. Our preliminary data suggesting the epigenetic nature and reports on various stress response to ionizing radiation are presented.

关键词： In AT EPIGENETIC NATURE OF RADIATION CARCINOGENESIS AT LOW DOSES Res

Support Operator’s Fault Diagnosis of Complex Plant Systemthrough Multilevel Flow Model and Ecological Interface Design

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Engineering Sciences 2005年第4期 61-69页

作者： OuYang Jun~1, Yang Ming~2, Hidekazu Yoshikawa~1, Zhou Yangping~1, Liu Jingquan~1(1.Graduate School of Energy Science, Japan Kyoto University, Yoshida Hon-machi, sakyo-ku, Japan Kyoto 606-8501 2. Power and Nuclear Engineering College of Harbin Engineering University, Harbin 150001)

The paper describes a new human-interface system design method by combining the conception of Multilevel Flow Model and Ecological Interface Design to support operators' fault diagnosis in the complex plant system. Modern man-made systems are always achieving many complex automatic and intelligent tasks so that they are becoming more and more complex and can be hardly understood by operators, who should be the primary role in system operating. This situation presents a big challenge to the operating support system that it should present the complex system in a direct and clear way to operators to and make operators understand the internal interaction of the system especially in the abnormal status to ensure the operating safety. The Multilevel Flow Model based on the idea of ”Abstraction Hierarchy”, aiming at decompressing a system by means-end and part-whole way, can be used to represent a complex system in a standard way and perform intelligent operating tasks such as fault diagnosis and process control. Ecological Interface Design, which based on the human cognitive properties, can present the internal interaction of the system in a direct way. This paper combines this two interface design conceptions to achieve two aspects, intelligent fault diagnosis and direct presentation of causal relationship of operating parameters, to support operators' fault diagnosis in complex plant system. The design method is applied to a PWR power plant in this paper as an application example.

关键词： MFM (Multilevel Flow Model) EID (Ecological Interface Design) AH (Abstraction Hierarchy) PWR (Pressurized Water Reactor)