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Cancer Biology & Medicine 2014年第1期11卷 1-19页

作者： Liem Minh Phan sai-ching jim yeung Mong-Hong Lee Department of Molecular and Cellular Oncology Department of General Internal Medicine Ambulatory Treatment and Emergency Care Department of Endocrine Neoplasia and Hormonal Disorders The University of Texas MD Anderson Cancer Center

Cancer cells are well documented to rewire their metabolism and energy production networks to support and enable rapid proliferation, continuous growth, survival in harsh conditions, invasion, metastasis, and resistance to cancer treatments. Since Dr. Otto Warhurg＇s discovery about altered cancer cell metabolism in 1930, thousands of studies have shed light on various aspects of cancer metabolism with a common goal to find new ways for effectively eliminating tumor cells by targeting their energy metabolism. This review highlights the importance of the main features of cancer metabolism, summarizes recent remarkable advances in this field, and points out the potentials to translate these scientific findings into life-saving diagnosis and therapies to help cancer patients.

关键词： Cell cycle energy metabolism glycolysis glutaminolysis mitochondria biogenesis

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Gastrointestinal adverse events associated with immune checkpoint inhibitor therapy

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Gastroenterology Report 2020年第1期8卷 25-30,I0001页

作者： Eva Rajha Patrick Chaftari Mona Kamal Julian Maamari Christopher Chaftari sai-ching jim yeung Department of Emergency Medicine The University of Texas MD Anderson Cancer CenterHoustonTXUSA Schoool of Medicine Lebanese American UniversityByblosLebanon Biomedical Engineering College of EngineeringTexas A&M UniversityCollege StationTXUSA

Immunotherapy with checkpoint inhibitors has revolutionized cancer therapy and is now the standard treatment for several different types of cancer,supported by favorable outcomes and good ***,it is linked to multiple immune manifestations,referred to as immune-related adverse events(irAEs).These adverse events frequently affect the skin,colon,endocrine glands,lungs,and *** gastrointestinal system is one of the most commonly affected organ systems and is responsible for the most frequent emergency visits resulting from ***,because immune checkpoint inhibitors are a recent addition to our arsenal of cancer drugs,many health-care providers remain unfamiliar with the management of *** involved in the treatment of oncology patients who have received checkpoint inhibitors are currently encountering cases of abdominal pain,diarrhea,and other nonspecific symptoms that may be challenging to *** article reviews the gastrointestinal,hepatic,and pancreatic toxicities of checkpoint inhibitors and provides an approach to their diagnosis and recommended *** also highlights the management of irAEs according to their toxicity grading and specifically discusses the instances in which corticosteroids should be administered and/or the immune checkpoint inhibitors should be withheld.

关键词： immune checkpoint inhibitor immune-related adverse events colitis enterocolitis liver toxicity pancreatic toxicity

Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORCl and scavenging ROS

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1907-1919页

作者： Jiao Wu sai-ching jim yeung Sicheng Liu Aiham Qdaisat Dewei Jiang Wenli Liu Zhuo Cheng Wenjing Liu Haixia Wang Lu Li Zhongmei Zhou Rong Liu Chuanyu Yang Ceshi Chen Runxiang Yang Department of the Second Medical Oncology The Third Affiliated Hospital of Kunming Medical UniversityKunmingYunnan ProvinceChina Department of Emergency Medicine The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingChina Department of Palliative Rehabilitation and Integrative MedicineThe University of Texas MD Anderson Cancer CenterHoustonTexasUSA department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdongChina KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingChina Institute of Translation Medicine Shenzhen Second People's HospitalThe First Affiliated Hospital of Shenzhen UniversityShenzhenChina

Weight loss and cachexia are common problems in colorectal cancer patients;thus,parenteral and enteral nutrition support play important roles in cancer ***,the impact of nonessential amino acid components of nutritional intake on cancer progression has not been fully *** this study,we discovered that gastrointestinal cancer patients who received cysteine as part of the parenteral nutrition had shorter overall survival(Pching chemotherapy-induced reactive oxygen species via synthesizing *** demonstrated that dietary deprivation of cystine suppressed colon cancer xenograft growth without weight loss in mice and boosted the antitumor effect of *** findings indicate that cyst(e)ine;as part of supplemental nutrition,plays an important role in colorectal cancer and manipulation of cyst(e)ine content in nutritional formulations may optimize colorectal cancer patient survival.

关键词： colon chemotherapy formulation

Impact of diabetes on promoting the growth of breast cancer

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Cancer Communications 2021年第5期41卷 414-431页

作者： Ping-Chieh Chou Hyun Ho Choi Yizhi Huang Enrique Fuentes-Mattei Guermarie Velazquez-Torres Fanmao Zhang Liem Phan Jaehyuk Lee Yanxia Shi James A.Bankson Yun Wu Huamin Wang Ruiying Zhao sai-ching jim yeung Mong-Hong Lee Department of Molecular and Cellular Oncology the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Disease the Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510020P.R.China Research Institute of Gastroenterology the Sixth Affiliated Hospital of Sun Yat-sen University GuangzhouGuangdong 510020P.R.China Department of Imaging Physics the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Pathology the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Emergency Medicine the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

Background:Type Ⅱ diabetes mellitus(DM2)is a significant risk factor for cancers,including breast ***,a proper diabetic breast cancer mouse model is notwell-established for treatment strategy ***,the precise diabetic signaling pathways that regulate cancer growth remain *** the present study,we established a suitable mouse model and demonstrated the pathogenic role of diabetes on breast cancer ***:We successfully generated a transgenic mouse model of human epidermal growth factor receptor 2 positive(Her2^(+) or ERBB2)breast cancer with DM2 by crossing leptin receptor mutant(Lepr^(db/+))mice with (MMTV-ErbB2/neu)*** administrated with antidiabetic drugs to assess the impacts of controlling DM2 in affecting tumor *** resonance spectroscopic imaging was employed to analyze the tumor ***:Treatment with metformin/rosiglitazone in MMTV-ErbB2/Lepr^(db/db) mousemodel reduced serum insulin levels,prolonged overall survival,decreased cumulative tumor incidence,and inhibited tumor ***-insulin resistance medications also inhibited glycolytic metabolism in tumors in vivo as indicated by the reduced metabolic flux of hyperpolarized ^(13)C pyruvate-to-lactate *** tumor cells from MMTV-ErbB2/Lepr^(db/db) transgenic mice treated with metformin had reprogrammed metabolism by reducing levels of both oxygen consumption and lactate *** decreased the expression of Myc and pyruvate kinase isozyme 2(PKM2),leading to metabolism ***,metformin attenuated the mTOR/AKT signaling pathway and altered adipokine ***:MMTV-ErbB2/Lepr^(db/db) mouse model was able to recapitulate diabetic HER2^(+) human breast ***,our results defined the signaling pathways deregulated in HER2^(+) breast cancer under diabetic condition,which can be intervened by anti-insulin resistance therapy.

关键词： diabetes human epidermal growth factor receptor 2 breast cancer metformin metabolism

线粒体凋亡途径在Manumycin诱导白血病细胞凋亡中的作用研究

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线粒体凋亡途径在Manumycin诱导白血病细胞凋亡中的作用研究

第10届全国实验血液学会议

作者：佘妙容杜欣林伟 sai-ching jim yeung 广东省人民医院血液科广东省人民医院血液科广东省人民医院血液科 MD Anderson Cancer Center Houston

＜正＞目的研究新的信号传导抑制剂法尼酰基转移酶抑制剂（farnesyltransferase inhibitors,FTIs）手霉素（Manumycin）诱导白血病细胞凋亡的作用,并探讨线粒体凋亡途径在Manumycin诱导白血病细胞凋亡的作用。方法采用MTT法观察Manumy...

＜正＞目的研究新的信号传导抑制剂法尼酰基转移酶抑制剂（farnesyltransferase inhibitors,FTIs）手霉素（Manumycin）诱导白血病细胞凋亡的作用,并探讨线粒体凋亡途径在Manumycin诱导白血病细胞凋亡的作用。方法采用MTT法观察Manumycin对急性白血病细胞株HL-60和U937的细胞毒作用,应用Nitric Oxide／Annexin v Dual Sensor dye流式细胞仪测定细胞的凋亡及直接测定细胞内一氧化氮（Nitric oxide,NO）的产生,明确凋亡和NO的关系,并使用N-acetyl-L-cysteine （NAC）阻断NO的产生,进一步明确NO产生和凋亡的关系。用PI染色检测细胞周期,应用Digi-

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糖尿病对促进乳腺癌生长的影响

癌症 2022年第3期41卷 107-124页

作者： Ping-Chieh Chou Hyun Ho Choi Yizhi Huang Enrique Fuentes-Mattei Guermarie Velazquez-Torres Fanmao Zhang Liem Phan Jaehyuk Lee Yanxia Shi James A.Bankson Yun Wu Huamin Wang Ruiying Zhao sai-ching jim yeung Mong-Hong Lee Department of Molecular and Cellular Oncology the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA 结直肠盆底疾病研究重点实验室中山大学第六附属医院广州广东510020 胃肠病学研究所中山大学第六附属医院广州广东510020 Department of Imaging Physics the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA 中山大学肿瘤防治中心肿瘤内科广州广东510060 Department of Pathology the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Emergency Medicine the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

背景与目的2型糖尿病(typeⅡdiabetes mellitus,DM2)是包括乳腺癌在内的多种癌症的危险因素。目前,尚未建立可用于研究的糖尿病乳腺癌小鼠模型。另外,调节癌症生长的糖尿病信号通路也尚未明确。在本研究中,我们建立了一个糖尿病乳腺癌... 详细信息

背景与目的2型糖尿病(typeⅡdiabetes mellitus,DM2)是包括乳腺癌在内的多种癌症的危险因素。目前,尚未建立可用于研究的糖尿病乳腺癌小鼠模型。另外,调节癌症生长的糖尿病信号通路也尚未明确。在本研究中,我们建立了一个糖尿病乳腺癌小鼠模型,并证实了糖尿病在乳腺癌进展中的影响。方法通过将瘦素受体突变(Lepr^(db/+))小鼠和MMTV-ErbB2/neu小鼠杂交,成功构建了人表皮生长因子受体2阳性(human epidermal growth factor receptor 2,Her2^(+)或ERBB2)的乳腺癌转基因小鼠模型。用抗糖尿病药物治疗该小鼠模型来评价治疗DM2对肿瘤生长的影响。用磁共振波谱成像分析肿瘤代谢情况。结果用二甲双胍/罗格列酮治疗MMTV-ErbB2/Lepr^(db/db)小鼠模型可降低血清胰岛素水平,延长生存,降低肿瘤累积发生率,抑制肿瘤进展。超极化^(13)C标记的丙酮酸/乳酸转换代谢流降低,表明抗胰岛素抵抗治疗抑制了体内实验中肿瘤糖酵解。用二甲双胍处理MMTV-ErbB2/Lepr^(db/db)转基因小鼠来源的肿瘤细胞,降低了耗氧量和乳酸产量,使细胞代谢发生了重新编程。二甲双胍可降低Myc和丙酮酸激酶M2型同工酶(pyruvate kinase isozyme 2,PKM2)的表达,引起代谢重编程。另外,二甲双胍可阻断mTOR/AKT信号通路并改变脂肪因子谱。结论MMTV-ErbB2/Lepr^(db/db)转基因小鼠模型可用于糖尿病HER2^(+)人乳腺癌的研究。本研究明确了糖尿病状态下HER2^(+)人乳腺癌中失调的信号通路,该通路可被抗胰岛素抵抗治疗干预。

关键词：糖尿病人表皮生长因子受体2 乳腺癌二甲双胍代谢

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台北艺术中心

城市环境设计 2014年第6期 54-59页

作者： Yannis Chan Hin-yeung Cheung Inge Goudsmit Vincent Kersten Chiaju Lin Kevin Mak jim Dodson Alasdair Graham Vivien Liu Kai Sun Luk Slobodan Radoman Roberto Requejo Saul Smeding Elaine Tsui Viviano Villarreal Casey Wang Leonie Wenz

为什么过去百年间最令人兴奋的剧场盛事总是发生在正规场所之外?建筑如何才能超越自身卑微的命运,摆脱那种限制各种可能的宿命?近年来,世界各地的演艺中心数目渐增,但不知何故,这些演艺中心似乎达成一种共识,呈现出雷同的空间组合:一座... 详细信息

为什么过去百年间最令人兴奋的剧场盛事总是发生在正规场所之外?建筑如何才能超越自身卑微的命运,摆脱那种限制各种可能的宿命?近年来,世界各地的演艺中心数目渐增,但不知何故,这些演艺中心似乎达成一种共识,呈现出雷同的空间组合:一座约2 000席的大型演艺厅和一个1 500席的中型剧院,再加上一个黑盒子剧场。标志性的外形掩饰以典型19世纪做法为基础的

关键词：艺术中心观众剧场文化机构剧院台北台湾

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台北艺术中心

建筑技艺 2012年第4期18卷 100-105页

作者： Yannis Chan Hin-yeung Cheung jim Dodson Inge Goudsmit Alasdair Graham Vincent Kersten Chiaju Lin Vivien Liu Kai Sun Luk Kevin Mak Slobodan Radoman Roberto Requejo Saul Smeding Elaine Tsui Viviano Villarreal Casey Wang Leonie Wenz Frans Parthesius Iwan Baan

正近年来,世界各地的演艺中心数目渐增,但不知何故,这些演艺中心似乎达成一种共识,呈现出雷同的空间组合:一座约2000席的大型演艺厅和一个1500席的中型剧院,再加上一个黑盒子剧场。标志性的外形,饰以典型19世纪做法的保守内部剧场布局,... 详细信息

正近年来,世界各地的演艺中心数目渐增,但不知何故,这些演艺中心似乎达成一种共识,呈现出雷同的空间组合:一座约2000席的大型演艺厅和一个1500席的中型剧院,再加上一个黑盒子剧场。标志性的外形,饰以典型19世纪做法的保守内部剧场布局,以及见证社会阶级观念的包厢。纵然剧院最基本的构造元素如舞台、镜框式剧场和观众席等已有三千多年的历史,但我们仍不应以此为借口,让现代剧场建筑的创新发展停滞不前。

关键词：艺术中心演艺中心创新发展标志性台北空间组合观众席构造元素剧场建筑阶级观念

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