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Subsurface Defect Evaluation of Selective-Laser-Melted Inconel 738LC Alloy Using Eddy Current Testing for Additive/Subtractive Hybrid Manufacturing

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Chinese Journal of Mechanical Engineering 2021年第6期34卷 224-239页

作者： sai guo Guanhui Ren Bi Zhang Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhenGuangdongChina State Key Laboratory of Ultra-precision Machining Technology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityKowloonHong KongChina

New materials and manufacturing technologies require applicable non-destructive techniques for quality assurance so as to achieve better *** study comprehensively investigated the effect of influencing factors includ-ing excitation frequency,lift-off distance,defect depth and size,residual heat,and surface roughness on the defect EC signals of an Inconel 738LC alloy produced by selective laser melting(SLM).The experimental investigations recorded the impedance amplitude and phase angle of EC signals for each defect to explore the feasibility of detecting sub-surface defects by merely analyzing these two key ***,this study revealed preliminary qualitative and roughly quantitative relationships between influencing factors and corresponding EC signals,which provided a prac-tical reference on how to quantitively inspect subsurface defects using eddy current testing(ECT)on SLMed parts,and also made solid progress toward on-line ECT in additive/subtractive hybrid manufacturing(ASHM)for fabricating SLMed parts with enhanced quality and better performance.

关键词： Eddy current testing Subsurface defect Additive/subtractive hybrid manufacturing Selective laser melting Inconel 738LC alloy

Surface Integrity of Ultrasonically-Assisted Milled Ti6Al4V Alloy Manufactured by Selective Laser Melting

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Chinese Journal of Mechanical Engineering 2021年第4期34卷 42-55页

作者： sai guo Wei Du Qinghong Jiang Zhigang Dong Bi Zhang Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055China School of Mechanical Engineering Dalian University of TechnologyDalian 116024China Key Laboratory for Precision and Non-Traditional Machining Technology of Ministry of Education Dalian University of TechnologyDalian 116024China

The Ti6Al4V parts produced by the existing selective laser melting(SLM)are mainly confronted with poor surface finish and inevitable interior defects,which substantially deteriorates the mechanical properties and performances of the *** this regard,ultrasonically-assisted machining(UAM)technique is commonly introduced to improve the machining quality due to its merits in increasing tool life and reducing cutting ***,most of the previous studies focus on the performance of UAM with ultrasonic vibrations applied in the tangential and feed directions,whereas few of them on the impact of ultrasonic vibration along the vertical *** this study,the effects of feed rate on surface integrity in ultrasonically-assisted vertical milling(UAVM)of the Ti6Al4V alloy manufactured by SLM were systemically investigated compared with the conventional machining(CM)*** results revealed that the milling forces in UAVM showed a lower amplitude than that in CM due to the intermittent cutting *** surface roughness values of the parts produced by UAVM were generally greater than that by CM owing to the extra sinusoidal vibration textures induced by the milling ***,the extra vertical ultrasonic vibration in UAVM was beneficial to suppressing machining *** feed rate increased,surface microhardness and thickness of the plastic deformation zone in CM raised due to more intensive plastic deformation,while these two material properties in UAVM were reduced owing to the mitigated impact effect by the high-frequency vibration of the milling ***,the improved surface microhardness and reduced thickness of the subsurface deformation layer in UAVM were ascribed to the vertical high-frequency impact of the milling cutter in *** general,the results of this study provided an in-depth understanding in UAVM of Ti6Al4V parts manufactured by SLM.

关键词： Ultrasonically-assisted vertical milling Surface integrity Ti6Al4V Selective laser melting

The Shortest First Coordination Mechanism for a Scheduling Game with Parallel-Batching Machines

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Journal of the Operations Research Society of China 2016年第4期4卷 517-527页

作者： Qing-Qin Nong sai-Jun guo Li-Hui Miao School of Mathematical Science Ocean University of ChinaQingdao 266100ShandongChina

This paper deals with a scheduling problem with parallel-batching machines from a game theoretic *** are m parallel-batching machines,each of which can handle up to b jobs simultaneously as a *** processing time of a batch is the time required for processing the longest job in the batch,and all the jobs in a batch start and complete at the same *** are n *** job is owned by a rational and selfish *** agent of a job chooses a machine for processing its own *** aim of each agent is to minimize the completion time of its job while the system tries tominimize the maximal completion time over all jobs,the *** design a coordination mechanism for the scheduling game *** discuss the existence of Nash equilibria of the mechanism and showthat it has a price of anarchy 2.

关键词： Scheduling Game Coordination mechanism Nash equilibrium Price of anarchy

Detwmination of Blood Flow in the Lower Leg of Patients withDiabetes Mellitus and the Effects of Treatment with thePrinciple of Vitalizing Blood and Solubilizing Thrombus

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Chinese Journal of Integrative Medicine 1995年第1期1卷 87-90页

作者： guo sai-shan (郭赛珊) Liang Xiao-chun (梁晓春) Yin Feng-hua (殷凤华) Wang Xiang-ding (王香定) (Peking Union Medical College Hospital, Beijing )(100730)guo sai-qi(郭赛琪) (Clinic of China News Press, Beijing) Peking Union Medical College Hospital Beijing Clinic of China News Press Beijing

Blood flow in the lower leg was determined in 50 cases of non-insulin dependent diabetesmellitus using an XLJ-2 bipolar rheoencephalometry impedance rheogram. In patients with leg pain (85legsi and diabetic foat (15 legs3, the blood flow of the lower leg was decreased as compared withhealthy legs (P<0. 01￣0. 001) . The group with diabetic foot showed a bigger decrease compared withthe leg pain group (PMO. 051 . Atter treatment with the principle of vitalizing blood and solubilizing throm-bus, 22 cases with leg pain (32 legs) showed a significant increase of blood flow in the lower leg (P<0. 001). The group with diabetic foot failed to show any significant increase, indicating the importance ofearly treatment. This method of determining blood flow in the lower leg will help early discovery of abnor-mal changes of blood supply in the lower leg. Treatment with the principle of vitalizing blood and solubiliz-ing thrombus can help improve the conditions of the patients.

关键词： blood flow in the lower leg diabetic foot Qi-Yin deficiency with blood stasis deficien-cy of both Yin and Yang with blood stasis

含利妥昔单抗方案治疗晚期套细胞淋巴瘤临床分析

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中国临床研究 2022年第2期35卷 167-171页

作者：单欣郭赛赛丹东市第一医院血液科辽宁丹东118000 大连医科大学辽宁大连116044

目的探讨含利妥昔单抗化疗方案治疗晚期套细胞淋巴瘤(MCL)患者临床疗效及预后。方法回顾性分析2011年7月至2021年7月丹东市第一医院收治的42例晚期MCL患者的临床资料,化疗方案中均包括利妥昔单抗。采用MCL国际预后指数(MIPI)评估患者预... 详细信息

目的探讨含利妥昔单抗化疗方案治疗晚期套细胞淋巴瘤(MCL)患者临床疗效及预后。方法回顾性分析2011年7月至2021年7月丹东市第一医院收治的42例晚期MCL患者的临床资料,化疗方案中均包括利妥昔单抗。采用MCL国际预后指数(MIPI)评估患者预后,ECOG评分评估患者功能状态,评估治疗疗效、疾病控制率(DCR)、客观缓解率(ORR)及不良反应发生率,采用Kaplan-Meier法评估无进展生存期(PFS)及总生存期(OS),应用Cox回归对筛选的临床特征、分子病理、治疗反应以及预后因素进行分析。结果42例患者中位发病年龄为70岁,其中男性31例、女性11例。27例接受利妥昔单抗联合CHOP方案化疗,6例接受利妥昔单抗联合苯达莫斯汀方案化疗,9例接受利妥昔单抗联合伊布替尼方案化疗。42例晚期MCL的客观缓解率为42.8%,疾病控制率为61.9%,中位OS为63个月(95%CI:50.030~75.930),中位PFS为18个月(95%CI:6.645~29.355)。皮疹和间质性肺炎为最常见的不良反应。结论晚期MCL患者应用含利妥昔单抗方案治疗具有较好的近期疗效,不良反应可耐受。利妥昔单抗联合苯达莫斯汀联合治疗可获得更高的疾病缓解率。

关键词：套细胞淋巴瘤利妥昔单抗苯达莫斯汀伊布替尼生存时间

CDK抑制剂夫拉平度抗冠状病毒作用机制研究

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药学学报 2024年第5期59卷 1280-1285页

作者：王丽丹郭赛赛岑山中国医学科学院、北京协和医学院医药生物技术研究所北京100050

冠状病毒属冠状病毒包含多种人类致病病毒,抗冠状病毒药物研发具有重要价值。开发靶向宿主细胞的抗病毒药物不仅有助于发展新的抗病毒策略,同时有利于解决病毒突变而带来的耐药性等问题。本课题组前期研究发现,细胞周期依赖性蛋白激酶(c... 详细信息

冠状病毒属冠状病毒包含多种人类致病病毒,抗冠状病毒药物研发具有重要价值。开发靶向宿主细胞的抗病毒药物不仅有助于发展新的抗病毒策略,同时有利于解决病毒突变而带来的耐药性等问题。本课题组前期研究发现,细胞周期依赖性蛋白激酶(cell cycle-dependent protein kinases,CDKs)参与冠状病毒的复制,成为潜在的抗病毒靶点。本研究发现广谱CDK抑制剂夫拉平度显著抑制严重急性呼吸系统综合征冠状病毒2 (severe acute respiratory syndrome coronavirus 2,SARS-CoV-2) RNA依赖性RNA聚合酶(RNA dependent RNA polymerase,RdRp)活性。进一步研究表明,夫拉平度抑制SARS-CoV-2 RdRp的RNA合成效率。此外,夫拉平度能够有效抑制人类冠状病毒OC43 (human coronavirus OC43,HCoV-OC43)的复制。本研究表明,CDK抑制剂夫拉平度可能是潜在的抗冠状病毒药物。

关键词：夫拉平度 CDK抑制剂冠状病毒抗病毒 RNA依赖性RNA聚合酶

环境保护税与黄河流域高质量发展——基于环保“费改税”的准自然实验

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税收经济研究 2023年第2期28卷 26-35页

作者：陈冲郭赛兰州财经大学财税与公共管理学院

文章利用2014—2020年黄河流域9省区101个地级市面板数据,构造强度双重差分模型,实证检验环境保护税与黄河流域高质量发展之间的关系。结果表明,环境保护税开征显著推动了黄河流域高质量发展,并且在考虑其他影响因素后结果仍然成立。具... 详细信息

文章利用2014—2020年黄河流域9省区101个地级市面板数据,构造强度双重差分模型,实证检验环境保护税与黄河流域高质量发展之间的关系。结果表明,环境保护税开征显著推动了黄河流域高质量发展,并且在考虑其他影响因素后结果仍然成立。具体到高质量发展的各个分维度指标,该政策对创新发展、协调发展与开放发展的影响积极显著,对绿色发展的影响还未显著体现,对共享发展具有负面影响。异质性分析发现:环境保护税对推动黄河流域下游地区的高质量发展作用最强,中游地区次之,上游地区最弱;对大、中、小型城市高质量发展的推动作用依次递减。

关键词：环境保护税费改税黄河流域高质量发展

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中西医结合治疗糖尿病的优势

中国中西医结合杂志 2005年第6期25卷 565-569页

作者：郭赛珊屈岭中国医学科学院中国协和医科大学北京协和医院北京100730

中西医结合治疗糖尿病的优势是多方面的,其中最主要的、也是最根本的是提高了临床疗效。已有许多学者从整体、细胞、亚细胞及分子水平中西医有机结合进行了临床研究,说明在控制高血糖、改善临床症状、改善胰岛素抵抗、治疗糖耐量低减、... 详细信息

中西医结合治疗糖尿病的优势是多方面的,其中最主要的、也是最根本的是提高了临床疗效。已有许多学者从整体、细胞、亚细胞及分子水平中西医有机结合进行了临床研究,说明在控制高血糖、改善临床症状、改善胰岛素抵抗、治疗糖耐量低减、恢复胰岛β细胞功能、治疗高糖高脂血症及糖尿病并发症等方面,中西医结合治疗优于单用西药和单用中药治疗,展示了独特的优势。本文就近10年来有关的文献报道进行了综述。

关键词：中西医结合治疗胰岛β细胞功能糖尿病并发症胰岛素抵抗糖耐量低减临床疗效临床研究有机结合分子水平临床症状高脂血症中药治疗单用西药文献报道亚细胞高血糖

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遗传算法求解多旅行商问题的相对解空间分析

智能系统学报 2018年第5期13卷 760-768页

作者：赵新超郭赛北京邮电大学理学院北京100876

首先介绍了多旅行商问题的模型,并指出遗传算法解决多旅行商问题的关键是染色体编码方案的设计,为了减少冗余解带来的代价,本文给出了传统的两种染色体编码方案(单染色体和双染色体),以及最新的两段式染色体编码方案;接着引入相对解空... 详细信息

首先介绍了多旅行商问题的模型,并指出遗传算法解决多旅行商问题的关键是染色体编码方案的设计,为了减少冗余解带来的代价,本文给出了传统的两种染色体编码方案(单染色体和双染色体),以及最新的两段式染色体编码方案;接着引入相对解空间概念,以此定量地给出不同染色体方案对应解空间的相对大小关系;基于相对解空间概念,本文分析了3种染色体编码方案对应的解空间在极限意义下的相对大小关系,并分析了旅行商数与城市数在不同情形下解空间的近似相对大小关系。本文对搜索空间定量分析的理论结果对工程问题的求解提供了科学的指导意义。

关键词：多旅行商问题遗传算法染色体编码相对解空间 Stirling公式