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Biomedical and Environmental Sciences 2021年第8期34卷 637-640页

作者： sahla belhadj Manel Gargouri Giulia Guerriero Olfa Hentati UFR Sciences University of BourgogneBoulevard Gabriel21000DijonFrance Laboratoire Génie de l'Environnement et Ecotechnologie(GEET-LR16ES19 Ecole Nationale d'Ingénieurs de Sfax(ENIS)Universitéde SfaxRoute de SoukraSfaxTunisie Institute of Technology University of BrestBrestFrance Department of Biology University of Naples FedericoⅡComplesso Universitario di Monte S.AngeloNaplesItaly Interdepartmental Research Center for Environment University of Naples FedericoⅡNaplesItaly Institut Supérieur de Biotechnologie de Sfax Universitéde SfaxRoute de SoukraSfaxTunisie

Diabetes mellitus(DM),the 10th leading cause of death worldwide,is a major and growing public health problem estimated to affect more than 578 million people in 2030 and 700 million people in 2045[1].In diabetic animals,protein glycation and glucose autoxidation generate free radicals,which cause lipid ***,reactive oxygen species(ROS)can quickly accumulate,decrease antioxidant activity,and cause deterioration of kidney and liver function.A disrupted redox balance in cells also damages crucial biomolecules such as deoxyribonucleic acid(DNA),proteins and *** stress(OS)is elevated in diabetes mellitus and may be a major factor in the development and evolution of the typical long-term pathophysiology of diabetes and its associated complications[2].

关键词： Antioxidant peroxidation elevated

A review of existing strategies for designing long-acting parenteral formulations: Focus on underlying mechanisms, and future perspectives

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Acta Pharmaceutica Sinica B 2021年第8期11卷 2396-2415页

作者： Yujie Shi An Lu Xiangyu Wang Zakia belhadj Jiancheng Wang Qiang Zhang Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems School of Pharmaceutical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China

The need for long-term treatments of chronic diseases has motivated the widespread development of long-acting parenteral formulations(LAPFs)with the aim of improving drug pharmacokinetics and therapeutic *** have been proven to extend the half-life of therapeutics,as well as to improve patient adherence;consequently,this enhances the outcome of therapy *** past decades,considerable progress has been made in designing effective LAPFs in both preclinical and clinical *** we review the latest advances of LAPFs in preclinical and clinical stages,focusing on the strategies and underlying mechanisms for achieving long *** strategies are classified into manipulation of in vivo clearance and manipulation of drug release from delivery systems,*** the current challenges and prospects of each strategy are *** addition,we also briefly discuss the design principles of LAPFs and provide future perspectives of the rational design of more effective LAPFs for their further clinical translation.

关键词： Long-acting Chemical modification Fc/HSA fusion Biomimetic strategies Hydrogels Nanocrystal suspensions Microneedles Implantable systems

Electrochemical behavior and analytical detection of Imidacloprid insecticide on a BDD electrode using square-wave voltammetric method

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Chinese Chemical Letters 2016年第5期27卷 666-672页

作者： Mabrouk Ben Brahim Hafedh belhadj Ammar Ridha Abdelhedi Youssef Samet Electrochemistry and Environmental Laboratory Department of Materials Engineering National Engineering School of Sfax University of Sfax B.P. I 1733038 Sfax Tunisia

A sensitive square-wave voltammetric method for the determination of lmidacloprid （IMD） was developed using electrochemically pretreated boron-doped diamond （BDD） electrode. Aqueous solutions were prepared with Confidor 200 SL as the commercial formulation of IMD. Sodium sulfate （Na2SO4） was used as supporting electrolyte. The influence of operating parameters, such as the pH of the medium, frequency, pulse amplitude, scan increment and the concentration of IMD was investigated. An irreversible cathodic peak, corresponding to the reduction oflMD is observed at 1.21 V （vs. SCE） and the electrode reaction was controlled by adsorption. Under optimized conditions, the square-wave reduction peak current was linear over the concentration range of （30-200 μmol L 1） with a detection and quantification limits of 8.60 μmol L 1 and 28.67 μmol L 1, respectively. The results were compared with spectrophotometry and HPLC methods under some conditions and found to be in good agreement. To investigate applicability to real samples, the proposed method was applied to the determination of IMD in plum juice.

关键词： Imidacloprid Square-wave volammetry Boron-doped diamond electrode Electrochemical detection

Bioactive hydrogels for bone regeneration

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Bioactive Materials 2018年第4期3卷 401-417页

作者： Xin Bai Mingzhu Gao sahla Syed Jerry Zhuang Xiaoyang Xu Xue-Qing Zhang Engineering Research Center of Cell&Therapeutic Antibody Ministry of EducationSchool of PharmacyShanghai Jiao Tong University800 Dongchuan RoadShanghai200240P.R.China Department of Chemical and Materials Engineering New Jersey Institute of TechnologyNewarkNJ07102USA

Bone self-healing is limited and generally requires external intervention to augment bone repair and *** traditional methods for repairing bone defects such as autografts,allografts,and xenografts have been widely used,they all have corresponding disadvantages,thus limiting their clinical *** the development of a variety of biomaterials,including metal implants,calcium phosphate cements(CPC),hydroxyapatite,etc.,the desired therapeutic effect is not fully ***,polymeric scaffolds,particularly hydrogels,are of interest and their unique configurations and tunable physicochemical properties have been extensively *** review will focus on the applications of various cutting-edge bioactive hydrogels systems in bone regeneration,as well as their advantages and *** will examine the composition and defects of the bone,discuss the current biomaterials for bone regeneration,and classify recently developed polymeric materials for hydrogel *** will also elaborate on the properties of desirable hydrogels as well as the fabrication techniques and different delivery ***,the existing challenges,considerations,and the future prospective of hydrogels in bone regeneration will be outlined.

关键词： Bone regeneration Hydrogel Biomaterials Tissue engineering

A two variable refined plate theory for the bending analysis of functionally graded plates

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Acta Mechanica Sinica 2010年第6期26卷 941-949页

作者： Ismail Mechab Hassen Ait Atmane Abdlouahed Tounsi Hichem Abdesselem belhadj EI Abbas Adda Bedia Laboratoire des Materiaux et Hydrologie Universite de Sidi Bel AbbesBP 89 Cite Ben M'hidi22000 Sidi Bel AbbesAlgerie Departement de genie civil Faculte des Sciences de l'IngenieurUniversite Hassiba Benbouali de ChlefChlefAlgerie

Bending analysis of functionally graded plates using the two variable refined plate theory is presented in this *** number of unknown functions involved is reduced to merely four,as against five in other shear deformation theories. The variationally consistent theory presented here has, in many respects,strong similarity to the classical plate theory. It does not require shear correction factors,and gives rise to such transverse shear stress variation that the transverse shear stresses vary parabolically across the thickness and satisfy shear stress free surface *** properties of the plate are assumed to be graded in the thickness direction with their distributions following a simple power-law in terms of the volume fractions of the *** equations are derived from the principle of virtual displacements, and a closed-form solution is found for a simply supported rectangular plate subjected to sinusoidal loading by using the Navier *** results obtained by the present theory are compared with available solutions,from which it can be concluded that the proposed theory is accurate and simple in analyzing the static bending behavior of functionally graded plates.

关键词： FG plates Shear deformation theory Refined plate theory Higher-order theory Navier solution

PD-1 induction through TCR activation is partially regulated by endogenous TGF-β

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Cellular & Molecular Immunology 2015年第5期12卷 648-649页

作者： Raja Rekik Nadia belhadj Hmida Ahlem Ben Hmid Imen Zamali ns Kammoun Melika Ben Ahmed Laboratory of Transmission Control and Immunobiology of Infection Institut Pasteur de Tunis Tunis Tunisia Laboratory of Clinical Immunology Institut Pasteur de Tunis Tunis Tunisia Faculte de Medecine de Tunis Universite Tunis El Manar Tunis Tunisia

The programmed death 1 （PD-1） pathway is a way of inhibiting T-cell proliferation and cytokine production. This pathway is important for maintaining peripheral tolerance. Different mechanisms and cytokines are involved in this pathway. Herein, we show the contribution of endogenous TGF-β to increasing PD-1 expression after T cell receptor （TCR） activation.

关键词： TGF-β 内源性 TCR 诱导活化细胞因子 T细胞增殖 T细胞受体

Finite Step Conjugate Gradients Methods for the Solution of an Impedance Operator Equation Arising in Electromagnetics

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Journal of Electromagnetic Analysis and Applications 2011年第10期3卷 416-422页

作者： Haifa belhadj Taoufik Aguili 不详

A class of finite step iterative methods, conjugate gradients, for the solution of an operator equation, is presented on this paper to solve electromagnetic scattering. The method of generalized equivalent circuit is used to model the problem and then deduce an electromagnetic equation based on the impedance operator. Four versions of the conjugate gradient method are presented and numerical results for an iris structure are given, to illustrate convergence properties of each version. Computational efficiency of these methods has been compared to the moment method.

关键词： Conjugate Gradient method Generalized Equivalent Circuit Method MoM Electromagnetic Computational Scattering

China-Maghreb relations Challenges and opportunities

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China-Maghreb relations Challenges and opportunities

作者： Imen belhadj Center for African Studies School of International StudiesPeking University

China’s engagement in Africa is sometimes wrongly perceived as a new form of’colonialism’in the African *** driving force of China’s engagement in Africa and in the Ivlaghreb region was ideological ***,China is promoting more pragmatic relations with Maghreb and other African ***’s African Policy aims to enhance cooperation with Africa based on five

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阿尔及尔多式联运公共交通系统模式选择研究

阿尔及尔多式联运公共交通系统模式选择研究

作者： belhadj Benziane Noureddine 北京交通大学

学位级别：硕士

随着阿尔及尔城市的快速发展,出行需求不断增加,且更加多元化。最近,阿尔及利亚政府推出了一个新的交通项目,将地铁和有轨电车系统作为整个可持续交通战略的关键部分。这个交通战略是基于允许限制集团领土的运输网络制定的。此外,交通... 详细信息

随着阿尔及尔城市的快速发展,出行需求不断增加,且更加多元化。最近,阿尔及利亚政府推出了一个新的交通项目,将地铁和有轨电车系统作为整个可持续交通战略的关键部分。这个交通战略是基于允许限制集团领土的运输网络制定的。此外,交通网络内部模式是地铁,有轨电车和通勤列车等不同的运输方式集成在一个网络中:以便能响应旅行需求的多样化。现在,通过阿尔及尔的多交通方式,旅客在一天内进行活动有多种选择。在这一章节中,对阿尔及尔的多交通方式进行调查,组织对能够代表阿尔及利亚所有人口类别的样本进行调查此外,基于多项logit模型的分析框架确定了使用的运输模式和最优的运输模式。此外,社会经济统计变量和旅行模式通过多元线性回归模型影响先前影响先前确定的质量维度。最后,本研究结果有助于理解阿尔及尔多交通方式的模式选择.

关键词：多模态调查地铁电车轨道通勤列车机动性多项式logit

Sol-Gel Processed Indium-Doped Zinc Oxide Thin Films and Their Electrical and Optical Properties

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New Journal of Glass and Ceramics 2014年第4期4卷 55-65页

作者： Radhouane Bel-Hadj-Tahar Abdellatif belhadj Mohamed Department of Chemistry Faculty of Science King Khalid University Abha KSA Photovoltaic Laboratory Research and Technology Center of Energy Borj-Cedria Science and Technology Park Hammem-Lif Tunisia

Transparent conducting films of zinc oxide and indium-doped zinc oxide have been prepared by a simple and economical sol-gel technique. This process is feasible for the fabrication of high quality TCO thin films when the processing parameters are optimized. It was found that the out-diffusion of oxygen during the vacuum annealing step was a crucial factor to prepare thin layer with superior properties. Annealing lowers the resistivity down to 4.7 10-3?Ω·cm for the 1 at.% doped films due to the liberation of high-valency In-dopants and the enhanced film density. At high indium concentrations, the free electron density stabilizes because an increasing number of dopant atoms form some kinds of neutral defects. The neutralized indium atoms do not contribute free electrons. The feasibility to deposit highly transparent ZnO thin films has been demonstrated.

关键词： Zinc Oxide Doping Electro-Optical Properties Sol-Gel