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Modulatory effects of diallyl sulfide against testosteroneinduced oxidative stress in Swiss albino mice

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Asian Journal of Andrology 2006年第6期8卷 719-723页

作者： sahdeo prasad neetu kalra yogeshwer shukla Environmental Carcinogenesis Division Industrial Toxicology Research CentreLucknow 226001India

Aim： To investigate the protective effect of diallyl sulfide （DAS）, a constituent of garlic, against testosterone-induced oxidative stress in male Swiss albino mice. Methods： The animals were given low （250 mg/animal） and high dose （500 mg/animal） of DAS in corn oil for 7 days along with testosterone （5 mg/kg body weight, i.p.）. At the end of the study period, the prostate and the liver were dissected to determine various antioxidant enzyme levels （catalase, superoxide dismutase, glutathione reductase, glutathione-s-transferase） and lipid peroxidation. Results： In testosterone treated mice, depleted antioxidant enzyme level was accompanied with enhancement in lipid peroxidation in prostate and liver. DAS significantly restored the testosterone-induced antioxidant enzymes and lipid peroxidation in the both organs. These changes appear to be mediated by the antioxidant-enhancing effects of DAS. Conclusion： The results of the present study suggest that DAS is effective in exerting antioxidant effects by inhibiting testosterone-induced oxidative stress and might be helpful in preventing prostate cancer.

关键词： oxidative stress antioxidants lipid peroxidation diallyl sulfide testosterone

Can we predict the incidence of high-grade Clavien-Dindo complications in patients with forgotten encrusted stents undergoing endourologic management?

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Asian Journal of Urology 2024年第1期11卷 99-104页

作者： Praanjal Gupta Ramanitharan Manikandan Lalgudi Narayanan Dorairajan Kodakattil Sreenivasan Sreerag Sidhartha kalra Swapnil singh Kushwaha Department of Urology Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherryIndia

Objective:Ureteral stents are customarily inserted to facilitate urinary drainage,but they come with their own glitches of being forgotten and/or encrusted leading to serious *** present study aimed to report the complications in patients with forgotten and encrusted stents according to the Clavien-Dindo system specific to urological procedures and identify the factors leading to high-grade(Clavien-Dindo Grade 4A or above)***:The hospital records of patients with forgotten encrusted double-J stents over a period of 8 years were *** parameters recorded included patient demographics,indwelling time,need for percutaneous nephrostomy,hemodialysis,urine culture,blood culture,total blood counts,serum creatinine,radiologic findings,management techniques,number of surgical interventions,modified Clavien-Dindo complications,follow-up,and mortality,if ***:Forty patients were included in the *** median age was 52(range 6-85)*** the total,25(62.5%)patients had a“significant”stent load;31(77.5%)had renal failure or acute kidney injury on presentation;19(47.5%)patients had sepsis at *** the patients presented with sepsis,11(57.9%)patients demonstrated a positive urine culture;and 7/11(63.6%)patients exhibited pan-resistant *** out of 40(30.0%)patients in our series developed high-grade Clavien-Dindo *** univariate analysis,sepsis at presentation(p=0.007),stent load(p=0.031),diabetes(p=0.023),positive urine culture(p=0.007),and stent indwelling time of more than 1 year(p=0.031)were found to be *** multivariate logistic regression analysis,sepsis at presentation(p=0.017)and positive urine culture(p=0.016)were significant predictors for high-grade ***:It is prudent to identify specific risk factors,namely sepsis at presentation and positive urine culture to triage and optimize these patients before surgical management.

关键词： Forgotten Encrusted stent Outcome Predictor Clavien-Dindo complication

Engaging the spikes: heparan sulfate facilitates SARS-CoV-2 spike protein binding to ACE2 and potentiates viral infection

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Signal Transduction and Targeted Therapy 2021年第2期6卷 211-212页

作者： Rajkumar singh kalra Ramesh Kandimalla IST-INDIA DAILAB National Institute of Advanced Industrial Science&Technology(AIST)Higashi 1-1-1TsukubaJapan Applied Biology CSIR-Indian Institute of Chemical Technology(IICT)Uppal RoadTarnakaHyderabadTelangana StateIndia Department of Biochemistry Kakatiya Medical CollegeWarangalTelangana 506004India

In a recent report published in Cell,Clausen et al.1 reveal that heparan sulfate(HS)functions as a necessary cofactor for SARSCoV-2 binding to the ACE2 at the host cell *** analysis identified that HS interacts with the receptor-binding domain(RBD)at the SI subunit of the SARS-CoV-2 trimeric S-protein,which facilitates the opening of S-protein conformation for ACE2 binding.

关键词： ACE2 al. infection

Driving Style Recognition System Using Smartphone Sensors Based on Fuzzy Logic

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Computers, Materials & Continua 2021年第11期69卷 1967-1978页

作者： Nidhi kalra Raman Kumar Goyal Anshu Parashar Jaskirat singh Gagan Singla Department of Computer Science and Engineering Thapar Institute of Engineering and TechnologyPatiala147001PunjabIndia Computer Science and Engineering University Institute of Engineering and TechnologyPanjab University160014ChandigarhIndia

Every 24 seconds,someone dies on the road due to road accidents and it is the 8th leading cause of death and the first among children aged 15–29 years.1.35 million people globally die every year due to road traffic *** additional 20–50 million suffer from non-fatal injuries,often resulting in longterm *** costs around 3%of Gross Domestic Product to most countries,and it is a considerable economic *** governments have taken various measures such as better road infrastructures and strict enforcement of motor-vehicle laws to reduce these ***,there is still no remarkable reduction in the number of *** ensure driver safety and achieve vision of zero accidents,there is a great need to monitor drivers’driving *** of the existing driving behavior monitoring solutions are based on expensive hardware *** most people are using smartphones in the modern era,a system based on mobile application is proposed,which can reduce the cost for developing intelligent transport systems(ITS)to a large *** this paper,we utilize the accelerometer sensor data and the global positioning system(GPS)sensor deployed in smartphones to recognize driving and speeding events.A driving style recognition system based on fuzzy logic is designed to classify different driving styles and control reckless driving by taking the longitudinal/lateral acceleration and speed as input ***,the proposed system uses fuzzy logic rather than taking the crisp values of the *** indicate that the proposed system can classify reckless driving based on fuzzy logic and,therefore,reduce the number of accidents.

关键词： Fuzzy logic accelerometer global positioning system driving style

Obtaining Crisp Priorities for Triangular and Trapezoidal Fuzzy Judgments

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Computer Systems Science & Engineering 2022年第4期41卷 157-170页

作者： Raman Kumar Goyal Jaskirat singh Nidhi kalra Anshu Parashar Gagan Singla Sakshi Kaushal Computer Science and Engineering Department Thapar Institute of Engineering and TechnologyPatialaPunjabIndia Computer Science and Engineering University Institute of Engineering and TechnologyPanjab UniversityChandigarhIndia

This paper proposes anoptimal fuzzy-based model for obtaining crisp priorities for Fuzzy-AHP comparison *** judgments cannot be given for real-life situations,as most of these include some level of fuzziness and *** these situations,judgments are represented by the set of fuzzy *** of the fuzzy optimization models derive crisp priorities for judgments repre-sented with Triangular Fuzzy Numbers(TFNs)*** do not work for other types of Triangular Shaped Fuzzy Numbers(TSFNs)and Trapezoidal Fuzzy Numbers(TrFNs).To overcome this problem,a sum of squared error(SSE)based optimization model is *** some other methods,the proposed model derives crisp weights from all of the above-mentioned fuzzy judgments.A fuzzy number is simulated using the Monte Carlo method.A threshold-based constraint is also applied to minimize the deviation from the initial *** Algorithm(GA)is used to solve the optimization *** have also conducted casestudiesto show the proposed approach’s advantages over the *** show that the proposed model outperforms other models to minimize SSE and deviation from initial ***,the proposed model can be applied in various real time scenarios as it can reduce the SSE value upto 29%compared to the existing studies.

关键词： Analytic hierarchy process comparison matrices priority vectors fuzzy judgments triangular fuzzy numbers triangular-shaped fuzzy numbers trapezoidal fuzzy numbers

Oral cysticercosis-a rare presentation

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Asian Pacific Journal of Tropical Medicine 2011年第7期4卷 587-588页

作者： singh Sunita Chhabra Sonia Aggarwal Garima kalra Rajnish Duhan Amrita Sen Rajeev Department of Pathology Pt.B.D.Sharma PGIMSRohtakIndia

Cysticercosis is a condition that occurs when man is infected with larvae of Taenia *** cysticercosis is a rare event,and it represenls difficulty in clinical diagnosis.A case of oral cysticercosis in 11 year old girl is presented which complained of painless swelling for 6 months. A FNAC was performed which revealed bluish pink fibrillary material and interspersed nuclei and fragments of wall of *** was treated with antihelminthic.

关键词： Oral cysticercosis Taenia solium Cysticercus celiuiosae

Imaging-based algorithmic approach to gallbladder wall thickening

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World Journal of Gastroenterology 2020年第40期26卷 6163-6181页

作者： Pankaj Gupta Yashi Marodia Akash Bansal Naveen kalra Praveen Kumar-M Vishal Sharma Usha Dutta Manavjit singh Sandhu Department of Radiodiagnosis and Imaging Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Pharmacology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India

Gallbladder(GB) wall thickening is a frequent finding caused by a spectrum of conditions. It is observed in many extracholecystic as well as intrinsic GB conditions. GB wall thickening can either be diffuse or focal. Diffuse wall thickening is a secondary occurrence in both extrinsic and intrinsic pathologies of GB, whereas, focal wall thickening is mostly associated with intrinsic GB pathologies. In the absence of specific clinical features, accurate etiological diagnosis can be challenging. The survival rate in GB carcinoma(GBC) can be improved if it is diagnosed at an early stage, especially when the tumor is confined to the wall. The pattern of wall thickening in GBC is often confused with benign diseases, especially chronic cholecystitis, xanthogranulomatous cholecystitis, and adenomyomatosis. Early recognition and differentiation of these conditions can improve the prognosis. In this minireview, the authors describe the patterns of abnormalities on various imaging modalities(conventional as well as advanced) for the diagnosis of GB wall thickening. This paper also illustrates an algorithmic approach for the etiological diagnosis of GB wall thickening and suggests a formatted reporting for GB wall abnormalities.

关键词： Gallbladder diseases Cholecystitis Rokitansky-Aschoff sinuses of the gallbladder Xanthogranulomatous cholecystitis Neoplasms Acute cholecystitis

Association of NFKB1 gene polymorphism (rs28362491) with levels of inflammatory biomarkers and susceptibility to diabetic nephropathy in Asian Indians

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World Journal of Diabetes 2017年第2期8卷 66-73页

作者： Amar Gautam Stuti Gupta Mohit Mehndiratta Mohini Sharma Kalpana singh Om P kalra Sunil Agarwal Jasvinder K Gambhir Department of Medicine University College of Medical Sciences (University of Delhi) and G.T.B. Hospital Molecular Diagnostic Laboratory Department of Biochemistry University College of Medical Sciences (University of Delhi) and G.T.B. Hospital

AIM To investigate the association of NFKB1 gene-94 ATTG insertion/deletion(rs28362491) polymorphism with inflammatory markers and risk of diabetic nephropathy in Asian *** A total of 300 subjects were recruited(100 each), normoglycemic,(NG); type 2 diabetes mellitus(T2DM) without any complications(DM) and T2 DM with diabetic nephropathy [DM-chronic renal disease(CRD)]. Analysis was carried out by polymerase chain reaction-restriction fragment length polymorphism and ELISA. Pearson's correlation, analysis of variance and logistic regression wereused for statistical *** The allelic frequencies of-94 ATTG insertion/deletion were 0.655/0.345(NG), 0.62/0.38(DM) and 0.775/0.225(DM-CRD). The-94 ATTG ins allele was associated with significantly increased levels of urinary monocyte chemoattractant protein-1(u MCP-1); u MCP-1(P = 0.026) and plasma tumor necrosis factor-alpha(TNF-α); TNF-α(P = 0.030) and almost doubled the risk of diabetic nephropathy(OR = 1.91, 95%CI: 1.080-3.386, P = 0.025).CONCLUSION-94 ATTG ins/ins polymorphism might be associated with increased risk of developing nephropathy in Asian Indian subjects with diabetes mellitus.

关键词： Diabetic nephropathy Inflammation NFKB1 -94 ATTG ins/del polymorphism Urinary monocyte chemoattractant protein-1 Tumor necrosis factor-alpha

Assessment of Right Ventricular Function in Post Operative Patients of Tetralogy of Fallots and Its Predictive Factors

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World Journal of Cardiovascular Surgery 2014年第8期4卷 139-150页

作者： Rana Sandeep singh Rajat kalra Rohit Manoj Kumar Nidhi Rawal Harkant singh Reena Das Department of Cardiothoracic Surgery & Cardiology Postgraduate Institute of Medical Education and Research Chandigarh India

Introduction: Right ventricular (RV) dysfunction can occur early and late in patients after intracardiac repair (ICR) for Tetralogy of Fallots (TOF). This study focuses on early RV dysfunction as there is limited data on it. Aims & Objective: RV function was studied with respect to its incidence, course over 3 months, co-relation with peri operative factors and serum iron levels. Material & Method: All patients of TOF undergoing ICR during July 2007-October 2008, done by single surgeon at a single centre, were prospectively studied. Patients were divided into group A (with RV dysfunction) and group B (without RV dysfunction). All patients underwent pre operative & post operative clinical assessment, biochemical evaluation (serum iron profile & CK MB) and 2D echocardiography (pulse Doppler & tissue Doppler). Echocardiography was done at 24 hours, 4 weeks & 12 weeks of ICR. Patients were also assessed for intra operative parameters including cross clamp time, by pass time, acidosis, RV and PA pressures. Results: 24 patients underwent ICR (transannular patch repair) with mean age of 7.31 ± 4.74 years. RV dysfunction was present in 13 patients (54.2%) but was persistent only in 15.3% (2/13) at 12 weeks. Presence of cyanotic spell (p = 0.006), recurrent chest infection (p = 0.002), raised heamatocrit (p = 0.02), and rise in serum iron level (p = 0.002) were significantly associated with post operative RV dysfunction. It resulted in prolong ICU stay and slower recovery. Pre operative RV dysfunction was associated with difficult weaning from bypass and poor post operative outcome (p < 0.001). Conclusion: RV dysfunction is commonly present even after satisfactory ICR. Its aetiology remains unclear in such setting. In our study, pre operative clinical profile and serum iron fluctuations were important determinants of post operative outcome.

关键词： Tetralogy of Fallot Early RV Dysfunction Predictive Factors