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A passive,reusable,and resonating wearable sensing system for ondemand,non-invasive,and wireless molecular stress biomarker detection

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Nano Research 2024年第8期17卷 7542-7556页

作者： Shingirirai Chakoma Xiaochang Pei Huiting Qin Anita Ghandehari sahar NajafiKhoshnoo Jerome Rajendran Rahim Esfandyarpour department of Electrical Engineering and Computer Science University of CaliforniaIrvineCA 92697USA Laboratory for Integrated Nano BioElectronics Innovation The Henry Samueli School of EngineeringUniversity of CaliforniaIrvineCA 92697USA Henry Samueli School of Engineering University of CaliforniaIrvineCA 92697USA

The significant impact of stress on health necessitates accurate assessment methods,where traditional questionnaires lack reliability and *** advancements like wearables with electrocardiogram(ECG)and galvanic skin response(GSR)sensors face accuracy and artifact *** biosensors detecting cortisol,a critical stress hormone,present a promising ***,existing cortisol assays,requiring saliva,urine,or blood,are complex,expensive,and unsuitable for continuous *** study introduces a passive,molecularly imprinted polymer-radio-frequency(mIP-RF)wearable sensing system for real-time,non-invasive sweat cortisol *** system is wireless,flexible,battery-free,reusable,environmentally stable,and designed for long-term monitoring,using an inductance-capacitance *** transducer translates cortisol concentrations into resonant frequency shifts with high sensitivity(~160 kHz/(log(μm)))across a physiological range of 0.025–1μ*** with near-field communication(NFC)for wireless and battery-free operation,and threedimensional(3d)-printed microfluidic channel for in-situ sweat collection,it enables daily activity cortisol level *** of cortisol circadian rhythm through morning and evening measurements demonstrates its effectiveness in tracking and monitoring sweat cortisol levels.A 28-day stability test and the use of cost-effective 3d nanomaterials printing enhance its economic viability and *** innovation paves the way for a new era in realistic,on-demand health monitoring outside the laboratory,leveraging wearable technology for molecular stress biomarker detection.

关键词： cortisol wearable flexible sensors three-dimensional(3d)nanomaterials printing reusable environmentally stable

Effect of probiotics on pro-inflammatory cytokines and NF-κB activation in ulcerative colitis

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World Journal of Gastroenterology 2010年第33期16卷 4145-4151页

作者： sahar K Hegazy mohamed m El-Bedewy department of Clinical Pharmacy Faculty of PharmacyTanta University Internal medicine Faculty of MedicineTanta University

AIm:To demonstrate the therapeutic effect of probiotics in patients with ulcerative colitis(UC),and their effect on inflammatory mediators and nuclear factor(NF)κB activation in these ***:Thirty patients with mild to moderate UC were randomly classified into two groups:sulfasalazine group,who received sulfasalazine 2400 mg/d;and probiotic group,who received sulfasalazine 2400 mg/d with *** patients were investigated before and after 8 wk of treatment with probiotic(Lactobacillus delbruekii and Lactobacillus fermentum).Colonic activity of myeloperoxidase(mPO)was assayed with UV spectrophotometry,the colonic content of interleukin(IL)-6 was determined by enzyme-linked immunosorbent assay(ELISA),fecal calprotectin was determined by ELISA,and expression of NF-κB p65 and tumor necrosis factor (TNF)-αproteins in colonic tissue was identified by immunohistochemistry and reverse transcription polymerase chain reaction,***:At the start of the study,colonic mucosal injury and inflammation were demonstrated in UC patients by hematoxylin and eosin staining,and an increase in colonic mPO activity,fecal calprotectin,and expression of colonic TNF-αand NF-κB p65 *** use of probiotic for 8 wk significantly ameliorated the inflammation by decreasing the colonic concentration of IL-6,expression of TNF-αand NF-κB p65,leukocyte recruitment,as demonstrated by a decrease in colonic mPO activity,and the level of fecal calprotectin compared to sulfasalazine group and the control group(Pmentation with probiotics could be helpful in maintaining remission and preventing relapse of UC.

关键词： Ulcerative colitis Probiotics Interleukin-6 Nuclear factor-κB

dielectric Function of Silicon Nanoclusters: Role of Hydrogen

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Chinese Physics Letters 2011年第9期28卷 241-244页

作者： SIB KRISHNA Ghoshal m.R.sahar m.S.Rohani Advanced Optical material Research Group Department of PhysicsFaculty of ScienceUniversiti Teknologi Malaysia81310 UTM SkudaiJohorMalaysia

Electronic and optical properties of small silicon quantum dots having 3 to 44 atoms per dot with and without surface passivation are investigated by computer simulation using the pseudo-potential *** empirical pseudo-potential hamiltonian,a plane-wave basis expansion and a basic tetrahedral structure with undistorted local bonding configurations are *** structures of the quantum dots are relaxed and optimized before and after hydrogen *** is found that the gap increases more for a hydrogenated surface than the unpassivated ***,both quantum confinement and surface passivation determine the optical and electronic properties of Si quantum *** luminescence is probably due to the radiative recombination of electrons and holes in the quantum-confined *** effect of passivation of the surface dangling bonds by hydrogen atoms and the role of surface states on the gap energy is also *** results for the density of states,the dielectric function,the frequency dependent optical absorption cross section,the extinction coefficient and the static dielectric constants of the size are *** importance of the confinement and the role of surface passivation on the optical effects are discussed.

关键词： quantum dielectric extinction

Synthesis and characterization of lithium niobium borate glasses containing neodymium

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Journal of Rare Earths 2016年第12期34卷 1199-1205页

作者： W.H.A.Kamaruddin m.S.Rohani m.R.sahar LIU Hong SANG Yuanhua AOmRG Lab Physics Department Faculty of Science Universiti Teknologi Malaysia State Key Laboratory of Crystal materials Shandong University

A series of（90–x）Li2B4O7-10Nb2O5-xNd2O3 glass samples（x=0, 5 mol.%, 10 mol.%, 15 mol.%, 20 mol.% and 25 mol.%） were synthesized using melt quenching technique. X-ray diffraction（XRd）, differential thermal analyzer（dTA）, Fourier transformed infrared（FTIR）, ultraviolet-visible-near-infrared（UV-Vis-NIR） spectrometer and photoluminescence（PL） spectroscopic characterizations were made to examine the influence of Nd3＋ concentration on the physical, structural and optical properties. Various physical properties such as glasses density, molar volume, thermal stability, ion concentration, polar on radius, inter-nuclear distance, field strength, cut-off wavelength, energy band gap and Urbach energy were calculated. The samples were amorphous in nature and confirmed from XRd pattern. The FTIR spectra revealed the presence of BO3 and BO4 functional groups. UV-Vis-NIR spectra exhibited nine prominent bands centered at 353, 430, 475, 524, 583, 681, 745, 803, 875 nm corresponding to the transitions from the ground state to ^4d（3/2）, ^2P（1/2）, ^2G（9/2）, ^4G（7/2）, ^4G（5/2）, ^4F（9/2）, ^4F（7/2）, ^4F（5/2）, ^4F（3/2） excited states, respectively. moreover, the emission spectra at 355 nm excitation displayed three peaks centered at 903 nm（^4F（3/2）→^4I（9/2））, 1059 nm（^4F（3/2）→^4I（11/2）） and 1333 nm（^4F（3/2）→^4I（13/2））, respectively. Fluorescence lifetime was recorded between 53.69 to 28.43 μs. It was found that varying concentration of Nd^（3＋） ions strongly affected the physical, structural and optical properties of the glass samples.

关键词： borate glass neodymium optical properties band gap luminescence rare earths

Characteristics of escape mutations from occult hepatitis B virus infected patients with hematological malignancies in South Egypt

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World Journal of Hepatology 2017年第9期9卷 477-486页

作者： Abeer Elkady Sayuki Iijima sahar Aboulfotuh Elsayed mostafa Ali douaa Sayed Nashwa m Abdel-Aziz Amany m Ali Shuko murakami masanori Isogawa Yasuhito Tanaka department of Clinical and Chemical Pathology Medical School of South Valley University department of Virology and Liver Unit Nagoya City University Graduate School of Medical Sciences department of Clinical and Chemica Pathology Medical School of Sohag University department of medical Oncology Medical School of Sohag University department of Clinical and Chemical Pathology South Egypt Cancer Institute department of medical Oncology South Egypt Cancer Institue

AIm To investigate the prevalence and virological characteristics of occult hepatitis B virus(HBV) infections in patients with hematological malignancies in South *** Serum samples were collected from 165 patients with hematological malignancies to monitor titers of HBV dNA, hepatitis B surface antigen(HBs Ag), and antibodies to HBV core(anti-HBc) and surface antigens. Serum samples negative for HBs Ag and positive for anti-HBc were subjected to nucleic acid extraction and HBV dNA detection by real-time polymerase chain reaction. dNA sequences spanning the S region were analyzed in cases with occult HBV infection. In vitro comparative study of constructed 1.24-fold wild type and S protein mutant HBV genotype d clones was further performed. RESULTS HBV dNA was detected in 23(42.6%) of 54 patients with hematological malignancies who were HBsA g negative, but anti-HBc positive, suggesting the presence of occult HBV infection. The complete HBV genome was retrieved from 6 occult HBV patients, and P120 T and S143 L were detected in 3 and 2 cases, respectively. Site directed mutagenesis was done to produce 1.24-fold genotype d clones with amino acid mutations T120 and L143. The in vitro analyses revealed that a lower level of extracellular HBsA g was detected by chemiluminescence enzyme immunoassay(CLEIA) with the clone containing T120 mutation, compared with the wild type or the clone with S143 L mutation despite the similar levels of extracellular and intracellular HBs Ag detected by Western blot. Southern blot experiments showed that the levels of intracellular HBV dNA were not different between these clones. CONCLUSION Occult HBV infection is common in patients with hematological malignancies and associated with P120 T and S143 L mutations. 120 T mutation impairs the detection of HBsA g by CLEIA.

关键词： Occult hepatitis B infection Hematological malignancies Escape mutation

On the mHd squeeze flow between two parallel disks with suction or injection via ham and HPm

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Frontiers of mechanical Engineering 2014年第3期9卷 270-280页

作者： d. d. GANJI m. ABBASI J. RAHImI m. GHOLAmI I. RAHImIPETROUdI department of mechanical Engineering Babol University of Technology Babol Iran department of mechanical Engineering Sari Branch Islamic AzadUniversity Sari Iran department of Electrical and Computer Engineering Babol Universityof Technology Babol Iran department of mechanical Engineering College of Mechanic TehranScience and Research Branch Islamic Azad University Darnavand Iran

An analysis has been performed to study the problem of magneto-hydrodynamic （mHd） squeeze flow of an electrically conducting fluid between two infinite, parallel disks. The analytical methods called Homotopy Analysis method （ham） and Homotopy Perturbation method （HPm） have been used to solve nonlinear differential equations. It has been attempted to show the capabilities and wide-range applications of the proposed methods in comparison with a type of numerical analysis as Boundary Value Problem （BVP） in solving this problem. Also, the velocity fields have been computed and shown graphically for various values of physical parameters. The objective of the present work is to investigate the effect of squeeze Reynolds number, Hartmann number and the suction/injection parameter on the velocity field. Furthermore, the results reveal that ham and HPm are very effective and convenient.

关键词： Homotopy Analysis method Homotopy Perturbation method incompressible flow magneto-hydrodynamic flow parallel disks

multi-redox phenazine/non-oxidized graphene/cellulose nanohybrids as ultrathick cathodes for high-energy organic batteries

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Nano Research 2021年第5期14卷 1382-1389页

作者： Youngjin ham Vitalii Ri Jin Kim Yeoheung Yoon Jinho Lee Kisuk Kang Ki-Seok An Chunjoong Kim Seokwoo Jeon department of materials Science and Engineering Advanced Battery CenterKorea Advanced Institute of Science and Technology(KAIST)Daejeon34141Republic of Korea department of materials Science and Engineering Chungnam National UniversityDaejeon34134Republic of Korea Thin Film materials Research Center Korea Research Institute of Chemical Technology(KRICT)Daejeon34114Republic of Korea department of materials Science and Engineering Seoul National UniversitySeoul08826Republic of Korea

Various redox-active organic molecules can serve as ideal electrode materials to realize sustainable energy storage systems. Yet, to be more appropriate for practical use, considerable architectural engineering of an ultrathick, high-loaded organic electrode with reliable electrochemical performance is of crucial importance. Here, by utilizing the synergetic effect of the non-covalent functionalization of highly conductive non-oxidized graphene flakes (NOGFs) and introduction of mechanically robust cellulose nanofiber (CNF)-intermingled structure, a very thick (≈ 1 mm), freestanding organic nanohybrid electrode which ensures the superiority in cycle stability and areal capacity is reported. The well-developed ion/electron pathways throughout the entire thickness and the enhanced kinetics of electrochemical reactions in the ultrathick 5,10-dihydro-5,10-dimethylphenazine/NOGF/CNF (dmPZ-NC) cathodes lead to the high areal energy of 9.4 mWh·cm−2 (= 864 Wh·kg−1 at 158 W·kg−1). This novel ultrathick electrode architecture provides a general platform for the development of the high-performance organic battery electrodes.

关键词： energy storage organic electrodes batteries graphene cellulose nanofibers

重症监护病人脑电数据的自动聚类分析（英文）

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西北大学学报（自然科学版） 2018年第1期48卷 6-9页

作者： Jin Jing Emile d′angremonta Senan Ebrahim mohammad Ghassemi Eric Rosenthal sahar Zafar m.Brandon Westover 哈佛医学院/麻省总医院神经内科美国波士顿02114 乌得勒支大学理学院荷兰乌得勒支80125 麻省理工学院理学院美国波士顿02114

癫痫性发作、持续状态及痫样节律性活动是常见的病理性脑部放电状态,通常会在急性脑损伤患者的脑电图(EEG)中表现出来。完成此类病理性波形的有效标记,是进一步诊断与治疗相关疾病的重要前提。为辅助神经内科专家对不同病理波形进行快... 详细信息

癫痫性发作、持续状态及痫样节律性活动是常见的病理性脑部放电状态,通常会在急性脑损伤患者的脑电图(EEG)中表现出来。完成此类病理性波形的有效标记,是进一步诊断与治疗相关疾病的重要前提。为辅助神经内科专家对不同病理波形进行快速标记,文中提出了一种全新的辅助检测标记系统。该系统分别采用特征提取、PCA降维和LE映射可视化等技术,实现EEG中同质模式簇的自动检测。所提方法对哈佛医学院/麻省总医院中10例ICU患者的长时程连续脑电图进行了系统分析。数值实验结果表明,海量脑电数据能够被有效地自动聚类为多种ICU典型标准波形,而且仅通过观测类中心及若干同类成员就能够达到有效标记的目标。同时,LE可视化结果也进一步证实了"发作间期-发作期"连续统假设是成立的。

关键词：聚类重症监护脑电图发作 “发作间期-发作期”连续统假设评分者间统一度

Fundamental principles and development of proximity-field nanopatterning toward advanced 3d nanofabrication

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Nano Research 2021年第9期14卷 2965-2980页

作者： Sang-Hyeon Nam Gayea Hyun donghwi Cho Seonggon Han Gwangmin Bae Haomin Chen Kisun Kim Youngjin ham Junyong Park Seokwoo Jeon department of materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea department of mechanical and Aerospace Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina School of materials Science and Engineering Kumoh National Institute of TechnologyGumiGyeongbuk 39177Republic of Korea department of Energy Engineering Convergence Kumoh National Institute of TechnologyGumiGyeongbuk 39177Republic of Korea KAIST Institute for NanoCentury(KINC) KAISTDaejeon 34141Republic of Korea

Three-dimensional(3d)nanoarchitectures have offered unprecedented material performances in diverse applications like energy storages,catalysts,electronic,mechanical,and photonic *** outstanding performances are attributed to unusual material properties at the nanoscale,enormous surface areas,a geometrical uniqueness,and comparable feature sizes with optical *** the practical use of the unusual nanoscale properties,there have been developments for macroscale fabrications of the 3d nanoarchitectures with process areas over centimeter *** the many fabrication methods for 3d structures at the nanoscale,proximity-field nanopatterning(PnP)is one of the promising techniques that generates 3d optical holographic images and transforms them into material structures through a lithographic *** conformal and transparent phase masks as a key factor,the PnP process has advantages in terms of stability,uniformity,and reproducibility for 3d nanostructures with periods from 300 nm to several *** merits of realizing precise 3d features with sub-100 nm and rapid processes are attributed to the interference of coherent light diffracted by phase *** this review,to report the overall progress of PnP from 2003,we present a comprehensive understanding of PnP,including its brief history,the fundamental principles,symmetry control of 3d nanoarchitectures,material issues for the phase masks,and the process area expansion to the wafer-scale for the target ***,technical challenges and prospects are discussed for further development and practical applications of the PnP technique.

关键词： proximity-field nanopatterning three-dimensional(3d)nanostructures phase mask interference lithography